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Chinese Chemical Letters 2025年第1期36卷 374-380页

作者： Panpan Wang Hongbao Fang Mengmeng Wang Guandong Zhang Na Xu yan su Hongke Liu Zhi su Jiangsu Collaborative Innovation Center of Biomedical Functional Materials College of Chemistry and Materials ScienceNanjing Normal UniversityNanjing 210023China

Metal complexes hold significant promise in tumor diagnosis and ***,their potential applications in photodynamic therapy(PDT)are hindered by issues such as poor photostability,low yield of reactive oxygen species(ROS),and aggregation-induced ROS *** address these challenges,we present a molecular self-assembly strategy utilizing aggregation-induced emission(AIE)conjugates for metal *** a proof of concept,we synthesized a mitochondrial-targeting cyclometalated Ir(Ⅲ)photosensitizer *** approach significantly enhances the photodynamic effect while mitigating the dark toxicity associated with AIE ***-TPE readily self-assembles into nanoaggregates in aqueous solution,leading to a significant production of ROS upon light *** Ir-TPE triggers multiple modes of death by excessively accumulating ROS in the mitochondria,resulting in mitochondrial DNA *** damage can lead to ferroptosis and autophagy,two forms of cell death that are highly cytotoxic to cancer *** aggregation-enhanced photodynamic effect of Ir-TPE significantly enhances the production of ROS,leading to a more pronounced cytotoxic *** vitro and in vivo experiments demonstrate this aggregation-enhanced PDT approach achieves effective in situ tumor *** study not only addresses the limitations of metal complexes in terms of low ROS production due to aggregation but also highlights the potential of this strategy for enhancing ROS production in PDT.

关键词： Metal complex AIEgens Mitochondria targeting Enhanced photodynamic therapy Anticancer agent

Recombinant chitinase-3-like protein 1 alleviates learning and memory impairments via M2 microglia polarization in postoperative cognitive dysfunction mice

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Neural Regeneration Research 2025年第9期20卷 2727-2736页

作者： Yujia Liu Xue Han yan su Yiming Zhou Minhui Xu Jiyan Xu Zhengliang Ma Xiaoping Gu Tianjiao Xia Department of Anesthesiology Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingJiangsu ProvinceChina Medical School Nanjing UniversityNanjingJiangsu ProvinceChina Jiangsu Key Laboratory of Molecular Medicine Nanjing UniversityNanjingJiangsu ProvinceChina State Key Laboratory of Pharmaceutical Biotechnology Nanjing UniversityNanjingJiangsu ProvinceChina Department of Anesthesiology Zhongshan HospitalFudan UniversityShanghaiChina

Postoperative cognitive dysfunction is a seve re complication of the central nervous system that occurs after anesthesia and surgery,and has received attention for its high incidence and effect on the quality of life of *** date,there are no viable treatment options for postoperative cognitive *** identification of postoperative cognitive dysfunction hub genes could provide new research directions and therapeutic targets for future *** identify the signaling mechanisms contributing to postoperative cognitive dysfunction,we first conducted Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses of the Gene Expression Omnibus GSE95426 dataset,which consists of mRNAs and long non-coding RNAs differentially expressed in mouse hippocampus3 days after tibial *** dataset was enriched in genes associated with the biological process"regulation of immune cells,"of which Chill was identified as a hub ***,we investigated the contribution of chitinase-3-like protein 1 protein expression changes to postoperative cognitive dysfunction in the mouse model of tibial fractu re *** were intraperitoneally injected with vehicle or recombinant chitinase-3-like protein 124 hours post-surgery,and the injection groups were compared with untreated control mice for learning and memory capacities using the Y-maze and fear conditioning *** addition,protein expression levels of proinflammatory factors(interleukin-1βand inducible nitric oxide synthase),M2-type macrophage markers(CD206 and arginase-1),and cognition-related proteins(brain-derived neurotropic factor and phosphorylated NMDA receptor subunit NR2B)were measured in hippocampus by western *** with recombinant chitinase-3-like protein 1 prevented surgery-induced cognitive impairment,downregulated interleukin-1βand nducible nitric oxide synthase expression,and upregulated CD206,arginase-1,pNR2B,and brain-derived neurotropic factor expr

关键词： Chil1 hippocampus learning and memory M2 microglia neuroinflammation postoperative cognitive dysfunction(POCD) recombinant CHI3L1

