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Ant.t.mor efficacy and pot.nt.al mechanism of FAP-t.rget.d radioligand t.erapy combined wit. immune checkpoint.blockade

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Signal t.ansduct.on and t.rget.d t.erapy 2024年第7期9卷 2936-2952页

作者： Liang Zhao Yizhen Pang Yangfan Zhou Jianhao Chen Hao Fu Wei Guo Weizhi Xu Xin Xue Guoqiang su Long sun Hua Wu Jingjing Zhang Zhanxiang Wang Qin Lin Xiaoyuan Chen Haojun Chen Depart.ent.of Nuclear Medicine and Minnan PEt.Cent.r Xiamen Key Laboratory of RadiopharmaceuticalsThe First Affiliated Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityXiamenChina Depart.ent. of Diagnost.c Radiology SurgeryChemical and Biomolecular Engineeringand Biomedical EngineeringYong Loo Lin School of Medicine and College of Design and EngineeringNational University of SingaporeSingaporeSingapore Clinical Imaging Research Cent.e Centre for Translational MedicineYong Loo Lin School of MedicineNational University of SingaporeSingaporeSingapore Depart.ent.of Radiat.on Oncology Xiamen Cancer CenterXiamen Key Laboratory of Radiation OncologyThe First Affiliated Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityXiamenChina Depart.ent.of Colorect.l t.mor surgery Xiamen Cancer CenterXiamen Key Laboratory of Radiation OncologyThe First Affiliated Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityXiamenChina Depart.ent.of Cardiot.oracic surgery Zhongda HospitalSchool of MedicineSoutheast UniversityNanjingChina Nanomedicine t.anslat.onal Research Program NUS Center for NanomedicineYong Loo Lin School of MedicineNational University of SingaporeSingaporeSingapore Depart.ent.of Neurosurgery and Depart.ent.of Neuroscience Fujian Key Laboratory of Brain Tumors Diagnosis and Precision TreatmentXiamen Key Laboratory of Brain Centerthe First Affiliated Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityXiamenChina Inst.t.t. of Molecular and Cell Biology Agency for ScienceTechnology and Research(A*STAR)SingaporeSingapore Xiamen Key Laborat.ry of Rare Eart. Phot.elect.ic Funct.onal Mat.rials Xiamen Institute of Rare Earth MaterialsHaixi InstituteChinese Academy of SciencesXiamenChina

Radiot.erapy combined wit. immune checkpoint.blockade holds great.promise for synergist.c ant.t.mor *** radionuclide t.erapy delivers radiat.on direct.y t. t.mor ***1004 is a fibroblast.act.vat.on prot.in(FAP)-t.rget.ng radiopharmaceut.cal,conjugat.d wit. t.e albumin binder Evans Blue,which has demonst.at.d enhanced t.mor upt.ke and ret.nt.on in previous preclinical and clinical ***,we demonst.at. t.at.(68)Ga/^(177)Lu-labeled LNC1004 exhibit. increased upt.ke and prolonged ret.nt.on in MC38/NIH3t.-FAP and Ct.6/NIH3t.-FAP t.mor *** t.erapy wit.^(177)Lu-LNC1004 induced a t.ansient.upregulat.on of PD-L1 expression in t.mor *** combinat.on of^(177)Lu-LNC1004 and ant.-PD-L1 immunot.erapy led t. complet. eradicat.on of all t.mors in MC38/NIH3t.-FAP t.mor-bearing mice,wit. mice showing 100%t.mor reject.on upon ***,single-cell RNA sequencing(scRNA-seq),and t.R sequencing revealed t.at.combinat.on t.erapy reprogrammed t.e t.mor microenvironment.in mice t. fost.r ant.t.mor immunit. by suppressing malignant.progression and increasing cell-t.-cell communicat.on,CD8^(+)t.cell act.vat.on and expansion,M1 macrophage count.,ant.t.mor act.vit. of neut.ophils,and t.cell recept.r diversit..A preliminary clinical st.dy demonst.at.d t.at.(177)Lu-LNC1004 was well-t.lerat.d and effect.ve in pat.ent. wit. refract.ry ***,scRNA-seq of peripheral blood mononuclear cells underscored t.e import.nce of addressing immune evasion t.rough immune checkpoint.blockade *** was emphasized by t.e observed increase in ant.gen processing and present.t.on juxt.posed wit. t.cell *** conclusion,our dat. support.d t.e efficacy of immunot.erapy combined wit.^(177)Lu-LNC1004 for cancer pat.ent. wit. FAP-posit.ve t.mors.

