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Lacidipine,thiamine pyrophosphate and their combination on the ocular ischemic syndrome induced by bilateral common carotid artery ligation

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International Journal of Ophthalmology(English edition) 2024年第5期17卷 815-821页

作者： Ibrahim Cicek Ahmet Mehmet Somuncu Durdu Altuner Bahadir suleyman Renad Mammadov Seval Bulut Taha Abdulkadir Coban Tugba Bal Tastan Halis suleyman Department of Ophthalmology Faculty of MedicineErzincan Binali Yildirim UniversityErzincan 24100Turkey Department of Pharmacology Faculty of MedicineErzincan Binali Yildirim UniversityErzincan 24100Turkey Department of Clinical Biochemistry Faculty of MedicineErzincan Binali Yildirim UniversityErzincan 24100Turkey Department of Histology and Embryology Faculty of MedicineErzincan Binali Yildirim University ErzincanErzincan 24100Turkey

AIM:To investigate the effect of lacidipine,thiamine pyrophosphate(TPP)and the combination of lacidipine and TPP against oxidative and inflammatory eye damage induced by bilateral common carotid artery ligation in ***:Male albino Wistar rats were categorized as those who underwent sham surgery(SG),right and left common carotid cross-clamping and unclamping procedure(CCU),lacidipine+CCU(LCCU),TPP+CCU(TCCU),and combination of lacidipine and TPP(LTC)+CCU(LTCCU).One hour before anesthesia,the LCCU(n=6)received lacidipine(4 mg/kg,orally)and the TCCU(n=6)received TPP(20 mg/kg,intraperitoneally).The SG(n=6)and CCU(n=6)received the same volume of distilled water from the same *** anesthesia(60 mg/kg ketamine,intraperitoneally),the necks of the rats were opened in the *** was created for 10min by placing clips on the right and left common carotid *** in the SG only underwent subcutaneous *** 10min,the clips were removed and reperfusion was achieved for six ***,the animals were euthanized(120 mg/kg ketamine,intraperitoneally)and the levels of oxidant,antioxidant and proinflammatory cytokines in the eye tissues were *** retinal tissue of the eye was also examined ***:Lacidipine,TPP,and LTC significantly prevent the increase in malondialdehyde,tumor necrosis factoralpha,interleukin-1β(IL-1β),and IL-6 levels,decrease in total glutathione levels,superoxide dismutase and catalase activities and histopathological retinal damage in eye tissue induced by bilateral common carotid artery ligation in *** impact of these drugs on protection is determined to be LTC>lacidipine>***:As a result of the study,it is concluded that LTC may be more effective than lacidipine and TPP alone in treating ocular ischemic syndrome.

关键词： ocular ischemic syndrome lacidipine thiamine pyrophosphate oxidative stress

SYNTHESIS,CHARACTERIZATION AND ANTIMICROBIAL PROPERTIES OF 4-[(4-HYDROXYBENZYLIDENE)AMINO]PHENOL AND ITS POLYMER

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Chinese Journal of Polymer Science 2007年第5期25卷 461-472页

作者： Ismet Kaya suleyman Culhaoglu Dilek Senol Department of Chemistry Faculty of Science and Arts Canakkale Onsekiz Mart University TR-17020 Canakkale Turkey

The oxidative polycondensation reaction conditions of 4-[（4-hydroxybenzylidene） amino] phenol （4-HBAP） were studied with H2O2, air oxygen and NaOCl in an aqueous alkaline medium between 50 and 90℃. The structures of the obtained monomer and polymer were confirmed by FT-IR, UV-Vis, 1H- and 13C-NMR and elemental analysis. The characterization was made by TG-DTA, size exclusion chromatography （SEC） and solubility tests. At the optimum reaction conditions, the yield of poly[4-（4-hydroxybenzylidene amino） phenol] （P-4-HBAP） was found to be 48.3% （for H2O2 oxidant）, 80.5% （for air O2 oxidant） and 86.4% （for NaOCl oxidant）. According to the SEC analysis, the number-average molecular weight （Mn）, weight-average molecular weight （Mw） and polydispersity index （PDI） values of P-4-HBAP was found to be 8950, 10970 g tool^-1 and 1.225, respectively, using H202; and l l610, 15190 g tool^-1 and 1.308 respectively, using air 02 and 7900, 9610 g mol^-1 and 1.216, respectively, using NaOC1. According to TG-DTA analyses, P-4-HBAP was more stable than 4-HBAP against thermal decomposition. The weight loss of P-4-HBAP was found to be 49.27% at 1000℃. The highest occupied molecular orbital （HOMO） and the lowest unoccupied molecular orbital （LUMO） values calculated from electrochemical measurement. Electrochemical energy gaps （Eg＇） of 4-HBAP and P-4-HBAP were found to be -5.46, -5.28; -2.26, -2.67; 3.20 and 2.61 eV, respectively. According to UV-Vis measurements, optical band gap （Eg） of 4-HBAP and P-4-HBAP were found to be 3.34 and 3.01 eV, respectively. Also, antimicrobial activities of 4-HBAP and P-4-HBAP were examined against selected some bacteria. The electrical conductivity of the polymer was measured after doping with iodine.

