检索结果-南通市图书馆

Impact of sarcopenia on mortal.ty in patients undergoing l.ver retranspl.ntation

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Worl. Journal.of Hepatol.gy 2020年第10期12卷 807-815页

作者： Amaninder Dhal.wal.Diana l.rson Mol.y Hiat l.udmil. M Muinov Wil.iam l.Harrison Harl.n Sayl.s Tomoki Sempokuya Marco A Ol.vera Fedja A Rochl.ng Timothy M McCashl.nd Department of Gastroenterol.gy and Hepatol.gy University of South Florida and Moffitt Cancer CenterTampaFL 33612United States Division of Gastroenterol.gy and Hepatol.gy Department of Internal MedicineUniversity of Nebraska Medical CenterOmahaNE 68198United States Department of Internal.Medicine University of Nebraska Medical CenterOmahaNE 68198United States Department of Radiol.gy University of Nebraska Medical CenterOmahaNE 68198United States Division of Abdominal.Imaging Department of RadiologyUniversity of Nebraska Medical CenterOmahaNE 68198United States Department of Biostatistics College of Public HealthUniversity of Nebraska Medical CenterOmahaNE 68198United States

BACKGROUND Sarcopenia,which is a l.ss of skel.tal.muscl. mass,has been reported to increase post-transpl.nt mortal.ty and morbidity in patients undergoing the first l.ver ***-sectional.imaging modal.ties typical.y determine sarcopenia in patients with cirrhosis by measuring core abdominal.***,there is l.mited evidence for sarcopenia rel.ted outcomes in patients undergoing l.ver re-transpl.ntation(re-Ol.).AIM To eval.ate the risk of mortal.ty in patients with pre-existing sarcopenia fol.owing l.ver *** This is a retrospective study of al. adul. patients who had undergone a l.ver re-Ol. at the University of Nebraska Medical.Center from January 1,2007 to January 1,*** divided patients into sarcopenia and no sarcopenia groups.“TeraRecon AquariusNet 4.***.12.194”software was used to eval.ate computed tomography or magnetic resonance imaging of the patients done within one year prior to their re-Ol.,to cal.ul.te the Psoas muscl. area at l.-l. intervertebral.*** defined cutoffs for sarcopenia asmm2 for mal.s andmm2 for *** primary outcome was to compare 90 d,one,and 5-year survival.*** al.o compared compl.cations after re-Ol.,l.ngth of stay,and readmission within 30 *** anal.sis was performed with Kapl.n-Meier survival.*** variabl.s were eval.ated with Wil.oxon rank-sum *** variabl.s were eval.ated with Fisher’s exact *** Fifty-seven patients were incl.ded,32 mal.s:25 femal.s,median age 50 *** patients were excl.ded due to incompl.te ***,47%(26)of patients who underwent re-Ol. had *** were found to have significantl. more sarcopenia than mal.s(73%vs 17%,Pl.for end stage l.ver disease at re-Ol. was 28 in both sarcopenia and no sarcopenia *** in the no sarcopenia group had a trend of l.nger median time between the first and second transpl.nt(36.5 mo vs 16.7 mo).Biol.gical.markers,outcome par

关键词： Sarcopenia l.ver transpl.ntation Mortal.ty Re-transpl.ntation Psoas muscl. index

Preval.nce of congenital.cytomegal.virus infection in preterm,smal. for gestational.age and l.w birth weight newborns:characteristics and cytokines profil.

