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Molecular Plant 2024年第7期17卷 1110-1128页

作者： Shen Zhang Devasantosh mohanty Adnan Muzaffar Min Ni Department of Plant and Microbial Biology University of Minnesota at Twin CitiesSaint PaulMinnesota MN 55108United States of AmericaUSA

Spatiotemporal regulation of gene expression by polycomb repressive complex 2(PRc2)is critical for animal and plant *** Arabidopsis fertilization independent seed(FIS)-PRC2 complex functions specifically during plant reproduction from gametogenesis to seed *** a double fertilization event,triploid endosperm proliferates early,followed by the growth of a diploid embryo,which replaces the endosperm in Arabidopsis and many *** genes critical for endosperm proliferation such as IKkU2 and MINI3 are activated after *** we report that two MADS-box AGAMOUS-LIKE(AGL)proteins associate with the key endosperm proliferation loci and recruit the FIS-PRC2 repressive complex at 4-5 days after pollination(DAP).Interestingly,AGL9 and AGL15 only accumulate toward the end of endosperm proliferation at 4-5 DAP and promote the deposition of H3K27me3 marks at key endosperm proliferation *** of AGL9 and AGL15 or overexpression of AGL9 or AGL15 significantly influence endosperm proliferation and ***-wide analysis with cleavage Under Targets and tagmentation(CUT&Tag)sequencing and RNA sequencing revealed the landscape of endosperm H3K27me3 marks and gene expression profiles in Col-0 and agl9 ***&Tag qPCR also demonstrated the occupancy of the two MADS-box proteins and FIS-PRC2 on a few representative target *** studies suggest that MADS-box proteins could potentially recruit PRc2 to regulate many other developmental processes in plants or even in fungi and animals.

关键词： AGL9 AGL15 embryo endosperm IKU2 MEDEA MINI3

Post-urethroplasty complications in hypospadias repair: a systematic review and meta-analysis comparing, polydioxanone and polyglactin sutures

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World Journal of Pediatric Surgery 2024年第1期7卷 1-9页

作者： Nitinkumar Borkar Charu Tiwari Debajyoti mohanty Tridip Dutta Baruah Manoj mohanty C K Sinha Pediatric Surgery All India Instituteof Medical Sciences-RaipurRaipurChhattisgardhIndia General Surgery All India Institute of Medical Sciences-RaipurRaipurChhattisgardhIndia Pediatric Surgery All India Institute of Medical Sciences-BhubaneswarBhubaneswarOrissaIndia St George's University of London LondonUK

Background Polyglactin(PG)and polydioxanone(PDS)sutures are extensively used based on the surgeon's *** development of post-reconstruction urethrocutaneous fistula(UCF)is variably attributed to the choice of suture material for *** meta-an alysiscompares complications of hypospadia srepair using PGand PDS *** The systematic review and meta-analysis were performed as per the Preferred Reporting Items for Systematic Reviews and Meta-Analyses *** authors conducted thorough searches in databases including MEDLINE,EMBASE,CENTRAL,Scopus,Google Scholar,and clinical trial *** measures included UCF,meatal stenosis,wound infection,urethral stricture,glans dehiscence,and overall *** analysis was used with fixed or random-effect models to find the pooled risk ratio and I2 *** The criteria for inclusion were met by five comparative studies with the inclusion of 1244 children *** analysis failed to show a statistically significant difference in the incidence of meatal stenosis,urethral stricture,wound infection,and total complications using PG and PDS ***,it showed a reduction in the incidence of UCF with PDS suture hypospadias repairs(risk ratio=0.66,95%Cl 0.48 to 0.92).Conclusions PDS sutures are associated with decreased incidence of UCF than PG after hypospadias *** incidence of meatal stenosis,urethral stricture,wound infection,and total complications was not affected by the type of suture material used for *** implications This meta-analysis suggests decreased incidence of UCF when PDS sutures are used for hypospadias repair which may impact the choice of suturematerialforrepair.