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浅水晃荡载荷特性与近似计算方法研究

振动与冲击 2025年第1期44卷 51-60页

作者：袁心怡苏焱中山大学海洋工程与技术学院广州510275

利用高精度的Boussinesq方程建立数值模型,并结合试验手段,深入分析了矩形水箱内部浅水晃荡运动的载荷特性。研究结果显示,当无因次外部激励频率接近液体固有频率时,晃荡运动与载荷时历曲线表现出相似的非线性特征,随着激励频率的增加,... 详细信息

利用高精度的Boussinesq方程建立数值模型,并结合试验手段,深入分析了矩形水箱内部浅水晃荡运动的载荷特性。研究结果显示,当无因次外部激励频率接近液体固有频率时,晃荡运动与载荷时历曲线表现出相似的非线性特征,随着激励频率的增加,呈现出多种不同的形式。通过对载荷时历曲线进行傅里叶分析,得到了不同外部激励频率下载荷的频域分布特征。基于晃荡载荷与自由液面波高频响曲线的相似性以及载荷特性的分析结果,建立了晃荡载荷的近似计算方法。该方法在不同水深及激励幅值下表现出优良的泛化性能,能够修正共振状态下线性近似对壁面载荷的过高估计,使跳跃频率处误差减少了50%以上。利用所提出的近似方法能够在已知波高的情况下快速估计壁面载荷,为工程设计提供技术支持。

关键词：浅水晃荡载荷特性近似方法模型试验

计算机视觉技术赋能大学英语课堂展示中的学习投入研究

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新疆师范大学学报（哲学社会科学版） 2025年第2期46卷 144-151页

作者：谭苏燕王晋军广州大学外国语学院广东广州510010

学习投入是预测学习者学习效果的重要指标,学术界对其与课堂展示间的相关性研究鲜有涉猎。文本以某综合性大学303名非英语专业本科生为研究对象,采用人工智能与计算机视觉技术模型YOLOv7对大学英语课堂中的课堂展示实录进行学习投入多... 详细信息

学习投入是预测学习者学习效果的重要指标,学术界对其与课堂展示间的相关性研究鲜有涉猎。文本以某综合性大学303名非英语专业本科生为研究对象,采用人工智能与计算机视觉技术模型YOLOv7对大学英语课堂中的课堂展示实录进行学习投入多模态数据分析,并辅以问卷调查,形成双向印证。研究发现,学生课堂展示中的行为投入、认知投入和情感投入值均等于或高于3.78,投入结果均值达4.01,说明学生在课堂展示中的学习投入情况良好。此外,不同时段课堂展示对学生行为投入的影响显著,学生专注度及参与度在课堂前10分钟的课堂展示中效果最佳。文本为课堂展示的有效性提供了智能化、多模态、多维度的实证支持,为课堂教学的数智技术应用提供了新视角。

关键词：大学英语课堂展示学习投入计算机视觉技术展示时段

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虚拟体验馆个性化人机交互设计研究

玩具世界 2025年第1期 188-190页

作者：苏岩辽宁地质工程职业学院

随着科技的飞速发展,虚拟体验馆作为一种新兴的数字娱乐与教育模式,正逐渐改变人们的生活方式。为了提升用户体验,文章深入分析如何在虚拟环境中实现更加贴合用户需求的个性化交互设计。研究内容涵盖了多个层面,包括对用户偏好的精准捕... 详细信息

随着科技的飞速发展,虚拟体验馆作为一种新兴的数字娱乐与教育模式,正逐渐改变人们的生活方式。为了提升用户体验,文章深入分析如何在虚拟环境中实现更加贴合用户需求的个性化交互设计。研究内容涵盖了多个层面,包括对用户偏好的精准捕捉、个性化内容的智能推荐,以及基于虚拟现实(Virtual Reality, VR)和人工智能技术的自然交互界面的开发。旨在通过这些设计手段,满足用户的个性化需求,增强其在虚拟环境中的沉浸感和互动性,促进虚拟体验馆在教育和娱乐领域的广泛应用,进一步推动数字交互技术的创新与进步。

关键词：虚拟体验馆个性化设计人机交互

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基于损伤因子的车用铰链轧制工艺优化

武汉科技大学学报 2025年第1期48卷 34-41页

作者：苏严李立新彭洲武汉科技大学钢铁冶金与资源利用省部共建教育部重点实验室湖北武汉430081 武汉科技大学材料学部湖北武汉430081

为了确定更适合于复杂断面型钢轧制成形工艺的韧性断裂准则,本文构建了包含韧性断裂准则的铰链型钢全轧程数值模型。通过分析轧件截面维氏硬度值与模拟计算的损伤因子之间的关系,确定了更适合在铰链型钢轧制成形工艺中应用的韧性断裂准... 详细信息

