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Distributed Graph Database Load Balancing Method Based on Deep Reinforcement Learning

Computers, Materials & Continua 2024年第6期79卷 5105-5124页

作者： Shuming sha Naiwang Guo Wang Luo Yong Zhang Nanjing NARI Information&Communication Technology Co. Ltd.Nanjing210032China State Grid Electric Power Research Institute Nanjing211106China State Grid shanghai Municipal Eleciric Power Company Shanghai200122China

This paper focuses on the scheduling problem of workflow tasks that exhibit *** indepen-dent batch tasks,workflows typically consist of multiple subtasks with intrinsic correlations and *** necessitates the distribution of various computational tasks to appropriate computing node resources in accor-dance with task dependencies to ensure the smooth completion of the entire *** scheduling must consider an array of factors,including task dependencies,availability of computational resources,and the schedulability of ***,this paper delves into the distributed graph database workflow task scheduling problem and proposes a workflow scheduling methodology based on deep reinforcement learning(DRL).The method optimizes the maximum completion time(makespan)and response time of workflow tasks,aiming to enhance the responsiveness of workflow tasks while ensuring the minimization of the *** experimental results indicate that the q-learning Deep Reinforcement Learning(q-DRL)algorithm markedly diminishes the makespan and refines the average response time within distributed graph database *** q.a.tifying makespan,q-DRL achieves mean reductions of 12.4%and 11.9%over established First-fit and random scheduling strategies,***,q-DRL surpasses the performance of both DRL-Cloud and Improved Deep q-learning Network(IDqN)algorithms,with improvements standing at 4.4%and 2.6%,*** reference to average response time,the q-DRL approach exhibits a significantly enhanced performance in the scheduling of workflow tasks,decreasing the average by 2.27%and 4.71%when compared to IDqN and DRL-Cloud,*** q-DRL algorithm also demonstrates a notable increase in the efficiency of system resource utilization,reducing the average idle rate by 5.02%and 9.30%in comparison to IDqN and DRL-Cloud,*** findings support the assertion that q-DRL not only upholds a lower average

关键词： Reinforcement learning workflow task scheduling load balancing

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Diagnosis of Acute q Fever in an Elderly Patient Using Metagenomic Next-Generation Sequencing:A Case Report

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Journal of Clinical and Nursing Research 2024年第9期8卷 36-39页

作者： shasha Zang sha Liu Lili Tan Department of Geratology The Affiliated Hospital of Hebei UniversityBaoding 071000Hebei ProvinceChina Department of Cardiology The Affiliated Hospital of Hebei UniversityBaoding 071000Hebei ProvinceChina

query fever(q fever)is a globally spread zoonotic disease caused by Coxiella burnetii,commonly found in natural foci but rarely seen in Hebei *** clinical manifestations of q fever are diverse and nonspecific,which often leads to missed or incorrect diagnoses in clinical *** article reports a case of acute q fever diagnosed in an elderly patient using metagenomic next-generation sequencing.

关键词： Elderly patient Acute q fever Metagenomic next-generation sequencing(mNGS)

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Investigation of the Nd-Ce-Mg-Zn/Substituted Hydroxyapatite Effect on Biological Properties and Osteosarcoma Cells

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Journal of Renewable Materials 2023年第3期11卷 1485-1498页

作者： suha q.a.-sha.ra.a.ee Hussein Alaa Jaber Department of Materials Engineering Baghdad10001Iraq

Cancerous diseases and diseases resulting from bacteria and fungi are some of the pressures that humans ***,the development of biomaterials that are resistant to cancerous diseases,bacteria,and fungi has become one of the requirements of the medical field to extend the life of the biomaterial and fight pathogens after implanting these materials inside the human *** of the important biomaterials used in the field of orthopedics is *** this research,Nano substituted hydroxyapatite was prepared by the wet precipitation method,including replacing 5%of the calcium ions with neodymium,cerium,magnesium,and zinc ions in cationic *** tests were carried out to characterize the prepared *** biological properties were evaluated by examining the resistance of the substituted hydroxyapatite to bacteria and fungi,in addition to testing the effect of the material on normal cells and bone cancer *** results showed a new structure of hydroxyapatite after the substitution process and a significant improvement in the biological properties of the prepared biomaterial compared to other researches.

