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Additively manufactured Ti–Ta–Cu alloys for the next-generation load-bearing implants

International Journal of Extreme Manufacturing 2024年第1期6卷 353-374页

作者： Amit bandyopadhyay Indranath Mitra Sushant Ciliveri Jose D Avila William Dernell stuart b Goodman Susmita bose W.M.Keck biomedical Materials Research Laboratory School of Mechanical and Materials EngineeringWashington State UniversityPullmanWA 99164United States of America Veterinary Clinical Sciences College of Veterinary MedicineWashington State UniversityPullmanWA 99164United States of America Department of Orthopedic Surgery Stanford University Medical CenterRedwood CityCA 94063United States of America

bacterial colonization of orthopedic implants is one of the leading causes of failure and clinical complexities for load-bearing metallic implants. Topical or systemic administration of antibiotics may not offer the most efficient defense against colonization, especially in the case of secondary infection, leading to surgical removal of implants and in some cases even limbs. In this study, laser powder bed fusion was implemented to fabricate Ti3Al2V alloy by a 1:1 weight mixture of CpTi and Ti6Al4V powders. Ti-Tantalum(Ta)–Copper(Cu) alloys were further analyzed by the addition of Ta and Cu into the Ti3Al2V custom alloy. The biological,mechanical, and tribo-biocorrosion properties of Ti3Al2V alloy were evaluated. A 10 wt.% Ta(10Ta) and 3 wt.% Cu(3Cu) were added to the Ti3Al2V alloy to enhance biocompatibility and impart inherent bacterial resistance. Additively manufactured implants were investigated for resistance against Pseudomonas aeruginosa and Staphylococcus aureus strains of bacteria for up to 48 h. A 3 wt.% Cu addition to Ti3Al2V displayed improved antibacterial efficacy, i.e.78%–86% with respect to CpTi. Mechanical properties for Ti3Al2V–10Ta–3Cu alloy were evaluated, demonstrating excellent fatigue resistance, exceptional shear strength, and improved tribological and tribo-biocorrosion characteristics when compared to Ti6Al4V. In vivo studies using a rat distal femur model revealed improved early-stage osseointegration for alloys with10 wt.% Ta addition compared to CpTi and Ti6Al4V. The 3 wt.% Cu-added compositions displayed biocompatibility and no adverse infammatory response in vivo. Our results establish the Ti3Al2V–10Ta–3Cu alloy’s synergistic effect on improving both in vivo biocompatibility and microbial resistance for the next generation of load-bearing metallic implants.

关键词： Ti6Al4V load-bearing implants additive manufacturing 3D printing antibacterial performance

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Macrophage polarization in response to wear particles in vitro

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Cellular & Molecular Immunology 2013年第6期10卷 471-482页

作者： Joseph K Antonios Zhenyu Yao Chenguang Li Allison J Rao stuart b Goodman Orthopaedic Research Laboratories Department of Orthopaedic Surgery Stanford University School of Medicine Stanford CA USA

Total joint replacement is a highly successful surgical procedure for treatment of patients with disabling arthritis and joint dysfunction. However, over time, with high levels of activity and usage of the joint, implant wear particles are generated from the articulating surfaces. These wear particles can lead to activation of an inflammatory reaction, and subsequent bone resorption around the implant （periprosthetic osteolysis）. Cells of the monocyte/macrophage lineage orchestrate this chronic inflammatory response, which is dominated by a pro-inflammatory （M 1） macrophage phenotype rather than an anti-inflammatory pro-tissue healing （M2） macrophage phenotype. While it has been shown that interleukin-4 （IL-4） selectively polarizes macrophages towards an M2 anti-inflammatory phenotype which promotes bone healing, rather than inflammation, little is known about the time course in which this occurs or conditions in which repolarization through I L-4 is most effective. The goal of this work was to study the time course of murine macrophage polarization and cytokine release in response to challenge with combinations of polymethyl methacrylate （PMMA） particles, lipopolysaccharide （LPS） and IL-4 in vitro. Treatment of particle-challenged monocyte/macrophages with IL-4 led to an initial suppression of pro-inflammatory cytokines and inducible nitric oxide synthase （iNOS） production and subsequent polarization into an M2 anti-inflammatory phenotype. This result was optimized when IL-4 was delivered before PMMA particle challenge, to an M 1 phenotype rather than to uncommitted （MO） macrophages. The effects of this polarization were sustained over a 5-day time course. Polarization of M1 macrophages into an M2 phenotype may be a strategy to mitigate wear particle associated periprosthetic osteolysis.