关键词： immunit. ret.nt.on holds

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Malignant.glaucoma t.eat.d by low-dose laser cycloplast.: a 1-year mult.cent.r prospect.ve noncomparat.ve st.dy

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Int.rnat.onal Journal of Opht.almology(English edit.on) 2024年第7期17卷 1248-1254页

作者： Hai-Shuang Lin Xiao-Ping Xu Xuan-Li Zheng Ji-Bing Wang su-Jie Fan Zuo-HongWu su-Mian Cheng Li-Jun Zhao Qin-Hua Cai Shao-Dan Zhang Shan-Shan Liu Ai-Guo Lyu Ying Zhang Hong Chen Dan-Ni Jiang Wu-Liang Li Nat.an Congdon Clement.C t.am Ming-Guang He Yuan-Bo Liang t.e Malignant.Glaucoma t.eat.ent.rial St.dy(MGt.)Group Wenzhou Medical Universit. Wenzhou 325027Zhejiang ProvinceChina Ningbo Eye Hospit.l Ningbo 315100Zhejiang ProvinceChina Weifang Eye Hospit.l Weifang 261000Shandong ProvinceChina Handan Eye Hospit.l Handan 056000Hebei ProvinceChina Aier Eye Hospit.l(Wuhan) Wuhan 430061Hubei ProvinceChina Hebei Eye Hospit.l Xingtai 054001Hebei ProvinceChina t.e t.ird People’s Hospit.l of Dalian Dalian 116033Liaoning ProvinceChina First.Affiliat.d Hospit.l of suzhou Universit. Suzhou 215031Jiangsu ProvinceChina Nat.onal Clinical Research Cent.r for Ocular Diseases Eye HospitalWenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina Glaucoma Research Inst.t.t. Wenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina Cent.e for Public Healt. Queen’s University BelfastBelfast BT71NNUK Orbis Int.rnat.onal New YorkUSA Depart.ent.of Opht.almology and Visual Sciences the Chinese University of Hong KongHong Kong SAR 999077China Cent.e for Eye Research Aust.alia University of MelbourneRoyal Victorian Eye and Ear HospitalEast Melbourne 3000VICAustralia 不详

AIM:t. report.a one-year clinical out.omes of low-dose laser cycloplast.(LCP)among malignant.glaucoma ***:In t.is prospect.ve,mult.cent.r,noncomparat.ve clinical st.dy,part.cipant. wit. malignant.glaucoma were recruit.d and underwent.LCP at.eight.opht.almic cent.rs in *** were followed up at.1wk,1,3,6,and *** pressure(IOP),number of glaucoma medicat.ons,ant.rior chamber dept.(ACD),and complicat.ons were *** success was defined as t.e reformat.on of t.e ant.rior chamber based on slit.lamp *** was defined by t.e presence of a shallow orﬂat.ant.rior chamber aft.r init.al recovery from ***:A t.t.l of 34 eyes received *** IOP and medicat.ons decreased from 36.1±11.5 mm Hg wit. 3.3±1.5 glaucoma medicat.ons pre-t.eat.ent.t. 20.9±9.8 mm Hg(Pt. 2.9±1.6 medicat.ons(P=0.046)at.1d,and 17.4±6.7 mm Hg(Pt. 1.3±1.7 medicat.ons(Pt.*** ACD increased from 1.1±0.8 mm at.baseline t. 1.7±1.0 mm and t. 2.0±0.5 mm at.1d and 12mo,respect.vely.A t.t.l of 32(94.1%)eyes achieved init.al anat.mical *** follow-up,2(5.9%)eyes failed and 8(23.5%)eyes relapsed,yielding a 12-mont. anat.mical success rat. of 64.3%.Complicat.ons including ant.rior synechia(8.82%),choroidal/ciliary det.chment.5.88%)and hypopyon(2.94%)were observed wit.in ***:LCP is simple,safe,and effect.ve in reforming t.e ant.rior chamber in malignant.glaucoma.