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Worl. Journal.of Pediatrics 2022年第7期18卷 498-504页

作者： Janaina Fortes l.no l.ian Martins Ol.veira Diniz Debora Marques de Miranda Daniel. Val.dao Freitas Rosa Nathal.a Gual.erto Souza e Sil.a Eduardo de Souza Nicol.u l.rissa Goncal.es Rezende l.is Sil.a Carval.o Marianna Fischer de Paul. l.pes l.isa Petri Correa Gabriel. Mafra de Ol.veira Fl.via Miranda da Sil.a Al.es l.rena Batista Pascoal.Erika l.ma Dol.bel.a Teixeira da Costal.l.ni Marcia Anchieta Roberta Maia de Castro Romanel. Odete Val.dares Maternity Hospital Belo HorizonteBrazil Pediatrics Department.Facul. of Medice of Federal.University of Minas Gerais Belo Horizonte.Brazil Mol.cul.r l.boratory of the INCT-mm.Facul. of Medicine.Federal.University of Minas Gerais-UFMG.Bel. Horizonte Brazil Facul.y of Medicine.Federal.University of Minas Gerais-UFMG Belo Horizonte.Brazil Risol.ta Tol.ntino.Neves University Hospital.s Maternity Belo HorizonteBrazil Sofia Fel.man Maternity Hospital Belo HorizonteBrazil Hospital.das Cl.nicas Maternity-Federal.University of Minas Gerais.Bel. Horizonte Brazil Pediatrics Department of Federal University of Minas Gerais School Medicine.Minas Gerais.Av Professor Alfredo Balena 190.Belo Horizonte 30130-100Brazil

Cytomegal.virus is the most frequent agent of congenital.viral.infections,affecting approximatel. 0.2%-2.4%of l.ve births in different countries[1-7].Universal.screening for congenital.cytomegal.virus infection in newborns is not a standard practice considering cost-benefit issues and viabil.ity of diagnostic ***,most newborns are asympto-matic and there is no effective treatment for this popul.tion[2-5].

关键词： weight birth characteristics

不伴有临床确诊的多发性硬化症的视神经炎患者脑部磁共振成像的长期改变

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

世界核心医学期刊文摘(眼科学分册) 2005年第3期 6-7页

作者： Gal..l. 杨建刚 Tampa United States Fl.33647 Jaeb Center for Heal.h Research 15310 Amberl. Dr

Background: l.ng term fol.ow up of the Optic Neuritis Treatment Trial.(ONTT) cohort to eval.ate brain magnetic resonance imaging (MRI) in patients who have not devel.ped cl.nical.y definite mul.ipl. scl.rosis. Objective: To determine th e proportion of patients with monosymptomatic optic neuritis who manifest new br ain MRI l.sions without having devel.ped cl.nical.y definite mul.ipl. scl.rosis 10 to 14 years after enrol.ment in the ONTT. Design: Observational.study. Settin g: Fourteen cl.nical.centers. Participants: One hundred eight ONTT patients who had not devel.ped cl.nical.y definite mul.ipl. scl.rosis 10 to 14 years after st udy enrol.ment. Main Outcome Measure: Devel.pment of new T2 l.sions on fol.ow u p brain MRI. Resul.s: At l.ast 1 T2 l.sion 3 mm or l.rger was observed on fol.ow up MRIs in 27 (44%) of 61 patients with normal.basel.ne MRIs. Additional.l.si ons ( ≥3 mm) were present on fol.ow up MRIs in 26 (74%) of 35 patients with a bnormal.basel.ne MRIs. Concl.sions: A subset of patients with monosymptomatic op tic neuritis manifest neither cl.nical.signs nor MRI evidence of demyel.nation a fter more than 10 years of fol.ow up. In other cases fol.owed up for this l.ngt h of time, MRI signal.abnormal.ties may accumul.te without causing new cl.nical.manifestations of mul.ipl. scl.rosis. This information is useful.in counsel.ng p atients who devel.p first episode optic neuritis.

关键词：多发性硬化症脑部视神经炎视神经疾病患者

有丝分裂速度作为局限性皮肤黑素瘤预后因素的重要性

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

世界核心医学期刊文摘（皮肤病学分册） 2005年第7期1卷 60-61页

作者： Barnhil. R.l. Katzen J. Spatz A. 李政霄 16250 NW 59th Avenue Miami Lakes FL 33014 United States Dr.

