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Endogenous biosynthesis of docosahexaenoic acid(DHA)regulates fish oocyte maturation by promoting pregnenolone production

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Zoological Research 2024年第1期45卷 176-188页

作者： Yi Li Xuehui Li Ding ye Ru Zhang Chengjie Liu Mudan He Houpeng Wang Wei hu Yonghua sun State Key Laboratory of Freshwater Ecology and Biotechnology Institute of HydrobiologyInnovation Academy for Seed DesignChinese Academy of SciencesWuhanHubei 430072China College of Advanced Agricultural Sciences University of Chinese Academy of SciencesBeijing 100049China hubei Hongshan Laboratory WuhanHubei 430070China

Omega-3 polyunsaturated fatty acids(n-3 PUFAs),particularly docosahexaenoic acid(22:6n-3,DHA),play crucial roles in the reproductive health of vertebrates,including ***,the underlying mechanism related to this phenomenon remains largely *** this study,we employed two zebrafish genetic models,i.e.,elovl2^(-/-)mutant as an endogenous DHAdeficient model and fat1(omega-3 desaturase encoding gene)transgenic zebrafish as an endogenous DHA-rich model,to investigate the effects of DHA on oocyte maturation and *** show that the elovl2^(-/-)mutants had much lower fecundity and poorer oocyte quality than the wild-type controls,while the fat1 zebrafish had higher fecundity and better oocyte quality than wildtype *** deficiency in elovl2^(-/-)embryos led to defects in egg activation,poor microtubule stability,and reduced pregnenolone *** study revealed that DHA promoted pregnenolone synthesis by enhancing transcription of cyp11a1,which encodes the cholesterol side-chain cleavage enzyme,thereby stabilizing microtubule assembly during *** turn,the hypothalamic-pituitary-gonadal axis was enhanced by *** conclusion,using two unique genetic models,our findings demonstrate that endogenously synthesized DHA promotes oocyte maturation and quality by promoting pregnenolone production via transcriptional regulation of cyp11a1.

关键词： Docosahexaenoic acid Oocyte maturation Oocyte quality Pregnenolone Microtubule

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Electrochemical construction of 2,5-diaryloxazoles via N–H and C(sp_(3))-H functionalization

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Chinese Chemical Letters 2024年第4期35卷 340-345页

作者： Tong Li Leping Pan Yan Zhang Jihu su Kai Li Kuiliang Li hu Chen Qi sun Zhiyong Wang Hefei National Center for Physical Sciences at Microscale Key Laboratory of Precision and Intelligent ChemistrySchool of Chemistry and Materials ScienceUniversity of Science and Technology of ChinaHefei 230026China Anhui University of Science and Technology Huainan 232001China CAS Key Laboratory of Microscale Magnetic Resonance Department of Modern PhysicsUniversity of Science and Technology of ChinaHefei 230026China

An efficient N–H and C(sp~3)-H functionalization of aryl ketones with benzylamines/amino acids was developed under mild conditions by virtue of anodic oxidation. A variety of functionalized 2,5-diaryloxazoles were obtained with good to excellent yields. Moreover, some important natural products can be prepared by this method. The reaction features a broad substrate scope, scalability, metal-free and chemical oxidant-free.

关键词： Electrochemical Metal-free Oxazole Oxidant-free

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Characterization and prediction of tailpipe ammonia emissions from in-use China 5/6 light-duty gasoline vehicles

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Frontiers of Environmental Science & Engineering 2024年第1期18卷 71-81页

作者： Lewei Zeng Fengbin Wang Shupei Xiao Xuan Zheng Xintong Li Qiyuan Xie Xiaoyang Yu Cheng huang Qingyao hu Yan You ye Wu College of Chemistry and Environmental Engineering Shenzhen UniversityShenzhen 518060China State Key Laboratory of Engines Tianjin UniversityTianjin 300072China China Automotive Technology and Research Center Co.Ltd. Tianjin 300300China CATARC Automotive Test Center(Guangzhou)Co.Ltd. Guangzhou 511300China State Environmental Protection Key Laboratory of Cause and Prevention of Urban Air Pollution Complex Shanghai Academy of Environmental SciencesShanghai 200233China National Observation and Research Station of Coastal Ecological Environments in Macao Macao Environmental Research InstituteMacao University of Science and TechnologyMacao SAR 999078China School of Environment State Key Joint Laboratory of Environment Simulation and Pollution ControlTsinghua UniversityBeijing 100084China

