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Hepatic steatosis is associated with dysregulated cholesterol metabolism and altered protein acetylation dynamics in chickens

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Journal of Animal Science and Biotechnology 2024年第1期15卷 53-67页

作者： Xiaoli Guo Qianqian Zhou Jiaming Jin Fangren Lan Chaoliang Wen Junying Li Ning Yang Congjiao sun National Engineering Laboratory for Animal Breeding and Key Laboratory of Animal Genetics Breeding and ReproductionMinistry of Agriculture and Rural AffairsChina Agricultural UniversityBeijing 100193China

Background Hepatic steatosis is a prevalent manifestation of fatty liver, that has detrimental effect on the health and productivity of laying hens, resulting in economic losses to the poultry industry. Here, we aimed to systematically investigate the genetic regulatory mechanisms of hepatic steatosis in laying *** Ninety individuals with the most prominent characteristics were selected from 686 laying hens according to the accumulation of lipid droplets in the liver, and were graded into three groups, including the control, mild hepatic steatosis and severe hepatic steatosis groups. A combination of transcriptome, proteome, acetylome and lipidome analyses, along with bioinformatics analysis were used to screen the key biological processes, modifications and lipids associated with hepatic *** The rationality of the hepatic steatosis grouping was verified through liver biochemical assays and RNA-seq. Hepatic steatosis was characterized by increased lipid deposition and multiple metabolic abnormalities. Integration of proteome and acetylome revealed that differentially expressed proteins(DEPs) interacted with differentially acetylated proteins(DAPs) and were involved in maintaining the metabolic balance in the liver. Acetylation alterations mainly occurred in the progression from mild to severe hepatic steatosis, i.e., the enzymes in the fatty acid oxidation and bile acid synthesis pathways were significantly less acetylated in severe hepatic steatosis group than that in mild group(P < 0.05). Lipidomics detected a variety of sphingolipids(SPs) and glycerophospholipids(GPs) were negatively correlated with hepatic steatosis(r ≤-0.5, P < 0.05). Furthermore, the severity of hepatic steatosis was associated with a decrease in cholesterol and bile acid synthesis and an increase in exogenous cholesterol *** In addition to acquiring a global and thorough picture of hepatic steatosis in laying hens, we were able to reveal the role of ac

关键词： Acetylation Cholesterol metabolism Hepatic steatosis Laying hens Multiomics

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基于离散小波变换的桥梁结构损伤识别方法

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天津城建大学学报 2016年第2期22卷 113-118页

作者：林贝贝毛毳孙良天津城建大学天津300384 天津大学天津300192

基于小波子带信号的能量曲率变化损伤识别方法,运用ANSYS软件对一简支梁桥在冲击激力下振动响应信号进行数值分析,采用离散小波变换,根据响应信号相对能量的曲率差损伤指标,对具有两处损伤的结构进行损伤位置识别定位.结果表明,在一定... 详细信息

基于小波子带信号的能量曲率变化损伤识别方法,运用ANSYS软件对一简支梁桥在冲击激力下振动响应信号进行数值分析,采用离散小波变换,根据响应信号相对能量的曲率差损伤指标,对具有两处损伤的结构进行损伤位置识别定位.结果表明,在一定条件下,该识别方法识别损伤简单有效,但损伤位置间距对识别效果有一定影响.

关键词：损伤离散小波变换能量曲率 ANSYS 简支梁损伤识别

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Design and Cryogenic Performance of a Hexapod Platform for a Large Ground-based Wide Field Survey Telescope

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Research in Astronomy and Astrophysics 2024年第1期24卷 178-187页

作者： Yang Yu Xue-Wen Wang Yu Zhang Jia-Lin sun Zhen-Bang Xu Jian-Li Wang Changchun Institute of Optics Fine Mechanics and PhysicsChinese Academy of SciencesChangchun 130033China Chinese Academy of Sciences Key Laboratory of On-orbit Manufacturing and Integration for Space Optics System Changchun 130033China University of Chinese Academy of Sciences Beijing 100049China

