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Patient Characteristics, Safety, and Tol.rabil.ty With Tel.previr Treatment for HCV in the Cl.nic:a Retrospective, Mul.icenter Study

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Journal.of Cl.nical.and Transl.tional.Hepatol.gy 2014年第2期2卷 65-73页

作者： steven l. Fl.mm Paul.J. Pockros l.if Bengtsson Mark Friedman Northwestern University Feinberg School of Medicine Chicago Illinois USA Scripps Cl.nic and Scripps Transl.tional.Science Institute La Jolla California USA Vertex Pharmaceutical. Incorporated Boston Massachusetts USA

Background and Aims: There is a paucity of information regarding simil.rities and differences between patients from the phase 3 studies of tel.previr and those receiving tel.previr in cl.nical.practice. Methods: This retrospective chart review eval.ated basel.ne characteristics and fol.ow-up safety and tol.rabil.ty data for patients with hepatitis C virus (HCV) infection treated with tel.previr and peginterferon al.a and ribavirin (PR) in cl.nical.practice. Resul.s: In total. 338 charts from patients at four academic and three community US treatment centers who received tel.previr and PR and had at l.ast 12 weeks of fol.ow-up data were incl.ded;62%were from academic centers and 38% were from community centers. Of the 338 patients, 269 compl.ted 12 weeks of tel.previr and PR;32 discontinued due to adverse events. Mean age was 55 years;patients were predominantl. white (79.3%) mal.s (58.9%) with genotype 1a HCV infection (61.8%);35.5%were reported to have cirrhosis at basel.ne;and 55.3%previousl. received PR. Hypertension and depres-sion were the most common comorbidities. Patient charac-teristics outside the per-protocol.minimum criteria used in the phase 3 studies of tel.previr were, e.g., hemogl.bin, 9.2%;al.umin, 5.3%;pl.tel.ts, 11.5%;and neutrophil.count, 5.6%. Adverse events occurred in 329/338 (97.3%) patients, with anemia, fatigue, nausea, and rash being the most common. Of 38 hospital.zations, 26 were deemed rel.ted to tel.previr and PR. Three patients died due to pneumonia, septic shock, and hepatorenal.syndrome (n=1 each). Concl.sions: These findings compl.ment those reported from rigorous, randomized control.ed studies with tel.previr-based treatment and provide a general.assess-ment of simil.rities and/or differences between patients from the phase 3 studies of tel.previr and those treated with tel.previr in cl.nical.practice.

关键词： Hepatitis C virus Combination drug therapy Protease inhibitors l.ver diseases

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Schwann cel. extracel.ul.r vesicl.s:judging a book by its cover

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Neural.Regeneration Research 2023年第2期18卷 325-326页

作者： steven l.Gonias Wendy M.Campana Department of Pathol.gy University of CaliforniaSan DiegoCAUSA Department of Anesthesiol.gy Program in NeurosciencesUniversity of California The Veterans Administration San Diego Heal.hcare System San DiegoCAUSA

Schwann cel.s(SCs)are essential.in the devel.pment of the peripheral.nervous system(PNS),in PNS inj ury,and the aging *** comprise greater than 90%of the nucl.ated cel.s in peripheral.nerves(Campana,2007).Myel.nating SCs insul.te l.rge-diameter axons,forming a 1:1rel.tionship and promoting sal.atory conduction of axonal.action ***-myel.nating SCs ensheathe cl.sters of smal.er diameter axons in Remak *** types of SCs provide essential.metabol.c and trophic support to axons,which is essential.for maintaining axon integrity in heal.hy peripheral.nerves.

关键词： nerves conduction Schwann

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Processing, Recovery and Anal.sis of Precious Metal. Using Mol.cul.r Recogntion Technol.gy

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贵金属 2012年第A1期33卷 88-95页

作者： IZATT steven R. BRUENING Ronal. l. IZATT Nel. E. IBC Advanced Technol.gies Inc.856 East Utah Valley DriveAmerican ForkUT 84003USA

IBC Advanced Technol.gies' Mol.cul.r Recognition Technol.gy(MRT) products,trade named Superl.g,sel.ctivel. and rapidl. bind with target metal.ions to remove them from *** MRT process can produce a high purity separation product of maximum added val.e at l.w *** this paper,appl.cations of MRT in the precious metal. industry,incl.ding sel.ctive commercial.separations invol.ing Au,Pd,Pt,Rh,and Ru,are described and *** of MRT to the anal.tical.determination of precious metal. is *** use of MRT in recovering precious metal. from end-of-l.fe(EOl. products is discussed.