关键词： complications wound suture

Seasonal Prediction of Indian Summer Monsoon Using WRF: A Dynamical Downscaling Perspective

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Open Journal of Modelling and Simulation 2024年第1期12卷 1-32页

作者： Manas Ranjan mohanty Uma Charan mohanty Department of Atmospheric and Oceanic Sciences University of California Los Angeles USA Centre for Climate Smart Agriculture Siksha O Anusandhan Deemed to Be University Odisha India

Seasonal forecasting of the Indian summer monsoon by dynamically downscaling the CFSv2 output using a high resolution WRF model over the hindcast period of 1982-2008 has been performed in this study. The April start ensemble mean of the CFSv2 has been used to provide the initial and lateral boundary conditions for driving the WRF. The WRF model is integrated from 1st May through 1st October for each monsoon season. The analysis suggests that the WRF exhibits potential skill in improving the rainfall skill as well as the seasonal pattern and minimizes the meteorological errors as compared to the parent CFSv2 model. The rainfall pattern is simulated quite closer to the observation (IMD) in the WRF model over CFSv2 especially over the significant rainfall regions of India such as the Western Ghats and the central India. Probability distributions of the rainfall show that the rainfall is improved with the WRF. However, the WRF simulates copious amounts of rainfall over the eastern coast of India. Surface and upper air meteorological parameters show that the WRF model improves the simulation of the lower level and upper-level winds, MSLP, CAPE and PBL height. The specific humidity profiles show substantial improvement along the vertical column of the atmosphere which can be directly related to the net precipitable water. The CFSv2 underestimates the specific humidity along the vertical which is corrected by the WRF model. Over the Bay of Bengal, the WRF model overestimates the CAPE and specific humidity which may be attributed to the copious amount of rainfall along the eastern coast of India. Residual heating profiles also show that the WRF improves the thermodynamics of the atmosphere over 700 hPa and 400 hPa levels which helps in improving the rainfall simulation. Improvement in the land surface fluxes is also witnessed in the WRF model.

关键词： Dynamical Downscaling Regional and Mesoscale Modeling Diabatic Heating WRF

Tubularized incised plateurethroplasty and grafted tubularized incised plate urethroplasty: systematic review, metaanalysis and trial sequential analysis

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World Journal of Pediatric Surgery 2024年第1期7卷 10-19页

作者： Nitinkumar Borkar Charu Tiwari Abhijit Nair Debajyoti mohanty C K Sinha Jai Kumar Mahajan Paediatric Surgery All India Institute of Medical Sciences-RaipurRaipurChhattisgardhIndia Department of Anaesthesiology Ibra HospitalbraOman General Surgery All India Institute of Medical Sciences-RaipurRaipurChhattisgardhIndia Paediatric Surgery St George's University Hospitals NHS Foundation TrustLondonUK Pediatric Surgery PGIMERChandigarhIndia

Background Hypospadias is one of the most common genital birth *** are around 300 various techniques available for the repair of *** study aims to compare the reported outcomes of Tubularized incised plate urethroplasty(TIP)and Grafted TIP(GTIP)repair in children undergoing primary *** This meta-analysisadhered to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines,and we framed our research question using the population,intervention,control and outcomes *** conducted comprehensive electronic searches across various databases,employing a Boolean search strategy with predefined search *** randomized controlled trials(RCTs)were included for quantitative *** Totally,10 RCTs met our inclusion criteria for quantitative *** results indicated that urethrocutaneous fistula,glans dehiscence,and stricture rates were comparable between the two *** incidence of meatal stenosis was found to be significantly lower in the GTIP group with a relative risk(RR)of 0.32(95%confidence interval(Cl)0.15 to 0.67).Conclusion The coucomes UCF,glans dehiscence,and stricture rates were comparable between the two ***,the incidence of meatal stenosis was found to be significantly lower in the grafted TIP *** terms of operative time,our quantitative synthesis demonstrated that the TIP group had a shorter operative time than the GTIP group with significant heterogeneity.

