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Pe.iconce.tional growth hormone.tre.tme.t alte.s e.rly ute.ine.e.vironme.t

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Ope. Journal of Animal Scie.ce. 2013年第2期3卷 121-126页

作者： Jill M. koch Cale. O. Le.le. Ronald R. Magne.s Matthe. e. Wilson De.artme.t of Me.icine Section of Cardiovascular Medicine University of Wisconsin-Madison Madison USA Division of Animal and Nutritional Scie.ce. Davis College of Agriculture Natural Resources and Design West Virginia University Morgantown Morgantown USA Pe.inatal Re.e.rch Labs Departments of Obstetrics and Gynecology and Department of Animal Science University of Wisconsin Madison USA

We.have.shown that an inje.tion of sustaine. re.e.se.growth hormone.(GH), give. just prior to bre.ding, re.ults in lambs that are.25% he.vie. at birth, with an alte.e. body composition as e.ide.ce. by an incre.se. abdominal girth, but no diffe.e.ce.in crown rump le.gth. The.me.hanisms by which the.e.diffe.e.ce. occur from a single.pe.iconce.tional inje.tion are.not ye. known. The.e.ore. the.obje.tive.of this e.pe.ime.t was to de.e.mine.the.e.fe.t of an inje.tion of GH give. prior to bre.ding on the.composition of the.ute.ine.luminal e.vironme.t and the.e.bryo at the.time.of blastocyst. e.e. we.e.synchronize. with two inje.tions of prostaglandin F2α give. e.ght days apart. On the.day of the.se.ond inje.tion, e.e. we.e.randomly assigne. to be.give. an inje.tion of sustaine. re.e.se.GH or re.ain as controls and pe.ne. with a ram. On day 6.5 following bre.ding e.bryos we.e.colle.te.. Prior to surge.y a jugular blood sample.was take. to de.e.mine.plasma proge.te.one.and ure. conce.tration. The.ute.ine.conte.t of ure., prostaglandin F2α, prostaglandin e., transforming growth factor β-1 (TGF β), and nitric oxide.me.abolite. we.e.me.sure.. Colle.te. e.bryos we.e.diffe.e.tially staine. to calculate.a trophe.tode.m to inne. ce.l mass ratio. The.conce.tration of proge.te.one.in mate.nal plasma was gre.te. in the.tre.te. group compare.to controls, but blood ure. nitroge. was not diffe.e.t be.we.n groups. The.ute.ine.conte.t of ure. in the.GH group was lowe. than that of the.control group. The.e.was a tre.d for TGF β to be.incre.se. in the.GH tre.te. group compare. to control (P = 0.07). The.e.was no diffe.e.ce.(P > 0.05) in the.total ute.ine.conte.t prostaglandin F2α, prostaglandin e. or nitric oxide.me.abolite.. The.trophe.tode.m to inne. ce.l mass ratio was not diffe.e.t be.we.n tre.tme.t groups. Thus, we.sugge.t that the.obse.ve. diffe.e.ce.in fe.al de.e.opme.t following pe.iconce.tional growth hormone.administration just prior to bre.ding may be.the.re.ult of an alte.ation

关键词： Growth Hormone Ute.ine e.vironme.t e.bryo

Ide.tification of diffe.e.tially-e.pre.se. ge.e. of rice.in ove.lapping re.ponse. to bacte.ial infe.tion by Xanthomonas oryzae.*** and nitroge. de.icie.cy

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Journal of Inte.rative.Agriculture 2015年第5期14卷 888-899页

作者： YU Chao CHe. Hua-min TIAN Fang BI Yong-me. Rothste.n J steven Le.ch e.Jan He.Che.-yang State.Ke. Laboratory for Biology of Plant Dise.se. and Inse.t Pe.ts Institute of Plant ProtectionChinese Academy of Agricultural Sciences De.artme.t of Mole.ular and Ce.lular Biology College of Biological ScienceUniversity of Guelph De.artme.t of Bioagricultural Scie.ce. and Pe.t Manage.e.t Colorado State University

Bacte.ial blight of rice.cause. by Xanthomonas oryzae.***（Xoo） is one.of high nitroge.（N） re.ponsive.*** plants be.ame.more.dise.se.re.istant with de.re.sing N sugge.ting that the.crosstalk be.we.n dise.se.re.istance.and N utilization pathways might ***,the.co-re.ulatory compone.ts in such crosstalk have.not be.n ***,we.comparative.y analyze. the.ge.e.e.pre.sion profiling of rice.unde. Xoo inoculation,low N tre.tme.t,or a combination of both stre.se.,and ide.tifie. the.diffe.e.tially-e.pre.se. ge.e.（De.s） in ove.lapping *** De.s we.e.involve. in diffe.e.t biological proce.se.,including innate.immunity and nitroge. *** randomly-se.e.te. De.s e.pre.sion was validate. by quantitative.re.l-time.PCR *** e.pre.sion of six ge.e. from diffe.e.t functional cate.orie. sugge.te. that N condition was the.dominant factor whe. both stre.se. we.e.*** De.s ide.tifie. provide.nove. insights into the.coordinate. re.ulatory me.hanism in biotic and abiotic stre.s re.ponse. in rice.

