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Application of Deep Learning on Single-cell RNA Sequencing Data Analysis:A Review

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Genomics, Proteomics & Bioinformatics 2022年第5期20卷 814-835页

作者： Matthew Brendel chang su Zilong Bai Hao Zhang Olivier Elemento Fei Wang Department of Population Health Sciences Weill Cornell MedicineCornell UniversityNew YorkNY 10065USA Institute for Computational Biomedicine Caryl and Israel Englander Institute for Precision MedicineDepartment of Physiology and BiophysicsWeill Cornell MedicineCornell UniversityNew YorkNY 10065USA Department of Health Service Administration and Policy Temple UniversityPhiladelphiaPA 19122USA

Single-cell RNA sequencing(scRNA-seq)has become a routinely used technique to quantify the gene expression profile of thousands of single cells *** of scRNA-seq data plays an important role in the study of cell states and phenotypes,and has helped elucidate biological processes,such as those occurring during the development of complex organisms,and improved our understanding of disease states,such as cancer,diabetes,and coronavirus disease 2019(COVID-19).Deep learning,a recent advance of artificial intelligence that has been used to address many problems involving large datasets,has also emerged as a promising tool for scRNA-seq data analysis,as it has a capacity to extract informative and compact features from noisy,heterogeneous,and high-dimensional scRNA-seq data to improve downstream *** present review aims at surveying recently developed deep learning techniques in scRNA-seq data analysis,identifying key steps within the scRNA-seq data analysis pipeline that have been advanced by deep learning,and explaining the benefits of deep learning over more conventional analytic ***,we summarize the challenges in current deep learning approaches faced within scRNA-seq data and discuss potential directions for improvements in deep learning algorithms for scRNA-seq data analysis.

关键词： Single-cell RNA sequencing Single-cell sequencing Deep learning Deep neural network Artificial intelligence

基于“风险源-承灾体-减灾力”的工业上楼安全风险评估研究

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工业建筑 2024年第2期54卷 18-24页

作者：黄文宏张英菊苏畅何望波深圳市城市公共安全技术研究院广东深圳518046 国家城市安全发展科技研究院广东深圳518046 城市安全风险监测预警应急管理部重点实验室广东深圳518046 西安科技大学安全科学与工程学院西安710054

工业上楼是一种新型产业空间模式,实现了城市产业空间的高效利用,也给产业园区带来了新的安全风险因素。为科学精准评估工业上楼安全风险,基于“风险源-承载体-减灾力”理论框架,提出由风险源控制、承灾体韧性、减灾力3个准则层和20个... 详细信息

工业上楼是一种新型产业空间模式,实现了城市产业空间的高效利用,也给产业园区带来了新的安全风险因素。为科学精准评估工业上楼安全风险,基于“风险源-承载体-减灾力”理论框架,提出由风险源控制、承灾体韧性、减灾力3个准则层和20个二级指标构成的工业上楼安全风险评估指标体系。同时,结合网络分析法(ANP)和物元可拓模型确定指标权重体系和评价方法,建立工业上楼安全风险评估模型,将工业上楼安全风险评估数据实现可拓量化,进而提升评估结果的客观性。以深圳某工业上楼园区为实例进行分析,结果表明该工业上楼园区安全风险等级为轻度风险,评估结果较好,符合实际情况;通过对比发现,提出的评估方法具有实用性、科学性;该园区应重点关注承灾体韧性水平建设,加强少量危化品管理,合理管控生产性振动等风险,加强风险监测预警能力建设,以更好地保障工业上楼安全。

关键词：工业上楼风险评估网络层次分析法物元可拓模型

Size analysis of slag eye formed by gas blowing in ladle refining

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Journal of Iron and Steel Research International 2017年第3期24卷 243-250页

作者： Ning-ning Lv Liu-shun Wu Hai-chuan Wang Yuan-chi Dong chang su School of Metallurgical Engineering Anhui University of Technology Ma'anshan 243032 Anhui China Key Laboratory of Metallurgical Emission Reduction & Resources Recycling Ministry of Education Ma' anshan 243002 AnhuiChina

The formation of slag eye in a gas stirred ladle was studied through cold models and industrial trials. In the cold model,water and sodium tungstate solution were employed to simulate liquid steel,and silicon oil was employed to simulate slag. The simulation results revealed that the gas flow rate and bath height had strong effects on the slag eye size. In particular,the thickness of slag layer played a strong role in the slag eye size. In addition,the slag eye could not be formed when the thickness of the top layer was more than 4 cm in water-silicone oil ***,the section area of vessel had a great impact on the slag eye size. Industrial trials results showed a similar trend that the gas flow rate was very significant on the slag eye size. The predictions of the existing models showed larger predictions deviations compared with the experimental data. Moreover,a new model without fitting parameters was developed based on force balance and mathematical derivation,and verified by the experimental data. The new model provides the prediction with small deviations by comparing with the data acquired from cold models and industrial trials.