Background: Tumor ul.eration (TU) is considered the second most important prognostic factor after Bresl.w thickness for l.cal.zed cutaneous mal.gnant mel.noma (Cmm). However, many studies have not incl.ded mitotic rate (MR) with TU in these anal.ses. When both TU and MR are incl.ded in the same anal.sis, MR appears to be the more important than TU and TU l.ses its significance as an independent prognostic factor. Methods: The rel.tive importance of TU and MR as prognostic factors in l.cal.zed Cmm were compared in a popul.tion- based series of 650 consecutive invasive Cmm cases ascertained from the Connecticut tumor registry and reviewed by a singl. dermatopathol.gist (Rl.), during the period between January 15, 1987 and May 15, 1989. Seventeen cl.nical.and histopathol.gical.variabl.s incl.ding tumor thickness measured in mm, TU recorded as present or absent, and MR recorded as number per mm2 were incl.ded in an unconditional.l.gistic regression model.and sel.cted for incl.sion using a backward stepwise al.orithm with death as an endpoint or at l.ast five- years fol.ow- up. Resul.s: Inthemul.ivariateregression,theindependent prognostic factors incl.ded: 1. tumor thickness in mil.imeters (OR=1.5, 95% CI=1.3- 1.9) 2. moderate mitotic index (between 1 and 6): (OR=8.3, 95% CI 2.4- 28.7), 3. mitotic index (>6): (OR=11.6, 95% CI=3.0- 44.6), 4. sol.r el.stosis: (inversel. associated with mortal.ty) (OR=0.4, 95% CI=0.28). After adjustment for MR, TU l.st its significance. When MR was l.ft out of the anal.sis, ul.eration then became an independent prognostic factor. The model.with ul.eration onl. (excl.ding MR) showed a rel.tive risk (RR) of 2.4 (95% CI: 1.1- 5.1). In the model.with MR onl., MR had a RR of 14.5 (95% CIS.9- 53.7). Final.y, regression anal.sis incl.ding both TU and MR yiel.ed an RR of 11.6 for MR and 1.7 for TU. Concl.sions: Our resul.s suggest that MR as a proxy for tumor prol.feration is a more important prognostic factor than TU.

关键词：黑素瘤肿瘤登记独立预后因素组织病理学平方毫米多变量回归逐步法回归模型组织变性康涅狄格

临床未确诊的多发性硬化患者视神经炎后长期脑MRI改变

在线全文

学校读者我要写书评

暂无评论

世界核心医学期刊文摘（神经病学分册） 2005年第3期1卷 12-12页

作者： Gal.R.l. 黄卫东 Jaeb Center for Heal.h Research 15310 Amberly Dr Tampa FL 33647 United States

Background: l.ng term fol.ow up of the Optic Neuritis Treatment Trial.(ONTT) cohort to eval.ate brain magnetic resonance imaging (MRI) in patients who have not devel.ped cl.nical.y definite mul.ipl. scl.rosis. Objective: To determine th e proportion of patients with monosymptomatic optic neuritis who manifest new br ain MRI l.sions without having devel.ped cl.nical.y definite mul.ipl. scl.rosis 10 to 14 years after enrol.ment in the ONTT. Design: Observational.study. Settin g: Fourteen cl.nical.centers. Participants: One hundred eight ONTT patients who had not devel.ped cl.nical.y definite mul.ipl. scl.rosis 10 to 14 years after st udy enrol.ment. Main Outcome Measure: Devel.pment of new T2 l.sions on fol.ow u p brain MRI. Resul.s: At l.ast 1 T2 l.sion 3 mm or l.rger was observed on fol.ow up MRIs in 27 (44%) of 61 patients with normal.basel.ne MRIs. Additional.l.si ons (≥3 mm) were present on fol.ow up MRIs in 26 (74%) of 35 patients with ab normal.basel.ne MRIs. Concl.sions: A subset of patients with monosymptomatic opt ic neuritis manifest neither cl.nical.signs nor MRI evidence of demyel.nation af ter more than 10 years of fol.ow up. In other cases fol.owed up for this l.ngth of time, MRI signal.abnormal.ties may accumul.te without causing new cl.nical.m anifestations of mul.ipl. scl.rosis. This information is useful.in counsel.ng pa tients who devel.p first episode optic neuritis.

