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A Weakly-Supervised Crowd Density Estimation Method Based on Two-Stage Linear Feature Calibration

IEEE/CAA Journal of Automatica Sinica 2024年第4期11卷 965-981页

作者： Yong-Chao Li Rui-Sheng Jia Ying-Xiang Hu Hong-mei sun the College of Computer Science and Engineering Shandong University of Science and TechnologyQingdao 266590 the Faculty of Information Science and Engineering Ocean University of ChinaQingdao 266000China the College of Computer Science and Engineering Shandong University of Science and TechnologyQingdao 266590China the College of Computer Science and Engineering Nanjing University of Science and TechnologyNanjing 210000China

In a crowd density estimation dataset,the annotation of crowd locations is an extremely laborious task,and they are not taken into the evaluation *** this paper,we aim to reduce the annotation cost of crowd datasets,and propose a crowd density estimation method based on weakly-supervised learning,in the absence of crowd position supervision information,which directly reduces the number of crowds by using the number of pedestrians in the image as the supervised *** this purpose,we design a new training method,which exploits the correlation between global and local image features by incremental learning to train the ***,we design a parent-child network(PC-Net)focusing on the global and local image respectively,and propose a linear feature calibration structure to train the PC-Net simultaneously,and the child network learns feature transfer factors and feature bias weights,and uses the transfer factors and bias weights to linearly feature calibrate the features extracted from the Parent network,to improve the convergence of the network by using local features hidden in the crowd *** addition,we use the pyramid vision transformer as the backbone of the PC-Net to extract crowd features at different levels,and design a global-local feature loss function(L2).We combine it with a crowd counting loss(LC)to enhance the sensitivity of the network to crowd features during the training process,which effectively improves the accuracy of crowd density *** experimental results show that the PC-Net significantly reduces the gap between fullysupervised and weakly-supervised crowd density estimation,and outperforms the comparison methods on five datasets of Shanghai Tech Part A,ShanghaiTech Part B,UCF_CC_50,UCF_QNRF and JHU-CROWD++.

关键词： Crowd density estimation linear feature calibration vision transformer weakly-supervision learning

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Reinforcement of High Impact Polystyrene by Aramid Nanoparticle Fillers Prepared via an In situ Bottom-up Approach

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Chinese Journal of Polymer Science 2024年第8期42卷 1167-1176页

作者： Xiang-Jun Gong Zhi-Ping Zhao Chang-mei sun Ying Zhang Rong-Jun Qu Ying Wang School of Chemistry and Materials Science Ludong UniversityYantai 264025China

In this work,aramid nanoparticles(ANPs)were prepared in dimethyl formamide(DMF)solution containing high impact polystyrene(HIPS)via a bottom-up *** electron microscopy(TEM)images showed that the obtained ANPs were evenly distributed in the HIPS matrix without any *** composition of the ANPs,i.e.,poly(p-phenyl-p-phenylenediamine)(PPTA),was confirmed by Fourier transform infrared spectroscopy(FTIR),X-ray photoelectron spectroscopy(XPS)and X-ray diffractometer(XRD).The ANP/HIPS composites,obtained after ethanol precipitation,were added to neat HIPS as fillers to fabricate ANP/HIPS composite *** surface roughness and the glass transition temperature(T_g)of the sheets were characterized by atomic force microscope(AFM)and differential scanning calorimetry(DSC),*** with neat HIPS,the mechanical properties of the composite sheet were significantly improved,and the Young's modulus increased from 246.55 MPa to 2025.12 MPa,the tensile strength increased from 3.07 MPa to 29.76 MPa,and the toughness increased from 0.32 N/mm^2 to 3.92 N/mm^2,with an increase rate of 721%,869%and 1125%,***,the thermal stability of the composites improved with the increase in ANP content.

关键词： High impact polystyrene PPTA nanoparticle Reinforce Mechanical property

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Commercial genetically modified corn and soybean are poised following pilot planting in China

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Molecular Plant 2024年第4期17卷 519-521页

作者： mei sun Suzhen Li Wenzhu Yang Bowen Zhao Youhua Wang Xiaoqing Liu Biotechnology Research Institute Chinese Academy of Agricultural ScienceBeijing 100081China Farmers'Daily Beijing 100025China

"Who will feed China?"This was a question raised by Lester Brown,the director of the World Watch Institute in the United States,in *** predicted that China's grain production would decrease from 340 million tons in 1990 to 272 million tons by 2030,a 20%decrease,while China's population would reach 1.6 billion(Brown,1995).If the dietary structure was not improved,China would need to import 200-369 million tons of grain,equivalent to the global grain trade at the *** projected the high possibility of a food crisis in China,which might further trigger a global food ***,with the joint efforts of national agricultural researchers,represented by Yuan Longping,and the Chinese government,China's grain production has achieved 18 consecutive increases from 2004 to *** 2022,grain production in China reached 633 million tons(NBS and Statistics,2022),while the population remained stable at 1.4 *** a result,China has achieved complete self-sufficiency in its staple food supply and has demonstrated to the international community through practical actions that the Chinese people can feed themselves.

