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Discovery and evaluation of a novel 18F-labeled vasopressin 1a receptor PET ligand with peripheral binding specificity

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Acta Pharmaceutica Sinica B 2024年第9期14卷 4014-4027页

作者： Junqi Hu Yinlong Li Chenchen Dong Huiyi Wei Kai Liao Junjie Wei Chunyu Zhao Ahmad Chaudhary Jiahui Chen Hao Xu Ke Zhong steven HLiang Lu Wang Weijian Ye Center of Cyclotron and PET Radiopharmaceuticals Department of Nuclear Medicine&Key Laboratory of Basic and Translational Research on Radiopharmaceuticalsthe First Affiliated Hospital of Jinan UniversityGuangzhou 510630China Department of Radiology and Imaging Sciences Emory UniversityAtlant1GA 30322USA Department of Pharmacy Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China

The arginine-vasopressin(AVP)hormone plays a pivotal role in regulating various physiological processes,such as hormone secretion,cardiovascular modulation,and social *** studies have highlighted the V1a receptor as a promising therapeutic ***-depth insights into V1a receptor-related pathologies,attained through in vivo imaging and quantification in both peripheral organs and the central nervous system(CNS),could significantly advance the development of effective V1a *** address this need,we develop a novel V1a-targeted positron emission tomography(PET)ligand,[18F]V1A-2303([18F]8),which demonstrates favorable in vitro binding affinity and selectivity for the V1a *** tracer binding in peripheral tissues was also confirmed through rigorous cell uptake studies,autoradiography,biodistribution ***,[18F]8 was employed in PET imaging and arterial blood sampling studies in healthy rhesus monkeys to assess its brain permeability and specificity,whole-body distribution,and kinetic *** research indicated[18F]8 as a valuable tool for noninvasively studying V1a receptors in peripheral organs,and as a foundational element for the development of next-generation,brain-penetrant ligands specifically designed for the CNS.

关键词： Vasopressin Autism V1a receptor Positron emission tomography PET imaging Radiolabeling Fluorine 18 Kinetic modeling

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Hepatic angiotensin-converting enzyme 2 expression in metabolic dysfunction-associated steatotic liver disease and in patients with fatal COVID-19

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World Journal of Gastroenterology 2024年第31期30卷 3705-3716页

作者： Angus K Jacobs steven D Morley Kay Samuel Katie Morgan Lyndsey Boswell Timothy J Kendall David A Dorward Jonathan A Fallowfield Peter C Hayes John N Plevris Hepatology Laboratory University of EdinburghEdinburgh EH164SBUnited Kingdom Scottish National Blood Transfusion Service Jack Copland CentreEdinburgh EH144BEUnited Kingdom Institute for Regeneration and Repair University of EdinburghEdinburgh EH164UUUnited Kingdom Edinburgh Pathology University of EdinburghEdinburgh EH164SBUnited Kingdom

BACKGROUND Metabolic dysfunction-associated steatotic liver disease(MASLD),characterised by hepatic lipid accumulation,causes inflammation and oxidative stress accompanied by cell damage and *** injury(LI)is also frequently reported in patients hospitalised with coronavirus disease 2019(COVID-19),while preexisting MASLD increases the risk of LI and the development of COVID-19-associated *** of injury at the cellular level remain unclear,but it may be significant that severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)which causes COVID-19,uses angiotensin-converting expression enzyme 2(ACE2),a key regulator of the‘anti-inflammatory’arm of the renin-angiotensin system,for viral attachment and host cell *** To determine if hepatic ACE2 levels are altered during progression of MASLD and in patients who died with severe *** ACE2 protein levels and localisation,and histological fibrosis and lipid droplet accumulation as markers of MASLD were determined in formalin-fixed liver tissue sections across the MASLD pathological spectrum(isolated hepatocellular steatosis,metabolic dysfunction-associated steatohepatitis(MASH)+/-fibrosis,end-stage cirrhosis)and in post-mortem tissues from patients who had died with severe COVID-19,using ACE2 immunohistochemistry and haematoxylin and eosin and picrosirius red staining of total collagen and lipid droplet areas,followed by quantification using machine learning-based image pixel *** ACE2 staining is primarily intracellular and concentrated in the cytoplasm of centrilobular hepatocytes and apical membranes of bile duct ***,ACE2 protein levels are elevated in non-fibrotic MASH compared to healthy controls but not in the progression to MASH with fibrosis and in ***2 protein levels and histological fibrosis are not associated,but ACE2 and liver lipid droplet content are significantly correlated across the MASLD *** A

关键词： Metabolic dysfunction-associated steatotic liver disease Angiotensin-converting enzyme 2 Immunohistochemistry COVID-19 COVID-19-associated cholangiopathy

