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Development of prosthetic arm using body actioned SEMG signals

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Journal of Innovative Optical Health Sciences 2016年第6期9卷 58-65页

作者： karan Veer Tanu Sharma Amod kumar EIED Department Thapar UniversityPatialaIndia CSED Department Global College of EngineeringKhanpur KuiIndia Chief Scientist CSIO-CSIRChandigarhIndia

People's working capability is badly affected when they sufer an amputated *** replacements with prosthetic devices to get a satisfactory level of performance for essential functions with the currently available prosthetic technology are very *** arm prostheses are becoming popular because they are operated by a natural contraction of intact ***,SEMG based artifdal arm was *** system cousists of diferent electronic and mechanical assemblies for operation of hand utilizing microcontroller in order to have minimum signal loss during its *** the hep of relay switching connected to low power DC motor,system is capable of opening and closing of grip according to individual wish.

关键词： SEMG electrodes variable gripping myoelectric controls electronic interface signals processing.

Diabetes more than retinopathy,it’s effect on the anterior segment of eye

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World Journal of Clinical Cases 2023年第16期11卷 3736-3749页

作者： Arvind kumar Morya Prasanna Venkatesh Ramesh Kirandeep Kaur Bharat Gurnani Aarti Heda karan Bhatia Aprajita Sinha Department of Ophthalmology All India Institute of Medical SciencesHyderabad 508126TelanganaIndia Glaucoma and Research Mahathma Eye Hospital Private LimitedTennurTrichy 620001Tamil NaduIndia Pediatric Ophthalmology and Strabismus Sadguru Netra ChikitsalayaSadguru Seva Sangh TrustJanaki-KundChitrakoot 485334Madhya PradeshIndia Cornea and Refractive Services Sadguru Netra ChikitsalayaSadguru Seva Sangh TrustJanaki-KundChitrakoot 485334Madhya PradeshIndia Department of Ophthalmology National Institute of OphthalmologyPune 411000MaharashtraIndia Department of Ophthalmology Manaktala Eye and Maternity HomeMeerut 250001Uttar PradeshIndia Department of Ophthalmology Worcestershire Acute HospitalWorcestershire 01601United Kingdom

Diabetes mellitus(DM)is one of the chronic metabolic noncommunicable diseases that has attained worldwide *** threatens healthy life around the globe,with mild-to-severe secondary complications and leads to significant illness including nephropathy,neuropathy,retinopathy,and macrovascular abnormalities including peripheral vasculopathy,and ischaemic heart *** into diabetic retinopathy(DR),which affects one-third of persons with diabetes,has made considerable strides in recent *** addition,it can lead to several anterior segment complications such as glaucoma,cataract,cornea,conjunctiva,lacrimal glands and other ocular surface *** DM also caused gradual damage to corneal nerves and epithelial cells,which raises the likelihood of anterior segment diseases including corneal ulcers,dry eye disease,and chronic epithelial *** DR and other associated ocular complications are well-known,the complexity of its aetiology and diagnosis makes therapeutic intervention *** glycaemic control,early detection and regular screening,and meticulous management is the key to halting the progression of the *** this review manuscript,we aim to provide an in-depth understanding of the broad spectrum of diabetic complications in the anterior segment of the ocular tissues and illustrate the progression of diabetes and its pathophysiology,epidemiology,and prospective therapeutic *** first such review article will highlight the role of diagnosing and treating patients with a plethora of anterior segment diseases associated with diabetes,which are often neglected.

关键词： Diabetes Ocular surface Cataract Glaucoma Lens Uvea

Targeting brain tumors with innovative nanocarriers:bridging the gap through the blood-brain barrier

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Oncology Research 2024年第5期32卷 877-897页

作者： karan WADHWA PAYAL CHAUHAN SHOBHIT kumar RAKESH PAHWA RAVINDER VERMA RAJAT GOYAL GOVIND SINGH ARCHANA SHARMA NEHA RAO DEEPAK KAUSHIK Department of Pharmaceutical Sciences Maharshi Dayanand UniversityRohtak124001India Department of Pharmaceutical Technology Meerut Institute of Engineering and Technology(MIET)NH-58Delhi-Roorkee HighwayMeerut250005India Institute of Pharmaceutical Sciences Kurukshetra UniversityKurukshetra136119India Department of Pharmaceutical Sciences Chaudhary Bansi Lal UniversityBhiwani127021India MM College of Pharmacy Maharishi Markandeshwar(Deemed to be University)Mullana-AmbalaHaryana133207India Delhi Pharmaceutical Sciences and Research University(DIPSAR) Delhi Pharmaceutical Sciences and Research UniversityNew Delhi110017India

