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Occurrence,seasonal variation and human exposure to pharmaceuticals and personal care products in surface water,groundwater and drinking water in lagos State,Nigeria

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Emerging Contaminants 2020年第1期6卷 124-132页

作者： Anekwe Jennifer Ebele Temilola Oluseyi Daniel S.Drage stuart Harrad Mohamed Abou-Elwafa Abdallah Division of Environmental Health and Risk Management School of GeographyEarthand Environmental SciencesUniversity of BirminghamBirminghamB152TTUK Chemistry Department University of LagosLagosNigeria Department of Analytical Chemistry Faculty of PharmacyAssiut University71526AssiutEgypt

The occurrence of 28 pharmaceuticals and personal care products(PPCPs)was investigated in 17 surface water samples(rivers,canals,and lagoons),12 groundwater samples(wells and boreholes,which can also be consumed for drinking)and 8 drinking water samples(bottles and sachets)during dry and rainy seasons in lagos state,*** most prevalent compound detected in all samples was amoxicillin(an antibiotic)at median concentrations of 1614,238 and 358 ng/l in surface water,ground water and drinking water,*** is of concern due to potential impact on development of antibioticresistant microbial *** frequently-detected compounds include acetaminophen,nicotine,ibuprofen,and codeine with detection frequencies of more than 70%.Investigation of seasonal variability revealed that glyburide,caffeine,naproxen and diclofenac concentrations were significantly(Ple Nicotine and Codeine levels were higher during the rainy season(summer).The factors influencing such seasonal variability include:dilution by extensive rainfall,agricultural activity(for nicotine)and usage patterns of pharmaceuticals among the local *** concentrations in drinking water samples were used to assess inadvertent human exposure to PPCPs in Nigerian *** revealed average daily exposures of 81,14 and 3 ngƩPPCPs/kg BW/day via drinking borehole,sachet water and bottled water,*** there exists no health-based limit value(HBlV)for chronic exposure to mixtures of PPCPs,our results raise concern and warrant further investigation of the potential health implications of such unintended PPCPs exposure.

关键词： Pharmaceuticals and personal care products PPCPs Freshwater Ground water Drinking water Seasonal variation Human exposure Nigeria

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点绿成金

商学院 2008年第11期 44-47页

作者： stuart l. Hart Dr. Thierry Delmarcelle 康奈尔大学庄臣管理学院管理学

面对国家制定的越来越严苛的环境法令,在企业面前是一副什么样的景象呢?是要达到环境排放标准,并思考长远发展策略;是不能过度耗费资源,还不能降低的产量;是打破环境贸易壁垒,还必须走在竞争对手前面;是必须履行的企业社会责任,还不能... 详细信息

面对国家制定的越来越严苛的环境法令,在企业面前是一副什么样的景象呢?是要达到环境排放标准,并思考长远发展策略;是不能过度耗费资源,还不能降低的产量;是打破环境贸易壁垒,还必须走在竞争对手前面;是必须履行的企业社会责任,还不能让股市受挫和不能滥用的企业财务权利面对这些,你能做什么?你应该做什么?

关键词：可持续环境问题工业文明短期效益恶之花企业资本责任

Mediastinal node staging by positron emission tomographycomputed tomography and selective endoscopic ultrasound with fine needle aspiration for patients with upper gastrointestinal cancer:Results from a regional centre

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World Journal of Gastrointestinal Endoscopy 2018年第1期10卷 37-44页

作者： Chris Harrington lyn Smith Jennifer Bisland Elisabet lópez González Neil Jamieson stuart Paterson Adrian John Stanley Glasgow Royal Infirmary Glasgow G4 0ETUnited Kingdom Forth Valley Royal Hospital Larbert FK5 4WRUnited Kingdom Raigmore Hospital Inverness IV2 3UJUnited Kingdom Hospital Vega Baja Orihuela 03314Spain