为了确定更适合于复杂断面型钢轧制成形工艺的韧性断裂准则,本文构建了包含韧性断裂准则的铰链型钢全轧程数值模型。通过分析轧件截面维氏硬度值与模拟计算的损伤因子之间的关系,确定了更适合在铰链型钢轧制成形工艺中应用的韧性断裂准则。研究结果表明,Brozzo韧性断裂准则在预测复杂断面型钢轧制过程中材料损伤演化方面表现最佳。此外,基于Brozzo准则计算的损伤因子,探究了不同轧制工艺参数组合对轧件最大损伤因子的影响规律。通过正交试验和多元回归分析,确定了影响轧件最大损伤因子显著的工艺参数依次为初轧温度、孔型偏转角和轧辊直径,而轧制速度的影响不显著。最终优化的工艺参数组合为:初轧温度1250℃,轧辊直径比1.15,孔型偏转角1.61°,轧辊转速148.9 r/min,此时轧件的最大损伤因子为7.92,相比于优化前减小了约20%。由此可见,选择适宜的工艺参数组合可以显著降低轧件的损伤因子,从而有效提高轧件质量。

关键词：铰链型钢韧性断裂准则轧制成形工艺参数优化正交试验维氏硬度

A multi-objective multi-memetic algorithm for network-wide conflict-free 4D flight trajectories planning

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Chinese Journal of Aeronautics 2017年第3期30卷 1161-1173页

作者： su yan Kaiquan CAI School of Electronics and Information Engineering Beihang University Beijing 100191 China Beijing Key Laboratory of Network Enabled Collaborative ATM Beijing 100191 China

Under the demand of strategic air traffic flow management and the concept of trajectory based operations（TBO）,the network-wide 4D flight trajectories planning（N4DFTP） problem has been investigated with the purpose of safely and efficiently allocating 4D trajectories（4DTs）（3D position and time） for all the flights in the whole airway *** that the introduction of large-scale 4DTs inevitably increases the problem complexity,an efficient model for strategiclevel conflict management is developed in this ***,a bi-objective N4 DFTP problem that aims to minimize both potential conflicts and the trajectory cost is *** consideration of the large-scale,high-complexity,and multi-objective characteristics of the N4DFTP problem,a multi-objective multi-memetic algorithm（MOMMA） that incorporates an evolutionary global search framework together with three problem-specific local search operators is *** is capable of rapidly and effectively allocating 4DTs via rerouting,target time controlling,and flight level ***,to balance the ability of exploitation and exploration of the algorithm,a special hybridization scheme is adopted for the integration of local and global *** studies using real air traffic data in China with different network complexities show that the proposed MOMMA is effective to solve the N4 DFTP *** solutions achieved are competitive for elaborate decision support under a TBO environment.

关键词： Air traffic flow management 4D trajectory planning Multi-memetic algorithm Multi-objective optimization Network-wide strategic conflict management

环境温度自适应修正的船载辐射特性测量系统联合定标方法

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中国光学(中英文) 2025年第01期18卷 134-141页

作者：孙晓东陈德明杨国庆苏龑赵李健中国卫星海上测控部中国科学院长春光学精密机械与物理研究所

红外数据作为信息化数据库的重要组成部分，在夜视侦察、武器制导、远程预警等方面具有广泛应用。红外辐射特性测量系统在环境温度变化时会产生温漂，从而导致目标的红外反演精度受到较大影响。针对该问题，本文提出一种基于环境温度自... 详细信息

红外数据作为信息化数据库的重要组成部分，在夜视侦察、武器制导、远程预警等方面具有广泛应用。红外辐射特性测量系统在环境温度变化时会产生温漂，从而导致目标的红外反演精度受到较大影响。针对该问题，本文提出一种基于环境温度自适应修正的内外联合定标方法。通过自适应插值的方式对环境温度变化的影响进行修正。以高精度面源黑体作为目标进行辐射反演测量试验。实验结果表明：最小误差为6.82%、最大误差为10.21%。同时对水上动态目标开展辐射特性反演实验，得到高置信度的实测目标辐射特性数据。通过黑体以及水上动态目标的测量试验可以得到：本方法可以在海洋气候复杂环境下实现环境温度变化对辐射反演精度的影响修正。验证了所提出的定标算法的有效性，同时可以基于修正参数进行红外系统环境温度敏感性的有效评估测试。

关键词：自适应辐射定标特性反演船载系统

Overexpression pattern,function,and clinical value of proteasome 26S subunit non-ATPase 6 in hepatocellular carcinoma

