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The steroid-induced microRNA let-7 regulates developmental growth by targeting cdc7 in the Drosophila body

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Insect Science 2021年第6期28卷 1621-1632页

作者： Dan-Yan Huang Xiao-Ling Xia Run Huang Sheng Li Dong-Wei Yuan su-ning liu Guangdong Provincial Key Laboratory of Insect Developmental Biology and Applied Technology Institute of Insect Science and Technology&School of Life SciencesSouth China Normal UniversityGuangzhou510631China

In insects,20-hydroxyecdysone(20E)limits systemic growth by triggering developmental *** studies have shown that 20E-induced let-7 exhibits crosstalk with the cell ***,we examined the underlying molecular mechanisms and physiological functions of 20E-induced let-7 in the fat body,an organ for energy storage and nutrient mobilization which plays a critical role in the larval ***,the overexpression of let-7 decreased the body size and led to the reduction of both nucleolus and cell sizes in the larval fat *** contrast,the overexpression of let-7-Sponge increased the nucleolus and cell ***,we found that cdc7,encoding a conserved protein kinase that controls the endocycle,is a target of ***,the mutation of cdc7 in the fat body resulted in growth ***,our findings revealed a novel role of let-7 in the control of endoreduplication-related growth during larval-prepupal transition in Drosophila.

关键词： cdc7 Drosophila fat body growth let-7

Acid-rock reaction kinetics in a two-scale model based on reaction order correction

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Petroleum Science 2024年第3期21卷 2089-2101页

作者： Xue-Song Li ning Qi Ze-Hui Zhang Lian liu Xia-Qing Li Xu-Hang su School of Petroleum Engineering China University of Petroleum(East China)Qingdao266580ShandongChina Key Lab of Unconventional Oil&Gas Development Ministry of EducationChina University of Petroleum(East China)Qingdao26650ShandongChina SINOPEC Northwest Oilfield Branch Company Urumqi830011XinjiangChina Petroleum Engineering Technology Research Institute SINOPEC Shengli Oilfield CompanyDongying257000ShandongChina

The reaction order plays a crucial role in evaluating the response rate of ***,the conventional two-scale model typically assumes that the reaction order is constant as one,which can lead to significant deviations from *** address this issue,this study proposes a novel multi-order dynamic model for acid-rock reaction by combining rotating disk experimental data with theoretical *** numerical simulations,this model allows for the investigation of the impact of acidification conditions on different orders of reaction,thereby providing valuable insights for on-site *** analysis reveals that higher response orders require higher optimal acid liquid flow rates,and lower optimal H+diffusion coefficients,and demonstrate no significant correlation with acid ***,it is recommended to increase the displacement and use high-viscosity acid for reservoirs with high calcite content,while reducing the displacement and using low-viscosity acid for reservoirs with high dolomite content.

关键词： Reaction order Two-scale model Wormhole propagation Carbonate rocks Numerical simulation

Grainy head signaling regulates epithelium development and ecdysis in Blattella germanica

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Insect Science 2021年第2期28卷 485-494页

作者： Zheng Zhao Liang Li Min Cheng An-Di Jing su-ning liu Shi-Ming Zhu Er-Xia Du Sheng Li Yun-Xia Luan Chong-Hua Ren Guangdong Provincial Key Laboratory of Insect Developmental Biology and Applied Technology Institute of Insect Science and TechnologySchool of Life SciencesSouth China Normal UniversityGuangzhouChina Guangmeiyuan R&D Center Guangdong Provincial Key Laboratory of Insect Developmental Biology and Applied TechnologySouth China Normal UniversityMeizhouGuangdong ProvinceChina

The transcription factor grainy head(Grh)functions in the protection of the epithelium against the external environment by generating strongly adhesive layers,and this function is conserved in vertebrates and *** Drosophila,the top model for holometabolous insects,Grh is necessary during embryonic development,epidermal differentiation,central nervous system specification and epithelial ***,the function of this gene in hemimetabolous insect epithelia remains *** examine the function of Grh signaling in regulating epithelium development in Hemimetabola,we focused on the Blattella germanica epidermal layer using a gene knockdown *** spatiotemporal expression pattern of BgGrh was detected,and knockdown of Bg-Grh and BgCad96ca,which provide positive feedback to BgGrh,caused severe defects in new epithelium development and impeded the molting process required to discard the old *** of the expression of BgGrh and BgCad96ca caused increased expression of chitin synthase gene{BgCHSl)and chitinase gene{BgCht5),the upregulations of which should be mediated by the higher level of hormone receptor 3{BgHr3)*** conclusion,epithelium development is regulated by Grh signaling,which might represent a potential target for the control of urban pest cockroaches.