关键词： IL-4 macrophage polarization osteolysis PMMA particles total joint replacement

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Modelling the development of biological structures displaying longitudinal geometries in vitro:culturing pluripotent stem cells on plasma-treated,growth factor-coupled polycaprolactone fibres

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Engineered Regeneration 2024年第1期5卷 124-138页

作者： badwi b.boumelhem stuart T.Fraser Syamak Farajikhah Rachel A.Shparberg Michael b.Morris Marcela M.M.bilek Anyu Zhang behnam Akhavan Simon Fleming Maryanne Large School of Physics Faculty of ScienceUniversity of SydneyAustralia Sydney Nano Institute University of SydneyAustralia School of Chemical and biomolecular Engineering University of SydneyAustralia School of Medical Sciences Faculty of Medicine and HealthUniversity of SydneyAustralia School of biomedical Engineering Faculty of EngineeringUniversity of SydneyAustralia School of Engineering University of NewcastleCallaghanNSW 2308Australia Hunter Medical Research Institute(HMRI) Precision Medicine ProgramNew Lambton Heights NSW 2305Australia

Many biological structures such as nerves,blood and lymphatic vessels,and muscle fibres exhibit longitudinal ge-ometries with distinct cell types extending along both the length and width of internal linear *** these three-dimensional structures in vitro is challenging:the best-defined stem-cell differentiation systems are mono-layer cultures or organoids using pluripotent stem *** stem cells can differentiate into functionally mature cells depending on the signals received,holding great promise for regenerative ***,the integration of in vitro differentiated cell types into diseased tissue remains a *** scaffolds can bridge this gap if the appropriate signalling systems are incorporated into the ***,we have taken a biomimicry approach to generate longitudinal structures in *** this approach,mouse embryonic stem cells are directed to differentiate to specific cell types on the surface of polycaprolactone(PCL)fibres treated by plasma-immersion ion implantation and to which with lineage-specifying molecules have been covalently *** demonstrate the simplicity and utility of our method for efficiently generating high yields of the following cell types from these pluripotent stem cells:neurons,vascular endothelial cells,osteoclasts,adipocytes,and cells of the erythroid,myeloid,and lymphoid *** arranged plasma-treated scaffolds with differentiated cell types could ultimately serve as a means for the repair or treatment of diseased or damaged tissue.

关键词： Pluripotent stem cells Lineage commitment Growth factors biomaterial engineering Plasma-immersion ion implantation Covalent biomolecule attachment Polycaprolactone

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biofabrication of nanocomposite-based scaffolds containing human bone extracellularmatrix for the differentiation of skeletal stem and progenitor cells

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bio-Design and Manufacturing 2024年第2期7卷 121-136页

作者： Yang-Hee Kim Janos M.Kanczler stuart Lanham Andrew Rawlings Marta Roldo Gianluca Tozzi Jonathan I.Dawson Gianluca Cidonio Richard O.C.Oreffo Faculty of Medicine Bone and Joint Research GroupCentre for Human DevelopmentStem Cells and RegenerationInstitute of Developmental SciencesUniversity of SouthamptonSouthampton SO166YDUK School of Pharmacy and biomedical Science University of PortsmouthPortsmouth PO12DTUK School of Engineering Faculty of Engineering and ScienceUniversity of GreenwichGreenwich ME44TBUK Center for Life Nano-and Neuro-Science(CLN2S) Italian Institute of Technology00161 RomeItaly

Autograft or metal implants are routinely used in skeletal ***,they fail to provide long-term clinical resolution,necessitating a functional biomimetic tissue engineering *** use of native human bone tissue for synthesizing a biomimeticmaterial inkfor three-dimensional(3D)bioprintingof skeletal tissueis anattractivestrategyfor ***,human bone extracellular matrix(bone-ECM)offers an exciting potential for the development of an appropriate microenvironment for human bone marrow stromal cells(HbMSCs)to proliferate and differentiate along the osteogenic *** this study,we engineered a novel material ink(LAb)by blending human bone-ECM(b)with nanoclay(L,Laponite®)and alginate(A)polymers using extrusion-based *** inclusion of the nanoﬁller and polymeric material increased the rheology,printability,and drug retention properties and,critically,the preservation of HbMSCs viability upon *** composite of human bone-ECM-based 3D constructs containing vascular endothelial growth factor(VEGF)enhanced vascularization after implantation in an ex vivo chick chorioallantoic membrane(CAM)*** inclusion of bone morphogenetic protein-2(bMP-2)with the HbMSCs further enhanced vascularization and mineralization after only seven *** study demonstrates the synergistic combination of nanoclay with biomimetic materials(alginate and bone-ECM)to support the formation of osteogenic tissue both in vitro and ex vivo and offers a promising novel 3D bioprinting approach to personalized skeletal tissue repair.