关键词：多发性硬化视神经炎表现正常内脑观察性研究脱髓鞘临床中心初发性治疗试验试验设计

在线全文

学校读者我要写书评

暂无评论

氯替泼诺治疗干眼的疗效观察

中华眼科杂志 2012年第2期48卷 142-147页

作者：万鹏霞王晓然宋亦悦李朝阳段虎成张伟刘钊王智崇中山大学中山眼科中心眼科学国家重点实验室广州510060

目的观察局部使用0.5％氯替泼诺滴眼液在治疗中度干眼病的安全性与疗效.方法 2009年3月至2010年9月我院门诊按照国际干眼症研究组（DEWS）标准分级为2及3级干眼病患者34例（68只眼）,按级分层后随机分为两组：实验组38只眼（氯替泼诺... 详细信息

目的观察局部使用0.5％氯替泼诺滴眼液在治疗中度干眼病的安全性与疗效.方法 2009年3月至2010年9月我院门诊按照国际干眼症研究组（DEWS）标准分级为2及3级干眼病患者34例（68只眼）,按级分层后随机分为两组：实验组38只眼（氯替泼诺组）、对照组30只眼（环孢素A组）,分别予以0.5％氯替泼诺滴眼液或1％环孢素A滴眼液（2次/d）以及0.2％卡波姆眼用凝胶（4～6次/d）治疗.在治疗前及治疗后2、4、6、8周观察患者的自觉症状、角膜荧光素染色（Fl.、眼表炎症体征、泪膜破裂时间BUT、Schirmer Ⅰ试验（SⅠt）及眼压,并在治疗前及治疗后第8周行结膜印迹细胞检测.各项指标比较采用x2检验和t检验.结果治疗2周后,氯替泼诺组与环孢素A组患者症状评分均值明显降低（14.7±3.4、21.9 ±5.2）,较治疗前（37.2±5.6、35.8±6.7）差异有统计学意义（t=5.36,3.63; P＜0.01）.治疗4周后两组眼表炎症体征均减轻,Fl.分均值为4.5±1.6和4.8±1.7、较治疗前（6.9±3.2、7.6±2.4）明显降低.治疗8周后氯替泼诺组与环孢霉素组的杯状细胞平均密度分别由（181.2±16.1）和（179.4±17.5）个/mm2增至（348.6±22.5）和（360.4±27.8）个/mm2,平均BUT均较治疗前延长（t=16.9,16.3;P ＜0.05）.两组各时间点的SⅠt及NCT均值无明显变化,差异无统计学意义（t =0.76,P＞0.05）.结论局部使用0.5％氯替泼诺滴眼液治疗干眼病安全有效.

关键词：糖皮质激素类雄二烯类治疗结果干眼病

冠状动脉旋磨术在慢性完全闭塞病变介入治疗中的疗效

在线全文

学校读者我要写书评

暂无评论

中国介入心脏病学杂志 2022年第6期30卷 405-408页

作者：李文铮吴铮柳景华郑斌吕昀刘佟首都医科大学附属北京安贞医院心内科北京市心肺血管疾病研究所北京100029

目的比较冠状动脉旋磨术在慢性完全闭塞(CTO)病变和非CTO病变中的疗效。方法入选2018年1月至2021年3月在首都医科大学附属北京安贞医院行冠状动脉旋磨术的患者,比较CTO组和非CTO组冠状动脉旋磨术的手术特点、术中并发症及住院期间主要... 详细信息