关键词： BgCad96ca cockroach ecdysis epithelium Grh signaling

Research on the navigation method of large-scale differential tail-control improvised guided munitions based on rotational speed constraints

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Defence Technology（防务技术） 2024年第8期38卷 155-170页

作者： ning liu Wenjiang Zhao Yao Wang Kai Shen Zhong su Wenhao Qi Yuedong Xie Beijing Key Laboratory of High Dynamic Navigation Technology Beijing Information Science and Technology UniversityBeijing100192China Hua an Industry Group Co. Ltd.Qiqihar161006China Integrated Navigation and Intelligent Navigation Laboratory Beijing Institute of TechnologyBeijing100081China Beijing Institute of Technology Beijing100081China

In the process of launching guided projectile under the conventional system, it is difficult to effectively obtain the precise navigation parameters of the projectile in the high dynamic environment. Aiming at this problem, this paper describes a new system of guided ammunition based on tail spin reduction. After analyzing the mechanism of the ammunition's tail spin reduction, a navigation method of large scale difference tail control simple guided ammunition based on speed constraint is proposed. In this method,the corresponding navigation constraints can be carried out by combining the rotation speed state of the ammunition itself, and the optimal solution of navigation parameters during the flight of the missile can be obtained by Extended Kalman Filter(EKF). Finally, the performance of the proposed method was verified by the simulation environment, and the hardware-in-the-loop simulation test and flight test were carried out to verify the performance of the method in the real environment. The experimental results show that the proposed method can achieve the optimal estimation of navigation parameters for simple guided ammunition with large-scale difference tail control. Under the conditions of simulation test and hardware-in-loop simulation test, the position and velocity errors calculated by the method in this paper converged. Under the condition of flight test, the spatial average error calculated by the method described in this paper is 6.17 m, and the spatial error of the final landing point is 3.50 *** this method, the accurate acquisition of navigation parameters in the process of projectile launching is effectively realized.

关键词： Guided projectiles Tail spin reduction RPM constraints Combined navigation Extended Kalman filter(EKF)

A Review on the Security of the Ethereum-Based DeFi Ecosystem

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Computer Modeling in Engineering & Sciences 2024年第4期139卷 69-101页

作者： Yue Xue Dunqiu Fan Shen su Jialu Fu ning Hu Wenmao liu Zhihong Tian Cyberspace Institute of Advanced Technology Guangzhou UniversityGuanzhou510000China Innovation Center NSFOCUS Inc.Beijing100089China Engineering Research Center of Integration and Application of Digital Learning Technology Ministry of EducationBeijing100816China

Decentralized finance(DeFi)is a general term for a series of financial products and *** is based on blockchain technology and has attracted people’s attention because of its open,transparent,and intermediary *** them,the DeFi ecosystem based on Ethereum-based blockchains attracts the most ***,the current decentralized financial system built on the Ethereum architecture has been exposed to many smart contract vulnerabilities during the last few ***,we believe it is time to improve the understanding of the prevailing Ethereum-based DeFi ecosystem security *** that end,we investigate the Ethereum-based DeFi security issues:1)inherited from the real-world financial system,which can be solved by macro-control;2)induced by the problems of blockchain architecture,which require a better blockchain platform;3)caused by DeFi invented applications,which should be focused on during the project *** on that,we further discuss the current solutions and potential directions ofDeFi *** to our research,we could provide a comprehensive vision to the research community for the improvement of Ethereum-basedDeFi ecosystem security.

关键词： Blockchain smart contract decentralized finance DeFi security

METTL3 regulates glucose transporter expression in placenta exposed to hyperglycemia through the mTOR signaling pathway

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Chinese Medical Journal 2024年第13期137卷 1563-1575页

作者： Jie ning Jing Huai Shuxian Wang Jie Yan Rina su Muqiu Zhang Mengtong liu Huixia Yang Department of Obstetrics and Gynaecology Peking University First HospitalBeijing 100034China Beijing Key Laboratory of Maternal Foetal Medicine of Gestational Diabetes Mellitus Beijing 100034China Peking University Beijing 100034China

