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Proton pump inhibitors as a risk factor for recurrence of Clostridium-difficile-associated diarrhea

World Journal of Gastroenterology 2010年第28期16卷 3573-3577页

作者： Ji Won Kim Kook Lae Lee Ji Bong Jeong Byeong Gwan Kim sue shin Joo Sung Kim Hyun Chae Jung In Sung Song Division of Gastroenterology and Hepatology Department of Internal MedicineSeoul National University Boramae Hospital Seoul National University College of Medicine Seoul 156-707South Korea Department of Laboratory Medicine Seoul National University Boramae Hospital Division of Gastroenterology and Hepatology Department of Internal MedicineSeoul National University Hospital Seoul National University College of Medicine Seoul 110-744South Korea

AIM:To investigate the risk factors for Clostridiumdifficile-associated diarrhea(CDAD)recurrence,and its relationship with proton pump inhibitors(PPIs). METHODS:Retrospective data of 125 consecutive hospitalized patients diagnosed with CDAD between January 2006 and December 2007 were collected by medical chart *** data included patient characteristics at baseline,underlying medical disease, antibiotic history before receiving a diagnosis of CDAD, duration of hospital stay,severity of CDAD,concurrenttreatment with PPIs,laboratory parameters,response to CDAD therapy,and recurrence of disease within 90 d of successful *** clinical and laboratory parameters were compared in patients in whom CDAD did or did not recur. RESULTS:Of the 125 patients(mean age,67.6± 13.9 years)that developed CDAD,98(78.4%)did not experience recurrence(non-recurrent group)and 27 (21.6%)experienced one or more recurrences(recurrent group).Prior to the development of CDAD,96% of the 125 patients were prescribed antibiotics,and 56(44.8%)of the patients received *** older than 65 years(P=0.021),feeding via nasogastric tube(NGT)(P=0.045),low serum albumin level(P =0.025),and concurrent use of PPIs(P=0.014) were found to be risk factors for CDAD recurrence by univariate ***,sex,length of hospital stay,duration and type of antibiotics used,severity of disease,leukocyte count and C-reactive protein(CRP) were not associated with risk of CDAD *** multivariate analysis,the important risk factors were advanced age(>65 years,adjusted OR:1.32,95% CI:1.12-3.87,P=0.031),low serum albumin level(< 2.5 g/dL,adjusted OR:1.85,95%CI:1.35-4.91,P= 0.028),and concurrent use of PPIs(adjusted OR:3.48, 95%CI:1.64-7.69,P=0.016). CONCLUSION:Advanced age,serum albumin level< 2.5 g/dL,and concomitant use of PPIs were found to be significant risk factors for CDAD recurrence.

关键词： Clostridium difficile Diarrhea Recurrence Risk factors Proton pump inhibitors

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Renewable Biofuel Production Using Red Ginseng Marc in Microbial Fuel Cells

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Journal of Sustainable Bioenergy Systems 2022年第1期12卷 1-11页

作者： Sung Jun Jang Immanuel H. Anaborne Jacqueline E. Chang Seohyun Shim sue Min shin Justin Kong Seunghan Baek Kunmin Kim Abraham Ha Paul S. Chung The Village School Houston USA Oakton High School Vienna USA Redondo Union High School Redondo Beach USA Branksome Hall Asia International School Jeju-do Korea School of Arts & Sciences Emory University Atlanta USA School of Arts & Sciences Washington University St. Louis USA School of Arts & Sciences Johns Hopkins University Baltimore USA Fuzbien Technology Institute Rockville USA

Microbial fuel cell (MFC) is one of the clean and sustainable energy technologies, often referred to as renewable energy, and directly chemical energy contained in organic matter into electrical energy by using the catalytic activity of microorganisms. Cellulosic biomass is a particularly attractive renewable resource for its abundant supply at low cost and its neutral carbon balance. However, methanogenesis had been negatively linked to anaerobic cellulosic power generation in MFCs. Ginseng root is a saponin-rich plant material and red ginseng marc (RGM) has not been reused as a high-value resource for industry although its residue contained both electron donors and saponin, the potential power generation enhancers for MFC. In this study, RGM was supplemented into MFC to evaluate its effects on methanogenesis and power generation. Two-chamber H-type MFCs were established using rumen fluid as anolyte to ferment cellulose at 2% (w/v). RGM, the residue from the steam and press process for red ginseng beverage preparation, was freeze-dried and ground to pass 0.5 mm sieve and added to the anode of MFC at 1% (w/v;Exp. 1) or 0.1% (Exp. 2) dose for treatment. Open circuit voltage, voltage and current across an external resistor were measured daily for 10d. On d10 of operation, collected biogases were measured for total gas production and analyzed for its components. In Exp. 1, power density was between 44.0 and 97.2 with an average of 83.8 mW/m2 in 1% RGM MFCs and was between 45.2 and 76.3 with an average of 61.5 mW/m2 in control. In Exp. 2, power density was between 44.8 and 75.6 with an average of 60.9 mW/m2 in 0.1% RGM MFCs and was between 45.1 and 54.1 with an average of 49.7 mW/m2 in control. Total gas production for 10d was 563 and 523 mL for RGM and control, respectively, in Exp 1, and was 546 and 477 mL for RGM and control, respectively, in Exp 2. Methane took up 58.6 and 67.9% of total gas for RGM and control, respective