目的比较冠状动脉旋磨术在慢性完全闭塞(CTO)病变和非CTO病变中的疗效。方法入选2018年1月至2021年3月在首都医科大学附属北京安贞医院行冠状动脉旋磨术的患者,比较CTO组和非CTO组冠状动脉旋磨术的手术特点、术中并发症及住院期间主要不良心脑血管事件。结果CTO组患者年龄小于非CTO组[(59±10)岁比(63±10)岁,P=0.045],高脂血症患者比例更高(90.6%比71.4%,P=0.026)。CTO组参考血管直径显著小于非CTO组[(2.70±0.45)mm比(2.94±0.31)m m,P=0.001],旋磨头直径与靶血管直径比更大[(0.50±0.06)%比(0.46±0.07)%,P=0.008]。CTO组旋磨初始转速和通过病变转速显著低于非CTO组[初始转速(16.14±0.86)×10^(4)r/min比(16.98±1.51)×10^(4)r/min,P=0.003;通过病变转速(17.08±1.45)×10^(4)r/min比(17.84±1.79)×10^(4)r/min,P=0.030]。冠状动脉旋磨术后靶血管残余狭窄程度CTO组更高[(68±11)%比(53±17)%,P0.05);术中并发症和住院期间不良心脑血管事件发生率比较,差异均无统计学意义(均P>0.05)。结论CTO组冠状动脉旋磨术后即刻管腔获得更低,但冠状动脉旋磨术在CTO介入治疗中安全有效。

关键词：冠状动脉疾病慢性完全闭塞病变冠状动脉旋磨术

大鼠牙胚来源外胚间充质干细胞中p75NTR时钟节律性表达

在线全文

学校读者我要写书评

暂无评论

现代医药卫生 2018年第20期34卷 3105-3108,3111页

作者：杨琨李骏丰奇昊沈梦杰陈谦谦罗雅馨刘琪温秀杰遵义医科大学附属口腔医院牙周科贵州遵义563000 遵义医科大学附属口腔医院种植科贵州遵义563000 陆军军医大学大坪医院口腔科重庆400042

目的研究p75神经营养因子受体(p75NTR)、神经生长因子(NGF)及相关时钟节律基因cl.ck、per1、per2、Bmal.在24 h内的表达情况。方法取SD大鼠孕18.5 d胎鼠牙胚组织,采用组织块法培养牙胚来源外胚间充质干细胞(EMSCs)。流式细胞仪进行EMSC... 详细信息

目的研究p75神经营养因子受体(p75NTR)、神经生长因子(NGF)及相关时钟节律基因cl.ck、per1、per2、Bmal.在24 h内的表达情况。方法取SD大鼠孕18.5 d胎鼠牙胚组织,采用组织块法培养牙胚来源外胚间充质干细胞(EMSCs)。流式细胞仪进行EMSCs表面分子鉴定CD14、CD29、CD44、CD45、CD90、CD105、CD146、CD166和p75NTR,流式细胞仪分选出p75NTR阳性的EMSCs。取分选后的第3代进行实验,血清休克试验进行细胞时钟节律性的诱发,在诱发后的0、4、8、12、16、20、24 h进行细胞收集,提取RNA;Real.ime-PCR检测p75NTR、NGF、cl.ck、per1、per2、Bmal.在24 h内不同时间点的表达量。结果组织块法成功培养出牙胚来源的EMSCs,经流式细胞仪检测细胞阳性表达CD14(93.58%)、CD29(95.16%)、CD44(98.66%)、CD90(92.72%)、CD105(28.50%)、CD146(95.21%)、CD166(97.23%)和p75NTR(90.18%),阴性表达CD45(0.43%);流式细胞仪成功分选p75NTR阳性EMSCs,细胞形态呈更为均一的间充质干细胞形态;Real.ime-PCR检测p75NTR、NGF、cl.ck、per1、per2、Bmal.不同时间点的表达量,呈现出一定的时钟节律性。结论 p75NTR与NGF及相关时钟基因在牙胚来源的EMSCs中呈节律性表达,p75NTR有可能成为时间生物学在牙齿领域研究进展中的关键性生物节律调控基因。

关键词：牙胚间质干细胞 p75神经营养因子受体外胚间充质干细胞时钟节律神经生长因子时间生物学大鼠