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Journal of Cance. The.apy 2021年第7期12卷 409-423页

作者： Justin D. Ande.son Jiuyun Hu Jing Li steven e. schild Mire. Fatyga De.artme.t of Radiation Oncology Mayo Clinic Phoenix Arizona USA School of Computing Informatics and Decision Systems Engineering Tempe Arizona USA School of Industrial and Syste.s e.gine.ring Georgia Institute of Technology Atlanta Georgia USA

Purpose. To e.amine.possible.association be.we.n he.rt irradiation and Ove.all Survival (OS) in lung SBRT patie.ts and to compare.obse.ve. associations with cardiac toxicity mode.s pre.iously de.ive. in LA-NSCLC patie...

Purpose. To examine possible association between heart irradiation and Overall Survival (OS) in lung SBRT patients and to compare observed associations with cardiac toxicity models previously derived in LA-NSCLC patient studies. Materials and Methods: 197 Patients treated with lung SBRT at Mayo Clinic Arizona were selected for this IRB-approved study. Multivariate Cox model with Akaike Information Criterion (AIC) was used to select patient specific covariates associated with OS. Heart dosimetry was represented by VD indices, which is a percentage of volume exposed to dose D or greater. Multivariate Cox models with patient e."font-family:Ve.dana;">e."font-family:Ve.dana;">e."font-family:Ve.dana;">spe.ific cova

关键词： Lung Cance. Lung SBRT Cardiac Toxicity Lung Radiation The.apy Non-Small Ce.l Lung Cance.

Statins and Me.formin Use.Is Associate. with Lowe. PSA Le.e.s in Prostate.Cance. Patie.ts Pre.e.ting for Radiation The.apy

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Journal of Cance. The.apy 2017年第2期8卷 73-85页

作者： Xiaonan Liu Jing Li steven e. schild Michae. H. schild William Wong Sujay Vora Michae. G. He.man Mire. Fatyga School of Computing Informatics Decision Systems Engineering Arizona State University Tempe AZ USA De.artme.t of Radiation Oncology Mayo Clinic Arizona Phoenix AZ USA De.artme.t of Radiation Oncology Mayo Clinic Rochester AZ USA

Background: A possible.association be.we.n the.le.e. of prostate.spe.ific antige. (PSA) and the.use.of some.commonly pre.cribe. me.ications has be.n re.orte. in re.e.t studie.. Most of the.e.studie. we.e.carrie. out in ge.e.al populations of me. who we.e.scre.ne. for prostate.cance. using the.PSA te.t. We.re.orte. on the.association be.we.n the.initial PSA le.e. and the.use.of statins, me.formin and alpha-blocke.s in patie.ts who we.e.diagnose. with prostate.cance. and pre.e.te. for radiation the.apy. Me.hods: Thre. hundre. and e.ghty one.patie.ts tre.te. be.we.n the.ye.rs of 2000-2005 and 2009-2012 we.e.include. in this re.rospe.tive.study. The.information about statin, me.formin and alpha-blocke.s use.was re.orde. imme.iate.y prior to tre.tme.t. Diffe.e.ce. in PSA le.e.s prior to tre.tme.t by me.ication status we.e.e.timate. using univariate.and multivariate.line.r re.re.sion on log PSA value.. Re.ults: Compare. with me. who we.e.not on the.e.me.ications, the.PSA le.e. at pre.e.tation was 20% lowe. for statin use.s (p = 0.002) and 33% lowe. for me.formin use.s (p = 0.004). We.did not obse.ve.statistically significant associations be.we.n the.use.of statins or me.formin and cance. stage. National Compre.e.sive.Cance. Ne.work (NCCN) risk score. or the.apy outcome. A statistically significant association be.we.n the.NCCN risk score.and the.use.of alpha-blocke.s was obse.ve. (p = 0.002). Conclusions: We.found that statins and me.formin we.e.associate. with lowe. PSA le.e.s in prostate.cance. patie.ts to an e.te.t that could influe.ce.manage.e.t de.isions. We.found no statistically significant associations be.we.n the.use.of the.e.me.ications and tre.tme.t outcome..

关键词： PSA Statins Me.formin Prostate Cance.

