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Chinese Chemical Letters 2022年第11期33卷 4948-4951页

作者： Lingyu Hang Chengying Shen baode Shen Hailong Yuan Department of Pharmacy Air Force Medical CenterPLABeijing 100142China College of Pharmacy Jiangxi University of Chinese MedicineNanchang 330004China Department of Pharmacy Jiangxi Provincial People's HospitalNanchang 330006China

Intravenous nanosuspensions are attracted growing attention as a viable strategy for development of intravenous formulations of poorly water-soluble ***,only few information about the biological fate of intravenous nanosuspensions is currently known,especially amorphous nanosuspensions are not reported *** this study,the in vivo fate of herpetrione(HPE)amorphous nanosuspensions following intravenous administration was explored by using an aggregation-caused quenching(ACQ)probe and HPLC *** ACQ probe is physically embedded into HPE nanoparticles via anti-solvent method to form HPE hybrid nanosuspensions(HPE-HNSs)for ***-HNSs emit strong and stable fluorescence,but fluorescence quenches immediately upon the dissolution of HPE-HNSs,confirming the selfdiscrimination of *** intravenous administration of HPE-HNSs,integral HPE-HNSs and HPE show similar degradation and biodistribution,with rapid clearance from blood circulation and obvious accumulation in liver and *** to the slower dissolution and enhanced recognition by reticuloendothelial system,450 nm HPE-HNSs accumulate more in liver,lung and spleen than that of 200 nm *** results demonstrate that integral HPE-HNSs determine the in vivo performance of *** study provides insight into the in vivo fate of intravenous amorphous nanosuspensions.

关键词： Amorphous nanosuspensions Herpetrione In vivo fate Intravenous delivery Aggregation-caused quenching

KIF26B在膀胱癌组织中的表达及对膀胱癌细胞增殖、侵袭、迁移的影响

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医学研究杂志 2024年第1期53卷 107-112页

作者：卢保德龙贤黄勇平右江民族医学院附属医院泌尿外科百色533000

目的基于公共数据库分析驱动蛋白家族成员26B(kinesin family member 26B,KIF26B)在膀胱癌中的表达水平,并探讨沉默KIF26B对膀胱癌细胞增殖、侵袭、迁移的影响。方法基于GEO和UaLcan数据库分析KIF26B在膀胱癌中的表达及与患者生存预后... 详细信息

目的基于公共数据库分析驱动蛋白家族成员26B(kinesin family member 26B,KIF26B)在膀胱癌中的表达水平,并探讨沉默KIF26B对膀胱癌细胞增殖、侵袭、迁移的影响。方法基于GEO和UaLcan数据库分析KIF26B在膀胱癌中的表达及与患者生存预后的关系;实时荧光定量聚合酶链反应(real-time quantitative polymerase chain reaction,RT-qPCR)和Western blot法检测膀胱癌细胞系(T24、J82)及膀胱正常上皮细胞SV-HUV-1中KIF26B的表达水平;将si-KIF26B、si-NC片段转染至T24细胞,采用噻唑蓝(methyl thiazolyl tetrazolium,MTT)法、Transwell实验和划痕实验检测沉默KIF26B后对T24细胞增殖、侵袭和迁移的影响;Western blot法检测沉默KIF26B后丝裂原活化蛋白激酶激酶(mitogen-activated protein kinase kinase,MEK)、磷酸化丝裂原活化蛋白激酶激酶(phosphorylated mitogen-activated protein kinase kinase p-MEK)、细胞外调节蛋白激酶(extracellular signal-regulated kinases,ERK)、磷酸化细胞外调节蛋白激酶(phosphorylated extracellular regulatory protein kinase,p-ERK)蛋白的表达水平。结果KIF26B在膀胱癌组织中高表达,KIF26B高表达患者的预后更差(P0.05)。结论KIF26B在膀胱癌组织和细胞中高表达,与患者预后不良相关,沉默KIF26B可抑制膀胱癌细胞增殖、侵袭和迁移,其机制可能通过MEK/ERK通路发挥作用。

关键词： KIF26B 膀胱癌增殖侵袭迁移

Climatic variation of tropical cyclones affecting China during the past 50 years

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Science China Earth Sciences 2011年第8期54卷 1226-1237页