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Fetal lung growth predicts the risk for early-life respiratory infections and childhood asthma

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World Journal of Pediatrics 2024年第5期20卷 481-495页

作者： Dimitra E.Zazara Olympia Giannou steven Schepanski Mirja Pagenkemper Anastasios D.Giannou Maike Pincus Ioannis Belios Stefan Bonn Ania C.Muntau Kurt Hecher Anke Diemert Petra Clara Arck Division for Experimental Feto-Maternal Medicine Department of Obstetrics and Fetal MedicineUniversity Medical Center Hamburg-Eppendorf(UKE)Martinistraße 5220251HamburgGermany University Children’s Hospital UKEHamburgGermany Computer Engineering and Informatics Department Polytechnic SchoolUniversity of PatrasPatrasGreece Institute of Developmental Neurophysiology Center for Molecular Neurobiology Hamburg(ZMNH)UKEHamburgGermany Department of Obstetrics and Fetal Medicine UKEHamburgGermany Department of General Visceral and Thoracic SurgeryUKEHamburgGermany Section of Molecular Immunology and Gastroenterology Ⅰ.Department of MedicineUKEHamburgGermany Pediatrics and Pediatric Pneumology Practice BerlinGermany Institute of Medical Systems Biology ZMNHUKEHamburgGermany Hamburg Center for Translational Immunology UKEHamburgGermany

Background Early-life respiratory infections and asthma are major health burdens during *** predicting an increased risk for early-life respiratory diseases are ***,we identified the predictive value of ultrasound-monitored fetal lung growth for the risk of early-life respiratory infections and *** Fetal lung size was serially assessed at standardized time points by transabdominal ultrasound in pregnant women participating in a pregnancy *** between fetal lung growth and respiratory infections in infancy or early-onset asthma at five years were ***-learning models relying on extreme gradient boosting regressor or classifier algorithms were developed to predict respiratory infection or asthma risk based on fetal lung *** model development and validation,study participants were randomly divided into a training and a testing group,respectively,by the employed *** Enhanced fetal lung growth throughout pregnancy predicted a lower early-life respiratory infection *** sex was associated with a higher risk for respiratory infections in *** lung growth could also predict the risk of asthma at five years of *** designed three machine-learning models to predict the risk and number of infections in infancy as well as the risk of early-onset *** models’R2 values were 0.92,0.90 and 0.93,respectively,underscoring a high accuracy and agreement between the actual and predicted *** variables included known risk factors and novel predictors,such as ultrasound-monitored fetal lung *** Sonographic monitoring of fetal lung growth allows to predict the risk for early-life respiratory infections and asthma.

关键词： Asthma Child risk Early-life respiratory infections Prenatal lung development Sexual dimorphism

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Generation of millijoule-level sub-5 fs violet laser pulses

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High Power Laser Science and Engineering 2024年第2期12卷 33-40页

作者： Xinhua Xie Yi Hung Yunpei Deng Adrian L.Cavalieri Andrius Baltuška steven L.Johnson SwissFEL Paul Scherrer InstituteVilligen PSISwitzerland Photonics Institute Technische Universität WienViennaAustria Institute of Applied Physics University of BernBernSwitzerland Institute for Quantum Electronics Physics DepartmentETH ZurichZurichSwitzerland

We demonstrate the generation,spectral broadening and post-compression of second harmonic pulses using a thin beta barium borate(BBO)crystal on a fused-silica substrate as the nonlinear interaction *** combining second harmonic generation in the BBO crystal with self-phase modulation in the fused-silica substrate,we efficiently generate millijoule-level broadband violet pulses from a single optical *** second harmonic spectrum covers a range from long wave ultraviolet(down to 310 nm)to visible(up to 550 nm)with a bandwidth of 65 ***,we compress the second harmonic beam to a duration of 4.8 fs with a pulse energy of 0.64 mJ(5 fs with a pulse energy of 1.05 mJ)using chirped *** all-solid free-space apparatus is compact,robust and pulse energy scalable,making it highly advantageous for generating intense second harmonic pulses from near-infrared femtosecond lasers in the sub-5 fs regime.

关键词： post-compression second harmonic generation self-phase modulation supercontinuum generation

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Pathways to carbon neutrality in the built environment: Phase change materials

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Green Carbon 2024年第2期2卷 197-204页

作者： Wenzhu Lin Xiaoxue Yao Wen Zhao Yiru Pu steven Wang Department of Mechanical Engineering City University of Hong KongHong KongChina

Phase change materials(PCMs)are increasingly capturing the spotlight in the realm of building design and construction owing to their capacity to absorb and release thermal energy throughout phase *** review provides a comprehensive overview of PCMs,outlining their properties and applications in improving energy efficiency,comfort,and sustainability in *** delves into various types of PCMs,discussing their selection criteria,integration methods,and their impact on indoor climate and energy *** exploration covers both passive and active PCM systems across diverse building components,including implications for walls,roofs,windows,and floors,and integrated heating,ventilation and air conditioning(HVAC)and solar energy ***,the review addresses challenges associated with PCM implementation in building applications while considering future prospects in this field.