On-road tailpipe ammonia (NH3) emissions contribute to urban secondary organic aerosol formation and have direct or indirect adverse impacts on the environment and human health. To understand the tailpipe NH3 emission characteristics, we performed comprehensive chassis dynamometer measurements of NH3 emission from two China 5 and two China 6 light-duty gasoline vehicles (LDGVs) equipped with three-way catalytic converters (TWCs). The results showed that the distance-based emission factors (EFs) were 12.72 ± 2.68 and 3.18 ± 1.37 mg/km for China 5 and China 6 LDGVs, respectively. Upgrades in emission standards were associated with a reduction in tailpipe NH3 emission. In addition, high NH3 EFs were observed during the engine warm-up period in cold-start cases owing to the intensive emissions of incomplete combustion products and suitable catalytic temperature in the TWCs. Notably, based on the instantaneous NH3 emission rate, distinct NH3–emitting events were detected under high/extra high velocity or rapid acceleration. Furthermore, NH3 emission rates correlated well with engine speed, vehicle specific power, and modified combustion efficiency, which were more easily accessible. These strong correlations were applied to reproduce NH3 emissions from China 5/6 LDGVs. The predicted NH3 EFs under different dynamometer and real-world cycles agreed well with existing measurement and prediction results, revealing that the NH3 EFs of LDGVs in urban routes were within 8.55–11.62 mg/km. The results presented here substantially contribute to improving the NH3 emission inventory for LDGVs and predicting on-road NH3 emissions in China.

关键词： NH3 instantaneous emissions Catalytic temperature Vehicle specific power Combustion efficiency Emission prediction

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Trunk‑Inspired SWCNT‑Based Wrinkled Films for Highly‑Stretchable Electromagnetic Interference Shielding and Wearable Thermotherapy

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Nano-Micro Letters 2024年第11期16卷 429-444页

作者： Xiaofeng Gong Tianjiao hu You Zhang Yanan Zeng ye Zhang Zhenhua Jiang Yinlong Tan Yanhong Zou Jing Wang Jiayu Dai Zengyong Chu College of Science National University of Defense TechnologyChangsha 410073People’s Republic of China Beijing Interdisciplinary Research Center National University of Defense TechnologyChangsha 410073People’s Republic of China School of Physics and Electronics Hunan UniversityChangsha 410082People’s Republic of China

Nowadays,the increasing electromagnetic waves generated by wearable devices are becoming an emerging issue for human health,so stretchable electromagnetic interference(EMI)shielding materials are highly *** trunks are capable of grabbing fragile vegetation and tearing trees thanks not only to their muscles but also to their folded *** by the wrinkled skin of the elephant trunks,herein,we propose a winkled conductive film based on single-walled carbon nanotubes(SWCNTs)for multifunctional EMI *** conductive film has a sandwich structure,which was prepared by coating SWCNTs on both sides of the stretched elastic latex cylindrical *** shrinking-induced winkled conductive network could withstand up to 200%tensile ***,when the stretching direction is parallel to the polarization direction of the electric field,the total EMI shielding effectiveness could surprisingly increase from 38.4 to 52.7 dB at 200%tensile *** is mainly contributed by the increased connection of the *** addition,the film also has good Joule heating performance at several voltages,capable of releasing pains in injured *** unique property makes it possible for strain-adjustable multifunctional EMI shielding and wearable thermotherapy applications.