作者： YING Ming YANG YuHua CHEN baode ZHANG Wei Laboratory of Typhoon Forecast Technique Shanghai Typhoon Institute China Meteorological Administration Shanghai 200030 China

Trends of the tropical cyclones (TCs) influence on China and its four subregions,namely the South China (SC),East China (EC),Northeast China (NEC),and China's inland area (CI),are detected by applying quantile regression to the CMA-STI tropical cyclone best track and related severe wind and precipitation observation *** results indicate that in the past 50 years,the number of TCs affecting China and its four subregions has remained steady,except that the frequency in extremely active years has decreased not only in China as a whole,but also in *** addition,TC activity is found to have weakened over the northwest South China Sea,Guangdong,and Shandong ***,the most important changes in seasonality are found in the first quartiles of the number of days of TCs affecting *** the extreme values of sustained winds all have decreasing trends,the extreme values of wind gusts are completely different not only among different orders of extreme values,but also among different ***,the trends of extreme TC rainfall,namely the maximum storm precipitation and the maximum 1-h precipitation,are not significant.

关键词： tropical cyclone wind and precipitation climatic variation China

Source of ore-forming material for the Huangtuliang gold deposit,Hebei Province and ore prospecting in the deep periphery

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Chinese Journal Of Geochemistry 2008年第3期27卷 225-234页

作者： NIU Shuyin sun Aiqun WANG baode HAN Yuchou WEI Minghui ZHANG Hai ZHANG Ge SHI Ping WANG Wenxing College of Resources Shijiazhuang University of Economics Shijiazhuang 050031 China Hebei Provincial Bureau of Geology and Mineral Resource Exploration and Development Shijiazhuang 050081 China Huangtuliang Gold Mine Chicheng County Zhangjiakou 075700 China

The Huangtuliang gold deposit is characterized by its wide and large ore belt,stable extension and closely spaced ***,no orebody was found by deep *** a result,ore prospecting in this region was once put into *** analysis of ore-forming and ore-controlling structures in the mining district by the authors has revealed that the ore-forming and ore-controlling structure in this mining district is a steeply dipping(85°-110°/∠70°-85° N-NNE),spade-shaped ductile shear zone,and the ore-controlling structures are a series of nearly erected second-ordered faults which are developed in the upper part of the ductile shear zone,intersecting with the ductile shear *** cutting of the ductile shear zone made it possible the ascending of ore fluids from the mantle plume at depth and these ore fluids would migrate upwards along the ductile shear zone under certain temperature and pressure *** their ascending path,the ore fluids would extract ore-forming elements from the country rocks and the extracted ore-forming elements would be deposited as ores in the hanging-wall second-ordered *** reason why no orebody was found in early prospecting at depth is that northward-dipping drilling in the southern part of the shear zone extended so deeply as to be beneath the shear *** shallow-level orebodies could be found by southward-dipping drilling practice in the northern part of the shear *** location where deep-seated orebodies occurred shifted northwards and the orebodies occurred at greater ***,it is natural that no orebody could be found when drill core passed through the shear *** the ore-forming and ore-controlling structures were well understood,the focus of ore prospecting was placed on the deep-level,northward-penetrating *** this way a number of new blind orebodies of great thickness have been *** the basis of research development in the mining district,a prospecting plan has

关键词：地幔分支结构地幔热流柱矿石河北

基于知识图谱的复杂薄壁零件机械加工工艺知识建模研究

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航空制造技术 2024年第11期67卷 76-86页

作者：肖彪徐宝德彭仕鑫尉渊丁国智王萌赵正彩南京航空航天大学南京210016 北京星航机电装备有限公司北京100074

智能工艺设计是数字孪生环境下工艺设计的核心,零件工艺知识建模是实现基于数字孪生的智能工艺设计的前提。为此,针对航空航天领域复杂薄壁零件机械加工工艺数据结构化程度低、难以重用的问题,提出了典型复杂薄壁零件机械加工工艺知识... 详细信息