关键词： planting soybean raised

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A novel fluorescent probe for volatile amine vapor detection

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Chinese Chemical Letters 2024年第3期35卷 3-4页

作者： Lulu Bu Daofu Liu Longde Wang mei sun Chao Gao Yongshu Xie School of Chemistry and Materials Engineering Anhui Province Key Laboratory of Low Temperature Co-Fired MaterialsHuainan Normal UniversityHuainan 232038China College of Material Chemistry and Chemical EngineeringKey Laboratory of Organosilicon Chemistry and Material Technology of Ministry of EducationHangzhou Normal UniversityHangzhou 311121China Shanghai Key Laboratory of Functional Materials Chemistry Key Laboratory for Advanced Materials and Institute of Fine ChemicalsSchool of Chemistry&Molecular EngineeringEast China University of Science&TechnologyShanghai 200237China

In recent years,fluorescent probes have gained significant prominence in the field of substance analysis and detection[1–4].The development of high-performance volatile amine gas sensors is crucial for applications i... 详细信息

关键词： volatile gained probe

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Pretreatment and analysis techniques development of TKIs in biological samples for pharmacokinetic studies and therapeutic drug monitoring

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Journal of Pharmaceutical Analysis 2024年第4期14卷 439-459页

作者： Lan Chen Yuan Zhang Yi-Xin Zhang Wei-Lai Wang De-mei sun Peng-Yun Li Xue-Song Feng Yue Tan School of Pharmacy China Medical UniversityShenyang110122China Institute of Pharmacology and Toxicology Institution National Engineering Research Center for Strategic DrugsBeijing100850China Department of Gastroenterology Shengjing Hospital of China Medical UniversityShenyang110022China

Tyrosine kinase inhibitors(TKIs)have emerged as the first-line small molecule drugs in many cancer therapies,exerting their effects by impeding aberrant cell growth and proliferation through the modulation of tyrosine kinase-mediated signaling ***,there exists a substantial inter-individual variability in the concentrations of certain TKIs and their metabolites,which may render patients with compromised immune function susceptible to diverse infections despite receiving theoretically efficacious anticancer treatments,alongside other potential side effects or adverse ***,an urgent need exists for an up-to-date review concerning the biological matrices relevant to bioanalysis and the sampling methods,clinical pharmacokinetics,and therapeutic drug monitoring of different *** paper provides a comprehensive overview of the advancements in pretreatment methods,such as protein precipitation(PPT),liquid-liquid extraction(LLE),solid-phase extraction(SPE),micro-SPE(μ-SPE),magnetic SPE(MSPE),and vortex-assisted dispersive SPE(VA-DSPE)achieved since *** also highlights the latest analysis techniques such as newly developed high performance liquid chromatography(HPLC)and high-resolution mass spectrometry(HRMS)methods,capillary electrophoresis(CE),gas chromatography(GC),supercritical fluid chromatography(SFC)procedures,surface plasmon resonance(SPR)assays as well as novel nanoprobes-based biosensing *** addition,a comparison is made between the advantages and disadvantages of different approaches while presenting critical challenges and prospects in pharmacokinetic studies and therapeutic drug monitoring.

关键词： TKIs Microextraction technique HRMS methods Pharmacokinetic studies Therapeutic drug monitoring

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Evaluating the Compatibility Mechanism of Shengxian Decoction Based on an Excretion Study of 18 Bioactive Constituents in Rat Biosamples

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World Journal of Traditional Chinese Medicine 2024年第1期10卷 40-52页

作者： Tao Pang Nan Weng Yong Chen Cui-Yun Huang mei sun Feng Zhang Wan-Sheng Chen Department of Pharmacy Changzheng HospitalNaval Medical University(Second Military Medical University)ShanghaiChina Department of Pharmacognosy Shenyang Pharmaceutical University ShenyangLiaoning ProvinceChina Traditional Chinese Medicine Resource and Technology Center Shanghai University of Traditional Chinese MedicineShanghaiChina