关键词： Slag eye Cold model Industrial trial Gas blowing Ladle refining

High Response Gas Sensors for Formaldehyde Based on Er-doped In_2O_3 Nanotubes

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Journal of Materials Science & Technology 2015年第12期31卷 1175-1180页

作者： Xuesong Wang Jinbao Zhang Lianyuan Wang Shouchun Li Li Liu chang su Lili Liu State Key Laboratory of superhard Materials College of PhysicsJilin University

Pure and Er-doped In 2O 3 nanotubes were systematically fabricated by using a single nozzle eletrospinning method followed by *** as-synthesized nanotubes were characterized by scanning electron microscopy（SEM）,energy-dispersive X-ray（EDX） spectrometry and X-ray powder diffraction（XRD）.Compared with pure In 2O 3 nanotubes,Er-doped In 2O 3 nanotubes exhibit improved formaldehyde sensing properties at 260 ℃.The response of Er-doped In 2O 3 nanotubes to 20 ppm formaldehyde is about 12,which is 4 times larger than that of pure In 2O 3 *** response and recovery times of Er-doped In 2O 3 nanotubes to 20 ppm formaldehyde are about 5 and 38 s,***,the response of Er-doped In 2O 3 nanotubes to 100 ppb formaldehyde is 2.19.

关键词： Er-doped In 2O 3 nanotubes Formaldehyde Gas sensor

Thermodynamic properties of San Carlos olivine at high temperature and high pressure

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Acta Geochimica 2018年第2期37卷 171-179页

作者： chang su Yonggang Liu Wei Song Dawei Fan Zhigang Wang Hongfeng Tang Key Laboratory of High-Temperature and High-Pressure Study of the Earth's Interior Institute of Geochemistry Chinese Academy of Sciences Guiyang 550081 China University of Chinese Academy of Sciences Beijing 100049China National Key Laboratory of Shock Wave and Detonation Physics Institute of Fluid Physics Chinese Academy of Engineering Physics Mianyang 621900 China

In this study, the thermal expansion and heat capacity of San Carlos olivine under high temperature and high pressure are reported. Combining accurate sound velocity data under different P–T conditions with density and heat capacity data at ambient pressure, the density,adiabatic bulk modulus, shear modulus, and most importantly, thermal expansion and heat capacity, of San Carlos are extracted to 14 GPa by a numerical procedure using classic thermodynamic relationships. These data are in agreement with published findings. To estimate the temperature gradient in the upper mantle, we also report the fitting equations of thermal expansion and heat capacity of San Carlos olivine as a function of both temperature and pressure to the P–T condition of the 410 km discontinuity,which provide the thermodynamic properties with increasing depth in the Earth's interior.

关键词： San Carlos olivine Thermodynamic property Thermal expansion Heat capacity Temperature gradient

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发酵类中药红曲的安全性质量控制研究进展

中国药学杂志 2024年第13期59卷 1186-1192页

作者：王淑红郭子瑜周碧乾何轶李东芮陶品润苏畅王冰马双成深圳市药品检验研究院广东深圳518057 国家药品监督管理局中药质量研究与评价重点实验室广东深圳518057 国家药典委员会北京100061

发酵类中药红曲食药用历史悠久,在国内外被广泛应用于医药、食品添加剂、发酵食品等领域,但目前对其研究尚不深入。近来,红曲作为保健食品的安全性问题引起国际上高度关注。本文综述了红曲的食药用历史、生产工艺、发酵产物和物质基础... 详细信息

发酵类中药红曲食药用历史悠久,在国内外被广泛应用于医药、食品添加剂、发酵食品等领域,但目前对其研究尚不深入。近来,红曲作为保健食品的安全性问题引起国际上高度关注。本文综述了红曲的食药用历史、生产工艺、发酵产物和物质基础研究及质量安全控制现状,旨在探究可能导致红曲质量安全风险的因素,为我国红曲及红曲产品的安全性质量控制及风险防控提供参考。

关键词：红曲中药安全性质量控制风险防控

Experimental investigation of the gate voltage range of negative differential capacitance in ferroelectric transistors

