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World Journal of Gastroenterology 2008年第18期14卷 2863-2866页

作者： Tae Hyeon Kim Hyo Jeong Oh Chang-Soo choi Dong Han Yeom suck chei choi Department of Internal Medicine and Digestive Disease Research Institute Wonkwang University School of Medicine Iksan 570180 Korea

AIM: To study the efficacy and the safety of laser lithotripsy without direct visual control by using a balloon catheter in patients with bile duct stones that could not be extracted by standard technique. METHODS: The seventeen patients (7 male and 10 female; mean age 67.8 years) with difficult common bile duct (CBD) stones were not amenable for conventional endoscopic maneuvers such as sphincterotomy and mechanical lithotripsy were included in this study. Laser wavelengths of 532 nm and 1064 nm as a double pulse were applied with pulse energy of 120 mJ. The laser fiber was advanced under fluoroscopic control through the ERCP balloon catheter. Laser lithotripsy was continued until the fragment size seemed to be less than 10 mm. Endoscopic extraction of the stones and fragments was performed with the use of the Dormia basket and balloon catheter. RESULTS: Bile duct clearance was achieved in 15 of 17 patients (88%). The mean number of treatment sessions was 1.7 ± 0.6. Endoscopic stone removal could not be achieved in 2 patients (7%). Adverse effects were noted in three patients (hemobilia, pancreatitis, and cholangitis). CONCLUSION: The Frequency Doubled Double Pulse Nd:YAG (FREDDY) laser may be an effective and safe technique in treatment of difficult bile duct stones.

关键词： Bile duct stones Frequency doubled double pulse Nd:YAG laser Transpapillary removal Mechanical lithotripsy Balloon catheter

Sweet food improves chronic stress-induced irritable bowel syndrome-like symptoms in rats

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World Journal of Gastroenterology 2014年第9期20卷 2365-2373页

作者： Sang-Gyun Rho Yong Sung Kim suck chei choi Moon Young Lee Department of Emergency Medical Services Sunmoon University Chungnam Asan 336-708 South Korea Department of Gastroenterology and Wonkwang Digestive Disease Research Institute Wonkwang University Sanbon Hospital Gyeonggi Gunpo 435-040 South Korea Department of Gastroenterology and Wonkwang Digestive Disease Research Institute School of MedicineWonkwang University Jeonbuk Iksan 570-974 South Korea Department of Physiology and Institute of Wonkwang Medical Science and Wonkwang Digestive Disease Research Institute School of Medicine Wonkwang UniversityJeonbuk Iksan 570-749 South Korea

AIM: To investigate whether palatable sweet foods have a beneficial effect on chronic stress-induced colonic motility and inflammatory cytokines.

关键词： Irritable bowel syndrome Colon Stress Adrenal hormones Cytokines Rat

Effects of ranitidine for exercise induced gastric mucosal changes and bleeding

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World Journal of Gastroenterology 2006年第16期12卷 2579-2583页

作者： suck Jun choi Yong Sung Kim Jeong Ryong Chae Hong Kwan Cho Tae Hyeon Kim Young Woo Sohn Yong Leol Oh Geom Seog Seo Yong-Ho Nah suck chei choi Department of Leisure and Sports Wonkwang Health Science CollegeIksanSouth Korea Department of Internal Medicine School of MedicineWonkwang University and Digestive Disease Research InstituteIksanSouth Korea Department of Physical Education College of Natural SciencesKunsan National UniversityKunsanSouth Korea Department of Internal Medicine School of MedicineWonkwang University and Digestive Disease Research InstituteIksanSouth Korea and Department of Physical EducationCollege of Natural SciencesKunsan National UniversityKunsanSouth Korea

AIM： To evaluate the effect of ranitidine on gastric mucosal changes and on GI bleeding in long distance runhers. METHODS： Twenty-four long distance runners （M： 16, F： 8, age： 18.2＋ 1.5 years） participated in this study. A symptom questionnaire, stool hemoccult test, and upper gastrointestinal （GI） endoscopy were performed on the subjects prior to the study. The subjects took oral ranitidine （150 mg, b.i.d.） for two weeks. The upper GI endoscopy and stool Hemoccult tests were repeated after the treatment. RESULTS： Twenty-two of the 24 runners had at least one upper G1 mucosal lesion before the medication. The Endoscopic improvements were seen in eleven of the 14 cases of erosive gastritis and four of the 5 cases of esophagitis. Six subjects were Heine occult positive prior to the study, but only one was positive after the medication. CONCLUSION： Gastric mucosal lesions and GI bleeding in long distance runners seem to be associated to acidrelated factors mediated by the high level of regular running. Ranitidine seems to be and effective prophylaxis to prevent gastric mucosal lesions and GI bleeding.