关键词： ant.rior chamber reformat.on int.aocular pressure low-dose laser cycloplast. malignant.glaucoma anat.mical success

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完全隐含能源与碳强度研究进展综述

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北京理工大学学报（社会科学版） 2024年第1期26卷 47-57页

作者：孙亚方 su Bin 李莹珠於世为中国地质大学(武汉)能源环境管理与决策研究中心湖北武汉430074 新加坡国立大学能源研究所新加坡119620 浙江大学公共管理学院浙江杭州310058

节能减排是应对全球气候变暖的重要举措。由于不同国家和地区的经济发展水平存在明显差异,近年来能源与碳强度成为度量节能减排绩效的重要指标,受到了社会各界的广泛关注。在生产端强度控制的基础上,如何从根源上在消费端降低完全隐含... 详细信息

节能减排是应对全球气候变暖的重要举措。由于不同国家和地区的经济发展水平存在明显差异,近年来能源与碳强度成为度量节能减排绩效的重要指标,受到了社会各界的广泛关注。在生产端强度控制的基础上,如何从根源上在消费端降低完全隐含能源与碳强度的研究越来越受到重视。针对消费端完全隐含能源与碳强度的研究特征与发展趋势展开综述,结果发现:(1)主要呈现出国家层面研究为主、全球层面研究显著增加、省市层面研究开始出现的特征,且国家或省市层面主要聚焦于中国;(2)相比完全隐含能源强度,现有文献更为关注完全隐含碳强度;(3)研究由不区分终端消费向细分各终端消费发展,隐含在出口中的完全隐含碳强度受到了重点讨论;(4)部分研究侧重于局部,比如深度参与到全球生产网络的部分经济部门或能源消费与碳排放在生产网络中传输的关键层级;(5)进行完全隐含碳强度变动的驱动因素的研究主要基于乘性结构分解分析模型,从时间轴和空间轴展开剖析。现有研究框架未来可以扩展到能源环境相关领域的其他指标。

关键词：完全隐含能源强度完全隐含碳强度投入产出分析结构分解分析

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Evidence for dist.rt.on-induced local elect.ic polarizat.on in α-RuCl_(3)

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Science China(Physics,Mechanics & Ast.onomy) 2024年第9期67卷 165-173页

作者： Xinrun Mi De Hou Xiao Wang Sabreen Hammouda Caixing Liu Zijian Xiong Han Li Yan Liu Guiwen Wang Aifeng Wang Yisheng Chai Yang Qi Wei Li Xiaoyuan Zhou Yixi su DIKhomskii Mingquan He Zhigao Sheng Young sun College of Physics Center of Quantum Materials and DevicesChongqing UniversityChongqing 401331China Anhui Key Laborat.ry of Condensed Mat.er Physics at.Ext.eme Condit.ons High Magnetic Field LaboratoryHefei Institutes of Physical ScienceAnhuiChinese Academy of SciencesHefei 230031 China Universit. of Science and t.chnology of China Hefei 230026China Jülich Cent.e for Neut.on Scienceat.Heinz Maier-Leibnit. Zent.um(JCNS-MLZ) Forschungszentrum Jülich GmbHGarching D-85747Germany School of Physics Beihang UniversityBeijing 100191China Analyt.cal and t.st.ng Cent.r Chongqing UniversityChongqing 401331China St.t. Key Laborat.ry of surface Physics Department of PhysicsFudan UniversityShanghai 200433China CAS Key Laborat.ry of t.eoret.cal Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China Ⅱ.Physikalisches Inst.t.t Universität zu KölnKöln D-50937Germany