关键词： plate grafted analysis

Impact of Cumulative Exposure to Circulating Ovarian Sex Hormones on Increasing the Risk of Hormone Receptor-Positive Breast Cancer

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生物组学研究杂志(英文) 2024年第1期07卷 36-43页

作者： mohanty Swati Sucharita mohanty Sumit Subhadarshi Panda Soumya Surath Sahoo Chita Ranjan mohanty Prafulla Kumar Padhy Rabindra Nath Siksha O Anusandhan University Institute of Medical Sciences and SUM Hospital Bhubaneswar Odisha India Regional Medical Research Centre Bhubaneswar Bhubaneswar Odisha India Khallikote Unitary University Brahmapur Odisha India

There were 2.3 million new cases of breast cancer registered in 2020, establishing it as the world’s leading cancer. The regular exposure of breast cells to circulating ovarian sex hormones may contribute to cancer growth at all stages. A literature review was performed by downloading research articles from PubMed Central, with keywords such as breast cancer, hormone exposure in breast cancer, estrogen/progesterone exposure in breast cancer, and breast cancer risk factors. Since breast cancer is a hormone-related disease, several factors that influence hormonal conditions or are indicators of alterations in hormonal conditions have been linked with the risk for breast cancer. Likewise, an elevated risk for breast cancer has been related to reproductive history and exogenous estrogen exposure because they may amplify lifetime estrogen exposure. All these factors address the total cumulative exposure to circulating ovarian sex hormones that a female is vulnerable to in her lifetime. A healthy lifestyle, a more extended breastfeeding period, and regular physical activity may help lower one’s risk. This review summarizes the factors that increase the risk of estrogen/progesterone (hormone receptor) receptor-positive breast cancer due to overall cumulative estrogen exposure, with an understanding of estrogen biosynthesis mechanisms and estrogen receptor signaling.

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Noscapine shows antimalarial activity against Plasmodium falciparum 3D7,its clinical isolate Pf140/SS,and Plasmodium berghei ANKA

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Asian Pacific Journal of Tropical Biomedicine 2024年第8期14卷 350-358页

作者： Swaraj Kumar Babu Sameer Maharana Satyaranjan Chhatria Dibya Ranjan Sahoo Ashirbad Nanda Satish Kanhar Prativa KBehera Sanjib mohanty Pradeep Kumar Naik Praveen Kishore Sahu Centre of Excellence in Natural Products and Therapeutics Department of Biotechnology and BioinformaticsSambalpur UniversityJyoti ViharSambalpur OdishaIndia Department of Molecular Biology and Infectious Diseases Community Welfare Society HospitalRourkelaOdishaIndia Molecular&Immunology Laboratory Infectious Disease Biology UnitIspat General HospitalRourkelaOdishaIndia Department of Pharmacy Centurion University of Technology and ManagementBhubaneswarOdishaIndia

Objective:To evaluate the antimalarial activity of noscapine against Plasmodium falciparum 3D7 strain(Pf3D7),its clinical isolate(Pf140/SS),and Plasmodium berghei ANKA(PbA).Methods:Using ring-stage survival assay,phenotypic assessments,and SYBR-green-based fluorescence assay,the antimalarial activities of noscapine were assessed compared with dihydroartemisinin(DHA)in in vivo and in vitro *** addition,hemolysis and cytotoxicity tests were carried out to evaluate its ***-PCR assay was also conducted to determine the effect of noscapine on papain-like cysteine protease Plasmodium falciparum falcipain-2(PfFP-2).Results:The antimalarial efficacy of noscapine against Pf3D7 and Pf140/SS was comparable to DHA,with IC50 values of(7.68±0.88)and(5.57±0.74)nM/mL,respectively,and>95%inhibition of PbA infected *** also showed a safe profile,as evidenced by low hemolysis and cytotoxicity even at high ***,PfFP-2 expression was significantly inhibited in both noscapine-treated Pf3D7 and Pf140/SS(P<0.01).Conclusions:Noscapine has antimalarial properties comparable to standard antimalarial DHA with better safety profiles,which may be further explored as a therapeutic candidate for the treatment of malaria.