Introduction:The Shengxian decoction(SXT),a Chinese herbal medication used to treat heart failure,is composed of Astragali Radix,Anemarrhenae Rhizoma,Bupleuri Radix,Cimicifuage Rhizoma,and Platycodonis *** of the excretion of the active compounds in this herbal medication is vital for investigating the underlying mechanisms behind its ***,this remains ***:Liquid chromatography coupled with mass spectrometry was performed in both positive and negative modes to assay 18 constituents of SXT from rat urinary,fecal,and biliary ***:The methodology was validated and showed good linearity(r≥0.9),precision,stability,repeatability,and *** relative standard deviations and relative errors for the precision and accuracy did not exceed 15%.The recoveries of all the compounds ranged from 77.37%to 114.82%,and the matrix effect was between 82.53%and 105.71%.The results suggested that,when combined with Platycodonis Radix,the levels of 14 constituents from the four herbs were reduced in the urine,while the levels of six constituents were reduced in the ***:The comparative excretion results indicated that Platycodonis Radix reduced the excretion of compounds in SXT,demonstrating the compatibility mechanism and holistic properties of these compounds,favoring the pharmacological effects of SXT.

关键词： Compatibility excretion liquid chromatography coupled with mass spectrometry Platycodonis Radix Shengxian decoction

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眼眶淋巴瘤的临床特点及诊断进展

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中华实验眼科杂志 2024年第8期42卷 774-779页

作者：孙梅首都医科大学附属北京同仁医院北京同仁眼科中心北京市眼科学与视觉科学重点实验室北京

眼眶淋巴瘤(OLs)是眼部淋巴瘤常见的类型。该病是一种结外恶性肿瘤, 既可原发于眼眶, 也可为全身淋巴瘤继发眼眶受累。OLs多发于女性, 通常表现为单侧眼球突出和眶周肿胀。惰性病变的症状持续时间较长, 而侵袭性病变往往发展较快还可伴... 详细信息

眼眶淋巴瘤(OLs)是眼部淋巴瘤常见的类型。该病是一种结外恶性肿瘤, 既可原发于眼眶, 也可为全身淋巴瘤继发眼眶受累。OLs多发于女性, 通常表现为单侧眼球突出和眶周肿胀。惰性病变的症状持续时间较长, 而侵袭性病变往往发展较快还可伴有疼痛和炎症反应。当肿瘤累及眶内不同组织时可出现上睑下垂、复视以及视力障碍等症状。其临床特征和影像学表现均不具有特异性, 需与多种眼眶疾病鉴别。因此, 当患者出现某些非特异性眼眶症状时, 需行眼眶CT、MRI等影像学检查以了解眼眶内情况, 再行进一步手术活检, 以早期确诊。目前, OLs诊断的金标准是组织病理学检查, 其分型分期则依赖于免疫组织化学分析和PET-CT。疾病的临床分期直接影响治疗方案的制定和预后结果, 因此一旦确定诊断并完成OLs的分型分期即可尽早制定合适的治疗方案。本文对近年来OLs的临床表现及诊断相关研究进行综述, 以期进一步了解该病并为临床工作提供参考。

关键词：眼眶淋巴瘤症状病理学影像学分期诊断

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Bilateral choroidal ganglioneuroma:a comprehensive analysis of vision decline in a 6-year-old boy

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International Journal of Ophthalmology(English edition) 2024年第9期17卷 1755-1759页

作者： Yi-Zhe Cheng Li-mei sun Min-Er Yuan Lin-Yan Zhang Shu-Ya Ke Xiao-Yan Ding State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangdong Provincial Key Laboratory of Ophthalmology and Visual ScienceGuangzhou 510060Guangdong ProvinceChina Guangdong Provincial Clinical Research Center for Ocular Diseases Guangzhou 510060Guangdong ProvinceChina

Dear Editor,We write to present a 6-year-old boy with bilateral choroidal ganglioneuroma(CG)by comprehensive multimodal imaging(MMI)in a duration of 6-year *** our knowledge,this is the first case report with elaborate data to delineate the natural history of visual function and MMI in a boy with rare bilateral CG,confirmed by choroid biopsy.

