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One Day Polyethylene Glycol-3350 for Bowel Preparation in Pediatrics: A Literature Review

Open Journal of Pediatrics 2015年第3期5卷 279-284页

作者： Shristi shakya sumisti shakya Zhongyue Li Department of Gastroenterology Children’s Hospital of Chongqing Medical University Chongqing China Department of Obstetrics and Gynaecology The Second Affiliated Hospital of Chongqing Medical University Chongqing China

Bowel preparation for colonoscopy in children is a challenging procedure. Wide variety of preparation protocols exist, varying with the hospital. Unlike in adults, there is a lack of uniform bowel preparation protocol in children. Ideally, the bowel preparation agents are assessed by their safety, efficacy and tolerability. Unfortunately, none of the preparations currently available meets all of these criteria. However, since last decade, Polyethylene Glycol-3350 (PEG-3350) is gaining popularity for bowel preparation with reported safety, efficacy, and tolerability. The only major drawback of PEG-3350 without electrolyte was 4 days long preparation time thus raising the question if the duration of preparation time could be minimized and yet have same efficacy, safety, and tolerability of the medicine. Hence, one day PEG-3350 regimen was introduced eventually and is now being studied with increased dosage or combined with other laxatives. This is the first review which compiles the study so far conducted on one day PEG-3350 without electrolyte as colonoscopy bowel preparation in children and tries to summaries if this regimen can be commonly used in children for colonoscopy bowel preparation.

关键词： Bowel Preparation One Day Preparation Pediatrics PEG-3350

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New-Onset Systemic Lupus Erythematosus and Pregnancy: A Systematic Review

New-Onset Systemic Lupus Erythematosus and Pregnancy: A Syst...

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作者： sumisti shakya 重庆医科大学

学位级别：硕士

BackgroundSystemic lupus erythematosus（SLE） is a chronic, multi-organ autoimmune disease that occurs predominantly among reproductive age women. When SLE is newly diagnosed during pregnancy or puerperium, it is known as new-onset SLE during pregnancy. The diagnosis of new-onset SLE tends to be delayed or missed diagnosed due to similar clinical feature presentation with normal physiological changes and common pathological disease（preeclampsia） encountered during pregnancy. Furthermore, new-onset SLE during pregnancy has major organ involvement with poor maternal and fetal outcomes. In addition, certain lupus medications are potentially teratogenic and are contraindicated during *** objective of this systematic review is to investigate the clinical features, laboratory findings, treatment, complications and outcomes of new-onset SLE during *** methodsSystematic reviewThe MEDLINE, EMBASE, Pub Med, SCOPUS data bases related to new-onset SLE were searched up to February *** review comprises of results of 21 studies;16 were case reports published between year 1994-2016 and remaining being retrospective study published between year 2005-2015. A total of 149 patients with new-onset SLE during pregnancy were identified and studied their course of disease. The mean maternal age of diagnosis of SLE was in their mid 20’s. The new-onset SLE generally have more severe disease with higher prevalence of renal and hematological involvement, which might have significant impact on health of mother and fetus. The most common maternal complication was preeclampsia. When lupus was missed diagnose with preeclampsia especially during third trimester it tended to delay diagnosis for 5 days to more than 12 months after delivery. Despite vigorous treatment with glucocorticoids and/or immunosupprestant, the outcome is poor with fetal loss, spontaneous abortion, preterm birth, maternal death and severe organ *** and awarenes

关键词：系统性红斑狼疮怀孕时期并发症

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