关键词： Malaria Plasmodium falciparum Plasmodium berghei Noscapine Antimalarial Dihydroartemisinin Cytotoxicity Falcipain-2

Optic nerve sheath diameters in nontraumatic brain injury:A scoping review and role in the intensive care unit

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World Journal of Critical Care Medicine 2024年第3期13卷 75-90页

作者： Madhura Bhide Deven Juneja Omender Singh Shakya mohanty Institute of Critical Care Medicine Kalinga Institute of Medical SciencesBhubaneshwar 751024OdishaIndia Institute of Critical Care Medicine Max Super Speciality HospitalSaketNew Delhi 110017India

BACKGROUND Neuromonitoring in medical intensive care units is challenging as most patients are unfit for invasive intracranial pressure(ICP)modalities or unstable to transport for ***-based optic nerve sheath diameter(ONSD)is an attractive option as it is reliable,repeatable and easily performed at the *** has been sufficiently validated in traumatic brain injury(TBI)to be incorporated into the ***,currently the data for non-TBI patients is inconsistent for a scientific recommendation to be *** To compile the existing evidence for understanding the scope of ONSD in measuring ICP in adult non-traumatic neuro-critical *** PubMed,Google Scholar and research citation analysis databases were searched for studies in adult patients with non-traumatic causes of raised *** from 2010 to 2024 in English languages were *** We found 37 articles relevant to our *** cutoff for ONSD in predicting ICP varied from 4.1 to 6.3 *** of the articles used cerebrospinal fluid opening pressure followed by raised ICP on computed tomography/magnetic resonance imaging as the comparator *** was also found to be a reliable outcome measure in cases of acute ischaemic stroke,intracerebral bleeding and intracranial ***,ONSD is of doubtful utility in septic metabolic encephalopathy,dysnatremias and aneurysmal subarachnoid *** ONSD is a useful tool for the diagnosis of raised ICP in non-traumatic neuro-critically ill patients and may also have a role in the prognostication of a subset of patients.

关键词： Intracranial hypertension Intracranial pressure monitoring Medical intensive care unit Neuro-monitoring Nontraumatic brain injury Optic nerve sheath diameter Optic nerve ultrasound

A Note on an Order Level Inventory Model with Varying Two-Phased Demand and Time-Proportional Deterioration

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American Journal of Operations Research 2024年第1期14卷 59-73页

作者： Sephali mohanty Trailokyanath Singh Sudhansu Sekhar Routary Chinmayee Naik Department of Mathematics C. V. Raman Global University Bhubaneswar India Department of Mathematics and Humanities Odisha University of Technology and Research Bhubaneswar India

The main purpose of this paper is to generalize the effect of two-phased demand and variable deterioration within the EOQ (Economic Order Quantity) framework. The rate of deterioration is a linear function of time. The two-phased demand function states the constant function for a certain period and the quadratic function of time for the rest part of the cycle time. No shortages as well as partial backlogging are allowed to occur. The mathematical expressions are derived for determining the optimal cycle time, order quantity and total cost function. An easy-to-use working procedure is provided to calculate the above quantities. A couple of numerical examples are cited to explain the theoretical results and sensitivity analysis of some selected examples is carried out.

关键词： Deteriorating Items EOQ (Economic Order Quantity) Inventory Time-Proportional Deterioration Two-Phased Demand

Obesity as potential breast cancer risk factor for postmenopausal women

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Genes & Diseases 2021年第2期8卷 117-123页

作者： Swati Sucharita mohanty Prafulla Kumar mohanty Cytogenetics Laboratory P.G.Department of ZoologyUtkal UniversityBhubaneswar751004OdishaIndia

Breast cancer is the second highest prevalent cancer globally after lung cancer with 2.09 million cases during *** about 1.9 billion were overweight and over 650 million out of these were obese during *** is a significant relationship between breast cancer risk and *** menopause and premenopausal obesity diminish the risk whereas postmenopausal obesity amplifies the risk,because adipose tissue acts as the major reservoir for estrogen biosynthesis after *** estrogen levels in serum along with enhanced peripheral site production of estrogen have been viewed as major reasons of developing breast cancer in overweight postmenopausal *** review explains body fat as a peripheral site for estrogen biosynthesis,estrogen exposure affecting body fat distribution,and the mechanism of estrogen production from body fats.

关键词： Adipocyte Aromatase Breast cancer Estrogen Obesity