关键词： Endoscopy Exercise, Gastrointestinal bleeding Ranitidine

Effect of itopride, a new prokinetic, in patients with mild GERD: A pilot study

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World Journal of Gastroenterology 2005年第27期11卷 4210-4214页

作者： Yong Sung Kim Tae Hyeon Kim Chang Soo choi Young Woo Shon Sang Wook Kim Geom Seog Seo Yong Ho Nah Myung Gyu choi suck chei choi Department of Internal Medicine

AIM： Itopride is a newly developed prokinetic agent, which enhances gastric motility through both antidopaminergic and anti-acetylcholinesterasic actions. The importance of esophageal motor dysfunction in the pathogenesis of gastro-esophageal reflux disease （GERD） makes it interesting to examine the effect of itopride on esophageal acid ***： The effect of itopride on esophageal acid reflux variables for 24 h was studied in 26 patients with GERD symptoms, pre-entry total acid exposure time （pH〈4） of more than 5% and mild esophagitis （SavaryMiller grades I, II） proven by endoscopy. Ambulatory 24hpH-metry and symptom assessment were performed after treatments with 150 or 300 mg itopride thrice a day （t.i.d.） for 30 d in random order, using an open label *** evaluating the safety of itopride, blood biochemical laboratory test was performed and the serum prolactin level was also examined before and after ***： Total symptom score was significantly decreased after treatment in 150- or 300-mg group. Itopride 300 mg was significantly effective than 150 mg on decreasing the total per cent time with pH〈4, total time with pH〈4 and DeMeester score. No serious adverse effects were observed with administration of itopride in both ***： Itopride 100 mg t.i.d, is effective on decreasing pathologic reflux in patient with GERD and therefore it has the potential to be effective in the treatment of this disease.

关键词： Gastro-esophageal reflux disease Itopride

Cerebral and pulmonary embolisms after transcatheter arterial chemoembolization for hepatocellular carcinoma

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World Journal of Gastroenterology 2008年第30期14卷 4834-4837页

作者： Chang Soo choi Ki Hoon Kim Geom Seog Seo Eun Young Cho Hyo Jeong Oh suck chei choi Tae Hyeon Kim Haak Cheoul Kim Byung Suk Roh Department of Internal Medicine and Digestive Disease Research Institute Wonkwang University School of Medicine Department of Radiology Wonkwang University School of Medicine

A cerebral lipiodol embolism is an extremely rare complication of transcatheter arterial chemoembolization for hepatocellular carcinoma. We present a case of cerebral lipiodol embolism that occurred after the third ar... 详细信息

关键词： Transcatheter arterial chemoembolization Cerebral embolism Complication Hepatocellular carcinoma Lipiodol

DA-9601, a standardized extract of Artemisia asiatica, blocks TNF-α-induced IL-8 and CCL20 production by inhibiting p38 kinase and NF-κ-B pathways in human gastric epithelial cells

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World Journal of Gastroenterology 2006年第30期12卷 4850-4858页

作者： suck-chei choi Eun-Ju choi Hyun-Mee Oh SungGa Lee Jeong-Kun Lee Meung-Su Lee Yong-Il Shin suck-Jun choi Jeong-Ryong Chae Kang-Min Lee Won-Jung Lee Jae-Sik Park Chang-Yell Shin Tae-Young Oh Chang-Duk Jun Digestive Disease Research Institute Wonkwang University School of Medicine Iksan Chonbuk 570-749 Korea Department Physical Education Kunsan National University Chonbuk 573-701 Korea Department of Life Science Gwangju Institute of Science and Technology Gwangju 500-712 Korea Department of Leisure Sports Wonkwang Health Science College Iksan Chonbuk 570-749 Korea Division of Biological Sciences College of Natural Science Chonbuk National University Jeonju Chonbuk 561-756 Korea Department of Physiology Kyungpook National University School of Medicine Taegu 700-422 Korea Research Institute Dong-A Pharmaceutical Co. Ltd. Yongin 449-905 Korea

