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A Novel Diagnostic and Therapeutic Strategy for Cancer Patients by Integrating Chinese Medicine Syndrome Differentiation and Precision Medicine

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Chinese Journal of Integrative Medicine 2022年第10期28卷 867-871页

作者： YU Shu-xian LIANG Zi-mao WU Qi-biao SHOU Lan HUANG xing-xing ZHU Qian-ru XIE Han MEI Ru-yi ZHANG Ruo-nan ZHAI Xiang-yang XIE Tian sui xin-bing School of Pharmacy and Department of Medical Oncology the Afﬁliated Hospital of Hangzhou Normal UniversityCollege of MedicineHangzhou Normal UniversityHangzhou(311121)China Key Laboratory of Elemene Class Anti-cancer Chinese Medicines Engineering Laboratory of Development and Application of Traditional Chinese MedicinesCollaborative Innovation Center of Traditional Chinese Medicines of Zhejiang ProvinceHangzhou Normal UniversityHangzhou(311121)China State Key Laboratory of Quality Research in Chinese Medicines Faculty of Chinese MedicineMacao University of Science and TechnologyMacaoChina

Applying Chinese medicine(CM) is an important strategy for malignant tumor treatment in China. One of the significant characteristics of CM is to treat diseases based on syndrome differentiation. For Western medicine, it is of important clinical significance to formulate guidelines for the diagnosis and treatment of cancer patients based on the characteristics of disease differentiation. In Chinese clinical practice, the combination of disease differentiation and syndrome differentiation is an important feature for cancer treatment in the past. Currently, molecular profiling and genomic analysis-based precision medicine optimizes the anticancer drug design and holds the greatest success in treating cancer patients. Therefore, we want to know which populations of cancer patients can benefit more from CM treatment if the theory of precision medicine is applied to CM clinical practice. So, we developed a novel diagnostic and therapeutic strategy "disease-syndrome differentiation-genomic profilingprescriptions" for cancer patients by CM syndrome differentiation and precision medicine. As a result, this strategy has greatly enhanced the anti-tumor efficacy of CM and improved clinical outcomes for cancer patients with some gene mutations. Our idea will hopefully establish a novel approach for the inheritance and innovation of CM.

关键词： Chinese medicine Western medicine syndrome differentiation precision medicine cancer treatment

Analysis of the redox environment and genesis of surface sediment in the northeast Indian Ocean at the Ninety-East Ridge

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Journal of Oceanology and Limnology 2025年第1期43卷 57-72页

作者： Zhourong CAI Qianru HUANG Zhengxin YIN xin sui Sibo LÜ Meng TANG Juan PENG School of Marine Sciences Sun Yat-sen UniversityZhuhai 519082China Guangdong Provincial Key Laboratory of Marine Resources and Coastal Engineering Zhuhai 519082China South China Sea Marine Survey Center Ministry of Natural ResourcesGuangzhou 510275China Key Laboratory of Marine Environmental Survey Technology and Application Ministry of Natural ResourcesGuangzhou 510275China

The Ninety-East Ridge(NER)is located in the semioceanic to oceanic region of the southern Bengal Fan in the Northeast Indian *** sedimentary environment,ocean currents,and scientific issues related to climate change have always been the focus of *** well understand the sedimentary environment of the sea area,we studied the modern sedimentary environment of the NER by analyzing the redox-sensitive trace elements(RSEs)and biomarkers in the surface sediments of the northern region and both sides of the NER and the mechanism of their *** ratios of Mo/U(average 2.22),(Cu+Mo)/Zn(average 1.51),and the results ofδCe<1 of the sediment samples,all indicate the reduction of the sedimentary *** addition,the ratio of pristane(Pr)to phytane(Ph),C30diahopane to C30 hopane,and diasterane to sterane were low in all samples,on average of 1.03,0.9,and 0.33,*** analysis of RSE and biomarker data revealed that the sedimentary environment on seabed of the NER is generally a rare low-oxygen reduction *** the analysis of sediment characteristics,material sources,and ocean currents,we preliminarily constructed a genetic model for the low-oxygen reducing environment of surface sediments in the *** believe that the low-oxygen reduction environment of surface sediment in the NER could be influenced by multiple factors,such as terrestrial input of materials,productivity at sea surface,and sediment particle size.