Background:Glioblastoma multiforme(GBM)is recognized as the most lethal and most highly invasive *** high likelihood of treatment failure arises fromthe presence of the blood-brain barrier(BBB)and stemcells around GBM,which avert the entry of chemotherapeutic drugs into the ***:Recently,several researchers have designed novel nanocarrier systems like liposomes,dendrimers,metallic nanoparticles,nanodiamonds,and nanorobot approaches,allowing drugs to infiltrate the BBB more efficiently,opening up innovative avenues to prevail over therapy problems and radiation ***:Relevant literature for this manuscript has been collected from a comprehensive and systematic search of databases,for example,PubMed,Science Direct,Google Scholar,and others,using specific keyword combinations,including“glioblastoma,”“brain tumor,”“nanocarriers,”and several ***:This review also provides deep insights into recent advancements in nanocarrier-based formulations and technologies for GBM *** of various scientific advances in conjunction with encouraging findings concerning the future perspectives and challenges of nanocarriers for effective brain tumor management has also been discussed.

关键词： Glioblastoma Brain tumor Blood-brain barrier Liposomes Metallic nanoparticles Nanocarriers

Detection and analysis of the effects of heat stress on EEG using wavelet transform ——EEG analysis under heat stress

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Journal of Biomedical Science and Engineering 2010年第4期3卷 405-414页

作者： Prabhat kumar Upadhyay Rakesh kumar Sinha Bhuwan Mohan karan 不详

Continuous wavelet transform (CWT) method has been applied to capture localized time-frequency information of rat electroencephalogram (EEG) in different vigilance states and analyze alterations in transients during awake, slow wave sleep (SWS), and rapid eye movement (REM) sleep stages due to exposure to high environmental heat. Rats were divided in three group (i) acute heat stress-subjected to a single exposure for four hours in the Biological Oxygen Demand (BOD) incubator at 38?C;(ii) chronic heat stress-exposed for 21 days daily for one hour in the incubator at 38?C, and (iii) handling control groups. After two hours long EEG recordings from young healthy rats, EEG data representing three sleep states was visually selected and further subdivided into 2 seconds long epoch. Powers of wavelet spectra corresponding to delta, theta, alpha, and beta bands at all scales and locations were computed and variation in their states investigated. The wavelet analysis of EEG signals following exposure to high environmental heat revealed that powers of subband frequencies vary with time unlike Fourier technique. Changes in higher frequency components (beta) were significant in all sleep-wake states following both acute and chronic heat stress conditions. Percentage power of different components of the four bands was always found to be varying at different intervals of time in the same signal of analysis.

关键词： Electroencephalogram Rat Sleep Wavelet transform

Predicting heat-stressed EEG spectra by self-organising feature map and learning vector quantizers——SOFM and LVQ based stress prediction

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Journal of Biomedical Science and Engineering 2010年第5期3卷 529-537页

作者： Prabhat kumar Upadhyay Rakesh kumar Sinha Bhuwan Mohan karan 不详

Self-Organising Feature Map (SOFM) along with learning vector quantizers (LVQ) have been designed to identify the alterations in brain electrical potentials due to exposure to high environmental heat in rats. Three groups of rats were considered—acute heat stressed, chronic heat stressed and control groups. After long EEG recordings following heat exposure, EEG data representing three different vigilance states such as slow wave sleep (SWS), rapid eye movement (REM) sleep and AWAKE were visually selected and further subdivided into 2 seconds long epoch. In order to evaluate the performance of artificial neural network (ANN) in recognizing chronic and acute effects of heat stress with respect to the control subjects, unsupervised learning algorithm was applied on EEG data. Mean performance of SOFM with quadratic taper function was found to be better (chronic-92.6%, acute-93.2%) over the other two tapers. The effect of LVQ after the initial SOFM training seems explicit giving rise to considerable improvements in performance in terms of selectivity and sensitivity. The percentage increase in selectivity with uniform taper function is maximum for chronic and its control group (4.01%) and minimum for acute group (1.29%) whereas, with Gaussian it is almost identical (chronic-2.57%, acute-2.03%, control- 2.33%). Quadratic taper function gives rise to an increase of 2.41% for chronic, 1.96% for acute and 2.91% for control patterns.