The thermal gradient is an important factor that causes degradation to the image quality of telescopes. In order to ensure the accurate alignment of the primary focus unit and the primary mirror, the hexapod platform(as a corrector) is investigated in this paper. First, a ground-based telescope with 2.5 m aperture and 3.5 deg field of view is described. The telescope is under construction, and it is expected to be finished in 2023. Second, the hexapod platform with flexure hinges utilized to adjust the primary focus unit is proposed, which is applied as a ***, the inverse kinematics of the platform is established and an open-loop control system is built based on ***, the cryogenic performance test for the hexapod platform is performed. The experimental results show that the resolution and repeatability of the translation for the hexapod platform can be achieved at the micrometer *** resolution and repeatability of the rotation can be achieved at the arc-second level. Therefore, the cryogenic performance of the hexapod platform can meet the optical imaging requirements of the wide-field ground-based telescope. The kinematic analysis and cryogenic performance tests in the paper provide a technical reference for the precise alignment of the primary focus unit and the primary mirror, which can improve the imaging quality of the telescope.

关键词： methods:miscellaneous space vehicles:instruments telescopes miscellaneous

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普通高校成人高等教育功利化的再探讨

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成人教育 2022年第10期42卷 15-21页

作者：赵彬孙焕良钟乐欧阳中万湖南农业大学继续教育学院长沙410128

成人高等教育“功利化”是其利益相关者急功近利、追名逐利的名利思想与不当行为,有悖于成人高等教育“公益性”的初衷,是成人高等教育持续、协调与健康发展的精神枷锁与行为桎梏。根据文献研究与实证研究相结合的方式,提出成人高等教... 详细信息

成人高等教育“功利化”是其利益相关者急功近利、追名逐利的名利思想与不当行为,有悖于成人高等教育“公益性”的初衷,是成人高等教育持续、协调与健康发展的精神枷锁与行为桎梏。根据文献研究与实证研究相结合的方式,提出成人高等教育功利化是什么、成人高等教育为什么功利化、怎样去成人高等教育功利化的思路,对成人高等教育功利化问题进行再探讨,以促使成人高等教育重返教书育人的本真与公益事业的初心。

关键词：成人高等教育功利化内涵表征归因矫治

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喷射混凝土液体速凝剂研究现状

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隧道建设 2017年第5期37卷 543-552页

作者：杨力远田俊涛杨艺博孙良郑州大学材料科学与工程学院河南郑州450052 思研建材科技有限公司河南郑州450052 南安普顿大学土木工程学院

概述了国内外液体速凝剂的发展现状,按主要促凝组分把液体速凝剂分为4大类:水玻璃型、铝酸钠(钾)型、硫酸铝型和无硫无碱型液体速凝剂,针对每类液体速凝剂,分别从制备、性能特点和促凝机制研究3个方面对其国内外研究进展和最新成果进行... 详细信息

概述了国内外液体速凝剂的发展现状,按主要促凝组分把液体速凝剂分为4大类:水玻璃型、铝酸钠(钾)型、硫酸铝型和无硫无碱型液体速凝剂,针对每类液体速凝剂,分别从制备、性能特点和促凝机制研究3个方面对其国内外研究进展和最新成果进行了阐述。指出目前液体速凝剂尤其是无碱液体速凝剂在掺量、价格、储存稳定性和安全环保等几个方面存在的问题,并提出了今后液体速凝剂研究方向。

关键词：液体速凝剂喷射混凝土水玻璃铝酸钠硫酸铝促凝机制

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交叉增益型波长转换器的参数优化

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中国激光 2001年第2期28卷 183-185页

作者：张新亮孙军强刘德明黄德修华中科技大学光电子工程系武汉430074

在考虑放大自发辐射消耗载流子的前提下 ,运用放大器的分段模型和传输矩阵方法 ,理论分析了交叉增益(XGM)型波长转换器应用于通信系统中的误码率特性。基于误码率特性的分析 ,对波长转换器中放大器有源腔长度和内部损耗、转换波长间隔... 详细信息