t.e spin-orbit.assist.d Mot. insulat.r α-RuCl_(3) is a prime candidat. for mat.rial realizat.on of t.e Kit.ev quant.m spin *** lit.le at.ent.on has been paid t. charge degrees of freedom,charge effect.,such as elect.ic polarizat.on,may arise in t.is ***,we report.dist.rt.on-induced local elect.ic polarizat.on in α-RuCl_(3) as evidenced by single-cryst.l X-ray diffract.on,second harmonic generat.on(SHG)and dielect.ic *** SHG signal appears at.room t.mperat.re and develops subst.nt.ally in t.e Kit.ev paramagnet.c st.t. when short.range spin correlat.ons come int. *** sizable pyroelect.ic current. in t.e Kit.ev paramagnet.c st.t.,t.e absence of hyst.resis in t.e polarizat.on-elect.ic field(P-E)point. t. t.e short.ange nat.re of elect.ic *** localized elect.ic polarizat.on is likely t.e result.of dist.rt.on-induced charge dimerizat.on,achieved t.rough virt.al hopping-induced charge *** addit.on,t.e elect.ic polarizat.on is boost.d by short.range spin correlat.ons via spin-phonon coupling in t.e Kit.ev paramagnet.c *** result. emphasize t.e import.nce of charge degrees of freedom in α-RuCl_(3),which est.blish a novel plat.orm t. invest.gat. charge effect. in Kit.ev mat.rials.

关键词： Mot. insulat.r Kit.ev quant.m spin liquid elect.ic polarizat.on

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物理生物医学——原创交叉研究的新领域

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科学通报 2024年第15期69卷 2008-2014页

作者：杜全生粟硕戴慧李舟国家自然科学基金委员会交叉科学部北京100085 中国科学院北京纳米能源与系统研究所北京101400 上海市重大传染病和生物安全研究院复旦大学公共卫生学院上海200032 北京大学基础医学院免疫学系北京100191

物理生物医学是物理学与生物医学深度融合的新兴交叉研究领域,融入了材料学、化学、信息科学、机械工程等多个领域物质科学的知识和技术.它的科学内涵在于揭示生命现象的物理规律,并利用物理的方法和技术实现对生命过程的调控.因此,物... 详细信息

物理生物医学是物理学与生物医学深度融合的新兴交叉研究领域,融入了材料学、化学、信息科学、机械工程等多个领域物质科学的知识和技术.它的科学内涵在于揭示生命现象的物理规律,并利用物理的方法和技术实现对生命过程的调控.因此,物理生物医学既要解析伴随生命活动所产生的内源性物理信号的奥秘.

关键词：信息科学生物医学深度融合物理规律物理信号机械工程交叉研究物理学

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Pancreat.c β-cell failure,clinical implicat.ons,and t.erapeut.c st.at.gies in t.pe 2 diabet.s

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Chinese Medical Journal 2024年第7期137卷 791-805页

作者： Daxin Cui Xingrong Feng Siman Lei Hongmei Zhang Wanxin Hu Shanshan Yang Xiaoqian Yu Zhiguang su Molecular Medicine Research Cent.r and Depart.ent.of Endocrinology and Met.bolism West China HospitalSichuan UniversityChengduSichuan 610041China St.t. Key Laborat.ry of Biot.erapy West China HospitalSichuan UniversityChengduSichuan 610041China Clinical t.anslat.onal Innovat.on Cent.r West China HospitalSichuan UniversityChengduSichuan 610041China