Using Nove. Statistical Te.hnique. to Accurate.y De.e.mine.the.Pre.ictive.Dose.Range.in a Study of Ove.all Survival afte. De.initive.Radiothe.apy for Stage.III Non-Small Ce.l Lung Cance. in Association with He.rt Dose

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Journal of Cance. The.apy 2021年第9期12卷 505-529页

作者： Joshua R. Niska Jiuyun Hu Jing Li Michae. G. He.man Came.on S. Thorpe.steven e. schild Mire. Fatyga De.artme.t of Radiation Oncology Banner MD Anderson Cancer Center Phoenix Arizona USA School of Computing Informatics and Decision Systems Engineering Tempe Arizona USA School of Industrial and Syste.s e.gine.ring Georgia Institute of Technology Atlanta Georgia USA De.artme.t of Radiation Oncology Mayo Clinic Rochester Minnesota USA De.artme.t of Radiation Oncology Mayo Clinic Phoenix Arizona USA

Purpose. Re.e.t studie. of radiothe.apy (RT) for stage.III non-small-ce.l lung cance. (NSCLC) have.associate. high dose.to the.he.rt with cardiac toxicity and de.re.se. ove.all survival (OS). We.use. advance. statisti... 详细信息

Purpose. Recent studies of radiotherapy (RT) for stage III non-small-cell lung cancer (NSCLC) have associated high dose to the heart with cardiac toxicity and decreased overall survival (OS). We used advanced statistical techniques to account for correlations between dosimetric variables and more accurately determine the range of heart doses which are associated with reduced OS in patients receiving RT for stage III NSCLC. Methods: From 2006 to 2013, 119 patients with stage III NSCLC received definitive RT at our institution. OS data was obtained from institutional tumor registry. We used multivariate Cox model to determine patient specific covariates predictive for reduced overall survival. We examined age, prescription dose, mean lung dose, lung V20, RT technique, stage, chemotherapy, tumor laterality, tumor volume, and tumor site as candidate covariates. We subsequently used novel statistical techniques within multivariate Cox model to systematically search the whole heart dose-volume histogram (DVH) for dose parameters associated with OS. Results: Patients were followed until death or 2.5 to 81.2 months (median 30.4 months) in those alive at last follow up. On multivariate analysis of whole heart DVH, the dose of 51 Gy was identified as a threshold dose above which the dose volume relationship becomes predictive for OS. We identified

关键词： Lung Cance. Cardiac Toxicity Lung Radiation The.apy Non-Small Ce.l Lung Cance. Radiation Toxicity

DNA alkylation promote. by an e.e.tron-rich quinone.me.hide. inte.me.iate

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Frontie.s of Che.ical Scie.ce.and e.gine.ring 2016年第2期10卷 213-221页

作者： Che.gyun Huang steven e. Rokita De.artme.t of Che.istry and Bioche.istry University of Maryland College Park MD 20742 USA Sichuan Institute.of Ge.logical e.gine.ring Inve.tigation Chengdu 610072 China De.artme.t of Che.istry Johns Hopkins University Baltimore MD 21218 USA

Biological application of conjugate. de.ive. from oligonucle.tide. and quinone.me.hide. have.pre. viously be.n limite. by the.slow e.change.of the.r covale.t se.f-adducts and subse.ue.t alkylation of targe. nucle.c acids. To e.hance.the.rate. of the.e.proce.se., a ne. quinone.me.hide.pre.ursor with an e.e.tron donating substitue.t has be.n pre.are.. Additionally, this substi- tue.t has be.n place. para to the.nasce.t e.o-me.hyle.e.group of the.quinone.me.hide.for maximum e.fe.t. A conjugate.made.from this pre.ursor and a 5＇-aminohe.- yloligonucle.tide.acce.e.ate. formation of its re.e.sible.se.f-adduct and alkylation of its comple.e.tary DNA as pre.icte. from prior mode. studie..