关键词： Hydroxyapatite neodymium cerium substitution

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Calculus bovis inhibits M2 tumor-associated macrophage polarization via Wnt/β-catenin pathway modulation to suppress liver cancer

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World Journal of Gastroenterology 2024年第29期30卷 3511-3533页

作者： Zhen Huang Fan-Ying Meng Lin-Zhu Lu q.a.-q.a. Guo Chang-Jun Lv Nian-Hua Tan Zhe Deng Jun-Yi Chen Zi-Shu Zhang Bo Zou Hong-Ping Long qing Zhou sha Tian Si Mei Xue-Fei Tian College of Integrated Chinese and Western Medicine Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina Hunan Key Laboratory of Translational Research in Formulas and Zheng of Traditional Chinese Medicine Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina Key Laboratory of Traditional Chinese Medicine for Mechanism of Tumor Prevention and Treatment Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina The First Clinical College of Traditional Chinese Medicine Hunan University of Traditional Chinese MedicineChangsha 410007Hunan ProvinceChina Department of Hepatology Hunan University of Chinese MedicineChangsha 410007Hunan ProvinceChina The First Hospital of Hunan University of Chinese Medicine Hunan University of Chinese MedicineChangsha 410007Hunan ProvinceChina Faculty of Medicine Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina

BACKGROUND Calculus bovis(CB),used in traditional Chinese medicine,exhibits anti-tumor effects in various cancer *** also constitutes an integral component of a compound formulation known as Pien Tze Huang,which is indicated for the treatment of liver ***,its impact on the liver cancer tumor microenvironment,particularly on tumor-associated macrophages(TAMs),is not well *** To elucidate the anti-liver cancer effect of CB by inhibiting M2-TAM polarization via Wnt/β-catenin pathway *** This study identified the active components of CB using UPLC-q-TOF-MS,evaluated its anti-neoplastic effects in a nude mouse model,and elucidated the underlying mechanisms via network pharmacology,transcriptomics,and molecular *** vitro assays were used to investigate the effects of CB-containing serum on HepG2 cells and M2-TAMs,and Wnt pathway modulation was validated by real-time reverse transcriptase-polymerase chain reaction and Western blot *** This study identified 22 active components in CB,11 of which were detected in the *** investigations have demonstrated the ability of CB to effectively inhibit liver tumor *** integrated approach employing network pharmacology,transcriptomics,and molecular docking implicated the Wnt signaling pathway as a target of the antineoplastic activity of CB by suppressing M2-TAM *** vitro and in vivo experiments further confirmed that CB significantly hinders M2-TAM polarization and suppresses Wnt/β-catenin pathway *** inhibitory effect of CB on M2-TAMs was reversed when treated with the Wnt agonist SKL2001,confirming its pathway *** This study demonstrated that CB mediates inhibition of M2-TAM polarization through the Wnt/β-catenin pathway,contributing to the suppression of liver cancer growth.

关键词： Calculus bovis M2 tumor-associated macrophage polarization Liver cancer Wnt/β-catenin pathway Tumor microenvironment

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猕猴桃皮多酚对脂多糖应激Caco-2细胞抗氧化能力的影响

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食品科学 2024年第16期45卷 105-112页

作者：徐瑞屿薛沙牛鸿艳黄群周艳贵州医科大学公共卫生与健康学院环境污染与疾病监控教育部重点实验室贵州省生态食品创制工程研究中心贵州贵阳561113

目的:探讨猕猴桃皮多酚(kiwifruit peel polyphenols,KPP)对脂多糖(lipopolysaccharide,LPS)应激Caco-2细胞抗氧化能力的影响。方法:采用CCK-8法测定不同处理组Caco-2的细胞活力,荧光分光光度计测定活性氧和线粒体膜电位,分光光度计测... 详细信息

目的:探讨猕猴桃皮多酚(kiwifruit peel polyphenols,KPP)对脂多糖(lipopolysaccharide,LPS)应激Caco-2细胞抗氧化能力的影响。方法:采用CCK-8法测定不同处理组Caco-2的细胞活力,荧光分光光度计测定活性氧和线粒体膜电位,分光光度计测定超氧化物歧化酶(superoxide dismutase,SOD)活力和谷胱甘肽(glutathione,GSH)、丙二醛(malonaldehyde,MDA)含量,实时荧光定量聚合酶链式反应测定核红细胞2相关因子2(nuclear factor erythroid 2-related factor 2,Nrf2)、Kelch样ECH相关蛋白1(Kelch-like ECH-associated protein 1,Keap1)、NAD(P)H:醌氧化还原酶1(NAD(P)H:quinone oxidoreductase 1,NqO1)、超氧化物歧化酶1(superoxide dismutase 1,S O D 1)、S O D 2基因的表达;蛋白印迹测定N r f 2、Ke a p 1及N q O 1蛋白表达水平。结果:与L P S组相比,经50μg/mL KPP干预后细胞活力显著升高(PqO1基因和蛋白表达(PqO1信号通路提高Caco-2的抗氧化水平,缓解LPS应激造成的细胞损伤。