关键词： Phase change material Building Latent heat Energy storage Energy saving

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异常热报告的确认

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电化学（中英文） 2024年第2期30卷 46-51页

作者： steven B.Krivit Melvin H.Miles New Energy Times 369-B 3rd St.#556San RafaelCA94901USA University of La Verne(Retired) 19503rd StLa VerneCA 91750USA

本文首次确认Nathan Lewis及其合作者于1989年5月1日在美国马里兰州巴尔的摩举行的美国物理学会(APS)会议上所犯的关键计算错误。Lewis等人分析了Martin Fleischmann及其合作者报告的9轮实验中的热测量结果,并报告在没有催化复合的情况... 详细信息

本文首次确认Nathan Lewis及其合作者于1989年5月1日在美国马里兰州巴尔的摩举行的美国物理学会(APS)会议上所犯的关键计算错误。Lewis等人分析了Martin Fleischmann及其合作者报告的9轮实验中的热测量结果,并报告在没有催化复合的情况下每轮实验都显示出异常的热功率损失。而本文使用相同的原始数据,经过正确的计算,再次确认每轮实验都显示出异常的功率增益。因此,这些数据意味着可能存在一种能产生能量的新物理现象。

关键词：低能核反应 LENR 超热

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80+款电影经典名表ICONIC WATCHES IN MOVIES

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钟表 2024年第2期 34-61页

作者： steven River 不详

不知道各位表迷是否都一样?每次看电影的时候,总会想知道主角们佩戴的是什么表。哪怕只有一个腕表特写镜头,当知道了是哪个品牌哪款表,便会很有满足感。手表在电影之中,有很重要的角色。它一方面代表角色的品味,亦暗示了角色的性格、社... 详细信息

不知道各位表迷是否都一样?每次看电影的时候,总会想知道主角们佩戴的是什么表。哪怕只有一个腕表特写镜头,当知道了是哪个品牌哪款表,便会很有满足感。手表在电影之中,有很重要的角色。它一方面代表角色的品味,亦暗示了角色的性格、社会阶层及行事作风。有时候即使没有手表大特写,只是说出品牌的名字已经可以有助剧情发展,甚至带出故事的中心思想。

关键词：特写镜头大特写满足感电影经典手表剧情发展中心思想品牌

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Updates on management of gliomas in the molecular age

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World Journal of Clinical Oncology 2024年第2期15卷 178-194页

作者： Ali Ahmed Mohamed Rakan Alshaibi steven Faragalla Youssef Mohamed Brandon Lucke-Wold Charles E.Schmidt College of Medicine Florida Atlantic UniversityBoca RatonFL 33431United States Herbert Wertheim College of Medicine Florida International UniversityMiamiFL 33199United States College of Osteopathic Medicine Kansas City UniversityJoplinMO 64804United States Department of Neurosurgery University of FloridaGainesvilleFL 32611United States

Gliomas are primary brain tumors derived from glial cells of the central nervous system,afflicting both adults and children with distinct characteristics and therapeutic *** developments have ushered in novel clinical and molecular prognostic factors,reshaping treatment paradigms based on classi-fication and grading,determined by histological attributes and cellular *** review article delves into the diverse treatment modalities tailored to the specific grades and molecular classifications of gliomas that are currently being discussed and used clinically in the year *** adults,the therapeutic triad typically consists of surgical resection,chemotherapy,and *** contrast,pediatric gliomas,due to their diversity,require a more tailored *** complete tumor excision can be curative based on the location and grade of the glioma,certain non-resectable cases demand a chemotherapy approach usually involving,vincristine and ***-tionally,if surgery or chemotherapy strategies are unsuccessful,Vinblastine can be *** recent advancements in treatment methodologies,there remains a need of exploration in the literature,particularly concerning the efficacy of treatment regimens for isocitrate dehydrogenase type mutant astrocytomas and fine-tuned therapeutic approaches tailored for pediatric *** review article explores into the therapeutic modalities employed for both adult and pediatric gliomas in the context of their molecular classification.