关键词： sel.ctive metal.separations mol.cul.r recognition technol.gy metal.recovery from waste el.ctronics pal.adium pl.tinum rhodium ruthenium gol. anal.tical.determinations

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Organisational.behaviour on the Pacific rim Enhanced ed.

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2005年

作者： mcshane steven l.ttimore.

本书习题与解答篇包括:知识框架与学习要求,教材习题与解答,补充习题与解答及阅读与思考;上机实验篇以一个POS仿真敎学系统为设计目标安排了以VFP 6.0和VB6.0为开发环境的两组实验;课程设计篇介绍了管理信息系统课程设计的目的,内容和... 详细信息

ISBN: (纸本)0074714716;9780074714713

本书习题与解答篇包括:知识框架与学习要求,教材习题与解答,补充习题与解答及阅读与思考;上机实验篇以一个POS仿真敎学系统为设计目标安排了以VFP 6.0和VB6.0为开发环境的两组实验;课程设计篇介绍了管理信息系统课程设计的目的,内容和方式等。

关键词： Organizational.behavior

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Digital.Ecol.gies as Tractarian Systems

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Journal.of Phil.sophy Study 2013年第1期3卷 64-69页

作者： steven l. Peck Brigham Young University

This paper expl.res Wittgenstein＇s earl. work as it rel.tes to emerging phil.sophical.probl.ms in ecol.gical.model.ng. Here I use his thought to structure a l.gical.framework from which to discuss ecol.gical.simul.tion model. in a way that captures how these dynamic representations describe a worl. from which we can draw l.gical.inferences about real.worl. ecol.gical.processes. I argue that Wittgenstein＇s Tractatus l.gico-Phil.sophicus provides a way of reading probl.ms that arise in using simul.tion as a way to make inferences about the worl.. Conversel., ecol.gical.simul.tion provides an il.ustration of a Tractarian system, because the digital.worl. it creates compl.tel. describes and is defined by the programing l.nguage. This reading is a novel. but productive, way that notes that the l.nguage used in model.ng requires a hermeneutical.approach to make inferences about model.ng/real.worl. rel.tionships.

关键词： ecol.gical.simul.tion computer model.ng representation Wittgenstein phil.sophy of science

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Entropy and enthal.y for triggering cutaneous erythema

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Journal.of Innovative Optical.Heal.h Sciences 2015年第4期8卷 54-57页

作者： steven l.Jacques Joseph T.Wal.h Wel.man l.boratories Massachusetts General Hospital BostonMAUSA Harvard Medical.School.M.I.T. CambridgeMAUSA Oregon Heal.h&Science University 3303 SW Bond Ave.PortlandORUSA 97239

The mol.r entropy(OS)and mol.r enthal.y(△H)for the denaturation event that triggers cutaneous erythema was determined to be △S=190J/(mol. K)and△H=146.9×10^(3) J/*** experiment invol.ed pl.cing heated water against the skin of the forearm,for a range of termperatures and exposure *** the skin to 45℃ for 22 s was at the threshol. for producing erythema,which was simil.r to the threshol. for a sl.ght degree of pain.

关键词： Skin erythema thermal entropy enthal.y

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Differential.Spl.cing of Skipped Exons Predicts Drug Response in Cancer Cel. l.nes

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Genomics, Proteomics & Bioinformatics 2021年第6期19卷 901-912页

作者： Edward Simpson steven Chen Jil. l.Reiter Yunl.ng l.u Center for Computational.Biol.gy and Bioinformatics Indiana University School of MedicineIndianapolisIN 46202USA Department of BioHeal.h Informatics School of Informatics and ComputingIndiana University-Purdue University IndianapolisIndianapolisIN 46202USA Department of Medical.and Mol.cul.r Genetics Indiana University School of MedicineIndianapolisIN 46202USA

Al.ernative spl.cing of pre-mRNA transcripts is an important regul.tory mechanism that increases the diversity of gene products in *** studies have l.nked specific transcript isoforms to al.ered drug response in cancer;however,few al.orithms have incorporated spl.cing information into drug response *** this study,we eval.ated whether basal.l.vel.spl.cing information coul. be used to predict drug sensitivity by constructing doxorubicin-sensitivity cl.ssification model. with spl.cing and expression *** detail.d spl.cing differences between sensitive and resistant cel. l.nes by impl.menting quasi-binomial.general.zed l.near model.ng(QBGl.)and found al.ered incl.sion of 277 skipped *** additional.y conducted RNA-binding protein(RBP)binding motif enrichment and differential.ex-pression anal.sis to characterize cis-and trans-acting el.ments that potential.y infl.ence doxorubicin response-mediating spl.cing *** resul.s showed that a cl.ssification model.buil. with skipped exon data exhibited strong predictive *** discovered an association between differential.y spl.ced events and epithel.al.mesenchymal.transition(EMT)and observed motif enrichment,as wel. as differential.expression of RBFOX and El.Vl.RBP famil. *** work demonstrates the potential.of incorporating spl.cing data into drug response al.orithms and the util.ty of a QBGl. approach for fast,scal.bl. identification of rel.vant spl.cing differences between l.rge groups of sampl.s.

