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Metformin reduces testosterone level in type 2 diabetes mellitus patients and its therapy by traditional medicine

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Clinical Traditional Medicine and Pharmacology 2024年第4期5卷 19-26页

作者： Gorika Tomar Mitushi Singh Isha Sharma Anuj Nautiyal Saurabh Aggarwal subhash Chandra Havagiray R.Chitme Cassio Rocha Medeiros Micheline de Azevedo Lima Lucia Raquel de Lima Henrique Douglas Melo Coutinho Bhavna kumar Department of Pharmacy Practice School of Pharmaceutical SciencesSGRR UniversityPatel NagarDehradun 248001UttarakhandIndia Department of Medicine Shri MahantIndiresh HospitalSGRR UniversityPatel NagarDehradun 248001UttarakhandIndia Department of Pharmaceutical Chemistry School of Pharmaceutical SciencesSGRR UniversityPatel NagarDehradun 248001UttarakhandIndia Department of Pharmacology and Toxicology Amity Institute of PharmacyAmity UniversitySector-125Noida 201313 UPGwaliorIndia CECAPE College Av.Padre Cícero3917-São JoséJuazeiro do Norte 63024-015CEBrazil Department of Molecular Biology Federal University of Paraiba-UFPBJoao Pessoa 58051-900ParaibaBrazil Department of Biological Chemistry Regional University of Cariri-URCACrato 63105-000CEBrazil Department of Pharmaceutics DIT UniversityDehradun 248009UttarakhandIndia

Background:Type 2 Diabetes Mellitus(T2DM)is a chronic metabolic disorder characterized by insulin resistance and ***,a commonly prescribed treatment for T2DM,is known for its effectiveness in improving glycemic *** studies suggest that metformin may also influence testosterone levels in male patients,a hormone crucial for male reproductive health,muscle mass maintenance,and overall quality of *** plants were traditionally used for influencing the testosterone level in the body which may be given as a therapy for the side–effects of metformin ***:To assess the impact of metformin treatment on testosterone levels in male patients with T2DM compared to non-diabetic males,and to evaluate the potential implications of traditional medical treatments in managing the consequences of reduced testosterone ***:This study is a prospective observational investigation conducted among a total of 60 patients,divided into two groups:30 males taking metformin as a hyperglycaemic agent with T2DM and 30 males without any diabetic *** study was be carried out in different outpatient department of Shri Mahant Indiresh Hospital,Patel Nagar,Dehradun to assess the level of testosterone in male patients with T2DM taking metformin and in non-Diabetic *** on these findings,potential traditional medicines methods for reducing testosterone levels were ***:It was demonstrated that male patients with T2DM undergoing metformin treatment exhibited significant reduction in testosterone serum levels compared to non-diabetic *** plants were examinedand,and clinical studies were conducted on *** was discovered that these plants have been effective in increasingtestosterone level,suggesting their potential use as therapy for ***:This study shows reduction in the testosterone levels,which may lead to low sex drives and induction of low testosterone induced erectile dy

关键词： Type 2 diabetes mellitus Testosterone Metformin Erectile dysfunction Hyperglycaemia

Double mulching improves soil properties and productivity of maize-based cropping system in eastern Indian Himalayas

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International Soil and Water Conservation Research 2020年第3期8卷 308-320页

作者： Bidyapati Ngangom Anup Das Rattan Lal Ramkrushna Gandhiji Idapuganti Jayanta Layek Savita Basavaraj subhash Babu Gulab Singh yadav Probir kumar Ghosh ICAR Research Complex for NEH Region UmiamMeghalayaIndia Krishi Vigyan Kendra-ICAR Research Complex for NEH Region Arunachal Pradesh CentreBasarArunachal PradeshIndia College of Post Graduate Studies Central Agricultural UniversityUmiamMeghalayaIndia ICAR Research Complex for NEH Region Tripura CentreLembucherraTripuraIndia Carbon Management and Sequestration Centre Ohio State UniversityUSA ICAR-Central Institute for Cotton Research NagpurMaharashtraIndia ICAR-KrishiVigyan Kendra IndiUniversity of Agricultural SciencesDharwadIndia ICAR-Indian Agricultural Research Institute New DelhiIndia ICAR-National Institute of Biotic Stress Management RaipurChhattisgarhIndia

A field experiment was conducted for two consecutive years at North Eastern Indian Himalayan region to assess the effect of soil moisture conservation measures on soil and water productivity of different rainfed maize(Zea mays L.)-based cropping *** revealed that double mulching with in-situ maize stover mulch(MSM)+fresh biomass of white hoary pea(WHP-Tephrosia candida)and MSM+fresh biomass of ragweed(RW-Ambrosia artemisiifolia)improved soil moisture content(SMC)and leaf relative water content of crops during dry *** soil organic carbon(SOC)content and stocks under MSM+WHP and MSM+RW mulches were significantly higher than that under no mulch at 0-15 cm *** soil microbial biomass carbon and dehydrogenase activity were maximum under MSM+WHP/*** highest system productivity was obtained from maize-French bean(Pole type-PT)sequence under MSM+RW followed by MSM+*** water productivity was the highest under MSM+*** SOC content was the highest under maize-French bean(PT),the maximum plant available nitrogen and phosphorus were obtained under maize-black gram ***,double mulching technology involving MSM and RW(available in plenty)is a viable option for improving soil,crop and water productivity under rainfed hill ecosystems of eastern Indian Himalayas.