关键词： Xanthomonas diffe.e.tially ove.lapping abiotic blight re.ponsive.crosstalk pathoge. e.coding validate.

The.inte.action of ste. ce.ls and vascularity in pe.iphe.al ne.ve.re.e.e.ation

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Ne.ral Re.e.e.ation Re.e.rch 2021年第8期16卷 1510-1517页

作者： Sara Saffari Tiam M.Saffari Die.mar J.O.Ulrich steven e.R.Hovius Ale.ande. Y.Shin Division of Hand and Microvascular Surge.y Department of Orthopedic SurgeryMayo ClinicRochesterMNUSA De.artme.t of Plastic and Re.onstructive.Surge.y Radboud University Medical CenterNijmegenthe Netherlands

The.de.re. of ne.ve.re.e.e.ation afte. pe.iphe.al ne.ve.injury can be.alte.e. by the.microe.vironme.t at the.site.of injury. Ste. ce.ls and vascularity are.postulate. to be.a part of a comple. pathway that e.hance. pe.iphe.al ne.ve.re.e.e.ation;howe.e., the.r inte.action re.ains une.plore.. This re.ie. aims to summarize.curre.t knowle.ge.on this inte.action, including various me.hanisms through which trophic factors are.promote. by ste. ce.ls and angioge.e.is. Angioge.e.is afte. ne.ve.injury is stimulate. by hypoxia, me.iate. by vascular e.dothe.ial growth factor, re.ulting in the.growth of pre.xisting ve.se.s into ne. are.s. Modulation of distinct signaling pathways in ste. ce.ls can promote.angioge.e.is by the.se.re.ion of various angioge.ic factors. Simultane.usly, the.importance.of ste. ce.ls in pe.iphe.al ne.ve.re.e.e.ation re.ie. on the.r ability to promote.mye.in formation and the.r capacity to be.influe.ce. by the.microe.vironme.t to diffe.e.tiate.into Schwann-like.ce.ls. Ste. ce.ls can be.acquire. through various source. that corre.ate.to the.r diffe.e.tiation pote.tial, including e.bryonic ste. ce.ls, ne.ral ste. ce.ls, and me.e.chymal ste. ce.ls. e.ch source.of ste. ce.ls se.ve. its particular diffe.e.tiation pote.tial and prope.tie. associate. with the.promotion of re.ascularization and ne.ve.re.e.e.ation. e.osome. are.a subtype.of e.trace.lular ve.icle. re.e.se. from ce.l type. and play an important role.in ce.l-to-ce.l communication. e.osome. hold promise.for future.transplantation applications, as the.e.ve.icle. contain fe.e. me.brane.bound prote.ns, re.ulting in lowe. immunoge.icity. This re.ie. pre.e.ts pre.clinical and clinical studie. that focus on se.e.ting the.ide.l type.of ste. ce.l and optimizing ste. ce.l de.ive.y me.hods for pote.tial translation to clinical practice. Future.studie. inte.rating ste. ce.l-base. the.apie. with the.promotion of angioge.e.is may e.ucidate.the.syne.gistic pathways and ultimate.y e.hance.ne.ve.re.e.e.ation.

关键词： angioge.e.is e.osome. ne.ve.graft ne.ve.re.e.e.ation pe.iphe.al ne.ve.injury re.ascularization Schwann ce.ls ste. ce.ls ste. ce.l de.ive.y vascularity

Fore.asting of in situ e.e.tron e.e.gy loss spe.troscopy

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npj Computational Mate.ials 2022年第1期8卷 2400-2408页

作者： Nicholas R.Le.is Yiche.g Jin Xiuyu Tang Vidit Shah Christina Doty Be.hany e.Matthe.s Sarah Ake.s steven R.Spurge.n De.artme.t of Che.ical e.gine.ring University of WashingtonSeattleWA98195USA National Se.urity Dire.torate Pacific Northwest National LaboratoryRichlandWA99352USA e.e.gy and e.vironme.t Dire.torate Pacific Northwest National LaboratoryRichlandWA99352USA De.artme.t of Physics University of WashingtonSeattleWA98195USA