智能工艺设计是数字孪生环境下工艺设计的核心,零件工艺知识建模是实现基于数字孪生的智能工艺设计的前提。为此,针对航空航天领域复杂薄壁零件机械加工工艺数据结构化程度低、难以重用的问题,提出了典型复杂薄壁零件机械加工工艺知识图谱的构建和质量评估方法。首先,对机械加工工艺知识组成和结构进行分析。其次,通过本体建模、知识抽取、知识储存等相关技术实现了工艺知识的可视化表征,并基于Neo4j图数据库实现机械加工工艺知识检索。最后,利用层次分析法对构建完成的知识图谱进行评估,并以框段类零件的机械加工工艺知识为验证对象,得到子图谱的综合准确度为92.28%。试验结果表明,基于知识图谱的工艺知识建模方法切实可行,有助于实现工艺知识的有效组织和重用,为数字孪生的智能工艺设计奠定基础。

关键词：复杂薄壁零件知识图谱工艺知识建模数据抽取图谱质量评估数字孪生

基于SBAS-InSAR技术的水工环地质调查在某矿山地质构造沉降检测中的应用

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中国锰业 2024年第4期42卷 70-75页

作者：寇保德周乐勋杨兴业青海省地质调查院青海西宁810012 青海省青藏高原北部地质过程与矿产资源重点实验室青海西宁810012 青海省遥感大数据工程技术研究中心青海西宁810012

为实现有效准确的地表沉降监测,研究利用改进合成孔径雷达干涉(Interferometric Synthetic Aperture Radar,InSAR)技术对某矿山的雷达视线(Radar Line of Sight,LOS)的向地表形变情况进行解算。同时,针对矿区本身较为复杂的地形,结合升... 详细信息

为实现有效准确的地表沉降监测,研究利用改进合成孔径雷达干涉(Interferometric Synthetic Aperture Radar,InSAR)技术对某矿山的雷达视线(Radar Line of Sight,LOS)的向地表形变情况进行解算。同时,针对矿区本身较为复杂的地形,结合升降轨影像对垂直向、东向、西向的形变进行解算,得到形变量之后分析其走向。研究结果表明,研究区域内垂直向的变形程度较小,平均变形速率为-3.26~3.26 mm/a;东向和西向的地形分布并不均匀,且变形较大,平均变形速率大部分都超过了20 mm/a。检测系统能够实现有效的三维地表沉降检测。

关键词： SBAS-InSAR 矿山地质沉降检测形变

Temporal-spatial distribution and ore-forming material source of gold,copper and silver polymetallic ore deposits in the Fuping mantle structure zone

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Chinese Journal Of Geochemistry 2010年第3期29卷 270-277页

作者： WANG baode NIU Shuyin sun Aiqun LIU Yaming XIE Yan JIANG Xiaoping ZHAO Yongli GAO Yincang ZHAO Fuwang Geological Survey Institute Shijiazhuang University of Economics Shijiazhuang 050031 China Shijiazhuang Comprehensive Geological Party Hebei Provineial Bureau of Geology and Mineral Resource Development and Exploration Shijiazhuang 050081 China

This study was conducted following research on metallogenesis in the Zhangjiajie-Xuanhua and East Hebei mantle branch structure zones. The Fuping mantle branch structure zone is one where Au, Cu and Ag poly-metallic ore resources are concentrated in North Hebei. However, there has existed a long-standing controversy on the temporal-spatial distribution of ore resources and their ore-forming material sources. In terms of age dating and the comprehensive analysis of S, Pb, O, C and Si isotopes, it is considered that the temporal-spatial distribution of ore resources in this mantle branch structure zone is obviously controlled by the Fuping mantle branch structure. In space there is developed such a metallogenic pattern as to be Ag, Pb and Zn polymetallic ore deposits with gold appearing inside and copper appearing outside. Metallogenesis is dated mainly at Yanshanian, the ore-forming materials were derived predominantly from the deep interior of the Earth, and ore-forming fluids were derived largely from Yanshanian magmatism.