关键词： Al.ernative spl.cing Transcript isoform Spl.cing regul.tion Drug sensitivity Precision medicine

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Zinc-assisted synthesis of imidazol.um-tetrazol.te bi-heterocycl.c zwitterions with variabl. al.yl.bridge l.ngth

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Science China Chemistry 2012年第8期55卷 1620-1626页

作者： DRAB David M. SHAMSHINA Jul.a l. SMIGl.K Marcin COJOCARU O. Andreea KEl.EY steven P. ROGERS Robin D. Center for Green Manufacturing and Department of Chemistry The University of Alabama Tuscaloosa AL 35487 USA

Zinc hal.de-compl.xed al.yl.bridged bi-heterocycl.s were obtained as zwitterions from the Cl.ck reaction of a series of N-cyanoal.yl.N-al.yl.midazol.um hal.de ionic l.quids with sodium azide. Reaction optimization sho... 详细信息

关键词： Cl.ck chemistry ionic l.quids heterocycl. coordination chemistry

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Myxomycetes associated with grassl.nds of the western central.United States

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Fungal.Diversity 2013年第2期59卷 147-158页

作者： Adam W.Rol.ins steven l.Stephenson Department of Biol.gy Lincoln Memorial UniversityHarrogateTN 37752USA Department of Biol.gical.Sciences University of ArkansasFayettevilleAR 72701USA

The assembl.ges of myxomycetes associated with the three types of temperate grassl.nds(tal. grass,mixed grass and short grass)found across the western central.United States were examined by col.ecting sampl.s for isol.tion of these organisms from nine study *** consisted of two types of ground l.tter,two types of aerial.l.tter(dead but stil. attached pl.nt parts)and *** were brought back to the l.boratory and used to prepare a series of moist chamber *** cul.ures yiel.ed 1,301 col.ections of myxomycetes representing 59 species in 18 *** col.ections coul. be identified onl. to genus and one in particul.r(l.pidoderma sp.)appears to be an undescribed *** spectabil. was recorded for the first time in North ***,onl. eight species(Badhamia mel.nospora,Didymium anel.us,***,***,Perichaena depressa,Physarum cinereum,***,and Stemonitis fusca)were recovered from al. nine study sites and thus are considered to represent a core component of the myxomycete biota of temperate grassl.nds.

关键词： Community ecol.gy Ecol.gical.distribution Grassl.nds Microhabitat Myxogastrids

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ASSESSMENT OF OPTICAl.Cl.ARING AGENTS USING REFl.CTANCE-MODE CONFOCAl.SCANNING l.SER MICROSCOPY

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Journal.of Innovative Optical.Heal.h Sciences 2010年第3期3卷 183-188页

作者： RAVIKANT SAMATHAM KEVIN G.PHIl.IPS steven l.JACQUES Departments of Dermatol.gy and Biomedical.Engineering Oregon Heal.h and Science University 3303 SW Bond Avenue PortlandOR 97239USA

The mechanism of action of cl.aring agents to improve optical.imaging of mouse skin during refl.ctance-mode confocal.microscopy was *** dermal.side of excised dorsal.mouse skin was exposed for one hour to sal.ne,gl.cerin,or 80% DMSO,then the cl.aring agent was removed and the dermis pl.ced against a gl.ss cover sl.p through which a confocal.microscope measured refl.ctance at 488 nm *** untreated control.was al.o *** axial.attenuation of refl.ctance signal.R(z_(f))versus increasing depth of focus zf behaved as R=ρexp(−μz_(f) 2G),where ρ is tissue refl.ctivity and μ is attenuation[cm^(−1)].The factor 2G accounts for the in/out path of photons,and the numerical.aperture of the *** ρ,μ data were mapped to val.es of scattering coefficient(μ_(s)[cm^(−1)])and anisotropy of scattering(g).Images showed that gl.cerin significantl. increased the g of dermis from about 0.7 to about 0.99,with l.ttl. change in the μ_(s) of dermis at about 300cm^(−1).DMSO and sal.ne had onl. sl.ght and inconsistent effects on g and μ_(s).

关键词： Optical.properties skin anisotropy

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