AIM: To investigate whether, or how, DA-9601, which is a new gastroprotective agent, inhibits TNF-α-induced inflammatory signals in gastric epithelial AGS cells. METHODS: Cell viability was determined by MTT assay. IL-8 and CCL20 promoter activities were determined by a luciferease reporter gene assay. NF-κB-dependent transcriptional activity was determined by I-κBαdegradation, NF-κB p65 nuclear translocation and a luciferase activity assay. IL-8 and CCL20 gene expression and protein secretion were determined by RT-PCR and an enzymelinked immunosorbent assay (ELISA). Total and phos-phorylated forms of mitogen-activated protein kinases (MAPKs) were determined by Western blot. RESULTS: Treatment of AGS cells with DA-9601 reduced TNF-α-induced IL-8 and CCL20 promoter activities, as well as their gene expression and protein release. TNF-αalso induced NF-κB-dependent transcriptional activity in AGS cells. In contrast, in cells treated with DA-9601, TNF-α-induced NF-κB activity was significantly blocked. Although all three MAP kinase family members were phosphorylated in response to TNF-α, a selective inhibitor of p38 kinase SB203580 only could inhibit both NF-κB-dependent transcriptional activity and IL-8 and CCL20 production, suggesting a potential link between p38 kinase and NF-κB-dependent pathways in AGS cells. Interestingly, DA-9601 also selectively inhibited p38 kinase phosphorylation induced by TNF-α. CONCLUSION: DA-9601 blocked TNF-α-mediated inflammatory signals by potentially modulating the p38 kinase pathway and/or a signal leading to NF-κBdependent pathways in gastric epithelial cells.

关键词： CCL20 IL-8 Artemisia asiatica DA-9601 TNF-α p38 kinase NF-κB

Randomized controlled trial to evaluate the efficacy and safety of fexuprazan compared with esomeprazole in erosive esophagitis

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World Journal of Gastroenterology 2022年第44期28卷 6294-6309页

作者： Kang Nyeong Lee Oh Young Lee Hoon Jai Chun Jin Il Kim Sung Kook Kim Sang Woo Lee Kyung Sik Park Kook Lae Lee suck chei choi Jae-Young Jang Gwang Ha Kim In-kyung Sung Moo In Park Joong Goo Kwon Nayoung Kim Jae Jun Kim Soo Teik Lee Hyun Soo Kim Ki Bae Kim Yong Chan Lee Myung-Gyu choi Joon Seong Lee Hwoon-Yong Jung Kwang Jae Lee Jie-Hyun Kim Hyunsoo Chung Department of Internal Medicine Hanyang University College of MedicineSeoul 04763South Korea Department of Internal Medicine Korea University Anam HospitalSeoul 02841South Korea Department of Internal Medicine The Catholic University of KoreaYeouido ST.Mary’s HospitalSeoul 07260South Korea Department of Internal Medicine Kyungpook National University HospitalDaegu 41944South Korea Department of Internal Medicine Korea University Ansan HospitalAnsan-si 15355South Korea Department of Internal Medicine Keimyung University Dongsan HospitalDaegu 42601South Korea Department of Internal Medicine Seoul Metropolitan Government Seoul National University Boramae Medical CenterSeoul 07061South Korea Department of Internal Medicine Wonkwang University HospitalIksan 54538South Korea Department of Internal Medicine KyungHee University Medical CenterSeoul 02447South Korea Department of Internal Medicine Pusan National University School of Medicine and Biomedical Research InstitutePusan National University HospitalBusan 47241South Korea Department of Internal Medicine KKonkuk University Medical CenterSeoul 05030South Korea Department of Internal Medicine Kosin University Gaspel HospitalBusan 49267South Korea Department of Internal Medicine Daegu Catholic University Medical CenterDaegu 42471South Korea Department of Internal Medicine Seoul National University Bundang HospitalSeongnam-si 13620Gyeonggi-doSouth Korea Department of Internal Medicine Samsung Medical CenterSeoul 06351South Korea Department of Internal Medicine Chonbuk National University HospitalJeonju-si 54907South Korea Department of Internal Medicine Chonnam National University HospitalGwangju 61469South Korea Department of Internal medicine Chungbuk National University School of MedicineCheong Ju 28644South Korea Department of Internal Medicine Severance HospitalSeoul 03722South Korea Department of Internal Medicine The Catholic University of KoreaSeoul ST.Mary’s HospitalSeoul 06591South Korea Digestive Disease Center Soon

BACKGROUND Fexuprazan,a novel potassium-competitive acid blocker,reversibly suppresses the K+/H+-ATPase enzyme in proton pumps within gastric parietal ***’s suppression of gastric acid was maintained in healthy individuals for 24 h in a dose-dependent *** To compare fexuprazan to esomeprazole and establish its efficacy and safety in patients with erosive esophagitis(EE).METHODS Korean adult patients with endoscopically confirmed EE were randomized 1:1 to receive fexuprazan 40 mg or esomeprazole 40 mg once daily for eight *** primary endpoint was the proportion of patients with healed EE confirmed by endoscopy at week *** secondary endpoints included the healing rate of EE at week 4,symptom response,and quality of life *** profiles and serum gastrin levels were compared between the *** Of the 263 randomized,218 completed the study per protocol(fexuprazan 40 mg,n=107;esomeprazole 40 mg,n=111).Fexuprazan was non-inferior to esomeprazole regarding the healing rate at week 8[99.1%(106/107)vs 99.1%(110/111)].There were no between-group differences in the EE healing rate at week 4[90.3%(93/103)vs 88.5%(92/104)],symptom responses,and quality of life ***,serum gastrin levels at weeks 4 and 8 and drug-related side effects did not significantly differ between the *** Fexuprazan 40 mg is non-inferior to esomeprazole 40 mg in EE healing at week *** suggest that fexuprazan is an alternative promising treatment option to PPIs for patients with EE.