关键词： quione.me.hide DNA alkylation re.e.sible.covale.t re.ction bioconjugation targe.-dire.te. modification of nucle.c acids

Ge.e.ic variability of the.stable.fly asse.se. on a global scale.using amplifie. fragme.t le.gth polymorphism

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Inse.t Scie.ce 2016年第5期23卷 695-703页

作者： Kathle.n M Kne.land steven R. Skoda John e. Foste. De.artme.t of e.tomology 103 Entomology Haft University of Nebraska-Lincoln Lincoln NE 68583 USDA-ARS-KBUSLIRL Scre.worm Re.e.rch Unit 2700 Fredericksburg Road Kern/ille TX 78028 USA

The.stable.fly, Stomoxys calcitrans （L.）（Dipte.a： Muscidae., is a blood-fe.ding, e.onomically important pe.t of animals and humans worldwide. Improve. manage.e.t strate.ie. are.e.se.tial and the.r de.e.opme.t would be.e.it from studie. on ge.e.ic di- ve.sity of stable.flie.. e.pe.ially if done.on a global scale. such re.e.rch could ge.e.ate.information ne.e.sary for the.de.e.opme.t and application of more.e.ficie.t control me.h- ods. He.e.n we.re.ort on a ge.e.ic study of stable.flie. using amplifie. fragme.t le.gth polymorphism, with sample. of 10-40 individuals acquire. from a total of 25 locations in the.Ne.rctic, Ne.tropic, Pale.rctic, Afrotropic and Australasian bioge.graphical re.ions. We.hypothe.ize. that ge.e.ic diffe.e.tiation would e.ist across ge.graphical barrie.s. Although Fsx （0.33） was mode.ate.y high, the.Gsx （0.05; re.re.e.ting ge.e.ic dive.sity be.we.n individuals） was ve.y low; Nm value. （re.re.e.ting ge.e.flow） we.e.high （9.36）. The.mismatch distribution and te.ts of ne.trality sugge.te. population e.pansion, with no ge.e.ic diffe.e.tiation be.we.n locations. The.analysis of mole.ular variance.（AMOVA） re.ults showe. the.majority of ge.e.ic dive.sity was within groups. The.mante. te.t showe. no corre.ation be.we.n ge.graphic and ge.e.ic distance. this strongly supports the.AMOVA re.ults. The.e.re.ults sugge.t that stable.flie. did not show ge.e.ic diffe.e.tiation but are.panmictic, with no e.ide.ce.of isolation by distance.or across ge.graphical barrie.s.

关键词： AFLP biting flie. e.te.nal parasite. ge.e.ic dive.sity live.tock pe.ts Stomoxys calcitrans

Se.e. possible.state. of ge.spatial data with re.pe.t to map proje.tion and de.inition: a nove. pe.agogical de.ice.for GIS e.ucation

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Ge.-Spatial Information Scie.ce 2018年第4期21卷 288-293页

作者： steven e.Gre.o De.artme.t of Human e.ology University of CaliforniaDavisCAUSA

Conce.tually,the.the.ry and imple.e.tation of“map proje.tion”in ge.graphic information syste.(GIS)te.hnology is difficult to compre.e.d for most introductory stude.ts and novice.*** this difficulty is the.conce.t of a“map proje.tion file.that de.ine. map proje.tion parame.e.s of ge.-spatial *** proble. of the.missing proje.tion file.appe.rs ubiquitous for all use.s,e.pe.ially in practice.whe.e.data is wide.y *** common proble. is inadve.te.t misapplication of the.De.ine.Proje.tion”tool that can re.ult in a GIS datase. with an incorre.tly de.ine. map proje.tion *** e.ucation should provide.more.guidance.in diffe.e.tiating the.conce.ts of map proje.tion ve.sus proje.tion file. by incre.sing unde.standing and minimizing common e.rors.A nove. pe.agogical de.ice.is introduce. in this pape.:the.se.e. possible.state. of GIS data with re.pe.t to map proje.tion and *** se.e. possible.state. are.(1)a proje.te. coordinate.syste.(PCS)that is corre.tly de.ine.,(2)a PCS that is incorre.tly de.ine.,(3)a PCS that is unde.ine.,(4)a ge.graphic coordinate.syste.(GCS)that is corre.tly de.ine.,(5)a GCS that is incorre.tly de.ine.,(6)a GCS that is unde.ine.,and(7)a *** cre.te. automate. trouble.hooting tools to de.e.mine.a missing map proje.tion file.are.discusse..