AIM To investigate the impact of endoscopic ultrasound-guided fine-needle aspiration(EUS-FNA) and positron emission tomography-computed tomography(PET-CT) in the nodal staging of upper gastrointestinal(GI) cancer in a tertiary referral *** We performed a retrospective review of prospectively recorded data held on all patients with a diagnosis of upper GI cancer made between January 2009 and December 2015. Only those patients who had both a PET-CT and EUS with FNA sampling of a mediastinal node distant from the primary tumour were included. Using a positive EUS-FNA result as the gold standard for lymph node involvement, the sensitivity, specificity, positive and negative predictive values(PPV and NPV) and accuracy of PET-CT in the staging of mediastinal lymph nodes were calculated. The impact on therapeutic strategy of adding EUS-FNA to PET-CT was *** One hundred and twenty one patients were included. Sixty nine patients had a diagnosis of oesophageal adenocarcinoma(Thirty one of whom were junctional), forty eight had oesophageal squamous cell carcinoma and four had gastric adenocarcinoma. The FNA results were inadequate in eleven cases and the PET-CT findings were indeterminate in two cases, therefore thirteen patients(10.7%) were excluded from further analysis. There was concordance between PET-CT and EUS-FNA findings in seventy one of the remaining one hundred and eight patients(65.7%). The sensitivity, specificity, PPV and NPV values of PET-CT were 92.5%, 50%, 52.1% and 91.9% respectively. There was discordance between PET-CT and EUS-FNA findings in thirty seven out of one hundred and eight patients(34.3%). MDT discussion led to a radical treatment pathway in twenty seven of these cases, after the final tumour stage was altered as a direct consequence of the EUS-FNA findings. Of these patients, fourteen(51.9%) experienced clinical remission of a median of nine months(range three to forty two months). CONClUSION EUS-FNA leads to altered sta

关键词： Endoscopic ultrasound Oesophago-gastric cancer staging Oesophageal cancer Positron emission tomography-computed tomography Mediastinal nodes

应用地理信息系统评价氮肥对地下水的潜在污染

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土壤学进展 1993年第4期21卷 24-27页

作者： stuart l.Halliday 李勇

本文应用地理信息系统(GRASS3.1)将氮肥有效性和地下水污染敏感性联系起来研究得克萨斯州潜在地下水水质问题。结果表明,得克萨斯州24%的土地位于高潜在污染类型内,34%的地下水露头区位于高潜在污染范围内。

关键词：地下水氮肥污染地理信息系统

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季节性情感障碍

中国全科医学 2013年第14期16卷 1571-1573页

作者： stuart l.Kurlansik Annamarie D.Ibay 周淑新梁剑虹 Virtua Family Medicine Residency 2225 Evesham RoadSte.101VoorheesNJ 08043USA 中国石油天然气集团公司中心医院

季节性情感障碍（SAD）是按季节出现的生物和情绪混合性障碍,以秋冬季发作、春夏季缓解为特征.每年约有5%的美国人患SAD,症状持续时间占全年的40%.虽然该病病情受季节限制,但相关的抑郁症状却给患者带来了严重危害.通过治疗可改善患者... 详细信息

季节性情感障碍（SAD）是按季节出现的生物和情绪混合性障碍,以秋冬季发作、春夏季缓解为特征.每年约有5%的美国人患SAD,症状持续时间占全年的40%.虽然该病病情受季节限制,但相关的抑郁症状却给患者带来了严重危害.通过治疗可改善患者的抑郁症状,秋冬季前实施治疗可起到预防作用.日光灯疗法耐受性良好,治疗后1～2周大多数患者病情会有所改善;为避免复发,日光灯疗法应持续至冬末,直至春季或夏季.抗抑郁药物疗法和认知行为疗法（CBT）也是合理的治疗方法,已证实与日光灯疗法同样有效（见表1）.鉴于治疗方法在有效性方面区别不大,可根据患者意愿制定一线管理方案[1].SAD是按季节出现的生物和情绪组合性障碍,以秋冬季发作、春夏季缓解为特征,可发生于其他季节[1].