关键词： Electromagnetic interference shielding Single-walled carbon nanotubes Wrinkles Stretchable Thermotherapy

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Dynamics design of a non-natural transcription factor responding to androst-4-ene-3,17-dione

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Synthetic and Systems Biotechnology 2024年第3期9卷 436-444页

作者： Ming Zhao Mengkai hu Rumeng Han Chao ye Xiangfei Li Tianwen Wang Yan Liu Zhenglian Xue Kun Liu Anhui Engineering Laboratory for Industrial Microbiology Molecular Breeding College of Biology and Food EngineeringAnhui Polytechnic UniversityWuhu 241000China

The production of androst-4-ene-3,17-dione(AD)by the steroidal microbial cell factory requires transcription factors(TFs)to participate in metabolic ***,microbial cell factory lacks effective TFs that can respond to AD in its metabolic ***,finding and obtaining natural TFs that specifically respond to AD is a complex and onerous *** this study,we devised an artificial TF that responds to AD,termed AdT,based on structure-guided molecular dynamics(MD)*** to MD analysis of the conformational changes of AdT after binding to AD,an LBD in which the N-and C-termini exhibited convergence tendencies was used as a microswitch to guide the assembly of a DNA-binding domain lexA,a linker(GGGGS)2,and a transcription activation domain B42 into an artificial *** a proof of design,a AD biosensor was designed and constructed in yeast on the basis of the ligand-binding domain(LBD)of hormone *** addition,the transcription factor activity of AdT was increased by 1.44-fold for its variant ***,we created non-natural TF elements for AD microbial cell factory,and expected that the design TF strategy will be applied to running in parallel to the signaling machinery of the host cell.

关键词： Protein design Artificial transcription factor Molecular dynamics Steriods Site-mutations

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Enhancing the electrochemical performance of Na metal anodes via local eutectic melting in porous Al-Cu alloy hosts

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Nano Research 2024年第7期17卷 6111-6118页

作者： Tao hu Qiang Wu Cheng Wang Jialu Chen Fu su Zibo Chen Yizhou Wang Jianyu Chen Yanwen Ma Jin Zhao State Key Laboratory of Organic Electronics and Information Displays&Institute of Advanced Materials(IAM) Nanjing University of Posts&Telecommunications9 Wenyuan RoadNanjing 210023China Materials Science and Engineering King Abdullah University of Science and Technology(KAUST)Thuwal 23955-6900Saudi Arabia suzhou Vocational Institute of Industrial Technology 1 Zhineng AvenueSuzhou International Education ParkSuzhou 215104China

Sodium(Na)metal batteries(SMBs)have emerged as promising alternatives to lithium metal batteries for large-scale energy storage applications,owing to their cost-effectiveness,abundance,and favorable redox ***,the practical implementation of SMBs faces several challenges associated with the Na metal anode,including the formation of dendrites,low Coulombic efficiency,and capacity ***,we propose a novel approach to enhance the electrochemical performance of Na metal anodes through a porous Al-Cu alloy host(PAC)fabricated by a local eutectic melting *** local eutectic melting facilitates the development of a conductive network,offering mechanical support,and the porous structure provides abundant channels for the diffusion of Na ions and accommodates volume fluctuations in the Na metal during charge–discharge ***,the PAC exhibits a high average Coulombic efficiency of 99.8%at 1 mA·cm^(−2)for 1 mAh·cm^(−2)and a low voltage polarization of 19 mV during 500 *** study provides valuable insight into the design and fabrication of highperformance Na metal anodes,which hold significant promise for the advancements of next-generation energy storage systems.

关键词： Na metal anode porous Al-Cu alloy porous current collector local eutectic melting

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Controlling the Si/C ratio in SiC matrix based on the modified polymethysilane for C/C-SiC composites with enhanced mechanical properties

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Journal of Advanced Ceramics 2024年第2期13卷 220-236页

作者： Mingdong Liao Xiebo hu Chenghao Zhong Ping Xu Xiaodong Wang Ze Zhang Peng Zhou Mingyu Zhang Zhean su Qizhong huang National Key Laboratory of Science and Technology on High-Strength Structural Materials Central South UniversityChangsha 410083China