Pancreat.cβ-cell failure due t. a reduct.on in funct.on and mass has been defined as a primary cont.ibut.r t. t.e progression of t.pe 2 diabet.s(t.D).Reserving insulin-producingβ-cells and hence rest.ring insulin product.on are gaining at.ent.on in t.anslat.onal diabet.s research,andβ-cell replenishment.has been t.e main focus for diabet.s *** findings inβ-cell proliferat.on,t.ansdifferent.at.on,pluripot.nt.st.m cell different.at.on,and associat.d small molecules have served as promising st.at.gies t. regenerat.β-*** t.is review,we summarize current.knowledge on t.e mechanisms implicat.d inβ-cell dynamic processes under physiological and diabet.c condit.ons,in which genet.c fact.rs,age-relat.d alt.rat.ons,met.bolic st.esses,and compromised ident.t. are crit.cal fact.rs cont.ibut.ng t.β-cell failure in *** art.cle also focuses on recent.advances in t.erapeut.c st.at.gies for diabet.s t.eat.ent.by promot.ngβ-cell proliferat.on,inducing non-β-cell t.ansdifferent.at.on,and reprograming st.m cell *** a significant.challenge remains for each of t.ese st.at.gies,t.e recognit.on of t.e mechanisms responsible forβ-cell development.and mat.re endocrine cell plast.cit. and remarkable advances in t.e generat.on of exogenousβ-cells from st.m cells and single-cell st.dies pave t.e way for developing pot.nt.al approaches t. cure diabet.s.

关键词： Pancreat.cβ-cell regenerat.on Diabet.s Insulin Dedifferent.at.on t.ansdifferent.at.on St.m cell

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MEt.L3 regulat.s glucose t.ansport.r expression in placent. exposed t. hyperglycemia t.rough t.e mt.R signaling pat.way

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Chinese Medical Journal 2024年第13期137卷 1563-1575页

作者： Jie Ning Jing Huai Shuxian Wang Jie Yan Rina su Muqiu Zhang Mengt.ng Liu Huixia Yang Depart.ent.of Obst.t.ics and Gynaecology Peking University First HospitalBeijing 100034China Beijing Key Laborat.ry of Mat.rnal Foet.l Medicine of Gest.t.onal Diabet.s Mellit.s Beijing 100034China Peking Universit. Beijing 100034China

Background:Alt.rat.ons in t.e placent.l expression of glucose t.ansport.rs(GLUt.),t.e crucial mat.rnal-fet.l nut.ient.t.ansport.rs,have been found in women wit. hyperglycemia in pregnancy(HIP).However,t.ere is st.ll uncert.int. about.t.e underlying effect.of t.e high-glucose environment.on placent.l GLUt. expression in ***:We quant.t.t.vely evaluat.d t.e act.vit. of mammalian t.rget.of rapamycin(mt.R)and expression of GLUt.(GLUt.,GLUt.,and GLUt.)in t.e placent. of women wit. normal pregnancies(Ct.L,n=12)and pregnant.women complicat.d wit. poorly cont.olled t.pe 2 diabet.s mellit.s(t.DM,n=12)by *** addit.on,BeWo cells were t.eat.d wit. different.glucose concent.at.ons t. verify t.e regulat.on of ***,changes in t.e expression of GLUt. following t.e act.vat.on or suppression of t.e mt.R pat.way were also assessed using MHY1485/rapamycin(RAPA)t.eat.ent.or small int.rfering RNA(siRNA)-mediat.d silencing ***,we furt.er explored t.e alt.rat.on and pot.nt.al upst.eam regulat.ry role of met.ylt.ansferase-like 3(MEt.L3)when exposed t. ***:mt.R,phosphorylat.d mt.R(p-mt.R),and GLUt. prot.in levels were upregulat.d in t.e placent. of women wit. t.DM compared wit. t.ose *** BeWo cells,mt.R act.vit. increased wit. increasing glucose concent.at.on,and t.e expression of GLUt.,GLUt.,and GLUt. as well as GLUt. cell membrane t.anslocat.on were upregulat.d by hyperglycemia t. varying *** t.e drug-mediat.d and genet.c deplet.on of mt.R signaling in BeWo cells suppressed GLUt. expression,whereas MHY1485-induced mt.R act.vat.on upregulat.d GLUt. ***,high glucose levels upregulat.d MEt.L3 expression and nuclear t.anslocat.on,and decreasing MEt.L3 levels suppressed GLUt. expression and mt.R act.vit. and vice ***,in MEt.L3 knockdown BeWo cells,t.e inhibit.ry effect.on GLUt. expression was eliminat.d by act.vat.ng t.e mt.R signaling pat.way using ***:High-g

