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Harmony Search Algorithm Based on Dual-Memory Dynamic Search and Its Application on Data Clustering

Complex System Modeling and Simulation 2023年第4期3卷 261-281页

作者： jinglin Wang Haibin Ouyang Zhiyu Zhou steven Li School of Mechanical and Electric Engineering Guangzhou UniversityGuangzhou 510006China Graduate School of Business and Law RMIT UniversityMelbourne 3000Australia

Harmony Search(HS)algorithm is highly effective in solving a wide range of real-world engineering optimization ***,it still has the problems such as being prone to local optima,low optimization accuracy,and low search *** address the limitations of the HS algorithm,a novel approach called the Dual-Memory Dynamic Search Harmony Search(DMDS-HS)algorithm is *** main innovations of this algorithm are as follows:Firstly,a dual-memory structure is introduced to rank and hierarchically organize the harmonies in the harmony memory,creating an effective and selectable trust region to reduce approach blind ***,the trust region is dynamically adjusted to improve the convergence of the algorithm while maintaining its global search ***,to boost the algorithm’s convergence speed,a phased dynamic convergence domain concept is introduced to strategically devise a global random search ***,the algorithm constructs an adaptive parameter adjustment strategy to adjust the usage probability of the algorithm’s search strategies,which aim to rationalize the abilities of exploration and exploitation of the *** results tested on the Computational Experiment Competition on 2017(CEC2017)test function set show that DMDS-HS outperforms the other nine HS algorithms and the other four state-of-the-art algorithms in terms of diversity,freedom from local optima,and solution *** addition,applying DMDS-HS to data clustering problems,the results show that it exhibits clustering performance that exceeds the other seven classical clustering algorithms,which verifies the effectiveness and reliability of DMDS-HS in solving complex data clustering problems.

关键词： harmony search dual-memory dynamic search optimization data clustering

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Impacts of 1-Aminocyclopropane-1-Carboxylic Acid as a Late Post-Bloom Thinner on Fruit Set, Yield, and Fruit Quality in “Gala” and “Fuji” Apples

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American journal of Plant Sciences 2022年第4期13卷 481-493页

作者： Esmaeil Fallahi steven j. McArtney Pomology and Viticulture Program Department of Plant Sciences University of Idaho Parma Research and Extension Center Parma ID USA Valent BioSciences Corporation Libertyville IL USA

A few post-bloom thinners are available for apple (Malus domestica Borkh.) and the prospects for additional thinners appear to be limited. Application of blossom thinners may present a risk of overthining in the areas where weather is less predictable. Thus, we studied the impacts of various rates of 1-aminocyclopropane-1-carboxylic acid (ACC) in three strains of “Fuji” apple and different rates of ACC and one rate of Ethrel in “Buckeye Gala” apple, when fruitlet diameter was about 20 mm, on fruit set, yield and fruit quality attributes at harvest, and return bloom in southwest Idaho in the Intermountain West region, USA. In 2013, application of Ethrel at 300 mg·L-1 did not affect fruit set, fruit weight, diameter (D), length(L), or L/D ratio 34 days after application, or yield, fruit weight, color, russet, and starch degradation pattern (SDP) at harvest, while application of ACC at 150 mg·L-1 or higher reduced fruit set by 19% to 34% in “Buckeye Gala” apple. In this cultivar, application of ACC at 350 mg·L-1 significantly increased fruit weight, diameter and length 34 days after application, and increased fruit weight, color, and SDP at harvest time. Application of ACC at all rates reduced total yield per tree in “Buckeye Gala”. Application of ACC at 300 mg·L-1 significantly reduced fruit set but applications of 150 mg·L-1 or 300 mg·L-1 ACC did not affect yield or quality attributes of “Sun Fuji” apple in Sunny Slope area in 2013. Application of ACC reduced fruit set and slightly increased fruit size in “Top Export Fuji” in 2013. Application of ACC at 600 mg·L-1 significantly reduced fruit set in “Aztec Fuji” apple in 2014. Application of ACC in a season never reduced bloom density (return bloom) of the next season. Overall, we conclude that ACC is an excellent tool as a late-season post-bloom fruit thinner and can be effective when applied

关键词： Bio-Regulators Crop Load Adjustment Ethylene Thinning

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Higher rates of autism and attention deficit/hyperactivity disorder in American children:Are food quality issues impacting epigenetic inheritance?