关键词： Gastroesophageal reflux Esophagitis Proton pump inhibitors Heartburn Quality of life

Machine Learning for QoS Optimization and Energy-Efficient in Routing Clustering Wireless Sensors

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Computers, Materials & Continua 2025年第1期82卷 327-343页

作者： Rahma Gantassi Zaki Masood Yonghoon choi Department of Electrical Engineering Chonnam National University Gwangju61186Republic of Korea

Wireless sensor network(WSN)technologies have advanced significantly in recent *** in WSNs,machine learning algorithms are crucial in selecting cluster heads(CHs)based on various quality of service(QoS)*** paper proposes a new clustering routing protocol employing the Traveling Salesman Problem(TSP)to locate the optimal path traversed by the Mobile Data Collector(MDC),in terms of energy and QoS *** bemore specific,to minimize energy consumption in the CH election stage,we have developed the M-T protocol using the K-Means and the grid clustering *** addition,to improve the transmission phase of the Low Energy Adaptive Clustering-Grid-KMeans(LEACH-G-K)protocol,the MDC is employed as an intermediary between the CH and the sink to improve the wireless sensor network(WSN)*** results of the experiment demonstrate that the M-T protocol enhances various Low Energy Adaptive Clustering protocol(LEACH)improvements such as the LEACH-G-K,LEACH-C,Threshold sensitive Energy Efficient Sensor Networks(TEEN),MDC maximum residual energy leach protocol.

关键词： LEACH-G-K MDC TSP QoS K-Means

Therapeutic potential of exercise-hormone irisin in Alzheimer's disease

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Neural Regeneration Research 2025年第6期20卷 1555-1564页

作者： Eunhee Kim Rudolph ETanzi Se Hoon choi Genetics and Aging Research Unit MassGeneral Institute for Neurodegenerative DiseaseDepartment of NeurologyMassachusetts General HospitalHarvard Medical SchoolCharlestownMAUSA McCance Center for Brain Health Massachusetts General HospitalBostonMAUSA

Irisin is a myokine that is generated by cleavage of the membrane protein fibronectin type Ⅲ domain-containing protein 5(FNDC5) in response to physical exercise. Studies reveal that irisin/FNDC5 has neuroprotective functions against Alzheimer's disease, the most common form of dementia in the elderly, by improving cognitive function and reducing amyloid-β and tau pathologies as well as neuroinflammation in cell culture or animal models of Alzheimer's disease. Although current and ongoing studies on irisin/FNDC5 show promising results, further mechanistic studies are required to clarify its potential as a meaningful therapeutic target for alleviating Alzheimer's disease. We recently found that irisin treatment reduces amyloid-β pathology by increasing the activity/levels of amyloid-β-degrading enzyme neprilysin secreted from astrocytes. Herein, we present an overview of irisin/FNDC5's protective roles and mechanisms against Alzheimer's disease.

关键词： Alzheimer's disease exercise fibronectin typeⅢdomain-containing protein 5(FNDC5) irisin

Apolipoprotein A-I binding protein-mediated neuroprotection in glaucomatous neuroinflammation and neurodegeneration

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Neural Regeneration Research 2025年第5期20卷 1414-1415页

作者： Sinwoo Hwang Seunghwan choi Soo-Ho choi Keun-Young Kim Yury I.Miller Won-Kyu Ju Hamilton Glaucoma Center and Shiley Eye Institute The Viterbi Family Department of OphthalmologyUniversity of California San DiegoLa JollaCAUSA Department of Medicine University of California San DiegoLa JollaCAUSA National Center for Microscopy and Imaging Research Department of NeurosciencesUniversity of California San DiegoLa JollaCAUSA

Glaucoma is a multifactorial eye disorder that can cause vision loss and irreversible blindness,affecting individ uals aged 40 to 80 yea rs *** to the aging population,it is expected that the number of people affected by glaucoma will surpass 111 million by 2040 as the disease becomes more *** primarily contributes to optic nerve axon loss and the progressive degeneration of retinal ganglion cells (RGCs),subsequently leading to vision impairment.

关键词： irreversible pass primarily