关键词： Glucose t.ansport.rs Hyperglycemia t.pe 2 diabet.s mellit.s Pregnancy Mammalian t.rget.of rapamycin Met.ylt.ansferase-like 3

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Efficacy and safet. of Qingfei Huat.n formula in t.e t.eat.ent.of acut. exacerbat.on of chronic obst.uct.ve pulmonary disease: A mult.-cent.e,randomised, double-blind, placebo-cont.olled t.ial

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Journal of Int.grat.ve Medicine 2024年第5期22卷 561-569页

作者： Hui-zhi Zhu Cheng-yi Li Liang-ji Liu Jia-bing t.ng Zhi-hui Lan Shu-guang t.an Qiao Li Xiang-li t.ng Ji-feng Wu Zhen-gang Zhu su-yun Li Jian-sheng Li Depart.ent.of Respirat.ry Medicine the First Affiliated Hospital of Anhui University of Traditional Chinese Medicine Graduat. School Anhui University of Traditional Chinese Medicine Depart.ent.of Respirat.ry Medicine Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine Depart.ent.of Respirat.ry Diseases the First Affiliated Hospital of Henan University of Traditional Chinese Medicine Depart.ent.of Pulmonary Diseases Taihe Hospital of Traditional Chinese Medicine Affiliated to Anhui University of Traditional Chinese Medicine Depart.ent.of Respirat.ry and Crit.cal Care Medicine Jiangxi Province Hospital of Integrated Chinese and Western Medicine Depart.ent.of Respirat.ry Medicine the First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine Collaborat.ve Innovat.on Cent.r for Respirat.ry Disease Diagnosis and t.eat.ent.and Chinese Medicine Development.of Henan Province

Background: Chronic obst.uct.ve pulmonary disease(COPD), a common respirat.ry disease, can be effect.vely t.eat.d by t.adit.onal Chinese medicine(t.M). Qingfei Huat.n, a t.M formula, has been report.d t. effect.vely alleviat. t.e clinical sympt.ms of COPD pat.ent.. However, t.ere is a lack of mult.-cent.e,randomised, double-blind, cont.olled clinical t.ials document.ng t.e clinical efficacy and safet. of t.is formula in t.e t.eat.ent.of acut. exacerbat.on of COPD(AECOPD).Object.ve: t.is st.dy evaluat.d t.e efficacy and safet. of Qingfei Huat.n formula in t.e t.eat.ent.of AECOPD, t.ereby providing high-qualit. clinical ***, set.ing, part.cipant. and int.rvent.ons: A t.t.l of 276 pat.ent. wit. AECOPD were included in t.is mult.-cent.e, randomised, double-blind, placebo-cont.olled t.ial and were randomised int. t.eat.ent.and cont.ol groups at.a rat.o of 1:1. Pat.ent. in t.e t.eat.ent.and cont.ol groups t.ok Qingfei Huat.n granules or simulat.d Qingfei Huat.n granules t.ice a day, for 14 days, in addit.on t. West.rn medicine t.eat.ent. All pat.ent. were followed up for 3 *** out.ome measures: t.e primary out.ome was t.me t.ken t. sympt.m st.bilisat.on. t.e secondary out.omes included durat.on of ant.biot.c use, clinical sympt.m and sign score, t.M syndrome score, dyspnoea score, and qualit. of life(QOL) score. Meanwhile, t.e safet. of t.e formula was assessed t.rough rout.ne urine and st.ol t.st., elect.ocardiograms, liver and kidney funct.on t.st., and t.e observat.on of adverse event. t.roughout.t.e ***: t.e t.me t.ken for effect.ve st.bilisat.on(P t.bilisat.on(P t.e durat.on of ant.biot.c use(P t.y short.r in t.e t.eat.ent.group t.an in t.e cont.ol group. On days 6, 9, 12 and 14 of t.eat.ent. clinical sympt.m and sign score decreased in bot. groups,part.cularly in t.e t.eat.ent.group(P t.eat.ent. t.e t.M syndrome scores of bot. groups were reduced(P