在考虑放大自发辐射消耗载流子的前提下 ,运用放大器的分段模型和传输矩阵方法 ,理论分析了交叉增益(XGM)型波长转换器应用于通信系统中的误码率特性。基于误码率特性的分析 ,对波长转换器中放大器有源腔长度和内部损耗、转换波长间隔、探测功率和平均抽运功率等参数进行了优化。

关键词：交叉增益型波长转换器误码率参数优化光电子器件

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Flux Balance Analysis Reveals Potential Anti-HIV-1 Metabolic Targets

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Infectious Diseases & Immunity 2024年第2期4卷 61-68页

作者： Runpeng Han Fei Luo Haisheng Yu Yajun Yan Yan Gong Conghua Xie liang Cheng Department of Radiation and Medical Oncology Medical Research InstituteZhongnan Hospital of Wuhan UniversityWuhan UniversityWuhan 430071China Frontier Science Center for Immunology and Metabolism Zhongnan Hospital of Wuhan UniversityState Key Laboratory of VirologyWuhan UniversityWuhan 430071China Guangzhou Eighth People's Hospital Guangzhou Medical UniversityGuangzhou 510440China Department of Infectious Diseases Zhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Biological Repositories Zhongnan Hospital of Wuhan UniversityWuhan 430071China Wuhan Research Center for Infectious Diseases and Cancer Chinese Academy of Medical SciencesWuhan 430071China

Background:Human immunodeficiency virus type 1(HIV-1)remains a persistent global health ***,a continuous exploration of novel therapeutic strategies is essential.A comprehensive understanding of how HIV-1 utilizes the cellular metabolism machinery for replication can provide insights into new therapeutic ***:In this study,we performed a flux balance analysis using a genome-scale metabolic model(GEM)integrated with an HIV-1 viral biomass objective function to identify potential targets for anti–HIV-1 *** generated a GEM by integrating an HIV-1 production reaction into CD4+T cells and optimized for both host and virus optimal states as objective functions to depict metabolic profiles of cells in the status for optimal host biomass maintenance or for optimal HIV-1 virion *** analysis was used to predict biochemical reactions altered optimal for HIV-1 *** addition,we conducted in silico simulations involving gene and reaction knock-outs to identify potential anti–HIV-1 targets,which were subsequently validated by human phytohemagglutinin(PHA)blasts infected with ***:Differential analysis identified several altered biochemical reactions,including increased lysine uptake and oxidative phosphorylation(OXPHOS)activities in the virus optima compared with the host *** silico gene and reaction knock-out simulations revealed de novo pyrimidine synthesis,and OXPHOS could serve as potential anti–HIV-1 metabolic *** vitro assay confirmed that targeting OXPHOS using metformin could suppress the replication of HIV-1 by 56.6%(385.4±67.5 pg/mL in the metformintreated group vs.888.4±32.3 pg/mL in the control group,P<0.001).Conclusion:Our integrated host-virus genome-scale metabolic study provides insights on potential targets(OXPHOS)for anti-HIV therapies.

关键词： HIV-1 Flux balance analysis Genome-scale metabolic models Viral biomass objective function Therapeutic target

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计及电热综合需求响应的综合能源系统优化调度

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电测与仪表 2022年第9期59卷 16-22页

作者：林佳兴孙亮李佳雯陈立东东北电力大学电气工程学院吉林吉林132012 国网天津电力公司蓟州供电分公司天津301900

综合能源系统能够提高系统运行的灵活性,提高对大规模风光等可再生能源的消纳。文章针对电热负荷的可调度性提出了一种考虑调度人员参与下的电热综合需求响应模型。对可时移电负荷的群聚合特性进行建模,以调度信号与负荷群聚合特性模型... 详细信息