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World Journal of Clinical Oncology 2025年第2期16卷 76-93页

作者： Sheng-Sheng Zhou Yu-Ping Ye Yi Chen Da-Tong Zeng Guang-Cai Zheng Rong-Quan He Bang-Teng Chi Lei Wang Qian Lin Qin-yan su Yi-Wu Dang Gang Chen Jia-Liang Wei Department of Medical Oncology The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Department of Clinical Laboratory The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Department of Pathology The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Department of Pathology Redcross Hospital of Yulin CityYulin 537000Guangxi Zhuang Autonomous RegionChina Department of surgery Redcross Hospital of Yulin CityYulin 537000Guangxi Zhuang Autonomous RegionChina

BACKGROUND In recent years,many studies have shown that proteasome 26S subunit non-ATPase 6(PSMD6)plays an important role in the occurrence and development of malignant ***,there are no reports on the evaluation of the potential role of PSMD6 in hepatocellular carcinoma(HCC).AIM To comprehensively evaluate the overexpression pattern and clinical significance of PSMD6 in HCC *** This study integrated PSMD6 mRNA expression profiles from 4672 HCC and 3667 non-HCC tissues,along with immunohistochemical scores from 383 HCC and adjacent tissues,to assess PSMD6 overexpression in *** regularly interspaced short palindromic repeats knockout technology evaluated PSMD6’s essential role in HCC cell *** enrichment analysis explored the molecular mechanism of PSMD6 abnormalities in *** sensitivity analysis and molecular docking analysed the effect of abnormal expression of PSMD6 on the drug sensitivity of HCC *** The results of 41 external and two internal datasets showed that PSMD6 mRNA(SMD=0.26,95%CI:0.09-0.42,Psults showed that PSMD6 had a significant overexpression pattern in HCC tissues(SMD=0.40,95%CI:0.15-0.66,Psuch as RNA degradation,ribosomes,and chemical carcinogenesis—reactive oxygen *** sensitivity analysis and a molecular docking model showed that high expression of PSMD6 was associated with the tolerance of HCC cells to drugs such as ML323,sepantronium bromide,and *** PSMD6 effectively distinguished HCC tissues(AUC=0.75,95%CI:0.71-0.79).CONCLUSION This study was the first to discover that PSMD6 was overexpressed in HCC ***6 is essential for the growth of HCC cell

关键词： Hepatocellular carcinoma Proteasome 26S subunit non-ATPase 6 Clustered regularly interspaced short palindromic repeats Ribosome biogenesis RNA splicing

妊娠糖尿病与妊娠期泌尿生殖感染之间的回顾性分析和孟德尔随机化研究

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现代预防医学 2025年第1期52卷 69-74页

作者：魏馨粟艳林王妍程利殷玲刘鹏敏谢清华南华大学附属长沙中心医院妇产科南华大学附属长沙中心医院病理科南华大学附属长沙中心医院检验科

目的本研究通过回顾性分析和孟德尔随机化分析（Mendelian randomization,MR），评估了妊娠期糖尿病（gestational diabetes mellitus,GDM）与妊娠期泌尿生殖道感染（genitourinary tract infections during pregnancy,GUTIs）之间的关联。方法对2020—2022年产检并分娩的7 751名孕妇进行了回顾性分析，比较GDM和非GDM妇女的GUTIs率。同时，选取了全基因组关联研究（genome-wide association study,GWAS）数据，采用逆方差加权法（inverse-variance weighted method,IVW）作为主要分析方法，加权中介方差（MR-Egger）回归、简单模态法（SM）、加权中位数法和加权众数法作为补充分析，通过MR-Egger回归、Cochran Q检验和留一法作为敏感性检验，进行双样本MR分析，来探讨GDM和GUTIs的因果关系。结果单因素χ2检验（P=2.2×10-16）与多因素逐步逻辑回归分析（P=2×10-16）均显示GDM与GUTIs间存在显著相关性；双样本MR研究进一步证实了两者之间的显著关联(IVW:β=0.211,P=0.013),MR-Egger回归法未发现明显的水平多效性（P=0.813），留一法、Cochran Q检验表明所有SNPs不存在明显异质性（P=0.876,P=0.938）。结论 GDM的存在可能增加GUTIs风险。有效的筛查和管理GDM患者，将有助于降低和预防GUTIs。

关键词：妊娠糖尿病妊娠期泌尿生殖道感染多因素逐步逻辑回归分析孟德尔随机化分析