关键词：银多金属矿成矿作用多金属矿床时空分布物质来源构造带黄金铜

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镁合金电子舱体浇注系统设计与快速熔模铸造

航天制造技术 2018年第2期 6-10页

作者：李飞孔振杨力祥孙东科赵彦杰汪东红李中权孙宝德上海市高温材料及其精密成形重点实验室上海交通大学上海200240 上海航天精密机械研究所上海201600 东南大学机械工程学院南京211189

为了满足航天器大型复杂薄壁镁合金构件减重与快速制造需求,以某镁合金电子舱体为例开展了熔模铸造工艺研究。通过选区激光烧结(SLS)3D打印技术制备了舱体熔模,设计了3种浇注系统,采用ProCAST软件对舱体的低压铸造过程和铸造缺陷进行了... 详细信息

为了满足航天器大型复杂薄壁镁合金构件减重与快速制造需求,以某镁合金电子舱体为例开展了熔模铸造工艺研究。通过选区激光烧结(SLS)3D打印技术制备了舱体熔模,设计了3种浇注系统,采用ProCAST软件对舱体的低压铸造过程和铸造缺陷进行了模拟。研究结果表明,3D打印的聚苯乙烯熔模在烧除过程中未导致型壳胀裂问题的出现。低压铸造结合缝隙式浇注系统可满足镁合金熔体的平稳充型和完全补缩,实现了镁合金舱体铸件的快速熔模铸造成形。

关键词： 3D打印镁合金电子舱体快速熔模铸造数值模拟

Study on the Metallogenetism of Sub-mantle Plume and Mantle Branches in the Gold Mineralization Concentration Area of Northwest Jiaodong Peninsula

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Acta Geologica Sinica(English Edition) 2014年第5期88卷 1409-1420页

作者： NIU Shuyin CHENG Guangsuo ZHANG Jianzhen sun Aiqun MA Baojun ZHANG Fuxiang WANG baode XU Meng WU Jichun ZHAO Rongxin WANG Shanfei Key Laboratory of Gold Mineralization Processes and Resource Utilization Subordinated to the Ministry of Land and Resources Shijiazhuang University of Economics Shandong Gold Group Co. Ltd.

The northwest of Jiaodong peninsula is characterized by its greatest gold concentration area, enormous gold reserves and limited time interval （115±5Ma） of gold mineralization in China. Studies show that the east area of north China began its mantle plume evolution since the Yanshanian movement, and the Laiyang sub-mantle plume and its surrounding mantle branches such as those in Guojiadian, Aishan and Panshidian were formed in the mineralization concentration area of northwestern Jiaodong peninsula. With the development of mantle plume →sub-mantle plume → mantle branch→ favorable expending structures, the deep-derived hydrothermal fluid moved up to the favorable places, such as brittle-ductile or ductile-brittle shearing zones, the internal and external contact zones of intrusions, dense fracturing zones and the contact zones between dikes and countryrocks, and concentrated into deposits. Then the gold mineralization concentration zones that are centralized on mantle branches were formed. This study takes Guojiadian mantle branch as an example to discuss their metallogenetism and conclude the metallogenetic mode.

关键词： sub-mantle plume mantle branch ore-controlling structure metallogenetism,metallogenetic mode northwest Jiaodong peninsula

THE BOUNDEDNESS FOR COMMUTATORS OF ANISOTROPIC CALDERóN-ZYGMUND OPERATORS

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Acta Mathematica Scientia 2020年第1期40卷 45-58页

作者： Jinxia LI baode LI Jianxun HE School of Mathematics and Information Sciences Guangzhou UniversityGuangzhou 510006China College of Mathematics and System Science Xinjiang UniversityUrumqi 830046China

Let T be an anisotropic Calderón-Zygmund operator andφ:R^n×[0,∞)→[0,∞)be an anisotropic Musielak-Orlicz function withφ(x,·)being an Orlicz function andφ(·,t)being a Muckenhoupt A∞(A)*** this paper,our goal is to study two boundedness theorems for commutators of anisotropic Calderon-Zygmund ***,when b∈BMOw(R^n,A)(a proper subspace of anisotropic bounded mean oscillation space BMO(R^n,A)),the commutator[b,T]is bounded from anisotropic weighted Hardy space H^1ω(R^n,A)to weighted Lebesgue space L^1ω(R^n)and when b∈BMO(R^n)(bounded mean oscillation space),the commutator[b,T]is bounded on Musielak-Orlicz space L^φ(R^n),which are extensions of the isotropic setting.

关键词： expansive dilation Muckenhoupt weight weighted Hardy space Calderón-Zygmund operator commutator