关键词： Cropping systems Rainfed agriculture Residual soil moisture Soil properties Water productivity

Continuity of cancer care in the era of COVID-19 pandemic: Role of social media in low- and middle-income countries

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World Journal of Clinical Cases 2021年第2期9卷 291-295页

作者： Sanjay kumar yadav Nishtha yadav Department of Surgery Netaji Subhash Chandra Bose Medical CollegeJabalpur 482003Madhya PradeshIndia Department of Radiology Super-specialty HospitalNetaji Subhash Chandra Bose Medical CollegeJabalpur 482003Madhya PradeshIndia

A novel coronavirus(severe acute respiratory syndrome coronavirus 2)first detected in Wuhan,China,has spread rapidly since December 2019,causing more than 1.4 million confirmed infections and 15000 fatalities(as of April 9,2020).The outbreak was declared a pandemic by the World Health Organization on March 11,***,quarantine,social distancing,and community containment measures were rapidly implemented in China,which helped in containing the ***,other low-and middle-income countries lack such extensive infrastructural capacities and *** patients are particularly at high risk of infection and mortality due to *** self-quarantine is recommended for ***,it is becoming impossible to maintain the continuity of care when cancer patients have to avoid physical *** media applications,e.g.,Facebook and WhatsApp,can provide educational group program and psychosocial support to these patients while maintain social *** have analyzed their use in this review article and how it could change the follow-up of cancer patients during this pandemic.

关键词： COVID-19 Telemedicine Cancer care Social media Low-and middleincome countries Remote monitoring

Improved thermoelectric property of cation-substituted CaMnO_3

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Chinese Physics B 2015年第9期24卷 542-547页

作者： Pradeep kumar subhash C.Kashyap Vijay kumar Sharma H.C.Gupta Department of Physics Shyam Lal CollegeUniversity of Delhi Department of Physics Indian Institute of Technology Delhi

Single-phase pristine and cation-substituted calcium manganite（Ca1-xBixMn1-yVyO3-δ） polycrystalline samples were synthesized by the solid state reaction technique. Their thermoelectric properties were measured by a set up that was designed and assembled in the laboratory. The Ca1-x BixMn1-yVyO3-δsample with x = y = 0.04 has shown a power factor（S^2σ） of 176 μW/m/K^2 at 423 K, which is nearly two orders of magnitude higher than that of the pristine sample（2.1 μW/m/K2）. The power factor of the substituted oxide remains almost temperature independent as the Seebeck coefficient increases monotonically with temperature, along with the simultaneous decrease in electrical resistivity which is attributed to enhanced electron density due to co-doping of bismuth and vanadium and grain boundary scattering. These cation-substituted calcium manganites can be used as a potential candidate for an n-type leg in a thermoelectric generator（module）.

关键词： thermoelectric materials solid state reaction Seebeck coefficient power factor

Crop productivity,soil health,and energy dynamics of Indian Himalayan intensified organic maize-based systems

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International Soil and Water Conservation Research 2021年第2期9卷 260-270页

作者： Raghavendra Singh subhash Babu R.K.Avasthe Gulab Singh yadav Anup Das K.P.Mohapatra Amit kumar Vinod K.Singh Puran Chandra ICAR-National Organic Farming Research Institute GangtokSikkim737102India Division of Agronomy ICAR-Indian Agricultural Research InstituteNew Delhi110012India ICAR Research Complex for NEH Region Tripura CentreLembucherraTripura799210India ICAR-National Bureau of Plant Genetic Resources New Delhi110012India

