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Current status of adjuvant chemotherapy for gastric cancer

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World Journal of Gastrointestinal Oncology 2019年第9期11卷 679-685页

作者： In-hwan kim Department of surgery Catholic University of Daegu

Although radical gastrectomy is a standard treatment for advanced gastric cancer,recurrence remains *** several large-scale controlled studies have shown the beneficial effects of adjuvant chemotherapy,that treatment emerged as a standard option for advanced gastric cancer after ***,various guidelines from different countries have suggested different adjuvant *** the differences between guidelines is very important for investigating further therapeutic ***,because there are many ongoing studies about new regimens for adjuvant treatment,it is expected that patients with gastric cancer after surgery will have better outcome.

关键词： Gastric cancer Adjuvant chemotherapy Perioperative chemotherapy Chemoradiotherapy Guidelines

Nanotribological properties and scratch resistance of MoS_(2)bilayerona SiO_(2)/Si substrate

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Friction 2023年第1期11卷 154-164页

作者： Si-hwan kim Hyo-sok AHN Department of Transdisciplinary Studies Seoul National UniversitySeoul 08826Republic of Korea Department of Manufacturing Systems and Design Engineering Seoul National University of Science and TechnologySeoul 08826 Republic of Korea

The tribological properties and scratch resistance of MoS_(2)bilayer deposited on SiO_(2)/Si substrates prepared via chemical vapor deposition are *** force microscopy(FFM)is employed to investigate the friction and wear properties of the MoS_(2)bilayer at the nanoscale by applying a normal load ranging from 200 to 1,000 *** resistance is measured using the scratch mode in FFM based on a linearly increasing load from 100 to 1,000 *** probe force microscopy(KPFM)is performed to locally measure the surface potential in the tested surface to qualitatively measure the wear/removal of Mos,layers and identify critical loads associated with the individual failures of the top and bottom *** analysis of the contact potential difference values as well as that of KPFM,friction,and height images show that the wear/removal of the top and bottom layers in the MoS_(2)bilayer system occurred *** FFM and KPFM results show that the top MoS_(2)layer begins to degrade at the end of the low friction stage,followed by the bottom layer,thereby resulting in a transitional friction stage owing to the direct contact between the diamond tip and SiO_(2)*** the stable third stage,the transfer of lubricious MoS_(2)debris to the tip apex results in contact between the MoS_(2)-transferred tip and SiO_(2).Nanoscratch test results show two ranges of critical loads,which correspond to the sequential removal of the top and bottom layers.

关键词： chemical vapor deposition(CVD)-grown MoS,bilayer friction force microscopy(FFM) nanoscratch test Kelvin probe force microscopy(KPFM) scratch resistance

Assessment of disease activity by fecal immunochemical test in ulcerative colitis

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World Journal of Gastroenterology 2016年第48期22卷 10617-10624页

作者： Dae Gon Ryu Hyung Wook kim su Bum Park Dae hwan Kang Cheol Woong Choi su Jin kim Hyeong Seok Nam Department of Internal Medicine Pusan National University School of Medicine and Research Institute for Convergence of Biomedical Science and Technology Pusan National University Yangsan Hospital

AIM To evaluate the efficacy of quantitative fecal immunochemical test(FIT) as biomarker of disease activity in ulcerative colitis(UC).METHODS Between February 2013 and November 2014, a total of 82 FIT results, obtained in conjunction with colonoscopies, were retrospectivelyevaluated for 63 patients with UC. The efficacy of FIT for evaluation of disease activity was compared to colonoscopic findings. Quantitative fecal blood with automated equipment examined from collected feces. Endoscopic disease severity were assessed using the Mayo endoscopic subscore(MES) classification. The extent of disease were classified by proctitis(E1), left sided colitis(E2), and extensive colitis(E3). Clinical activity were subgrouped by remission or *** All of 21 patients with MES 0 had negative FIT( 134.89 ng/m L. The sensitivity, specificity, positive predictive value(PPV), negative predictive value(NPV) and accuracy of negative FIT about mucosal healing were 73.33%, 81.82%, 91.49%, 51.43% and 73.17%, respectively. The sensitivity, specificity, PPV, NPV and accuracy of predictive value of positive FIT(cutoff value > 100 ng/mL) about active disease status were 45.45%, 93.33%, 71.43%, 82.35%and 26.83%, respectively. Among patients with clinical remission, FIT was negative in 31(81.6%) of 38 cases, with a mean fecal hemoglobin concentration of 6.12 ng/mL(range, negative to 80.9 ng/mL) for this group of patients. Among patients with clinical active disease, FIT was negative in 16(36.4%) out of 44 cases, with a mean fecal hemoglobin concentration > 167.4 ng/mL for this group of patients. FIT was positively correlated with endoscopic activity(r = 0.626, P < 0.01) and clinical activity(r = 0.496, P < 0.01). But, FIT did not correlate with the extent of disease(r =-0.047, P = 0.676)CONCLUSION Quantitative FIT can be a non-invasive and effective biomarker for evaluation of clinical and endoscopic activity in UC, but not