关键词： ANN EEG Heat Stress SOFM LVQ

Preparation, Characterization, Dielectric, Piezoelectric and Ferroelectric Properties of Yttrium and Praseodymium Doped Lead Titanate Ceramics

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材料科学与工程（中英文B版） 2014年第10期4卷 293-301页

作者： karan Singh Vishal Singh Rashmi Gupta Krishen kumar Bamzai Crystal Growth & Materials Research Laboratory Department of Physics and Electronics University of Jammu Jammu India

Conductivity Studies in Proton Irradiated AgI-Ag2O-V2O5-TeO2 Super-Ionic Glass System

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Materials Sciences and Applications 2010年第2期1卷 59-65页

作者： Poonam Sharma Dinesh kumar Kanchan Meenakshi Pant karan Pal Singh 不详

The electrical properties of proton ion beam irradiated glass samples are carried out by impedance spectroscopy in the frequency range from 10 Hz to 32 MHz. The ion beam of energy 3 MeV and fluence of of 1014 particles cm-2 was chosen for irradiation. The conductivity of the super ionic glass samples increases after irradiation and other electrical parameters like dielectric constant, dielectric loss and modulus of the proton irradiated glass samples as a function of glass composition and temperature are observed to change. The dielectric constant and the dielectric losses are increased after irradiation and the modulus parameters confirm the non-Debye nature for irradiated samples also.

关键词： Proton-Irradiated Glass DC Conductivity Silver-Ion Scaling Modulus

Using Pharmacokinetic Modeling and Electronic Health Record Data to Predict Clinical and Safety Outcomes after Methylprednisolone Exposure during Cardiopulmonary Bypass in Neonates

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Congenital Heart Disease 2023年第3期18卷 295-313页

作者： Henry P.Foote Huali Wu Stephen J.Balevic Elizabeth J.Thompson Kevin D.Hill Eric M.Graham Christoph P.Hornik karan R.kumar Department of Pediatrics Duke UniversityDurhamUSA Duke Clinical Research Institute DurhamUSA Department of Pediatrics Medical University of South CarolinaCharlestonUSA

Background:Infants undergoing cardiac surgery with cardiopulmonary bypass(CPB)frequently receive intraoperative methylprednisolone(MP)to suppress CPB-related inflammation;however,the optimal dosing strategy and efficacy of MP remain ***:We retrospectively analyzed all infants under 90 days-old who received intra-operative MP for cardiac surgery with CPB from 2014–2017 at our *** combined real-world dosing data from the electronic health record(EHR)and two previously developed population pharmacokinetic/pharmacodynamic models to simulate peak concentration(Cmax)and area under the concentration-time curve for 24 h(AUC24)for MP and the inflammatory cytokines interleukin-6(IL-6)and interleukin-10(IL-10).We evaluated the relationships between post-operative,safety,and other clinical outcomes obtained from the EHR with each predicted exposure using non-parametric ***:A total of 142 infants with median post-natal age 8(interquartile range[IQR]:5,37)days received a total dose of 30(19,49)mg/kg of ***(8%)died,37(26%)met the composite post-operative outcome,114(80%)met the composite safety outcome,and 23(16%)had a major *** median Cmax and AUC24 IL-6 exposure was significantly higher for infants meeting the composite post-operative outcome and those with major *** median Cmax and AUC24 MP exposure was significantly higher for infants requiring *** exposure was associated with death or other safety ***:Pro-inflammatory IL-6,but not MP exposure,was associated with post-operative organ dysfunction,suggesting current MP dosing may not adequately suppress IL-6 or increase IL-10 to impact clinical *** study will be required to define the optimal exposure-efficacy and exposure-safety profiles in these infants.

关键词： Neonates cardiopulmonary bypass methylprednisolone exposure

Cavitary lung lesion 6 years after renal transplantation

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World Journal of Transplantation 2016年第2期6卷 447-450页

作者： Arun kumar Subbiah Sudheer Arava Soumita Bagchi karan Madan Chandan J Das Sanjay kumar Agarwal Department of Nephrology All India Institute of Medical Sciences Department of Pathology All India Institute of Medical Sciences Department of Pulmonary medicine and sleep disorders All India Institute of Medical Sciences Department of Radiology All India Institute of Medical Sciences

The differential diagnoses of a cavitary lung lesion in renal transplant recipients would include infection, malignancy and less commonly inflammatory diseases. Bacterial infection, Tuberculosis, Nocardiosis, fungal infections like Aspergillosis and Cryptococcosis need to be considered in these patients. Pulmonary cryptococcosis usually presents 16-21 mo after transplantation, more frequently in patients who have a high level of cumulative immunosuppression. Here we discuss an interesting patient who never received any induction/anti-rejection therapy but developed both BK virus nephropathy as well as severe pulmonary Cryptococcal infection after remaining stable for 6 years after transplantation. This case highlights the risk of serious opportunistic infections even in apparently low immunologic risk transplant recipients many years after transplantation.

关键词： Lung cavity Immunosuppression Renal transplantation