关键词：猕猴桃皮多酚脂多糖 Caco-2细胞抗氧化活性 Nrf2通路

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Dioxin induces expression of hsa-mi R-146b-5p in human neuroblastoma cells

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Journal of Environmental Sciences 2018年第1期30卷 260-267页

作者： Tuan Xu Heidi q.Xie Yunping Li Yingjie Xia Rui sha Lingyun Wang Yangsheng Chen Li Xu Bin Zhao State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China

Dioxin can cause a series of neural toxicological effects. Micro RNAs（mi Rs） play important roles in regulating nervous system function and mediating cellular responses to environmental pollutants, such as dioxin. Hsa-mi R-146 b-5 p appears to be involved in neurodegenerative diseases and brain tumors. However, little is known about effects of dioxin on the expression of hsa-mi R-146 b-5 p. We found that the hsa-mi R-146 b-5 p expression and its promoter activity were significantly increased in dioxin treated SK-N-SH cells, a human-derived neuroblastoma cell line. Potential roles of hsa-mi R-146 b-5 p in mediating neural toxicological effects of dioxin may be due to the regulation of certain target genes. We further confirmed that hsa-mi R-146 b-5 p significantly suppressed acetylcholinesterase（ACh E） activity and targeted the3′-untranslated region of the ACh E T subunit, which has been down-regulated in dioxin treated SK-N-SH cells. Functional bioinformatic analysis showed that the known and predicted target genes of hsa-mi R-146 b-5 p were involved in some brain functions or cyto-toxicities related to known dioxin effects, including synapse transmission, in which ACh E may serve as a responsive gene for mediating the effect.

关键词： 2 3 7 8-Tetrachlorodibenzo-p-dioxin(TCDD) MicroRNA Acetylcholinesterase(AChE) Neuron Transcription regulation Post-transcriptional regulation

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太白茶HPLC指纹图谱的建立及UHPLC-qExactive Focus MS/MS联用分析

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药物分析杂志 2024年第4期44卷 585-593页

作者：李莎莎李雅娟王晓婷毛阿娟李凡李芳张红王卫锋陕西省中医药研究院西安710003 陕西中医药大学咸阳712046

目的:建立太白茶药材高效液相色谱(HPLC)指纹图谱分析方法,并运用超高效液相色谱-四极杆/静电场轨道阱高分辨质谱(UHPLC-q Exactive Focus MS/MS)法对太白茶中的特征峰进行定性分析。方法:采用Agilent TC-C18(250 mm×4.6 mm,5μm)色谱... 详细信息

目的:建立太白茶药材高效液相色谱(HPLC)指纹图谱分析方法,并运用超高效液相色谱-四极杆/静电场轨道阱高分辨质谱(UHPLC-q Exactive Focus MS/MS)法对太白茶中的特征峰进行定性分析。方法:采用Agilent TC-C18(250 mm×4.6 mm,5μm)色谱柱,以甲醇(A)-0.1%甲酸水溶液(B)为流动相,梯度洗脱,流速1.0 mL·min^(-1),柱温30℃,检测波长254 nm,进样量10μL。采用“中药色谱指纹图谱相似度评价系统2012年版”,建立指纹图谱并进行相似度评价。化学成分分析选用UHPLC-q Exactive Focus MS/MS技术,采用Waters Acquity UPLC BEH C18(50 mm×2.1 mm,1.7μm)色谱柱,以乙腈(A)-0.1%甲酸水(B)为流动相,梯度洗脱,流速0.3 mL·min^(-1),柱温30℃;质谱条件为电喷雾离子源(ESI),负离子模式扫描,扫描范围m/z 80~1200。结果:建立的太白茶特征指纹图谱中,标定共有峰8个,10批太白茶药材相似度均≥0.9,各批次之间共有峰的相对保留时间RSD均q-Exactive Focus-MS/MS的定性分析,可用于太白茶药材的整体质量综合评价。