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Science China(Information Sciences) 2022年第6期65卷 277-278页

作者： Mengxuan YANG Qianqian HUANG chang su Liang CHEN Yangyuan WANG Ru HUANG Key Laboratory of Microelectronic Devices and Circuits (MOE) Institute of MicroelectronicsPeking University Beijing Laboratory of Future IC Technology and Science Peking University

Dear editor,Recently, ferroelectric(FE)-based negative capacitance FET(NCFET) with ferroelectric/dielectric(FE/DE) gate stack has attracted extensive attention due to its capability of sub-60 mV/dec subthreshold swing... 详细信息

关键词： Ferroelectric Negative differential capacitance effect Polarization Low power subthreshold swing

尼帕病毒TaqMan探针荧光定量PCR检测方法建立

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中国动物传染病学报 2024年第1期32卷 122-128页

作者：孙彤孙竹筠刘静宜王培培苏苌陈鸿军中国农业科学院上海兽医研究所兽药评价中心上海200241

尼帕病毒病是一种人畜共患烈性传染病,为能够快速特异检测该病毒,本研究根据尼帕病毒(NiV)N基因序列保守区设计特异性引物和探针,建立一种针对NiV的TaqMan探针荧光定量PCR(qPCR)检测方法,该方法特异性好、敏感性高、稳定性强,可鉴别NiV... 详细信息

尼帕病毒病是一种人畜共患烈性传染病,为能够快速特异检测该病毒,本研究根据尼帕病毒(NiV)N基因序列保守区设计特异性引物和探针,建立一种针对NiV的TaqMan探针荧光定量PCR(qPCR)检测方法,该方法特异性好、敏感性高、稳定性强,可鉴别NiV与其他猪病病毒,扩增效率为102%,最低检测限14.8 copies/μL,敏感性高于常规PCR 10倍,该检测方法的建立可为NiV的快速检测提供技术手段,对促进猪类养殖业的健康发展具有重要意义。

关键词：尼帕病毒 N基因 TaqMan探针实时荧光定量PCR

2022年中国农业大学动物医院6822例犬X线检查病例回顾性分析

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中国兽医杂志 2024年第6期60卷 9-16页

作者：杨腾昆陈可欣刘钢傅梦竹苏畅张迪夏兆飞中国农业大学动物医学院兽医公共卫生安全全国重点实验室北京海淀100193 中国农业大学动物医院北京海淀100193

为了研究X线检查在犬临床诊疗过程中的具体应用情况和主要异常诊断等,本研究对2022年1—12月中国农业大学动物医院6 822例犬X线检查病例进行回顾性分析。结果显示,1岁以下684例(10.03%),1~7岁2 101例(30.80%),7岁以上4 037例(59.18%);雄... 详细信息

为了研究X线检查在犬临床诊疗过程中的具体应用情况和主要异常诊断等,本研究对2022年1—12月中国农业大学动物医院6 822例犬X线检查病例进行回顾性分析。结果显示,1岁以下684例(10.03%),1~7岁2 101例(30.80%),7岁以上4 037例(59.18%);雄性2 828例(41.45%),雄性去势1 169例(17.14%),雌性1 464例(21.46%),雌性绝育1 361例(19.95%)。共进行X线检查8 539例次,检查类型包括平片8 510例次,造影29例次。平片检查部位由多到少依次为胸部(3 191/8 510,37.50%)、四肢骨(3 023/8 510,35.52%)、中轴骨(1 476/8 510,17.34%)和腹部(820/8 510,9.64%)。胸部主要影像学异常为肺非结构间质型(939/3 191,29.43%)和心影增大(649/3 191,20.34%);四肢骨主要影像学异常为骨关节炎(1 089/3 023,36.02%);中轴骨主要影像学异常为椎间隙狭窄(876/1 476,59.35%)和退行性病变(443/1 476,30.01%);腹部主要影像学异常为下泌尿道结石(261/820,31.83%)。造影检查包括逆行性尿路造影25例次和消化道造影4例次。逆行性尿道造影检查检出的主要异常表现/诊断为尿道狭窄(7/25,28.00%),消化道造影检查检出的主要异常表现/诊断为造影剂残留(3/4,75.00%)。结果表明,X线检查在犬类临床疾病的诊断和治疗中应用广泛,尤其在心脏疾病、骨关节疾病和泌尿道疾病方面具有重要的临床应用价值。

关键词： X线回顾性分析犬影像学表现诊断