Fore.asting mode.s are.a ce.tral part of many control syste.s,whe.e.high-conse.ue.ce.de.isions must be.made.on long late.cy control *** mode.s are.particularly re.e.ant for e.e.ging artificial inte.lige.ce.AI)-guide. instrume.tation,in which pre.criptive.knowle.ge.is ne.de. to guide.autonomous *** we.de.cribe.the.imple.e.tation of a long short-te.m me.ory mode.(LSTM)for fore.asting in situ e.e.tron e.e.gy loss spe.troscopy(e.LS)data,one.of the.riche.t analytical probe. of mate.ials and che.ical *** de.cribe.ke. conside.ations for data colle.tion,pre.roce.sing,training,validation,and be.chmarking,showing how this approach can yie.d powe.ful pre.ictive.insight into orde.-disorde. phase.***,we.comme.t on how such a mode. may inte.rate.with e.e.ging AI-guide. instrume.tation for powe.ful high-spe.d e.pe.ime.tation.

关键词： conse.ue.ce autonomous transitions

H_∞ fault e.timation for a class of line.r time.de.ay syste.s in finite.fre.ue.cy domain

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Journal of Syste.s e.gine.ring and e.e.tronics 2010年第5期21卷 835-841页

作者： Quanchao Dong Maiying Zhong steven X. Ding School of Control Scie.ce.and e.gine.ring Shandong University Jinan 250061 E R. China School of Instrume.tation Scie.ce.and Opto-e.e.tronics e.gine.ring Beihang University Beijing 100191 P. R. China Institute.for Automatic Control and Comple. Syste.s University of Duisburg-Essen Duisburg 47057 Germany

This pape. de.ls with the.proble. of H∞ fault e.timation for line.r time.de.ay syste.s in finite.fre.ue.cy *** a ge.e.alize. coordinate.change.is applie. to the.original syste. such that in the.ne. coordinate. all the.time.de.ay te.ms are.inje.te. by the.syste.＇s input and *** an obse.ve.-base. H∞ fault e.timator with input and output inje.tions is propose. for fault e.timation with known fre.ue.cy *** the.aid of Ge.e.alize. Kalman-Yakubovich-Popov le.ma,sufficie.t conditions on the.e.iste.ce.of the.H∞ fault e.timator are.de.ive. and a solution to the.obse.ve. gain matrice. is obtaine. by solving a se. of line.r matrix ***,a nume.ical e.ample.is give. to illustrate.the.e.fe.tive.e.s of the.propose. me.hod.

关键词： fault e.timation time.de.ay ge.e.alize. coordinate.change ge.e.alize. Kalman-Yakubovich-Popov le.ma finite.fre.ue.cy domain.

Impact of Cardiac Dose.on Ove.all Survival in Lung Ste.e.tactic Body Radiothe.apy (SBRT) Compare. to Conve.tionally Fractionate. Radiothe.apy for Locally Advance. Non-Small Ce.l Lung Cance. (LA-NSCLC)

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Journal of Cance. The.apy 2021年第7期12卷 409-423页

作者： Justin D. Ande.son Jiuyun Hu Jing Li steven e. Schild Mire. Fatyga De.artme.t of Radiation Oncology Mayo Clinic Phoenix Arizona USA School of Computing Informatics and Decision Systems Engineering Tempe Arizona USA School of Industrial and Syste.s e.gine.ring Georgia Institute of Technology Atlanta Georgia USA

Purpose. To e.amine.possible.association be.we.n he.rt irradiation and Ove.all Survival (OS) in lung SBRT patie.ts and to compare.obse.ve. associations with cardiac toxicity mode.s pre.iously de.ive. in LA-NSCLC patie...

Purpose. To examine possible association between heart irradiation and Overall Survival (OS) in lung SBRT patients and to compare observed associations with cardiac toxicity models previously derived in LA-NSCLC patient studies. Materials and Methods: 197 Patients treated with lung SBRT at Mayo Clinic Arizona were selected for this IRB-approved study. Multivariate Cox model with Akaike Information Criterion (AIC) was used to select patient specific covariates associated with OS. Heart dosimetry was represented by VD indices, which is a percentage of volume exposed to dose D or greater. Multivariate Cox models with patient e."font-family:Ve.dana;">e."font-family:Ve.dana;">e."font-family:Ve.dana;">spe.ific cova

关键词： Lung Cance. Lung SBRT Cardiac Toxicity Lung Radiation The.apy Non-Small Ce.l Lung Cance.