关键词： Ninety-East Ridge(NER) surface sediment sedimentary environment redox-sensitive trace elements(RSEs) biomarker

3D Printed Chitosan Bioink Loaded with Chrysin for Repairing Bone Defects

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Chemical Research in Chinese Universities 2025年第1期41卷 155-164页

作者： ZHANG Hao TANG Wenshuo sui xin LI Lingfeng ZHANG Hongpu LI Yuran ZHANG Xueyi LIU Zhihui WANG Bowei Hospital of Stomatology Jilin UniversityChangchun130021P.R.China Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling Changchun130021P.R.China The Second Hospital of Jilin University Changchun130041P.R.China

This study aimed to investigate the potential of chrysin(C)to induce osteogenic differentiation of rat bone marrow mesenchymal stem cells(BMSCs)in ***(CS)was dissolved by repeated freeze-thawing of alkali/urea solutions,followed by co-printing of nano-hydroxyapatite(HAP)powders with different concentrations of C solutions(5,10,and 20µmol/L)compounded into CS *** rheological properties were modified with acetic acid/gelatin solution to construct C-CS-HAP(C-CS-H)composite scaffolds by extrusion printing *** characterization showed that the four groups of scaffolds had regularly interconnected porous structures with pore diameters of about 450–600µm,and the novel bioink exhibited shear-thinning properties,with the viscosity of the material decreasing in the shear rates range of 0.01–1000 s^(−1) and thus good *** osteogenic differentiation ability of BMSCs was confirmed by the CCK-8 test,alkaline phosphatase(ALP)test,Alizarin Red staining(ARS)test,osteogenesis-related genes OCN,ALP,Runx 2,and bone morphogenetic protein-2(BMP-2)test,which showed a significant promotion of the osteogenic differentiation ability of BMSCs with the increase of the content of *** above results indicate the potential of C-CS-H composite scaffolds in osteogenesis.

关键词： Chrysin Chitosan Bioscaffold 3D printing Hydroxyapatite

Rab1 and Syntaxin 17 regulate hematopoietic homeostasis through β-integrin trafficking in Drosophila

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Journal of Genetics and Genomics 2025年第1期52卷 51-65页

作者： Fangzhou Luo Luwei sui Ying Sun Zhixian Lai Chengcheng Zhang Gaoqun Zhang bing Bi Shichao Yu Li Hua Jin College of Life Sciences Northeast Forestry UniversityHarbinHeilongjiang 150040China Department of Developmental Immunology Max Planck Institute of Immunobiology and EpigeneticsFreiburgGermany

Hematopoiesis is crucial for organismal health,and Drosophila serves as an effective genetic model due to conserved regulatory mechanisms with *** larvae,hematopoiesis primarily occurs in the lymph gland,which contains distinct zones,including the cortical zone,intermediate zone,medullary zone,and posterior signaling center(PSC).Rab1 is vital for membrane trafficking and maintaining the localization of cell adhesion molecules,yet its role in hematopoietic homeostasis is not fully *** study investigates the effects of Rab1 dysfunction on β-integrin trafficking within circulating hemocytes and lymph gland ***1 impairment disrupts the endosomal trafficking of β-integrin,leading to its abnormal localization on cell membranes,which promotes lamellocyte differentiation and alters progenitor dynamics in circulating hemocytes and lymph glands,*** also show that the mislocalization of β-integrin is dependent on the adhesion protein *** reduction of β-integrin at cell boundaries in PSC cells leads to fewer PSC cells and lamellocyte ***,Rab1 regulates the trafficking of β-integrin via the Q-SNARE protein Syntaxin 17(Syx17).Our findings indicate that Rab1 and Syx17 regulate distinct trafficking pathways for β-integrin in different hematopoietic compartments and maintain hematopoietic homeostasis of Drosophila.

