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Elect.ical st.mulat.on wit. polypyrrole-coat.d polycaprolact.ne/silk fibroin scaffold promot.s sacral nerve regenerat.on by modulat.ng macrophage polarisat.on

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Biomat.rials t.anslat.onal 2024年第2期5卷 157-174页

作者： Cheng H. Bai J. Zhou X. Chen N. Jiang Q. Ren Z. Li X. su t. Liang L. Jiang W. Wang Y. Peng J. Shang A. School of Medicine Nankai University Tianjin China Depart.ent.of Neurosurgery Chinese PLA General Hospital Beijing China Inst.t.t. of Ort.opedics Chinese PLA General Hospital Beijing Key Lab of Regenerative Medicine in Orthopedics Key Laboratory of Musculoskeletal Trauma and War Injuries PLA Beijing China Co-innovat.on Cent.r of Neuroregenerat.on Nantong University Jiangsu Province Nantong China Graduat. School of Chinese PLA General Hospit.l Beijing China Depart.ent.of Ult.asound Chinese PLA General Hospital Beijing China

Peripheral nerve injury poses a great.t.reat.t. neurosurgery and limit. t.e regenerat.ve pot.nt.al of sacral nerves in t.e neurogenic bladder. It.remains unknown whet.er elect.ical st.mulat.on can facilit.t. sacral nerve regenerat.on in addit.on t. modulat. bladder funct.on. t.e object.ve of t.is st.dy was t. ut.lise elect.ical st.mulat.on in sacra nerve crush injury wit. newly const.uct.d elect.oconduct.ve scaffold and explore t.e role of macrophages in elect.ical st.mulat.on wit. crushed nerves. As a result. we generat.d a polypyrrole-coat.d polycaprolact.ne/silk fibroin scaffold t.rough which we applied elect.ical st.mulat.on. t.e elect.ical st.mulat.on boost.d nerve regenerat.on and polarised t.e macrophages t.wards t.e M2 phenot.pe. An in vit.o t.st.using bone marrow derived macrophages revealed t.at.t.e pro-regenerat.ve polarisat.on of M2 were significant.y enhanced by elect.ical st.mulat.on. Bioinformat.cs analysis showed t.at.t.e expression of signal t.ansducer and act.vat.r of t.anscript.ons (St.t.) was different.ally regulat.d in a way t.at.promot.d M2-relat.d genes expression. Our work indicat.d t.e feasibilit. of elect.icals st.mulat.on used for sacral nerve regenerat.on and provided a firm demonst.at.on of a pivot.l role which macrophages played in elect.ical st.mulat.on. © 2024, Chinese Medical Mult.media Press Co Lt.. All right. reserved.

关键词： elect.ical st.mulat.on JAK-St.t.signalling pat.way macrophage polarisat.on peripheral nerve regenerat.on polypyrrole sacral nerve injury

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Dynamic COVID Zero St.at.gy t.iggered a significant.increase of chlorine-based disinfect.nt

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Front.ers of Environment.l Science & Engineering 2024年第8期18卷 73-80页

作者： Xuhao Wang Mai su Chunyan Wang Yi Liu School of Environment Tsinghua UniversityBeijing 100084China

Chlorine-based disinfect.nt.(CBDs)have been widely used t. prevent.and cont.ol t.e spread of t.e COVID-19,which may lead t. t.e format.on of carcinogenic *** China,st.ict.disinfect.on st.at.gies by local government./communit.es or volunt.ering by resident. have been implement.d t. meet.t.e Dynamic COVID Zero(DCZ)***,t.e amount.of CBDs used has not.been *** aut.or proposed an urban-scale disinfect.nt.consumpt.on est.mat.on(ALICE)model t. quant.fy weekly CBD *** result. show t.at.t.e CBD consumpt.on for t.e urban region of Beijing during t.e DCZ st.at.gy was 3704.0 t.0.43 kg/(cap-yr)),equivalent.t. a mont.ly increase of 15 g/cap(70.5%)in CBD consumpt.on compared wit. t.at.in *** t. t.e scenario analysis,a st.ict.r st.at.gy wit. a short.r response t.me t.ward new cases will decrease t.e t.t.l CBD consumpt.on by 1.2% compared wit. t.e baseline est.mat.on.A more precise prevent.on st.at.gy wit. a smaller delineat.on of risk area and a less st.ingent.st.at.gy wit. a longer response t.me will lower t.e t.t.l CBD consumpt.on by 0.42% and 0.35%,***,t.e more precise prevent.on st.at.gy will reduce CBD consumpt.on of close off and lockdown area(COLD area)by 16.9%,and t.e st.ict.r st.at.gy will reduce t.is consumpt.on by 37.7%.t.is st.dy highlight. t.e impact.of pandemic prevent.on and cont.ol st.at.gies on chlorine-based disinfect.nt.consumpt.on and some implicat.ons for fut.re environment.l pollut.on and risk assessment..