关键词：太白茶高效液相色谱指纹图谱质量评价超高效液相色谱-四极杆/静电场轨道阱高分辨质谱定性分析

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Identification of differentially expressed genes response to TCDD in rat brain after long-term low-dose exposure

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Journal of Environmental Sciences 2017年第12期29卷 92-99页

作者： Yangsheng Chen Li Xu Heidi q.H.Xie Tuan Xu Hualing Fu Songyan Zhang Rui sha Yingjie Xia Bin Zhao State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China University of Chinese Academy of Sciences Beijing 100049China

Several cohort studies have reported that dioxin and dioxin-like polychlorinated biphenyls might impair the nervous system and lead to neurological or neurodegenerative diseases in the elder people, but there is limited research on the involved mechanism. By using microarray analysis, we figured out the differentially expressed genes between brain samples from SD rats after low-dose（0.1 μg/（kg？bw）） dioxin exposure for six months and controls. To investigate the function changes in the course of dioxin exposure, Gene Ontology（GO） annotation and Kyoto Encyclopedia of Genes and Genomes（KEGG） pathway analysis were performed on the differentially expressed genes. And the changes of several picked genes have been verified by real-time PCR. A total of 145 up-regulated and 64 down-regulated genes were identified. The metabolic processes, interleukin-1 secretion and production were significantly associated with the differentially expressed genes. And the genes regulated by dioxin also clustered to cholinergic synapse and long-term potentiation. Candidate biomarker genes such as egr1, gad2, gabrb3, abca1, ccr5 and pycard may be toxicological targets for dioxin. Furthermore, synaptic plasticity and neuro-immune system may be two principal affected areas by dioxin.

关键词： TCDD Long-term exposure Neurotoxicity Microarray Neuroinflammation

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Equilibrium mercury and lead isotope fractionation caused by nuclear volume effects in crystals

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Acta Geochimica 2021年第2期40卷 150-162页

作者： sha Yang Yun Liu Department of Geological Engineering Qinghai University.Xining 810016China State Key Laboratory of Ore Deposit Geochemistry Institute of GeochemistryChinese Academy of SciencesGuiyang 550081China International Center for Planetary Science College of Earth SciencesChengdu University of TechnologyChengdu 610059China CAS Center for Excellence in Comparative Planetology Hefei 230026China

To investigate equilibrium mercury(Hg)and lead(Pb)isotope fractionation caused by the nuclear volume effect(NVE)in crystals,the electron densities at nuclei(i.e.,|Ψ(0)|2)for Hg-or Pb-bearing crystalline compounds were investigated by using the relativistic spin orbit zeroth-order regular approximation(ZOra)method with a three-dimensional periodic boundary condition based on the density functional theory(DFT).Many isotope fractionation factors of crystalline compounds are provided for the first *** results show,even at1000℃,NVE-driven Hg and Pb isotope fractionation are meaningfully large,i.e.,range from 0.12‰to 0.49‰(202Hg/^(198)Hg),from-0.20‰to 0.17‰(208Pb/^(206)Pb)and from-0.08‰to 0.06‰(207Pb/^(206) Pb)relative to Hg0 vapor and Pb0 vapor,***,the fractionations range from-0.06‰to-0.20‰(208Pb/^(206)Pb)and from-0.02‰to-0.08‰(207Pb/^(206)Pb)for Pb2+-bearing species,from 0.10‰to 0.17‰(208Pb/^(206)Pb)and from 0.04‰to 0.06‰(207Pb/^(206)Pb)for Pb4+-bearing species in *** calculated Hg-bearing species in crystals will enrich heavier isotope(202Hg)relative to Hg0 ***,Pb4+-bearing species enrich heavier Pb isotopes(208Pb and 207Pb)than Pb^(2+)-bearing species in crystals,which the enrichment can be up to 0.37‰(208-Pb/^(206)Pb)and 0.14‰(207Pb/^(206)Pb)at 1000℃,due to their NVEs are in opposite *** NVE-driven MIFs of Hg isotopes,which are compared to the Hg202-Hg198baseline,are up to-0.158‰(ΔNV199Hg),-0.024‰(ΔNV200Hg)and-0.094‰(ΔNV201Hg)relative to Hg0 vapor at5000 *** all studied Hg-bearing species in crystals,the MIFs of two odd-mass isotopes(i.e.,ΔNV199Hg andΔNV201Hg)will be changed proportionally and their ratio(i.e.,ΔNV199Hg/ΔNV201Hg)will be a constant *** NVE can also cause mass-independent fractionations for 207Pb and 204 Pb compared to the baseline of 208Pb and *** largest NVEdriven MIFs are 0.043‰(ΔNV207Pb)and-0.040‰(ΔNV204Pb)among all the studied species relative to Pb0 vapor at 5000 *** magnit