The sustainability of prevailing maize-fallow system in rainfed ecosystems of the Eastern Himalayan region(EHR)of India is often questioned due to poor economic return and negative impact on soil ***,the six cropping systems,maize-fallow(M-F),maize t cowpea-rapeseed(M t C-Rs),maize t cowpea-buckwheat(M t C-Bw),maize t cowpea-barley(M t CeB),maize t cowpea-garden pea(M t C-GP)and maize t cowpeaerajmash(M t C-R)in the main plot and three soil moisture conservation measures,no-mulch(NM),maize stover mulch(MSM)and maize stover t weed biomass mulch(MSM t WBM)in sub-plot were evaluated for four consecutive years(2014-18)at a Research Farm in fixed plot *** indicated that cowpea co-culture with maize and inclusion of winter crop increased maize yield by 6.2e23.5%over *** the systems,the M t C-GP recorded the highest crop *** residual effect of MSM t WBM increased maize grain yield by 19.1%over *** of maize t cowpea-winter crops significantly improved the available N(3.2e12.9%),P(3.6 e12.7%),K(1.9e26.3%),organic carbon(9.2e16.8%),microbial biomass carbon-MBC(15.2e43.9%)and dehydrogenases-DHA(17.2e42.3%)in soil at 0e15 cm depth as compared to *** M t C-GP also recorded maximum net return(US$2460 ha1),benefit:cost(B:C)ratio(2.86)and energy use efficiency(7.9%).The MSM t WBM recorded higher net return(US$1680 ha1)and B:C ratio(2.46)over ***,cowpea t maize-garden pea(M t C-GP)along with the application of MSM t WBM is a sustainable production practice to intensify the organically managed maize-fallow system in rainfed regions of the EHR of India and other similar ecosystems.

关键词： Crop intensification Energy productivity Gross return Soil health Water productivity

The role and significance of Magnesium in modern day research-A review

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Journal of Magnesium and Alloys 2022年第1期10卷 1-65页

作者： S V Satya Prasad S B Prasad Kartikey Verma Raghvendra kumar Mishra Vikas kumar subhash Singh Department of Production and Industrial Engineering National Institute of Technology JamshedpurJharkhand831014India Department of Chemical Engineering Indian Institute of TechnologyKanpur208016India Enhanced Composites and Structures Center School of AerospaceTransport and ManufacturingCranfield UniversityBedfordshire MK43 OALUK Department of Automotive Technology Mechanical Department DivisionFederal TVET instituteAddis AbabaEthiopia

Magnesium is one of the largely available elements in the earth’s crust. It has a low structural density with high specific strength. This unique material property has forced an increase in the use of magnesium and its alloys in various applications pertaining to industrial sector,automobiles, aerospace and biomedical. Since magnesium is a highly reactive metal, it is prone to higher rate of corrosion as compared to its counterparts. Thus, it is essential to analyze the corrosion behavior of magnesium and its alloys in its applications. An appropriate process is to be followed in the design and development of magnesium alloys which overcome the limitations of magnesium and enhance the desired material properties in accordance to their applications. This review paper summarizes the importance of magnesium and its material properties. The influence of various alloying elements on the mechanical properties of magnesium is reviewed. The broad classification of Mg alloys and their behavioral trends are detailed. The corrosion behavior of magnesium and the influence of corrosion products on the material characteristics of magnesium, in aqueous medium, are discussed. The manufacturing techniques of magnesium alloys along with the secondary techniques are also covered. The various applications and the limitations of magnesium in these applications are covered. A complete section is dedicated towards detailing the recent trends of magnesium(Mg) alloys, i.e., the biodegradable nature and applications of Mg alloys. The influence of biocorrosion on Mg alloys and techniques to overcome it have been deliberated. This paper provides a thorough review on recent developments of magnesium with respect to engineering applications.

关键词： Magnesium alloys Biodegradable alloys Magnesium corrosion Biocorrosion

Musculoskeletal problems and expressed practices of body mechanics among nursing officers at All India Institute of Medical Sciences Jodhpur,Rajasthan,India

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Journal of Integrative Nursing 2021年第3期3卷 128-134页

作者： subhash kumar SAINI Vandna PANDEY Ashok kumar Abhay ELHENCE AIIMS Jodhpur2Department of College of NursingAIIMSJodhpur3Department of OrthopaedicsAIIMSJodhpurIndia

Objective:The objective of the study was to identify musculoskeletal problems(MSPs)among nursing *** and Methods:A nonexperimental research design was *** hundred and seventy nursing officers were selected by purposive sampling *** standardized Nordic questionnaire was used to assess the MSPs and self-structured three-point rating scale was used to assess expressed practice of body mechanics of nursing ***:The study findings revealed that 64.4% of nursing officers suffered from MSP such as ache,pain,and discomfort during the past 12 months and 43.7% during the past 7 *** problem in the low back and the neck were highest 45.1% and 22.2%,*** was followed by MSP of the upper back(14.0%),ankles(13.7%),knees(10.7%),shoulder(10.3%),hip/thighs(5.9%),wrists(4.4%),and elbows(3.3%).Around 49.2%complained that MSPs limit their *** was significant association of MSP with selected personal variables like body mass index(P=0.001)and family history(P=0.02).There were also significant association of expressed practices of body mechanics with gender(P=0.01),area of current work(P=0.00),professional experience(P=0.03)and physical activity(P=0.00).Conclusion:The study indicates the large number of nursing officers had MSPs with the two most common sites being the lower back and the *** creates a need for prompt hospital education programs aimed to create awareness among nursing officers on the prevalence of MSPs.