Fabricating SiC matrix with controllable Si/C ratio for C/C-SiC composites via precursor infiltration and pyrolysis is difficult to realize due to the absence of suitable ***,SiC precursors with Si-rich(Si/C=1.23),nearstoichiometric(Si/C=1.01),and C-rich(Si/C=0.88)pyrolyzed ceramics at 1200℃ were successfully synthesized by the novel modification of *** structure and ceramization of synthesized SiC precursors were studied,and C/C-SiC composites with similar Si/C ratio in SiC matrix were also *** results revealed that the defects and Young’s modulus of SiC matrix and the thermal residual stress on pyrolytic carbon coated carbon fiber were determined by the Si/C *** a result,the Si/C ratio exerted significant effects on the crack deflection behavior and the mechanical properties of the *** composites with near-stoichiometric SiC matrix showed excellent mechanical properties because of the effective crack deflection and the moderate Young’s modulus of their SiC *** flexural strength,flexural modulus,and compressive strength were 423±27 MPa,33.41±4.52 GPa,and 393±8 MPa,***,after a heat treatment at 1600℃,the role of carbon fiber toughening was improved and accompanied by a decrease in mechanical properties for all composites,which was attributed to the increased defects in SiC matrix and the damaged interfaces by the thermal residual stress.

关键词： SiC precursor Si/C ratio polymethysilane C/C–SiC composites mechanical properties

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Pd single atoms cooperate with S vacancies in ZnIn_(2)S_(4) nanosheets for photocatalytic pure-water splitting

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Science China Chemistry 2024年第3期67卷 855-861页

作者： Lin sun huiping Peng Fei Xue Shangheng Liu Zhiwei hu Hongbo Geng Xiaozhi Liu Dong su Yong Xu Xiaoqing huang State Key Laboratory of Physical Chemistry of Solid surfaces College of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China Guangzhou Key Laboratory of Low-Dimensional Materials and Energy Storage Devices Collaborative Innovation Center of Advanced Energy MaterialsSchool of Materials and EnergyGuangdong University of TechnologyGuangzhou 510006China Max Planck Institute for Chemical Physics of Solids Nothnitzer Strasse 40Dresden 01187Germany School of Materials Engineering Changshu Institute of TechnologyChangshu 215500China Beijing National Laboratory for Condensed Matter Physics Institute of Physics Chinese Academy of SciencesBeijing 100190China Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province(IKKEM) Xiamen 361005China

Photocatalytic water splitting has emerged as a new frontier for converting solar energy to green H_(2) and value-added ***,great challenges still remain for developing efficient photocatalysts for pure water splitting without sacrificial *** this work,we demonstrate that doping hexagonal ZnIn_(2)S_(4)(ZIS) with Pd single atoms(Pd_(0.03)/ZIS) can serve as a highly efficient photocatalyst for pure water splitting to simultaneously produce H_(2) and H_(2)O_(2) without any sacrificial *** from aberration-corrected high-angle annular dark field scanning transmission electron microscopy,X-ray fine spectroscopy,insitu electron paramagnetic resonance and diffuse Fourier transform infrared spectroscopy reveal that doping ZIS with Pd single atoms facilitates the formation of S vacancies(S_(v)),where the photogenerated electrons can transfer to Pd single atoms,as a result of enhanced separation of electron-hole pairs and improved photocatalytic ***,Pd_(0.03)/ZIS displays a stoichiometric ratio of H_(2) and H_(2)O_(2) with the productivity of 1,037.9 and 1,021.4μmol g^(-1)h^(-1),respectively,which has largely outperformed pure ZIS and other reported catalysts for pure water *** work provides an efficient photocatalyst for water splitting to produce H_(2) and H_(2)O_(2),which may attract rapid interest in materials science,chemistry,and heterogeneous catalysis.

关键词： ZnIn_(2)S_(4) Pd single atom S vacancy pure water splitting H_(2)O_(2)

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Relationships between blood chromium exposure and liver injury:Exploring the mediating role of systemic inflammation in a chromate-exposed population

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Journal of Environmental Sciences 2024年第9期143卷 224-234页

作者： Zekang su Yali Zhang Shiyi Hong Qiaojian Zhang Jiayu Xu Guiping hu Xiaojun Zhu Fang Yuan Shanfa Yu Tianchen Wang Guang Jia Department of Occupational and Environmental Health Sciences School of Public HealthPeking UniversityBeijing 100191China School of Engineering Medicine and Beijing Advanced Innovation Center for Big Data-Based Precision Medicine Beihang UniversityBeijing 100191China National Center for Occupational Safety and Health Beijing 102308China Department of Occupational Health and Radiological Health Chongqing Centers for Disease Control and PreventionChongqing 400042China Henan Institute for Occupational Medicine Zhengzhou 450052China Department of Clinical Laboratory Third Hospital of Peking UniversityBeijing 100191China