关键词： Ulcerative colitis Fecal immunochemical test Mayo endoscopic subscore Biomarker Disease activity

Totally laparoscopic total gastrectomy using the modified overlap method and conventional open total gastrectomy:A comparative study

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World Journal of Gastroenterology 2021年第18期27卷 2193-2204页

作者： Chang Seok Ko Nam Ryong Choi Byung Sik kim Jeong hwan Yook Min-Ju kim Beom su kim Department of surgery Asan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505South Korea Department of Clinical Epidemiology and Biostatistics Asan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505South Korea

BACKGROUND Although several methods of totally laparoscopic total gastrectomy(TLTG)have been *** best anastomosis technique for LTG has not been *** To investigate the effectiveness and surgical outcomes of TLTG using the modified overlap method compared with open total gastrectomy(OTG)using the circular stapled *** We performed 151 and 131 surgeries using TLTG with the modified overlap method and OTG for gastric cancer between March 2012 and December *** and oncological outcomes were compared between groups using propensity score *** addition,we analyzed the risk factors associated with postoperative *** Patients who underwent TLTG were discharged earlier than those who underwent OTG[TLTG(9.62±5.32)vs OTG(13.51±10.67),Psurvival between *** analysis demonstrated that body mass index[odds ratio(OR),1.824;95%confidence interval(CI):1.029-3.234,P=0.040]and American Society of Anaesthesiologists(ASA)score(OR,3.154;95%CI:1.084-9.174,P=0.035)were independent risk factors of early ***,age was associated with≥3 Clavien-Dindo classification and EJrelated *** Although TLTG with the modified overlap method showed similar complication rate and oncological outcome with OTG,it yields lower pain score,earlier bowel recovery,and *** should perform total gastrectomy cautiously and delicately in patients with obesity,high ASA scores,and older ages.

关键词： Laparoscopic surgery Gastrectomy Anastomosis Stomach neoplasms Totally laparoscopic total gastrectomy

Efficacy and safety of limited endoscopic sphincterotomy before self-expandable metal stent insertion for malignant biliary obstruction

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World Journal of Gastroenterology 2017年第9期23卷 1627-1636页

作者： Hyeong Seok Nam Dae hwan Kang Hyung Wook kim Cheol Woong Choi su Bum Park su Jin kim Dae Gon Ryu Department of Internal Medicine Pusan National University School of Medicine and Research Institute for Convergence of Biomedical Science and TechnologyPusan National University Yangsan HospitalYangsan-siGyeongsangnam-do 50612South Korea

To evaluate the safety and efficacy of limited endoscopic sphincterotomy (ES) before placement of self-expandable metal stent (SEMS).METHODSThis was a retrospective analysis of 244 consecutive patients with unresectable malignant biliary obstruction, who underwent placement of SEMSs following limited ES from December 2008 to February 2015. The diagnosis of malignant biliary obstruction and assessment of patient eligibility for the study was established by a combination of clinical findings, laboratory investigations, imaging and pathological results. All patients were monitored in the hospital for at least 24 h following endoscopic retrograde cholangio pancreatography (ERCP). The incidence of immediate or early post-ERCP complications such as post-ERCP pancreatitis (PEP) and bleeding related to limited ES were considered as primary outcomes. Also, characteristics and complications according to the cancer type were *** the 244 patients included, the underlying diagnosis was cholangiocarcinoma in 118 patients, pancreatic cancer in 79, and non-pancreatic or non-biliary malignancies in the remaining 47 patients. Early post-ERCP complications occurred in 9 patients (3.7%), with PEP in 7 patients (2.9%; mild, 6; moderate, 1) and mild bleeding in 2 patients (0.8%). There was no significant association between the incidence of post-ERCP complications and the type of malignancy (cholangiocarcinoma vs pancreatic cancer vs others, P = 0.696) or the type of SEMS used (uncovered vs covered, P = 1.000). Patients who had more than one SEMS placed at the first instance were at a significantly higher risk of post-ERCP complications (one SEMS vs two SEMS, P = 0.031). No other factors were predictive of post-ERCP *** ES is feasible and safe, and effectively facilitates the placement of SEMS, without any significant risk of PEP or severe bleeding.