Background:Alterations in the placental expression of glucose transporters(GLUTs),the crucial maternal-fetal nutrient transporters,have been found in women with hyperglycemia in pregnancy(HIP).However,there is still uncertainty about the underlying effect of the high-glucose environment on placental GLUTs expression in ***:We quantitatively evaluated the activity of mammalian target of rapamycin(mTOR)and expression of GLUTs(GLUT1,GLUT3,and GLUT4)in the placenta of women with normal pregnancies(CTRL,n=12)and pregnant women complicated with poorly controlled type 2 diabetes mellitus(T2DM,n=12)by *** addition,BeWo cells were treated with different glucose concentrations to verify the regulation of ***,changes in the expression of GLUTs following the activation or suppression of the mTOR pathway were also assessed using MHY1485/rapamycin(RAPA)treatment or small interfering RNA(siRNA)-mediated silencing ***,we further explored the alteration and potential upstream regulatory role of methyltransferase-like 3(METTL3)when exposed to ***:mTOR,phosphorylated mTOR(p-mTOR),and GLUT1 protein levels were upregulated in the placenta of women with T2DM compared with those *** BeWo cells,mTOR activity increased with increasing glucose concentration,and the expression of GLUT1,GLUT3,and GLUT4 as well as GLUT1 cell membrane translocation were upregulated by hyperglycemia to varying *** the drug-mediated and genetic depletion of mTOR signaling in BeWo cells suppressed GLUTs expression,whereas MHY1485-induced mTOR activation upregulated GLUTs ***,high glucose levels upregulated METTL3 expression and nuclear translocation,and decreasing METTL3 levels suppressed GLUTs expression and mTOR activity and vice ***,in METTL3 knockdown BeWo cells,the inhibitory effect on GLUTs expression was eliminated by activating the mTOR signaling pathway using ***:High-g

关键词： Glucose transporters Hyperglycemia Type 2 diabetes mellitus Pregnancy Mammalian target of rapamycin Methyltransferase-like 3

Application of controlled-release urea increases maize N uptake,environmental benefits and economic returns via optimizing temporal and spatial distributions of soil mineral N

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Pedosphere 2024年第1期34卷 222-235页

作者： Mingxue suN Juan LI Lili ZHANG Xiaomeng su ning liu Xiaori HAN Songjiang WU Zhentao suN Xiangdong YANG Institute of Agricultural Resources and Regional Planning Chinese Academy of Agricultural Sciences/State Key Laboratory of Efficient Utilization of Arid and Semi-arid Arable Land in Northern China/Key Laboratory of Plant Nutrition and FertilizerMinistry of Agriculture and Rural AffairsBeijing 100081China Agricultural Development Service Center of Zhuanghe Zhuanghe 116499China Agricultural Technology Extension Center Wafangdian 116300China College of Land and Environment Shenyang Agricultural UniversityShenyang 100866China

The creation of controlled-release urea (CRU) is a potent substitute for conventional fertilizers in order to preserve the availability of nitrogen (N) in soil,prevent environmental pollution,and move toward green *** main objectives of this study were to assess the impacts of CRU’s full application on maize production and to clarify the connection between the nutrient release pattern of CRU and maize nutrient *** order to learn more about the effects of CRU application on maize yields,N uptake,mineral N (N_(min)) dynamics,N balance in soil-crop systems,and economic returns,a series of field experiments were carried out in 2018–2020 in Dalian City,Liaoning Province,*** were 4 different treatments in the experiments:no N fertilizer input (control,CK);application of common urea at 210 kg ha^(-1)(U),the ideal fertilization management level for the study site;application of polyurethane-coated urea at the same N input rate as U (PCU);and application of PCU at a 20% reduction in N input rate (0.8PCU).Our findings showed that using CRU (i.e.,PCU and 0.8 PCU) may considerably increase maize N absorption,maintain maize yields,and increase N use efficiency (NUE) compared to *** grain yield showed considerable positive correlations with total N uptake in leaf in U and 0.8 PCU,but negative correlations with that in PCU,indicating that PCU caused excessive maize absorption while 0.8 PCU could achieve a better yield response to N ***,PCU was able to maintain N fertilizer in the soil profile 0–20 cm away from the fertilization point,and higher N_(min)content was observed in the 0–20 cm soil layer at various growth stages,particularly at the middle and late growing stages,optimizing the temporal and spatial distributions of N_(min).Additionally,compared to that in U,the apparent N loss rate in PCU was reduced by 36.2%,and applying CRU (PCU and 0.8 PCU) increased net profit by 8.5% to 15.2% with less labor and fertilization *** was co

关键词： apparent N loss fertilization management green agriculture maize yield N balance N use efficiency

A real-world study of the differences in Traditional Chinese Medicine diagnosis and treatment rules for coronavirus disease 2019 between Northern and Southern China