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World journal of Clinical Pediatrics 2023年第2期12卷 25-37页

作者： Renee j Dufault Raquel A Crider Richard C Deth Roseanne Schnoll steven G Gilbert Walter j Lukiw Amanda L Hitt Department of Research Food Ingredient and Health Research InstituteNaalehuHI 96772United States College of Graduate Health Studies A.T.Still UniversityKirksvilleMO 63501United States Department of Pharmaceutical Sciences Nova Southeastern UniversityFort LauderdaleFL 33314United States Department of Health and Nutrition Sciences Brooklyn College of CUNYBrooklynNY 11210United States Department of Research Institute of Neurotoxicology and Neurological DisordersSeattleWA 98105United States LSU Neuroscience Center Louisiana State University Health Sciences CenterNew OrleansLA 70112United States Food Integrity Campaign Government Accountability ProjectColumbiaWA 20006United States Department of Legal Food Ingredient and Health Research InstituteNaalehuHI 96772United States

In the United States,schools offer special education services to children who are diagnosed with a learning or neurodevelopmental disorder and have difficulty meeting their learning *** may play a key role in helping children access special education *** number of children ages 6-21 in the United States receiving special education services increased 10.4%from 2006 to *** receiving special education services under the autism category increased 242%during the same *** demand for special education services for children under the developmental delay and other health impaired categories increased by 184%and 83%*** student enrollment in American schools has remained stable since 2006,the percentage distribution of children receiving special education services nearly tripled for the autism category and quadrupled for the developmental delay category by *** heavy metal residues remain persistent in the American food supply due to food ingredient manufacturing *** clinical trial data indicate heavy metal exposures and poor diet are the primary epigenetic factors responsible for the autism and attention deficit hyperactivity disorder *** heavy metal exposures,especially inorganic mercury and lead may impact gene behavior across *** 2021,the United States Congress found heavy metal residues problematic in the American food supply but took no legislative *** health warning labels on select foods may be the only way to reduce dietary heavy metal exposures and improve child learning across generations.

关键词： Lead exposure Mercury Oxidative stress Methylation patterns Epigenetic inheritance Autism

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Activation of Plasma Membrane NADPH Oxidase and Generation of H_2O_2 Mediate the Induction of PAL Activity and Saponin Synthesis byEndogenous Elicitor in Suspension-Cultured Cells of Panax ginseng

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Acta Botanica Sinica 2003年第12期45卷 1434-1441页

作者：胡向阳 steven j NEILL 蔡伟明汤章城中国科学院上海生命科学研究院植物生理生态研究所上海200032 CentreforResearchinPlantScience UniversityoftheWestofEnglandBristolColdharbourLaneBristolBS161QYUnitedKingdom

Endogenous elicitor, termed cellulase-degraded cell wall (CDW), was prepared from the cell wall of suspension-cultured ginseng (Panax ginseng C.A. Meyer) cells via cellulase degradation. CDW activated the NADPH oxidase activity of isolated plasma membranes and stimulated in vivo H2O2 generation in ginseng cell suspensions. CDW also increased the activity of phenylalanine ammonia lyase (PAL), expression of a P. ginseng squalene epoxidase (sqe) gene and saponin synthesis. NADPH oxidase inhibitors inhibited both in vitro NADPH oxidase activity and in vivo H2O2 generation. Induction of PAL activity, saponin synthesis and sqe gene expression were all inhibited by such inhibitor treatments and reduced by incubation with catalase and HA scavengers. These data indicate that activation of NADPH oxidase and generation of H2O2 are essential signalling events mediating defence responses induced by the endogenous elicitor(s) present in CDW.