关键词：季节性情感障碍抑郁认知行为疗法日光灯疗法

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儿童骨科手术图谱第3版 3版

2004年

作者：（美）Raymmond T.Morrissy （美）stuart l.Weinstein （）Bernie Kida绘图刘海鹰主译

本图谱收录了117个最常用的手术，包括胸廓成形术，半锥体切除术，法语性髋脱位的前内测手术入路，股直肌转移术等新手术。

ISBN: (纸本)7506729326

本图谱收录了117个最常用的手术，包括胸廓成形术，半锥体切除术，法语性髋脱位的前内测手术入路，股直肌转移术等新手术。

关键词：儿科学:骨科学外科手术图谱

来源：汇雅图书（南通市图书馆... 评论

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什么才是可持续的

商学院 2008年第11期 46-47页

作者： stuart l.Hart Thierry Delmarcelle 康奈尔大学庄臣管理学院美国庄臣公司所属的企业可持续发展全球研究中心北卡罗来纳大学凯南-弗拉格勒商学院企业可持续发展企业中心

"可持续发展"是我们这个时代使用频率最高但理解最少的一个词汇,人们在滥用这个词的时候并未真正理解其含义,而是常常将它与"企业战略"一词相提并论。

关键词：可持续发展战略消费者清洁技术持续发展战略经济发展战略企业可持续发展驱动力量污染防治防治污染纵轴股东价值普锐斯丰田美誉度利益相关者

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Two-photon absorption and stimulated emission in poly-crystalline Zinc Selenide with femtosecond laser excitation

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Opto-Electronic Advances 2022年第1期5卷 1-12页

作者： Qianliang li Walter Perrie Zhaoqing li stuart P Edwardson Geoff Dearden laser Engineering Group School of EngineeringUniversity of LiverpoolLiverpoolL693GQUnited Kingdom laser Processing Research Centre School of MechanicalAerospace and Civil EngineeringUniversity of ManchesterManchester M139PLUnited Kingdom

The optical nonlinearity in polycrystalline zinc selenide(ZnSe),excited with 775 nm,1 kHz femtosecond laser pulses was investigated via the nonlinear transmission with material thickness and the Z scan *** measured two photon absorption coefficientβwas intensity dependent,inferring that reverse saturated absorption(RSA)is also relevant dur-ing high intensity excitation in *** low peak intensity Il properties of the broad blueish two-photon induced fluorescence(460 nm-500 nm)was studied,displaying self-ab-sorption near the band edge while the upper state lifetime was measured to be τ_(e)~3.3 *** emission was ob-served when pumping a 0.5 mm thick polycrystalline ZnSe sample within an optical cavity,confirmed by significant line narrowing fromΔλ=11 nm(cavity blocked)toΔλ=2.8 nm at peak wavelength λ_(p)=475 nm while the upper state life-time also *** results suggest that with more optimum pumping conditions and crystal cooling,polycrystal-line ZnSe might reach lasing threshold via two-photon pumping atλ=775 nm.

关键词： ZnSe femtosecond laser nonlinear absorption stimulated emission fluorescence

Dougherty博士与光敏剂Photofrin

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中国激光医学杂志 2019年第5期28卷 288-291页

作者：黄正 stuart l Marcus Ron R Allison 福建师范大学医学光电科学与技术教育部重点实验室和福建省光子技术重点实验室福州市350007 SlM Clinical Development Consulting LLC.New YorkUSA Carolina Radiation Medicine North CarolinaUSA

被称为现代光动力医学之父的美国Roswell Park癌症研究所(Roswell Park Cancer Institute,RPCI)光动力中心终身主任Thomas ***博士于2018年10月不幸病逝。Dougherty在上世纪七十年代研发的Photofrin是全球第一个获得批证的用于肿瘤光动... 详细信息

被称为现代光动力医学之父的美国Roswell Park癌症研究所(Roswell Park Cancer Institute,RPCI)光动力中心终身主任Thomas ***博士于2018年10月不幸病逝。Dougherty在上世纪七十年代研发的Photofrin是全球第一个获得批证的用于肿瘤光动力疗法的光敏剂,目前仍在欧美和亚洲部分国家和地区使用。他的工作也是现代光动力医学的一个重要里程碑。根据Dougherty本人以及和他共事过的美国同事提供的资料,本文对Dougherty博士和Photofrin研发过程中的一些重要历史人物和事件做一回顾性介绍。

关键词：癌症研究所光动力 Photofrin 光敏剂肿瘤光动力疗法