关键词： Gliomas Chemotherapy Radiotherapy Isocitrate dehydrogenase type mutant Pediatric gliomas Astrocytoma Oligodendroglioma 1p/19q-codeleted

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亚洲高山流域千年尺度地表剥蚀的制约因素

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中国科学:地球科学 2024年

作者：杨业 steven A.BINNIE 徐胜刘丛强 Tibor J.DUNAI 天津大学地球系统科学学院表层地球系统科学研究院 Institute of Geology and Mineralogy University of Cologne

本研究利用前人1233个亚洲高山流域沉积物宇宙成因核素10Be数据统一计算了地表剥蚀速率,以约束构造、气候和地形如何影响和控制地表剥蚀过程.基于高程数据逐个像元的核素产率,使用蒙特卡洛模拟方法重新计算了10Be流域剥蚀速率.剥蚀速率... 详细信息

本研究利用前人1233个亚洲高山流域沉积物宇宙成因核素10Be数据统一计算了地表剥蚀速率,以约束构造、气候和地形如何影响和控制地表剥蚀过程.基于高程数据逐个像元的核素产率,使用蒙特卡洛模拟方法重新计算了10Be流域剥蚀速率.剥蚀速率变化范围从（7.4±0.7）mm ka-1（1σ;青藏高原内部）到(9,646744+777)mm ka-1（1σ;青藏高原南部）跨四个数量级,中位数为186mm ka-1.逐个像元计算的核素产率与传统模型使用质心坐标和平均高程计算的核素产率相比,后者96.6%核素产率被低估,其中高程差越大越被低估.两种方法计算的产率偏差可达40%,究其原因可能是流域高程分布不均和核素产率随海拔和纬度呈非线性变化.通过量化地表剥蚀速率与构造、气候、地形和岩性之间的相关性将有助于推演未知流域的剥蚀速率.从局部小尺度分析,亚热带台湾岛地区剥蚀速率可能主要受降水和新构造驱动的山体滑坡影响,而降水变化范围较窄的青藏高原东部的剥蚀速率主要受控于地形;冰川覆盖的高原地区剥蚀速率受冰川作用影响,如帕米尔、青藏高原内部和南部地区;青藏高原内部剥蚀速率较低是因为较低的降水和较高的侵蚀基准面,从而限制了河流的下切和地表起伏度演化.与局部小尺度强调单一主控因素不同,本研究对亚洲高山流域宏观大尺度进行量化分析发现:（1）地形指标（包括坡度、地形起伏度和河道陡峭指数）与剥蚀速率在千年尺度呈现一致的幂函数关系,而非简单线性;（2）剥蚀速率与气候（包括与海拔相关的降水、温度和植被覆盖度）和新构造活动（地震核密度分布）呈近似幂函数关系,为次要控制因素;（3）岩性与剥蚀速率没有明显的相关性,可能受限于流域复杂的岩性混合和低分辨率的可侵蚀指数数据.

关键词： Be剥蚀速率气候变化构造抬升地形梯度亚洲高山流域

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Platelet-rich plasma for de Quervain’s tenosynovitis: A systematic review and meta-analysis

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World Journal of Orthopedics 2024年第9期15卷 858-869页

作者： Nucki Nursjamsi Hidajat Raden Moechammad Satrio Nugroho Magetsari Gregorius steven Jethro Budiman Gregorius Thomas Prasetiyo Department of Orthopaedics and Traumatology Padjadjaran UniversityBandung 45363Jawa BaratIndonesia General Practitioner Panti Wilasa Citarum HospitalSemarang 50121Indonesia

BACKGROUND Platelet-rich plasma(PRP)injection is used as an alternative non-operative management for de Quervain’s tenosynovitis(DQT)to regenerate tendon *** To assess and conclude the research-based study systematically to analyse the efficacy of PRP on *** This systematic review used the Cochrane Handbook for Systematic Reviews and the guideline of preferred reporting items for systematic review and metaanalysis.A systematic literature search was applied to 11 *** authors assessed the study quality and risk of bias of each included *** of the meta-analysis were presented using mean difference(MD)/standardized mean difference(SMD)and 95%condence interval(CI).RESULTS The authors evaluated 275 studies found in the literature search;12 studies met the criteria for this review,and then the study quality and risk of bias were *** analysis of data from two studies involving 194 subjects with DQT showed that,compared with conservative treatment,PRP injection was associated with a greater reduction in visual analog scale pain in one month and six months after treatment(MD:-0.67,P value<0.00001;MD:-1.16,P value<0.00001)and the increase of Mayo’s wrist score in one month and six months after treatment(SMD:3.72,P value<0.00001;SMD:4.44,P value<0.00001).CONCLUSION PRP can be used as an alternative non-operative treatment for DQT due to the tissue regenerative effect of PRP.

关键词： De Quervain’S disease De Quervain’S tenosynovitis Platelet-rich plasma Stenosing tenosynovitis

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