关键词： plasma membrane NADPH oxidase H2O2 elicitor Panax ginseng

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MgCl2和Gpp（NH）p对腺苷A1受体激动剂和拮抗剂结合的作用比较（英文）

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Acta Pharmacologica Sinica 2003年第8期24卷 3-14+110页

作者： Keith FINLAYSON,MAEMOTO Takuya,steven P BUTCHER,john SHARKEY,Henry j OLVERMAN Fujisawa Institute of Neuroscience Fujisawa Institute of Neuroscience Fujisawa Institute of Neuroscience Division of Neuroscience University of Edinburgh Level 6 Appleton Tower Crichton Street. Edinburgh EH8 9LE UK Division of Neuroscience University of Edinburgh Level 6 Appleton Tower Crichton Street. Edinburgh EH8 9LE UK

AIM: To investigate modulation of antagonist and agonist binding to adenosine A1receptors by MgCl2and 5'-guanylimidodiphosphate (Gpp（NH）p) using rat brain membranes and the A1antagonist [3H]-8-cyclopentyl-1,3-dipropylxanthine （[3H]DPCPX） and the A1agonist [3H]-2-chloro-N6-cyclopentyladenosine （[3H]CCPA）. METHODS: Parallel saturation and inhibition studies were performed using well-characterised radioligand binding assays and a Brandel Cell Harvester. RESULTS: MgCl2produced a concentration-dependent decrease （44%）, whereas Gpp（NH）p increased [3H]DPCPX binding （19%）. In [3H]DPCPX competition studies, agonist affinity was 1.5-14.6-fold higher and 4.6-10-fold lower in the presence of 10 mmol/L MgCl2and 10 μmol/L Gpp（NH）p respectively; antagonist affinity was unaffected. The decrease in agonist affinity with increasing Gpp（NH）p concentrations was due to a reduction in the proportion of binding to the high affinity receptor state. In contrast to [3H]DPCPX, MgCl2produced a concentration-

关键词：嘌呤P1受体放射配位体测定氯化镁鸟苷酰亚氨二磷酸脑

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FC-DIRECTED ANTIBODY CONjUGATION OF MAGNETIC NANOPARTICLES FOR ENHANCED MOLECULAR TARGETING

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journal of Innovative Optical Health Sciences 2009年第4期2卷 387-396页

作者： ROBABEH REZAEIPOOR RENU jOHN steven G.ADIE ERIC j.CHANEY MARINA MARjANOVIC AMY L.OLDENBURG STEPHANIE A.RINNE STEPHEN A.BOPPART Biophotonics Imaging Laboratory Beckman Institute for Advanced Science and Technology University of Illinois at Urbana-Champaign UrbanaILUSA Departments of Electrical and Computer Engineering Bioengineeringand Internal Medicine University of Illinois at Urbana-Champaign UrbanaILUSA

In this study, we report the fabrication of engineered iron oxide magnetic nanoparticles (MNPs)functionalized with anti-human epidermal growth factor receptor type 2 (HER2) antibody totarget the tumor antigen HER2. The Fc-directed conjugation of antibodies to the MNPs aidstheir efficient immunospecific targeting through free Fab portions. The directional specificity ofconjugation was verified on a macrophage cell line. Immunofluorescence studies on macrophagestreated with functionalized MNPs and free anti-HER2 antibody revealed that the antibodymolecules bind to the MNPs predominantly through their Fc portion. Different cell lines with different HER2 expression levels were used to test the specificity of our functionalized nanoprobe formolecular targeting applications. The results of cell line targeting demonstrate that these engineered MNPs are able to differentiate between cell lines with different levels of HER2 expression.

