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Biological analysis of an innovative biodegradable antibiotic eluting bioactive glass/gypsum composite bone cement for treating experimental chronic MRSA osteomyelitis

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Journal of Pharmaceutical Analysis 2022年第1期12卷 164-177页

作者： Surajit Mistry subhasish burman Subhasis Roy Nilendu Jyoti Maitra Rajiv Roy Abhijit Chanda Department of Periodontics Burdwan Dental College&HospitalBurdwan713101India Department of Oral&Maxillofacial Surgery Burdwan Dental College&HospitalBurdwan713101India Department of Veterinary Clinical Complex(Surgery&Radiology) West Bengal University of Animal&Fishery SciencesKolkata700037India Directorate of Research Extension&Farms West Bengal University of Animal&Fishery SciencesKolkata700037India Department of Orthopaedics Calcutta National Medical College&HospitalKolkata700014India School of Bio-Science&Engineering Jadavpur UniversityKolkata734432India

A multi-barrier antibiotics loaded biodegradable composite bone cement for resolving chronic osteomyelitis has been studied to understand the physico-mechanical properties,drug loading/eluting efficiency,and different merits and demerits prior to clinical *** successful induction of bone infection in 28 rabbits using methicillin-resistant Staphylococcus aureus(MRSA)strains,calcium sulfate/bioactive glass based composite cement was implanted in 12 defects to assess its performance over parenteral therapy with microscopic and radiological examination for 90 *** composite cement revealed acceptable physico-mechanical properties and controlled drug elution ***,the antibiotics concentrations in bone up to 42 days were sufficient to kill MRSA without eliciting adverse drug *** striking feature of platelets aggregation by composite cement could assist bone *** controlled degradation with simultaneous entrapment of composite cement within the osteoid tissues and complete repair of infected cortical defects(holes)in rabbit tibia at 6 weeks indicated the excellent anti-infective and osteoconductive properties of composite ***,the animal study demonstrated the superiority of composite over injectable antibiotic therapy based on infection resolution and bone *** thereby conclude that the composite cement can be effectively applied in the treatment of resistant cases of chronic osteomyelitis.

关键词： Antibiotics Biodegradable composite Osteomyelitis MRSA strains Osteoconduction

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