关键词： Microbial Fuel Cell Red Ginseng Marc Cellulose Methanogenesis Electricity

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Common Methods of Contraception Used at Monkey Bay Community Hospital in Mangochi District, Malawi

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Advances in Infectious Diseases 2021年第1期11卷 13-20页

作者： David S. Chung Peter S. Park Sohyun Jeon sue Min shin Ji Woo Han Chaieun Lee Andrew Mun William Mun Yun Jae shin Lorie Kim Jairos B. Makangano Fatsani Manase Thomas Nyirenda School of Medicine University of Virginia Charlottesville VA USA Youth with Talents Fairfax VA USA Perelman School of Medicine University of Pennsylvania Philadelphia PA USA Clinical Research Education and Management Service Lilongwe Malawi

To determine commonly used methods of contraception at Monkey Bay Community hospital, to compare different methods of contraception used by people of various age groups, parity, Human Immunodeficiency Virus (HIV) and Marital status, a clinical audit of family planning methods used by clients at Monkey Community hospital from January 2018 to June 2019 was done. Data was collected from the registers. A total number of 1734 clients reported at family planning clinic of Monkey-Bay Community Hospital between January 2018 and June 2019. All the clients were females. Most of these clients were in the age range of 15 - 34 years (83.33%). There were 1,486 (87%) HIV negative clients, 208 (12%) HIV positive clients and 24 (1%) had unknown HIV status. Most clients had a parity of 1 - 2 (905, 52.71%) followed by 3 - 4 (540, 31.45%) and 5 or plus (272, 15.84%). There were more married people (1641, 97.23%) than unmarried ones (46, 2.73%). There was only one person who was divorced (1, 0.05%). Education status was not recorded. The five commonly used contraceptive methods were: Intramuscular (IM) injectable Depo-IM (1366, 79.51%), Jadelle (122, 7.10%), Subcutaneous (SC) injectable Depo-SC (65, 3.78%), Combined Oral Contraceptives (COC) (60, 3.49%) and Implanon (40, 2.33%). None of the clients was used female condoms as a method of contraception. The contraceptive use was common between the age group of 15 - 24 (707, 44.92%) and 25 - 34 (709, 45%). Depo-IM was most used in age group 25 - 34 (44.5%) while Jadelle was mostly used by 15 - 24 years old (48%). 1181 clients (79.5%) of HIV negative clients used Depo-IM as the contraceptive method while 164 clients (78.8%) of HIV positive clients used Depo IM as a method of contraception. More HIV negative clients used Jadelle and COC as compared to HIV positive clients. The choice of a particular method of contraception was influenced by many factors. Parity, marital status, age as well as HIV status did have some association with the pre

关键词： Contraception Parity HIV Mangochi Malawi

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Case of a tumor comprising gastric cancer and duodenal neuroendocrine tumor

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World Journal of Gastroenterology 2016年第36期22卷 8242-8246页

作者： Hiroaki Kaneko Akio Miyake Yasuaki Ishii Soichiro sue Haruo Miwa Tomohiko Sasaki Toshihide Tamura Masaaki Kondo shin Maeda Department of Gastroenterology Yokohama City University Graduate School of Medicine Department of Pathology Yokohama City University Graduate School of Medicine

The present report describes a rare case of a tumor composed of early gastric cancer and a duodenal neuroendocrine tumor(NET). A 78-year-old woman underwent esophagogastroduodenoscopy at a local institution for screening of the upper gastrointestinal tract which revealed a protruded tumor through the pyloric ring from the pyloric antrum. The tumor was too large to treat at the facility; consequently, she was referred to our hospital for further management. Esophagogastroduodenoscopy with tumor biopsy of the lesion revealed the diagnosis of early gastric cancer. Endoscopic submucosal dissection was performed with sufficient free margins in both vertical and horizontal directions. Histopathological findings showed NET confined to the submucosal layer and covered by welldifferentiated adenocarcinoma. Immunohistochemical stainings showed that the two lesions existed continuously. While the possibility of a collision cancer was considered, it was suggested that the two lesions existed continuously. Finally, the tumor was diagnosed as gastric cancer composed of duodenal NET G1, with a lymphatic invasion of NET component.

关键词： Gastric cancer Endoscopic submucosal dissection Neuroendocrine tumor Composite-type tumor Duodenum

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Knock out Fall Incidence

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Journal of Health Science 2014年第9期2卷 405-427页

作者： Magdalene Ng Kim Choo Juweita Bte Arba'in Heng Lili Joline NurJannah Zhong Tan sue Ching Mardielene Cunanan Mercado Nur Amelia Binte Azman Jayanthi d/o Sivam Pillay Israel Jimenez Bernal Connie Besas Oepulango Chong Lai Ling Ang shin Yuh Ward 53C Department of Internal Medicine Singapore General Hospital 169608 Republic of Singapore Ward 77H Department of Haematology Singapore General Hospital 169608 Republic of Singapore Nursing Division Singapore General Hospital 169608 Republic of Singapore Nursing Quality Department Singapore General Hospital 169608 Republic of Singapore

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