关键词： Extracellular matrix Nanoclay bone 3D bioprinting

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广泛分布的四环素抗性决定子

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国外医药（抗生素分册） 1989年第5期10卷 362-364,376页

作者： stuart b.Levy 朱汝锦

1947年从金霉素链霉菌培养液中发现金霉素,它是一族对革蓝氏阳性菌和阴性菌具显著活性的新抗生素。该族抗生素包括的四环素显示广谱抗菌活性和低毒,它们干扰核糖体上蛋白合成而抑制细胞生长。虽然,在世界各地四环素仍然作为第二个普遍... 详细信息

1947年从金霉素链霉菌培养液中发现金霉素,它是一族对革蓝氏阳性菌和阴性菌具显著活性的新抗生素。该族抗生素包括的四环素显示广谱抗菌活性和低毒,它们干扰核糖体上蛋白合成而抑制细胞生长。虽然,在世界各地四环素仍然作为第二个普遍使用的抗生素,然而其有效性因微生物抗性的高发生率而已减弱。四环素抗性决定子是非均质的,广泛分散的、有很多实例和能诱导的,它们编码数个独特机理,致使细胞有效地对付444-道尔顿四环的四环素分子以及该族抗生素中其它衍生物。数年前我们特别提到当药物进入同一宿主微生物时。

关键词：四环素抗性决定子

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微生物及其质粒在环境中的传播

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生物技术通报 1988年第4期 1-6页

作者： stuart b.Levy 王璋瑜

抗菌素抗性基因可作为阐明环境微生物间遗传物质自然传播的一种模型。这些基因因为易于识别,并且在人、畜和农业病害的防治上具有医学意义而引人注目。分子生物学与流行病学数据已揭示,这些基因在自然界中惊人地以多种形式发生交流。... 详细信息

抗菌素抗性基因可作为阐明环境微生物间遗传物质自然传播的一种模型。这些基因因为易于识别,并且在人、畜和农业病害的防治上具有医学意义而引人注目。分子生物学与流行病学数据已揭示,这些基因在自然界中惊人地以多种形式发生交流。微生物间的遗传交换细菌可通过质粒和转座子进行部分DNA交换。质粒本身即使不能在新的寄主中存活,也能将它所编码的一个或多个基因引入该寄主。这些基因可由转座子携带,从进入的质粒跳跃到新寄主的染色体上或者该寄主本身具有的质粒上。这样,该固有质粒或者染色体就获得

关键词：转座子决定子流行病学数据环境微生物抗菌素治疗受体菌微生物环境 DNA 流感嗜血菌肠杆菌科

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前视红外仪的低温制冷选择

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红外技术 1984年第6期 15-22页

作者： stuart b.Horn 欧阳勇

制冷军用夜视器件目前有三种方法。闭合循环机械制冷器是在能够容许一定重量和功率的场合下使用。现在有三种闭合循环制冷器正用于军用系统。温差电制冷器主要用于手持系统。由于这种制冷器没有运动部件,因而无噪音。这种制冷方法有助... 详细信息

制冷军用夜视器件目前有三种方法。闭合循环机械制冷器是在能够容许一定重量和功率的场合下使用。现在有三种闭合循环制冷器正用于军用系统。温差电制冷器主要用于手持系统。由于这种制冷器没有运动部件,因而无噪音。这种制冷方法有助于最大限度地减轻制冷器的重量、缩小体积、降低成本,但缺点是制冷温度只能达到200K左右。焦一汤节流制冷器在80K温度条件下使用。它为制冷到80K温度提供了重量轻、无振动的冷却方法,但是存在着严重的后勤供给问题。这些制冷方法的分析计算将在本文中加以叙述。除低温制冷器的设计和制造问题外,制冷器与杜瓦瓶的配合也是关键问题。本文对几种配合联接方法要进行讨论,同时对大大减小由机械制冷器引起聚焦平面振动的新方法也要作介绍。

关键词：制冷器前视红外低温制冷

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非复杂性下呼吸道感染不良预后预测因素的调查研究

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中国全科医学 2019年第25期22卷 3109-3109页

作者：本刊编辑部(整理) MOORE M stuart b LOWN M University of Southampton Primary Care and Population Sciences Aldermoor Health Centre Southampton United Kingdom mvm198@soton.ac.uk. University of Southampton Primary Care and Population Sciences Aldermoor Health Centre Southampton United Kingdom. University of Oxford Nuffield Department of Primary Health Care Sciences Radcliffe Observatory Quarter Oxford United Kingdom. University of Washington Seattle Washington.