Hexavalent chromium and its compounds are prevalent pollutants,especially in the work environment,pose a significant risk for multisystem toxicity and *** it is known that chromium accumulation in the liver can cause damage,the dose-response relationship between blood chromium(Cr)and liver injury,as well as the possible potential toxic mechanisms involved,remains poorly *** address this,we conducted a follow-up study of 590 visits from 305 participants to investigate the associations of blood Cr with biomarkers for liver injury,including serum alanine aminotransferase(ALT),aspartate aminotransferase(AST),total bilirubin(TBIL),and direct bilirubin(DBIL),and to evaluate the mediating effects of systemic ***(PLT)and the platelet-to-lymphocyte ratio(PLR)were utilized as biomarkers of systemic *** the linear mixed-effects analyses,each 1-unit increase in blood Cr level was associated with estimated effect percentage increases of 0.82%(0.11%,1.53%)in TBIL,1.67%(0.06%,3.28%)in DBIL,0.73%(0.04%,1.43%)in ALT and 2.08%(0.29%,3.87%)in AST,***,PLT mediated 10.04%,11.35%,and 10.77%increases in TBIL,DBIL,and ALT levels induced by chromate,*** addition,PLR mediated 8.26%and 15.58%of the association between blood Cr and TBIL or *** findings shed light on the mechanisms underlying blood Cr-induced liver injury,which is partly due to worsening systemic inflammation.

关键词： Blood chromate Liver injury Systemic inflammation Mediation analysis

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The Immense Impact of Reverse Edges on Large Hierarchical Networks

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Engineering 2024年第5期36卷 240-249页

作者： Haosen Cao Bin-Bin hu Xiaoyu Mo Duxin Chen Jianxi Gao ye Yuan Guanrong Chen Tamás Vicsek Xiaohong Guan Hai-Tao Zhang MOE Engineering Research Center of Autonomous Intelligent Unmanned Systems State Key Laboratory of Intelligent Manufacturing Equipment and TechnologySchool of Artificial Intelligence and AutomationHuazhong University of Science and TechnologyWuhan 430074China School of Mechanical and Aerospace Engineering Nanyang Technological UniversitySingapore 639798Singapore Jiangsu Key Laboratory of Networked Collective Intelligence School of MathematicsSoutheast UniversityNanjing 210096China Department of Computer Science Rensselaer Polytechnic InstituteTroyNY 12180USA Department of Electronic Engineering City University of Hong KongHong Kong 999077China Department of Biological Physics Eötvös UniversityBudapest 1117Hungary MOE Key Laboratory for Intelligent Networks and Network Security School of Automation Science and EngineeringXi’an Jiaotong UniversityXi’an 710049China

Hierarchical networks are frequently encountered in animal groups,gene networks,and artificial engineering systems such as multiple robots,unmanned vehicle systems,smart grids,wind farm networks,and so *** structure of a large directed hierarchical network is often strongly influenced by reverse edges from lower-to higher-level nodes,such as lagging birds’howl in a flock or the opinions of lowerlevel individuals feeding back to higher-level ones in a social *** study reveals that,for most large-scale real hierarchical networks,the majority of the reverse edges do not affect the synchronization process of the entire network;the synchronization process is influenced only by a small part of these reverse edges along specific *** surprisingly,a single effective reverse edge can slow down the synchronization of a huge hierarchical network by over 60%.The effect of such edges depends not on the network size but only on the average in-degree of the involved *** overwhelming majority of active reverse edges turn out to have some kind of“bunching”effect on the information flows of hierarchical networks,which slows down synchronization *** finding refines the current understanding of the role of reverse edges in many natural,social,and engineering hierarchical networks,which might be beneficial for precisely tuning the synchronization rhythms of these *** study also proposes an effective way to attack a hierarchical network by adding a malicious reverse edge to it and provides some guidance for protecting a network by screening out the specific small proportion of vulnerable nodes.

关键词： Synchronizability Large hierarchical networks Reverse edges Information flows Complex networks

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