关键词： Endoscopic sphincterotomy Endoscopic retrograde cholangio pancreatography Complications Pancreatitis Bleeding Cholestasis Self-expandable metal stent

Distributed framework for yard planning in container terminals

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2010年第12期11卷 992-997页

作者： Kap hwan kim Xiao-hui ZHANG Department of Industrial Engineering Pusan National University Department of Logistics Information Technology Pusan National University

This study discusses a yard planning system,which considers various resources such as storage space,yard cranes,and traffic areas in container *** system is based on the function for estimating resource requirements of yard *** a given yard plan,the proposed system allows planners to check the feasibility of the plan which requires a certain amount of workload of resources in related blocks during a planning *** yard planning system in this study is aimed at balancing workloads among the blocks and providing the ability to modify current yard plans by detecting blocks and periods with overloaded *** system implements its planning function in a distributed manner in which planners construct yard plans under their individual control and send and receive only limited necessary information for the negotiation.

关键词： Workload Yard planning Container terminal Distributed planning

An Experimental Study of Condensation Heat Transfer in sub-Millimeter Rectangular Tubes

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Journal of Thermal Science 2004年第4期13卷 350-357页

作者： Jeong Seob SHIN Moo hwan kim Department of Mechanical Engineering POSTECH Pohang KoreaDepartment of Mechanical Engineering POSTECH Pohang Korea

The characteristics of local heat transfer and pressure drops were experimentally investigated using condensing R134a two-phase flow, in single rectangular tubes, with hydraulic diameter of 0.494, 0.658, and 0.972 mm. New experimental techniques were used to measure the in-tube condensation heat transfer coefficient especially for the low heat and mass flows. Tests were performed for a mass flux of 100, 200, 400, and 600 kg/m2s, a heat flux of 5 to 20 kW/m2, and a saturation temperature of 40℃. In this study, effect of heat flux, mass flux, vapor qualities, and hydraulic diameter on flow condensation were investigated and the experimental local condensation heat transfer coefficients and frictional pressure drop are shown. The experimental data of condensation Nusselt number are compared with previous correlations, most of which are proposed for the condensation of pure refrigerant in a relatively large inner diameter round tubes.

关键词： condensation hydraulic diameter rectangular in-tube multiphase flow.

Joint On-Demand Pruning and Online Distillation in Automatic Speech Recognition Language Model Optimization

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Computers, Materials & Continua 2023年第12期77卷 2833-2856页

作者： Soonshin Seo Ji-hwan kim Clova Speech Naver CorporationSeongnam13561Korea Department of Computer Science and Engineering Sogang UniversitySeoul04107Korea

Automatic speech recognition(ASR)systems have emerged as indispensable tools across a wide spectrum of applications,ranging from transcription services to voice-activated *** enhance the performance of these systems,it is important to deploy efficient models capable of adapting to diverse deployment *** recent years,on-demand pruning methods have obtained significant attention within the ASR domain due to their adaptability in various deployment ***,these methods often confront substantial trade-offs,particularly in terms of unstable accuracy when reducing the model *** address challenges,this study introduces two crucial empirical ***,it proposes the incorporation of an online distillation mechanism during on-demand pruning training,which holds the promise of maintaining more consistent accuracy ***,it proposes the utilization of the Mogrifier long short-term memory(LSTM)language model(LM),an advanced iteration of the conventional LSTM LM,as an effective alternative for pruning targets within the ASR *** rigorous experimentation on the ASR system,employing the Mogrifier LSTM LM and training it using the suggested joint on-demand pruning and online distillation method,this study provides compelling *** results exhibit that the proposed methods significantly outperform a benchmark model trained solely with on-demand pruning ***,the proposed strategic configuration successfully reduces the parameter count by approximately 39%,all the while minimizing trade-offs.

关键词： Automatic speech recognition neural language model Mogrifier long short-term memory pruning distillation efficient deployment optimization joint training

Fabrication of Piezoelectric Cellulose Paper and Audio Application

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Journal of Bionic Engineering 2009年第1期6卷 18-21页

作者： Jung-hwan kim sungryul Yun Joo-Hyung kim Jaehwan kim Creative Research Center for EAPap Actuator Department of Mechanical EngineeringINHA University253 Young-Hyun DongNam GuIncheon402-751Republic of Korea

We report the fabrication process of piezoelectric cellulose paper and the enhancement method of its piezoelectric property. Stretching method with different wet-drawing ratios was introduced to increase the piezoelectric property of cellulose paper during regeneration *** is observed that the Young's modulus and the piezoelectric charge constants are very dependent on the drawing ratio and the direction of nanofibrils of piezoelectric *** the enhanced piezoelectric property,we prove that the flexible regenerated piezoelectric cellulose can be applied to the potential acoustic applications such as thin piezoelectric paper speaker.

关键词： piezoelectric speaker piezoelectricity cellulose wet-drawing process