关键词： Air oxygen H2O2 NaOCl Poly[4-(4-hydroxybenzylidene amino) phenol] Oxidative polycondensation Thermal analysis Conductivity Antimicrobial and bad gap.

Effect of thermal treatment on the swelling and surface roughness of common alder and wych elm wood

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Journal of Forestry Research 2016年第1期27卷 225-229页

作者： Ayhan Aytin suleyman Korkul Program of Furniture and Decoration Duzce Vocational School Duzce University Diizce Turkey Department of Forest Industry Engineering Faculty of Forestry Duzce University Diizce Turkey

Wood heat treatment has increased signifi- cantly in recent years and is still growing as an industrial process to improve some wood properties. We studied the change of swellingand surface roughness of common alder （Alnus glutinosa （L.） Gaertn. ***） and wych elm （Ulmus glabra Huds.） woods after heat treatment at two different temperatures and durations. The temperatures were 180 and 200 ℃ and the durations were 2 and 4 h. A stylus method was employed to evaluate the surface char- acteristics of the samples. Roughness measurements by the stylus method were made in the direction perpendicular to the fiber on the wood surface. Four main roughness parameters, mean arithmetic deviation of profile （Ra）, mean peak-to-valley height （Rz）, root mean square roughness （Rq）, and maximum roughness （Ry） were used to evaluate the effect of heat treatment on the surface characteristics of the specimens. Swelling and surface roughness parameters （Ra, Rz, Ry, and Rq） differed significantly for two temper- atures and two durations of heat treatment. Swelling and surface roughness values decreased with increasing treat- ment temperature and treatment times.

关键词： Heat treatment Swelling Surfaceroughness. Common alder Wych elm

A case of asymptomatic fungal and bacterial colonization of an intragastric balloon

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World Journal of Gastroenterology 2009年第45期15卷 5751-5753页

作者： Halil Coskun suleyman Bozkurt Department of General Surgery Goztepe Training and Research Hospital

Intragastric balloon therapy, as a part of a multidisciplinary weight management program, is an effective short-term intervention for weight loss. Although the insertion procedure is easy and generally well tolerated by patients, a few complications can occur. We report here a heavy smoker with intragastric balloon inser-tion complicated by colonization with opportunistic organisms. The 27-year-old female, body mass index 35.5 kg/m2, had a BioEnterics Intragastric Balloon inserted under conscious sedation without any perioperative complications. Six months later, when the standard removal time arrived, the balloon was seen to be covered with a necrotic white-gray material. Microbiological examination revealed Enterobacter cloacae and Candida species yeast colonies. We recommend that asymptomatic fungal and/or bacterial colonization should be considered among the complications of the intragastric balloon procedure, despite its rarity.

关键词： Gastric balloon Obesity, Complications Infection

Serum arylesterase and paraoxonase activity in patients with chronic hepatitis

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World Journal of Gastroenterology 2005年第46期11卷 7351-7354页

作者： suleyman Sirri Kilic suleyman Aydin Nermin Kilic Fazilet Erman Suna Aydin Ilhami Celik Department of Infection and Clinical MicrobiologyMedical School (Firat Medical Center) Firat UniversityElazig 23119Turkey Department of Biochemistry and Clinical BiochemistryMedical School (Firat Medical Center) Firat UniversityElazig 23119Turkey Department of Medical EducationMedical School (Firat Medical Center) Elazig 23119Turkey

AIM： To investigate the relationship between serum paraoxonase （PON1）, AST, ALT, GGT, and arylesterase （AE） activity alterations and the degree of liver damage in patients with chronic hepatitis. METHODS： We studied 34 chronic hepatitis patients and 32 control subjects, aged between 35 and 65 years, in the Department of Infection and Clinical Microbiology at the Firat University School of Medicine. Blood samples were collected from subjects between 8：00 and 10：00 a.m. following a 12-h fast. Baseline and salt-stimulated PON1 activities were measured by the hydrolysis of paraoxon. Phenyl acetate was used as the substrate and formed phenol was measured spectrophotometrically at 270 nm after the addition of a 10-fold diluted serum sample in AE activity measurements. RESULTS： The results of this investigation revealed that the levels of AE activity decreased from 132±52 to 94± 36 （29%）, baseline PON1 activity from 452±112 to 164 ±67 （64%）, salt-stimulated PON1 activity from 746± 394 to 294±220 （61%）, HDL from 58.4±5.1 to 47.2±5.6 （200）, triglyceride from 133±51.2 to 86±34.0 （350）, while a slight increase in the level of LDL （from 163± 54.1 to 177.3±56.0; 9%） and significant increases in the levels of AST （from 29±9.3 to 98±44）, ALP （from 57.2±13.1 to 91±38.1）, ALT （from 27.9±3.32 to 89± 19.1）, GGT （from 24.3±2.10 to 94±48.2）, total bilirubin （from 0.74±0.02 to 1.36±0.06; 84%） and direct bilirubin （from 0.18±0.01 to 0.42±0.04; 133%） were detected. However, the levels of albumin, total protein, cholesterol, and uric acid were almost the same in chronic hepatitis and the control subjects.CONCLUSION： Low PON1 and AE activity may contribute to the increased liver dysfunction in chronic hepatitis patients by reducing the ability of HDL to retard LDL oxidation and might be clinically useful for monitoring the disease of chronic hepatitis.