关键词： Nanoprobe molecular imaging cancer

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The impact of COVID-19 on clinical outcomes of burn patients

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Burns & Trauma 2023年第1期11卷 792-799页

作者： Elliot T.Walters Alen Palackic Camila Franco-Mesa Nikhil R.Shah Michael j.Erickson steven E.Wolf Department of Surgery University of Texas Medical Branch301 UniversityGalvestonTXUSA Division of Plastic Aesthetic and Reconstructive SurgeryDepartment of SurgeryMedical University of GrazGrazAustria

Background:Multiple studies have shown the SARS-CoV-2 virus(COVID-19)to be associated with deleterious outcomes in a wide range of *** impact of COVID-19 has not been well investigated among burned *** suspect that patients will have worsened respiratory and thrombotic complications,ultimately leading to increased *** objective of this study is to determine the impact a concurrent infection of COVID-19 has on clinical outcomes after a burn ***:This is a retrospective,propensity matched,cohort *** examined a de-identified database of electronic medical records of over 75 million patients across 75 health care associations in the United States for patients treated for thermal burns from 1 january 2020,to 31 july 2021,and those who also were diagnosed with COVID-19 infection within one day before or after injury based on International Classification of Disease,tenth revision(ICD-10)*** participants included adults who were treated for a burn injury during the study ***:We included 736 patients with burn injury and concomitant COVID-19 infection matched to 736 patients with burn injury and no concurrent COVID-19 infection(total 1472 patients,mean age 36.3±24.3).We found no significant increase in mortality observed for patients with concurrent COVID-19(OR 1.203,95%CI 0.517-2.803;p=0.6675).We did observe significant increase in infections(OR 3.537,95%CI 2.798-4.471;p=0.0001),thrombotic complications(OR 2.342,95%CI 1.351-4.058;p=0.0018),as was the incidence of hypertrophic scarring(OR 3.368,95%CI 2.326-4.877;p=0.0001).Conclusions:We observed that concurrent COVID-19 infection was associated with an increase in infections,thrombosis and hypertrophic scarring but no increase in mortality in our cohort of burn patients.

关键词： COVID-19 infection mortality burn thrombosis scarring

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Oncoselectivity in Oncolytic Viruses against Colorectal Cancer

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journal of Cancer Therapy 2014年第13期5卷 1153-1174页

作者： steven j. Conrad Karim Essani Laboratory of Virology Department of Biological Sciences Western Michigan University Kalamazoo USA

In humans colorectal cancer (CRC) is a significant cause of morbidity and mortality. New treatment options are urgently needed to supplement existing therapies. Replication-competent oncolytic viruses (RCOVs) for the treatment of cancerous tumors?in vivo?is a relatively new therapeutic modality with great but largely unrealized potential against CRC. In the context of oncolytic virus safety, oncoselectivity is an important criterion. It is at the conceptual intersection of viral replication strategy and tumor cell biology that RCOVs acquire their oncoselectivity, and thus their safety. Every aspect of tumor molecular biology which distinguishes it from normal, non-neoplastic cells is a potential target for exploitation. In the first section of this review we will provide an explanation of some of the successful and widely used strategies for improving oncoselectivity in wild-type viruses to make them more suitable as RCOVs. In the second section we will describe some of the characteristics of CRC biology which can be exploited to provide oncoselectivity against CRC. Throughout the review examples of successfully-engineered RCOVs which embody the approach or strategy under discussion are noted. By showing what has been done, we hope to highlight what is possible and what remains to be done to generate oncoselective RCOVs for use against CRC in humans.

关键词： Colorectal Cancer Replication-Competent Oncolytic Virus Oncoselectivity Virotherapy

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Radiofrequency electric-field heating behaviors of highly enriched semiconducting and metallic single-walled carbon nanotubes

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Nano Research 2015年第9期8卷 2859-2870页

作者： Stuart j. Corr Mustafa Raoof Brandon T. Cisneros Alvin W. Orbaek Matthew A. Cheney justin j. Law Nadia C. Lara Andrew R. Barron Lon j. Wilsor steven A. Curley Division of Surgery Baylor College of Medicine Houston TX 77030 USA Department of Surgical Oncology University of Texas M.D. Anderson Cancer Center Houston TX 77030 USA Department of Chemistry and the Richard E. Smalley Institute for Nanoscale Science and Technology Rice University Houston TX 77005 USA Department of Surgery The University of Arizona College of Medicine Tucson AZ 85724 USA Department of Chemistry and Biochemistry University of California San Diego La Jolla CA 92093 USA College of Engineering Swansea University Singleton Park Swansea SA2 8PP Wales UK Department of Mechanical Engineering and Materials Science Rice University Houston TX 77005 USA