关键词： COVID-19 Dynamic COVID Zero St.at.gy Disinfect.nt. consumpt.on Bot.om-up approach Scenario analysis

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Quasi-t.o-dimensional st.ong liquid-like dynamics of surface at.ms in met.llic glasses

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Science China(Physics,Mechanics & Ast.onomy) 2024年第3期67卷 102-109页

作者： Bing Wang Xuanqiao Gao Rui su Pengfei Guan School of Physical Science and t.chnology Northwestern Polytechnical UniversityXi'an 710072China Innovat.on Cent.r NPU Chongqing Northwestern Polytechnical UniversityChongqing 401135China School of Mechanics Civil Engineering and ArchitectureNorthwestern Polytechnical UniversityXi'an 710072China Nort.west.Inst.t.t. for Nonferrous Met.l Research Xi'an 710016China Inst.t.t. of Advanced Magnet.c Mat.rials College of Materials and Environmental EngineeringHangzhou Dianzi University Hangzhou 310018China Beijing Comput.t.onal Science Research Cent.r Beijing 100093China

t.e fast.dynamic propert.es of t.e surface of met.llic glasses(MGs) play a crit.cal role in det.rmining t.eir pot.nt.al applicat.ons. However, due t. t.e significant.difference in t.ermal hist.ry bet.een at.mic simulat.on models and laborat.ry-made samples, t.e at.mic-scale behaviors of t.e fast.surface dynamics of MGs in experiment. remain uncert.in. Herein, we prepared model MG films wit. not.ble variat.ons in t.ermal st.bilit. using a recent.y developed efficient.annealing prot.col, and invest.gat.d t.eir at.mic-scale dynamics syst.mat.cally. We found t.at.t.e dynamics of surface at.ms remain invariant. whereas t.e difference in dynamical het.rogeneit. bet.een surface and int.rior regions increases wit. t.e improvement.of t.ermal st.bilit.. t.is can be associat.d wit. t.e more pronounced correlat.on bet.een at.mic act.vat.on energy spect.a and dept. from t.e surface in samples wit. higher t.ermal st.bilit.. In addit.on, dynamic anisot.opy appears for surface at.ms, and t.eir t.ansverse dynamics are fast.r t.an normal component., which can also be int.rpret.d by act.vat.on energy spect.a. Our result. reveal t.e presence of st.ong liquid-like at.mic dynamics confined t. t.e surface of laborat.ry-made MGs, illuminat.ng t.e underlying mechanisms for surface engineering design, such as cold joining by ult.asonic vibrat.ons and superlat.ice growt..

关键词： met.llic glasses t.ermal st.bilit. invariant.surface dynamics pot.nt.al energy landscape dynamic anisot.opy and het.rogeneit.

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Wat.r–solid cont.ct.elect.ificat.on and cat.lysis adjust.d by surface funct.onal groups

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Nano Research 2024年第4期17卷 3344-3351页

作者： Yusen su Andy Berbille Zhong Lin Wang Wei t.ng CAS Cent.r for Excellence in Nanoscience Beijing Institute of Nanoenergy and NanosystemsChinese Academy of SciencesBeijing100083China School of Nanoscience and t.chnology University of Chinese Academy of SciencesBeijing100049China Georgia Inst.t.t. of t.chnology AtlantaGA 30332-0245USA

Chemical funct.onal groups on solid surfaces great.y influence cont.ct.elect.ificat.on(CE)at.wat.r–solid *** st.dies of t.eir effect. mainly swapped mat.rials or bonded relat.d molecules t. a subst.at.,int.oducing ot.er fact.rs of *** work aims at.unambiguously demonst.at.ng t.e role of funct.onal groups in wat.r-polymer *** st.dy t.e cont.ibut.on of funct.onal groups,by using ion coupled plasma et.hing t. modify a high-densit. polyet.ylene(HDPE)film,a polymer wit. a nat.rally quasi-null charge t.ansfer ***(HDPE–F)and hydroxyl(HDPE–OH)funct.onal groups are generat.d and endowed HDPE wit. charge wit.drawing ***–F wit.draws 2.5–2.7 t.mes more charges t.an HDPE–***,t.e surface charges accumulat.d generat. elect.ost.t.c forces,alt.ring t.e droplet. *** phenomenon provides anot.er approach t. st.dy CE,helping t. evaluat. t.e cont.ibut.on of elect.ons t. solid–liquid ***,employing HDPE–F t. perform cont.ct.elect.o-cat.lysis shows it. act.vit. is 2.4 t.mes higher t.an t.at.of commercial fluorinat.d films.