关键词： comprehensive modal fir

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Accuracy of FreeStyle Libre flash glucose monitoring in patients with type 2 diabetes who migrated from highlands to plains

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World Journal of Diabetes 2024年第6期15卷 1254-1262页

作者： Zeng-mei sun Yuan-Ze Du Su-Yuan Wang Shu-Yao sun Yan Ye Xue-Ping sun Ming-Xia Li Hua He Wun-Chun Long Cheng-Hui Zhang Xuan-Yu Yao Wu-Yi Fan Ling Wang Yun-Hong Wu Department of Endocrinology and Metabolism Hospital of the People's Government of the Tibet Autonomous Region in ChengduChengdu 614000Sichuan ProvinceChina Department of Nursing Hospital of Chengdu Office of the People's Government of Tibet Autonomous RegionChengdu 610041Sichuan ProvinceChina Department of Endocrinology Hospital of Chengdu Office of the People's Government of Tibet Autonomous RegionChengdu 610041Sichuan ProvinceChina

BACKGROUND The FreeStyle Libre flash glucose monitoring(FGM)system entered the Chinese market in 2017 to complement the self-monitoring of blood *** to its increased usage in clinics,the number of studies investigating its accuracy has ***,its accuracy has not been investigated in highland populations in *** To evaluate measurements recorded using the FreeStyle Libre FGM system compared with capillary blood glucose measured using the enzyme electrode method in patients with type 2 diabetes(T2D)who had migrated within 3 mo from highlands to *** Overall,68 patients with T2D,selected from those who had recently migrated from highlands to plains(within 3 mo),were hospitalized at the Department of Endocrinology from August to October 2017 and underwent continuous glucose monitoring(CGM)with the FreeStyle Libre FGM system for 14 *** the study period,fingertip capillary blood glucose was measured daily using the enzyme electrode method(Super GL,China),and blood glucose levels were read from the scanning probe during fasting and 2 h after all three ***,the time interval between reading the data from the scanning probe and collecting fingertip capillary blood was controlled to<5 *** accuracy of the FGM system was evaluated according to the CGM ***,the factors influencing the mean absolute relative difference(MARD)of this system were analyzed by a multiple linear regression *** Pearson’s correlation analysis showed that the fingertip and scanned glucose levels were positively correlated(R=0.86,P=0.00).The aggregated MARD of scanned glucose was 14.28±13.40%.Parker's error analysis showed that 99.30%of the data pairs were located in areas A and *** to the probe wear time of the FreeStyle Libre FGM system,MARD_(1 d) and MARD_(2-14 d) were 16.55%and 14.35%,respectively(t=1.23,P=0.22).Multiple stepwise regression analysis showed that MARD did not correlate with blood glucose when

关键词： Type 2 diabetes Flash glucose monitoring Accuracy Continuous glucose monitor High altitude

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Heavy ion energy influence on multiple-cell upsets in small sensitive volumes:from standard to high energies

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Nuclear Science and Techniques 2024年第5期35卷 109-121页

作者： Yang Jiao Li-Hua Mo Jin-Hu Yang Yu-Zhu Liu Ya-Nan Yin Liang Wang Qi-Yu Chen Xiao-Yu Yan Shi-Wei Zhao Bo Li You-mei sun Pei-Xiong Zhao Jie Liu Institute of Modern Physics Chinese Academy of ScienceLanzhou 730000China University of Chinese Academy of Science Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China China Electronics Technology Group Corporation No.58 Research Institute Wuxi 214000China Beijing Microelectronics Technology Institute Beijing 100084China Institute of Microelectronics Chinese Academy of SciencesBeijing 100029China Key Laboratory of Science and Technology on Silicon Devices Chinese Academy of SciencesBeijing 100029China

The 28 nm process has a high cost-performance ratio and has gradually become the standard for the field of radiation-hardened ***,owing to the minimum physical gate length of only 35 nm,the physical area of a standard 6T SRAM unit is approximately 0.16μm^(2),resulting in a significant enhancement of multi-cell charge-sharing ***-cell upsets(MCUs)have become the primary physical mechanism behind single-event upsets(SEUs)in advanced nanometer node *** range of ionization track effects increases with higher ion energies,and spacecraft in orbit primarily experience SEUs caused by high-energy ***,ground accelerator experiments have mainly obtained low-energy ion irradiation ***,the impact of ion energy on the SEU cross section,charge collection mechanisms,and MCU patterns and quantities in advanced nanometer devices remains *** this study,based on the experimental platform of the Heavy Ion Research Facility in Lanzhou,low-and high-energy heavy-ion beams were used to study the SEUs of 28 nm SRAM *** influence of ion energy on the charge collection processes of small-sensitive-volume devices,MCU patterns,and upset cross sections was obtained,and the applicable range of the inverse cosine law was *** findings of this study are an important guide for the accurate evaluation of SEUs in advanced nanometer devices and for the development of radiation-hardening techniques.

关键词： 28 nm static random access memory(SRAM) Energy effects Heavy ion Multiple-cell upset(MCU) Charge collection Inverse cosine law

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