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Journal of Traditional Chinese Medicine 2024年第4期44卷 822-829页

作者： su Rui su Youzhu WANG Shuo FAN Jie liu Qingquan liu Mifeng Department of infectious diseases Capital Medical University Beijing Hospital of Traditional Chinese MedicineBeijing 100010China

OBJECTIVE:To explore the differences in Traditional Chinese Medicine(TCM)diagnosis and treatment rules for coronavirus disease 2019(COVID-19)between Northern and Southern China based on the real-world data from 982 COVID-19 ***:All consecutive cases of COVID-19 admitted to the TCM department of designated COVID-19 hospitals in eight provinces and cities were retrospectively *** were divided into a Northern and a Southern group according to the location of the admitting *** symptoms,syndrome elements,syndrome distribution and herbal treatments were *** core prescriptions were extracted using the multiscale backbone-based network comparison algorithm(msbNC).REsuLTS:The distribution of syndrome elements showed that dampness was common in Northern and Southern China,wind and heat were more often present in the South,while fire toxin and spleen deficiency were more often encountered in the *** distribution of syndromes showed that the South was dominated by heat dampness accumulating in the lung(55.69%),while the North was dominated by dampness-toxin stagnating in the lung(44.90%).The results of core prescription mining showed that dispelling dampness,dispersing wind,clearing heat and strengthening spleen were the common treatment methods in Northern and Southern *** mild cases,Jinyinhua(Flos Lonicerae)and Lianqiao(Fructus Forsythiae suspensae)were often used in the South to clear heat and relieve exterior symptoms,while Chaihu(Radix Bupleuri Chinensis)and Huangqin(Radix Scutellariae Baicalensis)were often used in the North to relieve muscles by expelling *** moderate cases,Chaihu(Radix Bupleuri Chinensis),Qinghao(Herba Artemisiae Annuae),and Shigao(Gypsum Fibrosum)were often used to clear heat of Tri-jiao Channel and stomach in the South,while Fuling(Poria),Chenpi(Pericarpium Citri Reticulatae),and Dangshen(Radix Codonopsis)were often used to invigorate spleen and remove dampness in the *** severe cases

关键词： COVID-19 medicine,Chinese traditional North-South difference core prescription syndrome retrospective studies

PPB structure elimination,DRX nucleation mechanisms and grain growth behavior of the3rd-generation PM superalloy for manufacturing aviation components

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Chinese Journal of Aeronautics 2024年第1期37卷 325-344页

作者： Baoyun ZHANG Yongquan ning Zhaotian WANG Qiaomu liu School of Materials Science and Engineering Northwestern Polytechnical UniversityXi’an 710072China AECC Sichuan Gas Turbine Establishment Chengdu 610500China

Previous Particle Boundary(PPB),as the detrimental structure in Powder Metallurgy(PM)components,should be eliminated by subsequent hot process to improve the mechanical *** objective is to investigate the Dynamic Recrystallization(DRX)nucleation mechanisms and grain growth behavior of the 3rd-generation PM superalloy with PPB *** observation reveals that PPB decorated with(Ti,Ta,Nb)C carbides belongs to the discontinuous chain-like *** elimination of PPB networks can be achieved effectively via hot deformation due to the occurrence of *** different DRX nucleation mechanisms were proposed and discussed in detail according to the special microstructure characteristics of the PM ***,local lattice rotations can be detected in the vicinity of(Ti,Ta,Nb)C carbides during hot deformation and thus PPB structure serves as the preferential nucleation sites for DRX grains via Particle-Stimulated Nucleation(PSN).Then,Discontinuous-DRX(DDRX)characterized by grain boundary bulging dominates the microstructure refinement and Continuous-DRX(CDRX)operated by subgrain rotation can be regarded as an important assistant *** last,the initial Σ3 boundaries would lose their twin characteristics owing to the crystal rotation and then transform into the general High Angle Grain Boundaries(HAGBs).The distorted twins provide additional DRX nucleation sites,viz.,twin-assisted *** attention was focused on the grain growth behavior of the PM superalloy in subsequent annealing *** recrystallization temperature was determined to be about 1110.C and 1140.C can be considered as the critical temperature for grain *** findings would provide theoretical support for microstructure refinement of the 3rd-generation PM superalloy,which is of pivotal significance for improving the mechanical properties of aviation components.

关键词： PM superalloy Previous Particle Boundary(PPB) DRX nucleation Grain growth Microstructure refinement