关键词： Acut. exacerbat.on of chronic obst.uct.ve pulmonary disease Clinical t.ial Syndrome of phlegm-heat.congest.ng lung Qingfei Huat.n formula t.adit.onal Chinese medicine

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Init.al COVID-19 severit. influenced by SARS-CoV-2-specific t.cells imprint. t.cell memory and inversely affect. reinfect.on

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Signal t.ansduct.on and t.rget.d t.erapy 2024年第6期9卷 2791-2803页

作者： Gang Yang Jinpeng Cao Jian Qin Xinyue Mei Shidong Deng Yingjiao Xia Jun Zhao Junxiang Wang t.o Luan Daxiang Chen Peiyu Huang Cheng Chen Xi sun Qi Luo Jie su Yunhui Zhang Nanshan Zhong Zhongfang Wang t.e Affiliat.d Hospit.l of Kunming Universit. of Science and t.chnology.Depart.ent.of Respirat.ry and Crit.cal Care Medicine The First People’s Hospital of Yunnan provinceKunmingYunnanChina Guangzhou Nat.onal Laborat.ry BiolandGuangzhouGuangdongChina St.t. Key Laborat.ry of Respirat.ry Disease&Nat.onal Clinical Research Cent.r for Respirat.ry Disease Guangzhou Institute of Respiratory Healththe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou Medical UniversityGuangzhouChina

t.e immunoprot.ct.ve component. cont.ol COVID-19 disease severit.,as well as long-t.rm adapt.ve immunit. maint.nance and subsequent.reinfect.on risk discrepancies across init.al COVID-19 severit.,remain ***,we longit.dinally analyzed SARS-CoV-2-specific immune effect.rs during t.e acut. infect.on and convalescent.phases of 165 pat.ent. wit. COVID-19 cat.gorized by *** found t.at.early and robust.SARS-CoV-2-specific CD4^(+)and CD8^(+)t.cell responses ameliorat. disease progression and short.ned hospit.l st.y,while delayed and at.enuat.d virus-specific CD8^(+)t.cell responses are prominent.severe COVID-19 *** ant.viral ant.body generat.on rat.er t.an t.t.r level associat.s wit. severe ***,init.al COVID-19 severit. imprint. t.e long-t.rm maint.nance of SARS-CoV-2-specific adapt.ve immunit.,demonst.at.ng t.at.severe convalescent. exhibit.d more sust.ined virus-specific ant.bodies and memory t.cell responses compared t. mild/moderat. ***,init.al COVID-19 severit. inversely correlat.s wit. SARS-CoV-2 reinfect.on ***,our st.dy unravels t.e complicat.d int.ract.on bet.een t.mporal charact.rist.cs of virus-specific t.cell responses and COVID-19 severit. t. guide fut.re SARS-CoV-2 wave management.

关键词： severit. immunit. infect.on

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基层治理视角下社区矫正多元参与体系研究

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河北学刊 2024年第2期44卷 205-217页

作者：苏明月北京师范大学法学院暨刑事法律科学研究院

人是社会中、具体社区中的人,作为社区内处遇的社区矫正,无论是执行主体还是被执行对象都依赖社区而存在。社区矫正作为开放式的刑事执行制度,不是简单地将矫正对象置于社会内放任自流,而是要求积极利用社会资源、合理整合社会力量,构... 详细信息

人是社会中、具体社区中的人,作为社区内处遇的社区矫正,无论是执行主体还是被执行对象都依赖社区而存在。社区矫正作为开放式的刑事执行制度,不是简单地将矫正对象置于社会内放任自流,而是要求积极利用社会资源、合理整合社会力量,构建多元主体参与的社区矫正体系。中国社区治理的发展路径是党政主导下的多元共治,社区矫正法确立的社区矫正多元参与体系,在理论逻辑上与多元共治理念一致,同时实践中存在多元共治的基层体系与社区矫正多元参与体系如何融合发展的问题。社区矫正是一项与基层治理密切相关的实践问题,其发展中的成绩与存在的问题是中国基层治理体系与治理能力现代化发展进程中的一个缩影。

关键词：基层治理体系治理能力现代化社区矫正多元参与多元共治

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