目的急性下呼吸道感染是基层医疗机构的常见疾病。本研究旨在帮助基层临床医生识别具有严重不良后果(死亡、住院、迟发性肺炎)风险的急性下呼吸道感染患者。方法本项前瞻性队列研究在急性下呼吸道感染患者中开展。记录患者特征和临床表... 详细信息

目的急性下呼吸道感染是基层医疗机构的常见疾病。本研究旨在帮助基层临床医生识别具有严重不良后果(死亡、住院、迟发性肺炎)风险的急性下呼吸道感染患者。方法本项前瞻性队列研究在急性下呼吸道感染患者中开展。记录患者特征和临床表现,并通过图表分析30 d内发生的不良事件。采用多因素Logistic回归分析急性下呼吸道感染发生不良后果的预测因素。结果从522个英国全科诊所在2009-2013年期间接诊的患者中,纳入28 846例没有立即转诊至医院治疗的成年急性下呼吸道感染患者。共有325例(1.1%)患者发生了严重不良事件。发生严重不良事件的8个独立预测因素为:用于评估急性下呼吸道感染严重程度的参数(无鼻炎、有发热、胸痛,有临床医生评估的症状的严重性)、患者自身易感性(>65岁,有并发症)、生理影响参数(血氧饱和度<95%、低血压)。总的来说,上述8个因素预测发生严重不良事件的价值为中等[AUC=0.71,95%CI(0.68,0.74)]。具有上述5个或更多因素的患者占4%,发生严重不良事件的风险程度为高(5.7%)。具有上述3或4个因素的患者占35%,发生严重不良事件的风险程度为中(2.0%)。具有上述1或2个因素的患者占61%,发生严重不良事件的风险程度为低(0.5%)。结论在基层医疗机构常规诊疗中,大多数急性下呼吸道感染患者可以被识别出是否具有发生严重不良事件的中度或低度的风险。

关键词：急性下呼吸道感染预测因素多因素Logistic回归分析不良预后复杂性基层医疗机构感染患者不良事件

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2023年美国麻醉医师学会神经肌肉阻滞监测与拮抗实践指南:美国麻醉医师学会工作组关于神经肌肉阻滞的报告

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中华麻醉学杂志 2024年第5期44卷 518-542页

作者： Stephan R.Thilen Wade A.Weigel Michael M.Todd Richard P.Dutton Cynthia A.Lien stuart A.Grant Joseph W.Szokol Lars I.Eriksson Myron Yaster Mark D.Grant Madhulika Agarkar Anne M.Marbella Jaime F.blanck Karen b.Domino 西雅图华盛顿州明尼阿波里斯明尼苏达州达拉斯得克萨斯州密尔沃基威斯康星州教堂山北卡罗来纳州洛杉矶加利福尼亚州斯德哥尔摩瑞典丹佛科罗拉多州绍姆堡伊利诺斯州巴尔的摩马里兰州

本实践指南基于证据提供了全身麻醉期间及术后神经肌肉功能监测与阻滞拮抗的管理推荐。主要关注神经肌肉功能监测的类型与部位及阻滞拮抗的过程,以减少肌肉松弛药残留阻滞。

关键词：神经肌肉阻滞肌肉松弛药神经肌肉功能监测舒更葡糖钠新斯的明

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减少沙门氏菌在盲肠内定植的联合干扰技术

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中国家禽 2007年第20期 59-59页

作者： stuart b.Price Haroldo Toro Shelly R.Mckee 王宏俊

预防食源性沙门氏菌感染是全世界研究食品安全的科学家所面临的重大挑战,污染沙门氏菌的禽类是重要的污染源之一。我们利用伤寒沙门氏菌(ST)作为血清型模型,研究一种减少禽类沙门氏菌污

关键词：沙门氏菌血清型定植血清变种盲肠大肠噬菌体干扰技术

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