关键词： Mercury and lead isotopes Crystals Nuclear volume effect DFT relativistic effect calculations

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巨桉GRF基因家族生物信息学分析及其在不同氮水平下的组织表达模式

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西北农林科技大学学报（自然科学版） 2024年第3期52卷 62-72页

作者：杨雪芮陈少雄王建忠何沙娥中国林业科学研究院速生树木研究所广东湛江524022 南京林业大学林学院江苏南京210037 广西国有东门林场广西崇左532108

【目的】从全基因组水平上鉴定巨桉生长调节因子(growth-regulating factor,GRF)基因家族成员,分析其在不同氮素水平下的组织表达模式,为巨桉GRF基因功能研究及氮高效利用桉树品种的培育奠定基础。【方法】在NCBI网站中选择巨桉基因组,... 详细信息

【目的】从全基因组水平上鉴定巨桉生长调节因子(growth-regulating factor,GRF)基因家族成员,分析其在不同氮素水平下的组织表达模式,为巨桉GRF基因功能研究及氮高效利用桉树品种的培育奠定基础。【方法】在NCBI网站中选择巨桉基因组,用拟南芥和毛果杨的GRF蛋白序列与巨桉基因组数据库进行BLAST蛋白序列同源比对,并通过InterPro和SMART数据库进行保守结构域分析,获得巨桉GRF基因。利用在线网站Ex-pasy protparam、SignalP-5.0、WoLF PSORT和SOPMA,对巨桉GRF蛋白进行基本理化性质分析、信号肽预测、亚细胞定位及二级结构预测。利用MEGA7.0软件构建系统进化树,使用MEME在线平台分析EgrGRF蛋白的保守结构域和基序,用Plant CARE预测基因上游的顺式作用元件,并使用TBtools软件将结果可视化。以2年生巨桉苗为供试材料,浇灌氮素浓度分别为45(高氮)、15(常规氮)和1.5(低氮)mmol/L的营养液,4 d后取样,采用实时荧光定量PCR技术检测EgrGRF基因在3种氮素水平下的叶片、茎和根中的表达情况。【结果】鉴定得到6个巨桉GRF基因家族成员(EgrGRF1~EgrGRF6),分布于4条染色体上;6个EgrGRF蛋白的氨基酸数目为296~605个,分子质量为33415.86~64630.89 u,理论等电点为7.29~8.85,脂溶指数为39.93~64.79,均为亲水性蛋白;无规则卷曲和α-螺旋为主要二级结构元件,均定位于细胞核上,未检测到信号肽存在。系统进化树分析表明,巨桉、毛果杨和拟南芥的GRF家族成员可分为4组,各组中EgrGRF蛋白数量分别为0,3,1和2个,多数EgrGRF成员与毛果杨亲缘关系较近。基因结构及蛋白基序分析结果显示,巨桉GRF基因家族成员具有2~4个内含子;6个EgrGRF蛋白均具有CX_(9)CX_(10)CX_(2)H和qX_(3)LX_(2)q保守基序。顺式作用元件分析表明,EgrGRF基因启动子区含有茉莉酸甲酯、脱落酸、分生组织表达及低温等响应元件。实时荧光定量PCR结果显示,EgrGRF2和EgrGRF6基因在低氮处理的巨桉叶片中优势表达,EgrGRF2、EgrGRF3、EgrGRF5和EgrGRF6基因在低氮处理根中的表达量较高氮和常规氮处理显著升高,EgrGRF4基因在常规氮处理茎中的表达量最高。【结论】鉴定获得6个巨桉GRF基因家族成员,其中EgrGRF4基因可能参与茎生长发育的调控,EgrGRF2、EgrGRF3、EgrGRF5和EgrGRF6基因可能参与了巨桉对低氮胁迫的响应。

关键词：巨桉 GRF基因家族生物信息学分析基因表达氮响应

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