关键词： Hematopoiesis Lymphgland Rab1 Syntaxin 17 β-integrin Drosophila

Constriction-susceptible lithium support for fast cycling of solid-state lithium metal battery

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Chinese Chemical Letters 2025年第2期36卷 36-37页

作者： Dong sui Jiayi Liu Henan Key Laboratory of Function-Oriented Porous Materials College of Chemistry and Chemical Engineering Luoyang Normal University

Recently, lithium metal batteries (LMBs) have been intensively explored owing to its high capacity and low potential of Li as the anode [1]. However, challenging problems for LMBs easily occur during cycling process [2], e.g., the growth of Li dendrites,the formation of unstable electrode-electrolyte interphases and side reactions inside the battery [3]. These problems can lead to reduced battery performances and short circuit [4], which are tried to be solved by some strategies including various threedimensional (3D) supports for Li deposition, electrolyte additives and Li alloys. However, it is still difficult to solve the stability of Li cycling effectively. 3D supports are demonstrated to be effective for tolerating the volume change during Li deposition.

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Rock fracture mechanism of buffer blasting with cushion layer at the borehole bottom

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 325-334页

作者： xinguang Zhu Chenxi Ding Zhe sui Hong Su Xu Guo School of Civil and Resources Engineering University of Science and Technology BeijingBeijing 100083China Key Laboratory for Mechanics in Fluid Solid Coupling Systems Institute of MechanicsChinese Academy of SciencesBeijing 100190China School of Mechanics and Civil Engineering China University of Mining and Technology(Beijing)Beijing 100083China School of Chemical and Blasting Engineering Anhui University of Science and TechnologyHuainan 232001China

This study primarily investigates the rock fracture mechanism of bottom cushion layer blasting and explores the effects of the bottom cushion layer on rock *** involves analyses of the evolution patterns of blasting stress,characteristics of crack distribution,and rock fracture features in the ***,blasting model experiments were carried out using the dynamic caustics principle to investigate the influence of bottom cushion layers and initiation methods on the integrity of the bottom rock *** experimental results indicate that the combined use of bottom cushion layers and inverse initiation effectively protects the integrity of the bottom rock ***,the process of stress wave propagation and dynamic crack propagation in rocks was simulated using the continuum-discontinuum element method(CDEM)and the Landau explosion source model,with varying thicknesses of bottom cushion *** numerical simulation results indicate that with increasing cushion thickness,the absorption of energy generated by the explosion becomes more pronounced,resulting in fewer cracks in the bottom rock *** illustrates the positive role of the cushion layer in protecting the integrity of the bottom rock mass.

关键词： bottom cushion layer blasting crack propagation continuum-discontinuum element method dynamic stress intensity factor

Recent advances of cerium compounds in functional coatings:Principle,strategies and applications

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Journal of Rare Earths 2025年第2期43卷 227-245页

作者： Kai An Youqiang Wang Yi sui Yongquan Qing Wei Tong Xuezhao Wang Changsheng Liu School of Mechanical and Automotive Engineering Qingdao University of Technology State Key Laboratory of Baiyunobo Rare Earth Resource Researches and Comprehensive Utilization Baotou Research Institute of Rare Earths School of Materials Science and Engineering Northeastern University Center for Nano and Micro Mechanics Tsinghua University

Cerium(Ce) compounds have attracted considerable attention as key components in functional coatings due to their many outstanding *** work provides a comprehensive review of recent advances in the application of Ce in functional *** role of Ce in the improvement of functional properties such as corrosion-resistance,self-healing,superhydrophobicity,wear-resistance,and UV shielding is reviewed from the perspective of functional mechanism and applied ***,the strategies,processes,practical problems,and current challenges in the research of functional coatings containing Ce are summarized and *** objective is to highlight the great potential of Ce in functional coatings,and to explore new applications of Ce in the development of novel ***,this work aims to enhance the application value of Ce,solving the problem of unbalanced application of rare-earth elements.