关键词： GIS e.ucation map proje.tion e.ror map proje.tion file de.ine.proje.tion

Scale. of snow de.th variability in high e.e.ation range.and sage.rush

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Frontie.s of e.rth Scie.ce 2017年第3期11卷 469-481页

作者： Molly e. Te.e.CHe.steven R. FASSNACHT Paul J. Me.MAN Wate.she. Scie.ce Department of Ecosystem Science and Sustainability Colorado State University Fort Collins CO 80523-1476 USA Inte.ational Arctic Re.e.rch Ce.te. Water & Environmental Research Center Institute of Northern Engineering University of Alaska Fairbanks Fairbanks AK 99775 USA Coope.ative.Institute.for Re.e.rch in the.Atmosphe.e Fort Collins CO 80523-1375 USA Natural Re.ource. e.ology Laboratory Fort Collins CO 80523-1499 USA Abt. Kartographie GIS & Femerkundung Geographisches Institut Georg-August-Universitat Gottingen 37077 Gottingen Germany Range.and e.osyste. Scie.ce Department of Forest and Rangeland Stewardship Colorado State University Fort Collins CO 80523 USA

In high e.e.ation se.i-arid range.ands, sage. brush and othe. shrubs can affe.t transport and de.osition of wind-blown snow, e.abling the.formation of snowdrifts. Datase.s from thre. fie.d e.pe.ime.ts we.e.use. to inve.tigate.the.scale. of spatial variability of snow de.th around big mountain sage.rush （Arte.isia tride.tata Nutt.） at a high e.e.ation plate.u range.and in North Park, Colorado, during the.winte.s of 2002, 2003, and 2008. Data we.e.colle.te. at multiple.re.olutions （0.05 to 25 m） and e.te.ts （2 to 1000 m）. Fine. scale.data we.e.colle.te. spe.ifically for this study to e.amine.the.corre.ation be.we.n snow de.th; sage.rush microtopogra- phy, the.ground surface. and the.snow surface. as we.l as the.te.poral consiste.cy of snow de.th patte.ns. Vario- grams we.e.use. to ide.tify the.spatial structure.and the.Moran＇s I statistic was use. to de.e.mine.the.spatial corre.ation. Re.ults show some.te.poral consiste.cy in snow de.th at se.e.al scale.. Plot scale.snow de.th variability is partly a function of the.nature.of individual shrubs, as the.e.is some.corre.ation be.we.n the.spatial structure.of snow de.th and sage.rush, as we.l as be.we.n the.ground and snow de.th. The.optimal sampling re.olution appe.rs to be.25-cm, but ove. a large.are., this would re.uire.a multitude.of sample., and thus a random stratifie. approach is re.omme.de. with a fine.me.sure.e.t re.olution of 5-cm.

关键词： snow hydrology high e.e.ation range.ands,spatial statistics variograms snow pack spatial variability,snow drifts

Nutrition and me.abolism in burn patie.ts

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Burns & Trauma 2017年第2期5卷 95-106页

作者： Audra Clark Jonathan Imran Tarik Madni steven e. Wolf Unive.sity of Te.as Southwe.te.n Me.ical Ce.te. 5323 Harry Hines Blvd.Dallas TX 75390 USA

Se.e.e.burn cause. significant me.abolic de.ange.e.ts that make.nutritional support unique.y important and challe.ging for burne. patie.ts. Burn injury cause. a pe.siste.t and prolonge. hype.me.abolic state.and incre.se. catabolism that re.ults in incre.se. muscle.wasting and cache.ia. Me.abolic rate. of burn patie.ts can surpass twice.normal, and failure.to fulfill the.e.e.e.gy re.uire.e.ts cause. impaire. wound he.ling, organ dysfunction,and susce.tibility to infe.tion. Ade.uate.asse.sme.t and provision of nutritional ne.ds is impe.ative.to care.for the.e.patie.ts. The.e.is no conse.sus re.arding the.optimal timing, route. amount, and composition of nutritional support for burn patie.ts, but most clinicians advocate.for e.rly e.te.al nutrition with highcarbohydrate.*** support must be.individualize., monitore., and adjuste. throughout re.ove.y. Furthe. inve.tigation is ne.de. re.arding optimal nutritional support and accurate.nutritional e.dpoints and goals.

关键词： Burn Nutrition Me.abolism Critical care

Proton be.m the.apy for locally advance. lung cance.: A re.ie.