It is theorized that enhanced thermal heating may result from exposing single-walled carbon nanotubes （SWNTs） embedded in a conductive host to radiofrequency （RF） electric fields. We examine the RF-induced （13.56 MHz） heating behaviors of 95% metallic- and semiconducting-enriched SWNTs （m-/s-SWNTs） suspended in aqueous solutions with varying NaC1 molarity （0.001 mM-1 M）. The heating effects were only evident for host molarities below 1 mM （equivalent to 0.1 S/m） at which the s-SWNT heating rates dominated those of the m-SWNTs. The heating effects were localized to aligned and aggregated ＂SWNT ropes＂ -1 cm in length that formed in suspension, parallel to the electric-field vector, during the RF exposure. For molarities above 1 mM, no enhancements were evident, owing to the large heating effects of the bulk ionic NaC1 suspensions, which were observed in previous studies. Although larger enhancement effects proportional to the host conductivity have been theoretically predicted for m-/s-SWNT suspensions, this was not observed most likely because of the aggregation and screening effects, which diminished the scattered electric field near the m-/s-SWNTs. Our research may further the development of better nanoparticle heating agents for applications such as non-invasive RF-induced cancer hyperthermia.

关键词： rad.iofrequency,carbon nanotubes,metallic,semiconducting,hyperthermia

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Role of extracellular vesicles secretion in paclitaxel resistance of prostate cancer cells

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Cancer Drug Resistance 2022年第3期5卷 612-624页

作者： Ashish Kumar Pawan Kumar Mitu Sharma Susy Kim Sangeeta Singh steven j.Kridel Gagan Deep Department of Cancer Biology Atrium Health Wake Forest BaptistWinston-SalemNC 27157USA Division of Pathology Indian Veterinary Research InstituteIzatnagarBareillyUP 243122India Wake Forest Baptist Comprehensive Cancer Center Atrium Health Wake Forest BaptistWinston-SalemNC 27157USA

Aim:The development of chemotherapy resistance is the major obstacle in the treatment of advanced prostate cancer(PCa).Extracellular vesicles(EVs)secretion plays a significant role among different mechanisms contributing to ***,inhibition of EVs release may increase the efficacy of chemotherapeutic drugs against ***:Paclitaxel(PTX)resistant PCa cells(PC3-R and DU145-R)were treated with GW4869,a known exosome biogenesis *** were isolated from the conditioned media by ExoQuick-based precipitation method and characterized for concentration and size distribution by nanoparticle tracking *** effect of GW4869 treatment on the survival and growth of PCa cells was assessed by MTT,and colony formation assays in vitro,and ectopic PC3-R xenografts in male athymic nude mice in *** effect of other EV biogenesis inhibitors,imipramine and dimethyl amiloride(DMA),treatment was also analyzed on the survival of PC3-R ***:GW4869(10-20μM)treatment of PTX resistant PCa cells significantly reduced the release of small EVs(50-100 nm size range)while increasing the release of larger EVs(>150 nm in size),and inhibited their ***,GW4869(5-20μM)treatment(24-72h)significantly inhibited the survival of PC3-R cells in a dose-dependent *** observed a similar growth inhibition with both imipramine(5-20μg/mL)and DMA(5-20μg/mL)treatment in PC3-R ***,GW4869 treatment(IP)in mice bearing PC3-R xenografts significantly reduced the tumor weight(65%reduction,P=0.017)compared to the vehicle-treated control mice without causing any noticeable ***:Inhibiting the release of EVs could sensitize the resistant PCa cells to chemotherapy.

关键词： Prostate cancer extracellular vesicles GW4869 chemoresistance paclitaxel

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