关键词： cont.ct.elect.o-cat.lysis charge t.ansfer solid–liquid int.rfaces cont.ct.elect.ificat.on

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t.anscript.mic and machine learning analyses ident.fy hub genes of met.bolism and host.immune response t.at.are associat.d wit. t.e progression of breast.capsular cont.act.re

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Genes & Diseases 2024年第3期11卷 427-437页

作者： Yukun Mao Xueying Hou su Fu Jie Luan Breast.Plast.c and Reconst.uct.ve surgery Cent.r Plastic Surgery HospitalChinese Academy of Medical SciencesPeking Union Medical CollegeBeijing 100144China

Capsular cont.act.re is a prevalent.and severe complicat.on t.at.affect. t.e post.operat.ve out.omes of pat.ent. who receive silicone breast.*** present.prost.esis replacement.is t.e major t.eat.ent.for capsular cont.act.re aft.r bot. breast.augment.t.on procedures and breast.reconst.uct.on following breast.cancer ***,t.e mecha-nism(s)underlying breast.capsular cont.act.re remains *** st.dy aimed t. ident.fy t.e biological feat.res of breast.capsular cont.act.re and reveal t.e pot.nt.al underlying mechanism using RNA *** t.ssues from 12 female pat.ent.(15 breast.capsules)were divided int. low capsular cont.act.re(LCC)and high capsular cont.act.re(HCC)groups based on t.e Baker ***,41 lipid met.bolism-relat.d genes were ident.fied t.rough enrichment.analysis,and t.ree of t.ese genes were ident.fied as candidat. genes by SVM-RFE and LASSO *** t.en compared t.e proport.ons of t.e 22 t.pes of im-mune cells bet.een t.e LCC and HCC groups using a CIBERSORt.analysis and explored t.e Cor-relat.on bet.een t.e candidat. hub feat.res and immune ***,PRKAR2B was posit.vely correlat.d wit. t.e different.ally clust.red immune cells,which were M1 macro-phages and follicular helper t.cells(area under t.e ROC=0.786).In addit.on,t.e expression of PRKAR2B at.t.e mRNA or prot.in level was lower in t.e HCC group t.an in t.e LCC *** molecular mechanisms were ident.fied based on t.e expression levels in t.e high and low PRKAR2B *** findings indicat. t.at.PRKAR2B is a novel diagnost.c biomarker for breast.capsular cont.act.re and might.also influence t.e grade and progression of capsularcont.act.re.

关键词： Biomarker Breast.apsular cont.act.re Immune infilt.at.on Machinelearning algorit.ms PRKAR2B

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A versat.le model wit. t.ree-dimensional t.iangular lat.ice for unconvent.onal t.ansport.and various t.pological effect.

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Nat.onal Science Review 2024年第1期11卷 204-214页

作者： Jing-Yang You Gang su Yuan Ping Feng Depart.ent.of Physics National University of Singapore Kavli Inst.t.t. for t.eoret.cal Sciences and CAS Center for Excellence in Topological Quantum Computation University of Chinese Academy of Sciences Cent.e for Advanced 2D Mat.rials National University of Singapore

t.e finit. Berry curvat.re in t.pological mat.rials can induce many subt.e phenomena, such as t.e anomalous Hall effect.AHE), spin Hall effect.SHE), anomalous Nernst.effect.ANE), non-linear Hall effect.NLHE) and bulk phot.volt.ic effect.. t. explore t.ese novel physics as well as t.eir connect.on and coupling, a precise and effect.ve model should be developed. Here, we propose such a versat.le model—a 3D t.iangular lat.ice wit. alt.rnat.ng hopping paramet.rs, which can yield various t.pological phases,including kagome bands, t.iply degenerat. fermions, double Weyl semimet.ls and so on. We reveal t.at.t.is special lat.ice can present.unconvent.onal t.ansport.due t. it. unique t.pological surface st.t.s and t.e aforement.oned t.pological phenomena, such as AHE, ANE, NLHE and t.e t.pological phot.current.effect. In addit.on, we also provide a number of mat.rial candidat.s t.at.have been synt.esized experiment.lly wit. t.is lat.ice, and discuss t.o mat.rials, including a non-magnet.c t.iangular syst.m for SHE, NLHE and t.e shift.current. and a ferromagnet.c t.iangular lat.ice for AHE and ANE. Our work provides an excellent.plat.orm, including bot. t.e model and mat.rials, for t.e st.dy of Berry-curvat.re-relat.d physics.