关键词： Cerium Functional coatings Corrosion Superhydrophobicity UV resistance Rare earths

Mn/S diatomic sites in C3N4 to enhance O2 activation for photocatalytic elimination of emerging pollutants

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Journal of Environmental Sciences 2025年第3期149卷 512-523页

作者： Chengji sui Zixuan Nie Xiaobin Xie Yifeng Wang Lingshuai Kong Shou-Qing Ni Jinhua Zhan Key Laboratory for Colloid&Interface Chemistry of Education Ministry School of Chemistry and Chemical EngineeringShandong UniversityJinan 250100China Institute of Eco-Environmental Forensics School of Environmental Science and EngineeringShandong UniversityQingdao 266237China

Oxygen activation leading to the generation of reactive oxygen species(ROS)is essential for photocatalytic environmental *** limited efficiency of O_(2)adsorption and reductive activation significantly limits the production of ROS when employing C_(3)N_(4)for the degradation of emerging *** with metal single atoms may lead to unsatisfactory efficiency,due to the recombination of photogenerated electron-hole ***,Mn and S single atoms were introduced into C_(3)N_(4),resulting in the excellent photocatalytic ***/S-C_(3)N_(4)achieved 100%removal of bisphenol A,with a rate constant 11 times that of pristine C_(3)N_(4).According to the experimental results and theoretical simulations,Satoms restrict holes,facilitating the photo-generated carriers’***-atom Mn acts as the O_(2)adsorption site,enhancing the adsorption and activation of O_(2),resulting the generation of *** study presents a novel approach for developing highly effective photocatalysts that follows a new mechanism to eliminate organic pollutants from water.

关键词： Photocatalytic degradation O_(2)activation Reactive oxygen species Emerging pollutants Single-atom catalyst

Interfacial electron rearrangement of 3D Fe_(3)O_(4)/h-YFeO_(3)composites for efficient electromagnetic wave absorption

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International Journal of Minerals,Metallurgy and Materials 2025年第3期32卷 609-618页

作者： Yi sui Yingde Zhang Guang Liu Lei Ji Junyu Yue Chen Wu Mi Yan School of Materials Science and Engineering Zhejiang UniversityHangzhou 310027China State Key Laboratory of Baiyunobo Rare Earth Resource Researches and Comprehensive Utilization Baotou Research Institute of Rare EarthsBaotou 014030China Key Laboratory of Rare Earths Chinese Academy of SciencesGanzhou 341119China Shanxi-Zheda Institute of Advanced Materials and Chemical Engineering Taiyuan 030032China

Interface modulation is an important pathway for highly efficient electromagnetic wave ***,tailored interfaces between Fe_(3)O_(4)particles and the hexagonal-YFeO_(3)(h-YFeO_(3))framework were constructed via facile *** resulting interfa-cial electron rearrangement at the heterojunction led to enhanced dielectric and magnetic loss *** results and density function theory(DFT)simulations demonstrate a transition in electrical properties from a half-metallic monophase to metallic Fe_(3)O_(4)/h-YFeO_(3)composites,emphasizing the advantages of the formed *** transformation of electron behavior is also accompan-ied by a redistribution of electrons at the Fe_(3)O_(4)/h-YFeO_(3)heterojunction,leading to the accumulation of localized electrons around the Y-O-Fe band bridge,consequently enhancing the polarization.A minimum reflection loss of-34.0 dB can be achieved at 12.0 GHz and 2.0 mm thickness with an effective bandwidth of 3.3 GHz due to the abundant interfaces,enhanced polarization,and rational ***,the synergistic effects endow the Fe_(3)O_(4)/h-YFeO_(3)composites with high performance and tunable functional properties for efficient electromagnetic absorption.

关键词： self-assembling heterojunction electron rearrangement interface modulation electromagnetic wave absorption