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World Journal of Clinical Oncology 2014年第4期5卷 568-575页

作者： steven e.schild William G Rule.Jonathan B Ashman Sujay A Vora Same.r Ke.le.Aman Anand We. Liu Martin Bue. De.artme.t of Radiation Oncology Mayo Clinic Arizona ScottsdaleAZ 85259 United States

Protons inte.act with human tissue.diffe.e.tly than do photons and the.e.diffe.e.ce. can be.e.ploite. in an atte.pt to improve.the.care.of lung cance. patie.ts. This re.ie. e.amine. proton be.m the.apy(PBT) as a compone.t of a combine. modality program for locally advance. lung cance.s. It was spe.ifically writte. for the.non-radiation oncologist who de.ire. gre.te. unde.standing of this ne.e. tre.tme.t modality. This re.ie. de.cribe. and compare. photon(X-ray) radiothe.apy(XRT) to PBT. The.physical diffe.e.ce. of the.e.be.ms are.de.cribe. and the.clinical lite.ature.is re.ie.e.. Protons can be.use. to cre.te.tre.tme.t plans de.ive.ing significantly lowe. dose. of radiation to the.adjace.t organs at risk(lungs, e.ophagus, and bone.marrow) than photons. Clinically, PBT combine. with che.othe.apy has re.ulte. in low rate. of toxicity compare.to XRT. e.rly re.ults sugge.t a possible.improve.e.t in survival. The.clinical re.ults of proton the.apy in lung cance. patie.ts re.e.l re.ative.y low rate. of toxicity and possible.survival be.e.its. One.randomize. study is be.ng pe.forme. and anothe. is planne. to clarify the.clinical diffe.e.ce. in patie.t outcome.for PBT compare. to XRT. Along with the.de.e.opme.t of be.te. syste.ic the.apy, ne.e. forms of radiothe.apy such as PBT should positive.y impact the.care.of lung cance. patie.ts. This re.ie. provide. the.re.de. with the.curre.t status of this ne. te.hnology in tre.ting locally advance. lung cance..

关键词： Protons Proton be.m the.apy Lung cance. Photons X-rays 3-D radiothe.apy Inte.sity modulate. photon radiothe.apy Inte.sity modulate. radiothe.apy Inte.sity modulate. proton the.apy

A Surve. of Unbalance. Flow Diagnostics and The.r Application

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Advance. in Atmosphe.ic Scie.ce. 2000年第2期17卷 165-183页

作者： Fuqing Zhang steven e. Koch Christophe. A. Davis and Michae. L. Kaplan De.artme.t of Marine Earth and Atmospheric Sciences North Carolina State University Raleigh NC

This pape. pre.e.ts an e.te.sive.surve. of the.most commonly use. tools for diagnosing unbalance. flow in the.atmosphe.e. name.y the.Lagrangian Rossby numbe., Psi ve.tor, dive.ge.ce.e.uation, nonline.r balance.e.uation, ge.e.alize. ome.a-e.uation, and de.arture.from fie.ds obtaine. by pote.tial vorticity (PV) inve.sion. The.basic thoe.y, assumptions as we.l as imple.e.tation and limitations for e.ch of the.tools are.all discusse.. The.e.tools are.applie. to high—re.olution me.oscale.mode. data to asse.s the.role.of unbalance. dynamics in the.ge.e.ation of a me.oscale.gravity wave.e.e.t ove. the.e.st Coast of the.Unite. State.. Comparison of the.e.tools in this case.study shows that the.e.various me.hods agre. to a large.e.te.t with e.ch othe. though the. diffe. in de.ails. Ke. words Unbalance. flow - Ge.strophic adjustme.t - Gravity wave. - Nonline.r balance.e.uation - Pote.tial vorticity inve.sion - Ome.a e.uations - Rossby numbe. This re.e.rch was conducte. unde. support from NSF grant ATM-9700626 of the.Unite. State.. The.nume.ical computations de.cribe. he.e.n we.e.pe.forme. on the.Cray T90 at the.North Carolina Supe.computing Ce.te. and the.Cray supe.compute. at the.NCAR Scie.tific Computing Division, which also provide. the.initialization fie.ds for the.MM5. Thanks are.e.te.de. to Mark Stoe.inga at Unive.sity of Washington for the.RIP post-proce.sing package.

关键词： Unbalance. flow Ge.strophic adjustme.t Gravity wave. Nonline.r balance.e.uation Pote.tial vorticity inve.sion Ome.a e.uations Rossby numbe.