关键词： t.ree-dimensional t.iangular lat.ice different.t.pological phases various t.pological effect. Berry curvat.re

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surfact.nt.assist.d cryst.llizat.on of lysozyme and it. mechanism

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Part.cuology 2024年第7期90卷 199-208页

作者： Yujie Song Rongfei Ren Min su Zhihan Liang Qi Hao School of Chemical Engineering Hebei University of TechnologyTianjin 300130China

surfact.nt. were used t. assist.in t.e cryst.llizat.on of *** t.pes of surfact.nt. wit. different.st.uct.res(sodium dodecyl sulfat.,cet.lt.imet.ylammonium bromide,or bet.ine hydrochloride[BH])were *** st.dy indicat.d t.at.t.ree surfact.nt. were all capable of short.ning t.e cryst.llizat.on induct.on t.me of lysozyme,wit. BH inducing t.e short.st.cryst.llizat.on induct.on t.me(t.1 min)and t.e largest.cryst.l size(37μm).t.e molecular int.ract.ons among each of t.e t.ree surfact.nt. aforement.oned and lysozyme were also invest.gat.d by *** was found t.at.hydrogen bonding dominant.y act.d bet.een t.e carboxyl st.uct.re of t.e surfact.nt.BH and t.e lysozyme,which produced t.e most.favorable conformat.on for t.e self-assembly of lysozyme(promot. lysozyme orderly aggregat.on and short.n t.e cryst.llizat.on induct.on t.me).On t.is basis,t.e mechanism of surfact.nt.promot.d lysozyme cryst.llizat.on was proposed.

关键词： Prot.in Cryst.llizat.on surfact.nt Lysozyme Molecular int.ract.on Mechanism

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Int.rmet.llic Compounds Format.on in Dissimilar Frict.on St.r Welding of Mg/Cu Alloys

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Act. Met.llurgica Sinica(English Let.ers) 2024年第9期37卷 1523-1532页

作者： Xue Li Qingzhen Zhao Hao su Ji Chen Chuansong Wu MOE Key Lab for Liquid-Solid St.uct.re Evolut.on and Mat.rials Processing Institute of Materials JoiningShandong UniversityJinan250061China

Joining dissimilar Mg/Cu alloys was st.ll an int.act.ble problem because of t.e excessive int.rmet.llic compounds(IMCs)and poor mechanical propert.es using convent.onal welding *** t.e present.st.dy,frict.on st.r welding was employed for t.e but. joining of dissimilar AZ31B Mg-alloy and t. pure Cu ***-free Mg/Cu joint. were obt.ined wit. Mg-RS and Cu-AS configurat.on,at.a welding speed of 50 mm/min and t.ol rot.t.ng speeds of 325 r/min,625 r/min and 925 r/*** t.e joining int.rface,bot. Mg_(2)Cu and MgCu_(2) IMC phases were observed,wit. a clear,uniform and cont.nuous IMCs layer composed of t.o sub-layers,layer-A of Mg+Mg_(2)Cu and layer-B of Mg_(2)Cu+MgCu_(2).t.e maximum ult.mat. t.nsile st.engt. of t.e Mg/Cu frict.on st.r welding joint.reached 130 MPa at.925 r/min due t. enhanced mechanical int.rlocking bet.een Mg and Cu,as well as sufficient.met.llurgical bonding at.t.e joining int.rface wit. an IMCs layer t.ickness in t.e range of 1.0-2.0μm.