关键词： Paraoxonase Arylesterase Chronic hepatitis Lipoproteins

Influence of Temperatures on the Tautomerism of the N-（1H- Imidazoline-2-yl）-lH-benzimidazol-2-amine and Investigation of Its Electrochemical Behaviour

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Chinese Journal of Chemistry 2012年第2期30卷 400-404页

作者： Servi, suleyman Genc, Murat Saydam, Sinan Department of Chemistry Faculty of Science University of Firat TR-23119 Elazig Turkey Department of Chemistry Faculty of Science and Art University of Adiyaman TR-02040Adiyaman Turkey

Synthesis of N-（1H-imidazoline-2-yl）-lH-benzimidazol-2-amine was carried out under microwave irradiation （MWI） conditions. Dynamic 1H NMR investigation of N-（lH-imidazoline-2-yl）-lH-benzimidazol-2-amine compound was reported at temperature range of 223--333 K in DMF-d7. Some physical parameters, such as coalescence temperature （Tc）, the free energy of activation （△G＊） and rate constant （k） values were calculated from its IH NMR spectra at various temperatures. Electrochemical feature of this compound was investigated by cyclic （CV） and square wave voltammetry （SWV）.

关键词： benzimidazole tautomerism dynamic NMR cyclic voltammetry

Statistical optimization of adsorption processes for removal of 2,4-dichlorophenol by activated carbon derived from oil palm empty fruit bunches

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Journal of Environmental Sciences 2007年第6期19卷 674-677页

作者： Md.Zahangir ALAM suleyman A.MUYIBI Juria TORAMAE Bioenvironmental Engineering Research Unit Department of Biotechnology EngineeringFaculty of EngineeringInternational Islamic UniversityMalaysia Jalan Gombak53100 Kuala LumpurMalaysia

The adsorption capacity of activated carbon produced from oil palm empty fruit bunches through removal of 2,4-dichlorophenol from aqueous solution was carried out in the laboratory. The activated carbon was produced by thermal activation of activation time with 30 min at 800℃. The adsorption process conditions were determined with the statistical optimization followed by central composite design. A developed polynomial model for operating conditions of adsorption process indicated that the optimum conditions for maximum adsorption of phenolic compound were： agitation rate of 100 r/min, contact time of 8 h, initial adsorbate concentration of 250 mg/L and pH 4. Adsorption isotherms were conducted to evaluate biosorption process. Langmuir isotherm was more favorable （R^2=0.93） for removal of 2,4-dichlorophenol by the activated carbon rather than Freundlich isotherm （R^2=0.88）.

关键词： activated carbon adsorption oil palm empty fruit bunches 2,4-dichlorophenol

MOTIONS OF CURVES IN THE GALILEAN SPACE G_3

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Acta Mathematica Scientia 2015年第5期35卷 1046-1054页

作者： Ufuk OZTURK suleyman CENGIZ Esra Betul KOC OZTURK Department of Mathematics Faculty of Science ank?r? Karatekin University

In this article, we study the flows of curves in the Galilean 3-space and its equiform geometry without any constraints. We find that the Frenet equations and the intrinsic quantities of the inelastic flows of curves are independent of time. We show that the motion of curves in the Galilean 3-space and its equiform geometry are described by the inviscid and viscous Burgers＇ equations.

关键词： Galilean geometry equiform geometry motions of curves inextensible flows Burgers' equation Frenet frames

An investigation into ball burnishing process of magnesium alloy on CNC lathe using different environments

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Journal of Magnesium and Alloys 2020年第4期8卷 1061-1070页

作者： suleyman Cinar Cagan Catalin Iulian Pruncu Berat Baris Buldum Department of Mechanical Engineering Mersin University33343CiftlikkoyMersinTurkey Department of Mechanical Engineering Imperial College LondonExhibition RoadLondon SW72AZUnited Kingdom Mechanical Engineering School of EngineeringUniversity of BirminghamBirmingham B152TTUnited Kingdom

Ball burnishing routine permits through a simple,fast and economical manner to obtain free chip on the manufactured *** generates a superior surface finish by rotating a ball tool against a *** burnishing process is commonly developed in industry in order to improve the surface quality,which is a critical issue in the manufacturing *** experimental study were carried out to determine the best surface quality for magnesium alloy subjected to d iff ere ni *** of magnesium alloy was performed varying four different mediums and combining different burnishing *** design the experiment were used the classical Taguchi method through which were developed the L16 orthogonal *** strategy allowed to detect the driving parameters that generate the best surface roughness value by computing the signal-to-noise *** driving parameters values for this study are 400 N(force),0.05 mm/min(feed rate),three number of passes and boron oil as *** results are paramount important for designing heavy parts used in transportation vehicles such as automobiles,airplanes,high-speed trains etc.

关键词： Magnesium alloy Surface roughness Medium Taguchi method Ball burnishing