综合能源系统能够提高系统运行的灵活性,提高对大规模风光等可再生能源的消纳。文章针对电热负荷的可调度性提出了一种考虑调度人员参与下的电热综合需求响应模型。对可时移电负荷的群聚合特性进行建模,以调度信号与负荷群聚合特性模型的偏差值最小为目标函数。再根据人体对温度的感知具有模糊性这一特点构建了热负荷调度模型。算例结果表明,考虑调度人员期望信号的综合需求响应提高了新能源的消纳且降低了系统的运行成本,更大程度上减轻了各机组频繁调节出力的压力以及抵偿新能源出力的变动。

关键词：调度信号群聚合综合能源系统电热综合需求响应优化调度

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平行光管发散角对多角度偏振成像仪几何定标精度的影响及校正方法

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光学学报 2021年第24期41卷 63-70页

作者：向光峰孟炳寰黄禅李双许孙龙李扬韩琳孙亮骆冬根洪津中国科学院合肥物质科学研究院安徽光学精密机械研究所安徽合肥230031 中国科学技术大学安徽合肥230026 中国科学院通用光学定标与表征技术重点实验室安徽合肥230031

为提高多角度偏振成像仪(DPC)的实验室几何定标精度,分析了平行光管发散角对像点定位精度的影响,建立了误差模型,并通过改进几何模型参数拟合时的目标方程来校正像点定位误差。对比验证实验结果表明,所提方法提升了基于平行光管的几何... 详细信息

为提高多角度偏振成像仪(DPC)的实验室几何定标精度,分析了平行光管发散角对像点定位精度的影响,建立了误差模型,并通过改进几何模型参数拟合时的目标方程来校正像点定位误差。对比验证实验结果表明,所提方法提升了基于平行光管的几何定标方法的定标精度,在视场角较大时提升效果更明显,当平行光管发散角为2°且入射视场角50°时,定标精度至少提升0.15 pixel。高精度的实验室几何定标将为DPC实现在轨高精度地理定位,多角度、多光谱及偏振图像配准提供精确的初始几何参数。

关键词：几何光学几何定标误差分析平行光管多角度偏振成像仪

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Iterative Signal Detection Based Soft Interference Cancellation for Satellite-Terrestrial Downlink NOMA Systems

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China Communications 2024年第8期21卷 249-263页

作者： sun Meng Zhang Qi Yao Haipeng Gao Ran Xin Xiangjun Tian Feng Feng Weiying Chen Dong School of Electronic Engineering Beijing University of Posts and Telecommunications(BUPT)Beijing 100876China Beijing Key Laboratory of Space-Ground Interconnection and Convergence State Key Laboratory of Information Photonics and Optical CommunicationsSchool of Electronic EngineeringBeijing University of Posts and Telecommunications(BUPT)Beijing 100876China School of Information and Communication Engineering Beijing University of Posts and Telecommunications(BUPT)Beijing 100876China Beijing Institute of Technology Beijing 100081China Beihang University Beijing 100191China China Academy of Space Technology(CAST) Beijing 100094China

To improve the bit error rate(BER)performance of multi-user signal detection in satelliteterrestrial downlink non-orthogonal multiple access(NOMA)systems,an iterative signal detection algorithm based on soft interference cancellation with optimal power allocation is *** that power allocation has a significant impact on BER performance,the optimal power allocation is obtained by minimizing the average BER of NOMA *** to the allocated powers,successive interference cancellation(SIC)between NOMA users is performed in descending power *** each user,an iterative soft interference cancellation is performed,and soft symbol probabilities are calculated for soft *** improve detection accuracy and without increasing the complexity,the aforementioned algorithm is optimized by adding minimum mean square error(MMSE)signal estimation before detection,and in each iteration soft symbol probabilities are utilized for soft-decision of the current user and also for the update of soft interference of the previous *** results illustrate that the optimized algorithm ***-IDBSIC significantly outperforms joint multi-user detection and SIC detection by 7.57dB and 8.03dB in terms of BER performance.

关键词： non-orthogonal multiple access(NOMA) resource allocation satellite-terrestrial communication signal detection soft interference cancellation

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