关键词： Expressed practice musculoskeletal problems nursing officers

Comparison of gliclazide vs linagliptin on hypoglycemia and cardiovascular events in type 2 diabetes mellitus: A systematic review

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World Journal of Diabetes 2022年第12期13卷 1168-1183页

作者： Viswanathan Mohan subhash Wangnoo Sambit Das Rajnish Dhediya kumar Gaurav Department of Diabetes Madras Diabetes Research Foundation&Dr Mohan’s Diabetes Specialties CentreChennai 600086Tamil NaduIndia Department of Diabetes Apollo Hospital Education and Research FoundationNew Delhi 110001India Department of Endocrinology Endeavour ClinicsBhubaneswar 750017India Medical Affairs Dr.Reddy’s Laboratories LtdHyderabad 500016India

BACKGROUND Cardiovascular outcome trials have demonstrated cardiovascular safety of glimepiride(a sulfonylureas) against dipeptidyl peptidase-4 inhibitor ***(another newer sulfonylureas) has shown similar glycemic efficacy and 50% decreased risk of hypoglycemia compared to *** Considering the absence of cardiovascular outcome trials for gliclazide, we decided to conduct a systematic review of the literature to assess the cardiovascular(CV) safety by assessing the risk for major adverse CV events and hypoglycemia risk of gliclazide vs linagliptin in patients with type 2 diabetes(T2D).METHODS This systematic review followed the current Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines to analyze all the clinical studies published from 2008 that compared the two drugs in patients with T2D with no risk of CV disease(CVD). We included only evidence designated high quality by the Oxford Center for Evidence-based Medicine-Levels of *** Eight clinical studies were included in the narrative descriptive analysis(gliclazide: 5 and linagliptin: 3). The CV safety of gliclazide in the Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified Release Controlled Evaluation trial and of linagliptin in the Cardiovascular and Renal Microvascular Outcome Study With Linagliptin(CARMELINA) and CARdiovascular Outcome study of LINAgliptin vs glimepiride in patients with T2D(CAROLINA)trials were excluded from the comparative analysis as these trials demonstrated CV and hypoglycemia benefits in patients at high risk of CVD. However, since these are landmark trials,they were discussed in brief to show the CV benefits and low hypoglycemia risk of gliclazide and linagliptin. We did not find any study comparing gliclazide with linagliptin. Hence, direct comparison of their major adverse CV events and hypoglycemia risk could not be carried ***, the literature meeting the inclusion criteria showed that b

关键词： Linagliptin Gliclazide Hypoglycemia Major cardiovascular adverse events Type 2 diabetes

Larvicidal activity of Dregea volubilis and Bombax malabaricum leaf extracts against the filarial vector Culex quinquefasciatus

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Asian Pacific Journal of Tropical Medicine 2011年第6期4卷 436-441页

作者： Emdad Hossain Anjali Rawani Goutam Chandra subhash C.Mandal Jayanta kumar Gupta Pharmacy College AzamgarhItauraPO:ChandeshwarAzamgarh 276128Uttar PradeshIndia Department of Zoology Mosquito Research UnitParasitology LaboratoryThe University of BurdwanBurdwan 713104West BengalIndia Department of Pharmaceutical Technology Jadavpur UniversityKolkata 700032India

Objective:To analyze the larvicidal activity of two plant leaf powder and leaf-extracts, Dregea volubilis and Bombax malabaricum against Culex ***:The larvicidal bioassay was done for powdered leaves of Dregea volubilis and Bombax malabaricum individually and their methanol extracts against first-,second-,third- and fourth-instar larval forms of Culex *** rate was recorded after 24,48 and 72 h of postexposure. LC50 and LG90 values were calculated at different time intervals for third instar larvae. Results:All the graded concentration（0.1%,0.2%,0.3%,0.4%,0.5%） of powdered leaves showed significant（P 50 values were 56.97 ppm and 48.85 ppm,respectively after 24 h of *** is no mortality of non-target organism such as Chironomous circumdatus,Oreochromis niloticus niloticus and Diplonichus annulatum within 72 h of post exposure to 0.1%,0.2%,0.3%crude powdered leaves and methanolic extracts of both the two individual plants under the laboratory *** results of preliminary qualitative phytochemical analysis of both the plants revealed the presence of many bioactive principles such as steroids,tannins,flavonoids,triterpenoids,saponins,etc. that may be responsible for their bio-control ***:The results have shown potential and eco-friendly use of both plant extracts against larva of Culex quinquefasciatus for the first time.

关键词： Bombax malabaricum Culex quinquefasciatus Dregea volubilis Larvicidal activity