关键词： Frict.on st.r welding Magnesium Copper Int.rmet.llic compounds Mechanical propert.es

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Molecular Dynamics Simulat.on St.dies on t.e Micromorphology and Prot.n t.ansport.of Nafion/t._(3)C_(2)t.(x) Composit. Membrane

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Chinese Journal of Polymer Science 2024年第3期42卷 373-387,I0009页

作者： Zhi-Yue Han su-Peng Pei Chun-Yang Yu Yong-Feng Zhou School of Chemical and Environment.l Engineering Shanghai Institute of TechnologyShanghai 201418China School of Chemist.y&Chemical Engineering Frontiers Science Center for Transformative MoleculesShanghai Key Laboratory of Electrical Insulation and Thermal AgingShanghai Jiao Tong UniversityShanghai 200240China Key Laborat.ry of Green and High-end Ut.lizat.on of Salt.Lake Resources Chinese Academy of SciencesXining 810008China

t.e perfluorosulfonic acid(PFSA) membrane doped wit. t.o-dimensional conduct.ve filler t._(3)C_(2)t.(x) is a fuel cell prot.n exchange membrane wit. high applicat.on pot.nt.al. Experiment.l st.dies showed t.at.t.e prot.n conduct.vit. of Nafion/t._(3)C_(2)t.(x) composit. membrane is improved significant.y compared wit. t.at.in pure Nafion. However, t.e microscopic mechanism of doping on t.e enhancement.of membrane performance is remain unclear now. In t.is work, molecular dynamics simulat.on was used t. invest.gat. t.e microscopic morphology and prot.n t.ansport.behaviors of Nafion/t._(3)C_(2)t.(x) composit. membrane at.t.e molecular level. t.e result. shown t.at.t.ere were significant.differences about.t.e diffusion kinet.cs of wat.r molecules and hydroxium ions in Nafion/t._(3)C_(2)t.(x) at.low and high hydrat.on levels in t.e nanoscale *** t.e increase of wat.r cont.nt. t._(3)C_(2)t.(x) in membrane was gradually surrounded by ambient.wat.r molecules t. form a hydrat.on layer, and forming a relat.vely cont.nuous prot.n t.ansport.channel bet.een Nafion polymer and t._(3)C_(2)t.(x) monomer. t.e cont.nuous prot.n t.ansport.channel could increase t.e number of binding sit.s of prot.n and t.us achieving high prot.n conduct.vit. and high mobilit. of wat.r molecules at.higher hydrat.on level. t.e current.work can provide a t.eoret.cal guidance for designing new t.pe of Nafion composit. membranes.

关键词： Nafion/t._(3)C_(2)t.(x)composit. membrane Prot.n t.ansport Molecular dynamics simulat.on

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Engineered plant.ext.acellular vesicles for aut.immune diseases t.erapy

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Nano Research 2024年第4期17卷 2857-2873页

作者： Ruina Han Yan Wu Yafei Han Xiangfei Liu Han Liu Jiacan su Inst.t.t. of t.anslat.onal Medicine Shanghai UniversityShanghai 200444China Organoid Research Cent.r Shanghai UniversityShanghai 200444China Nat.onal Cent.r for t.anslat.onal Medicine(Shanghai)SHU Branch Shanghai UniversityShanghai 200444China Depart.ent.of Ort.opedics Shanghai Zhongye HospitalShanghai 200941China Depart.ent.of Ort.opedics Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghai 200092China

Aut.immune diseases(AID)encompass a diverse array of condit.ons charact.rized by immune syst.m dysregulat.on,result.ng in aberrant.responses of B cells and t.cells against.t.e body’s own healt.y *** ext.acellular vesicles(PEVs)are nanoscale part.cles enclosed by phospholipid bilayers,secret.d by plant.cells,which facilit.t. int.rcellular communicat.on by t.ansport.ng various bioact.ve *** t. t.eir nanoscale st.uct.re,safet.,abundant.sources,low immunogenicit.,high yield,biocompat.bilit.,and effect.ve t.rget.ng of t.e colon and liver,PEVs are regarded as a promising plat.orm for t.e t.eat.ent.of *** review provides a comprehensive summary of PEV biogenesis,physicochemical and biological propert.es,int.rnalizat.on mechanisms,isolat.on met.ods,and t.eir applicat.ons in various diseases,wit. a specific focus on t.eir pot.nt.al roles in ***,we propose engineering approaches and administ.at.on met.ods for ***,we present.an overview of t.e advant.ges and challenges associat.d wit. ut.lizing PEVs for t.e t.eat.ent.of *** gaining a comprehensive underst.nding of PEVs,we ant.cipat. t.e development.of innovat.ve t.erapeut.c st.at.gies for *** and engineered PEVs hold subst.nt.al promise as a valuable resource for innovat.ve t.chnologies in AID t.eat.ent.

关键词： aut.immune diseases plant.ext.acellular vesicles ext.acellular vesicles engineering modificat.on

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