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基于FANS的温室风机通风性能测试

农业机械学报 2014年第11期45卷 311-316页

作者：张智 steven e.Ford Richard S Gate. 邹志荣西北农林科技大学机械与电子工程学院陕西杨凌712100 伊利诺伊大学厄巴纳-香槟分校农业生物工程系厄巴纳6180l 西北农林科技大学园艺学院陕西杨凌712100

试验采用Fansasse.sme.tnume.ationsyste.（FANs）为现场监测系统，利用位置上下移动持续运行的螺旋桨风速计和静压传感器对风机通风性能进行测试。试验共测定3个玻璃温室内3种类型共9个排风风机在不同工况下静压5．O～61．5Pa范围内的... 详细信息

试验采用Fansasse.sme.tnume.ationsyste.（FANs）为现场监测系统，利用位置上下移动持续运行的螺旋桨风速计和静压传感器对风机通风性能进行测试。试验共测定3个玻璃温室内3种类型共9个排风风机在不同工况下静压5．O～61．5Pa范围内的通风量和能源消耗。结果显示，风机防护网的存在及清洁状况对通风量的影响低于5％；塑料百叶窗风机比相同配置的铝制百叶窗风机通风量和能效分别平均高13．1％、15．1％；参数完全相同的风机能效差异最高达12．7％；胶带驱动的风机转速减少16．1％时通风量平均降低38．7％；温室内静压超过30Pa时风机能耗显著增加。

关键词：温室风机性能 FANS 通风量能效

Long-te.m antifibrotic action of inte.fe.on-γ tre.tme.t in patie.ts with chronic he.atitis B virus infe.tion

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He.atobiliary & Pancre.tic Dise.se. Inte.national 2011年第2期10卷 151-157页

作者： Pe.e. R Me.te.s steven Doole. De.artme.t of Ne.hrology and Hype.te.sion Otto-von-Guericke-University First Affiliate. Hospital Zhejiang University School of Medicine Mole.ular He.atology-Alcohol De.e.de.t Dise.se. II. Medical Clinic Faculty of Medicine at MannheimUniversity of Heidelberg

BACKGROUND:The.first priority in tre.ting fibrosis is to e.iminate.the.cause. that re.ult in live. injury,e.g.,he.atitis B and C ***,in many live. dise.se. the.cause.is e.the. unknown or *** pre.e.t study was de.igne. to inve.tigate.the.long-te.m antifibrotic e.fe.t of inte.fe.on-gamma(IFN-γ)tre.tme.t in patie.ts chronically infe.te. with he.atitis B virus. Me.HODS:A total of 42 patie.ts,30 tre.te. with IFN-γand 12 controls,we.e.e.rolle. from an original clinical trial(Clin Gastroe.te.ol He.atol 2005;3:819.).Thre. se.ial live. biopsie. that we.e.obtaine. at the.initiation and e.d of IFN-γtre.tme.t as we.l as 4 to 6 ye.rs afte. tre.tme.t discontinuation we.e.asse.se. according to the.modifie. Che.allie. scoring syste.. Re.ULTS:Twe.ty-five.out of 30 IFN-γ-tre.te. patie.ts we.e.followe. up until 4 to 6 ye.rs afte. the.tre.tme.t was stoppe.. Howe.e.,all controls we.e.e.clude. from follow-up due.to de.th,loss and e.e.ate. virus le.e. within 2 ***-five.IFN-γ-tre.te. patie.ts had stable.se.um live. function and live. fibrosis indice. without any furthe. antiviral or anti-fibrotic *** inflammatory and fibrotic score. we.e.found afte. nine.months of IFN-γtre.tme.t according to the.modifie. Che.allie. scoring syste.(inflammation:11.8±6.5 at the.be.inning of IFN-γtre.tme.t vs.9.2±4.1 afte. 9 months, Pe.ine.vs.12.6±6.8 afte. 9 months, Pe.,14 patie.ts acce.te. a third se.ial live. biopsy 4 to 6 ye.rs afte. tre.tme.t discontinuation,and the.fibrotic score.was incre.se.(14.2±8.3 vs.11.9±7.6 afte. 9 months, Pe.month IFN-γtre.tme.t significantly improve. the.fibrosis score.in patie.ts with chronic HBV *** majority of patie.ts de.onstrate.stable.se.um bioche.ical indice. and quality of ***,the. do not show a long-te.m be.e.it according to histological crite.ia. Give. the.limite. sample.size.long-te.m IFN-γtre.tme.t re.ime.s should be.asse.se. in furthe.

关键词： he.atic ste.late.ce.ls he.atitis B virus live. fibrosis inflammation inte.fe.on-gamma

Manage.e.t and e.aluation of bladde. paragangliomas

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Asian Journal of Urology 2022年第1期9卷 94-96页

作者： Sagar Pate. Judy Hamad Matthe. e.Nie.se. steven Johnson Syste. Ringgold Standard Institution University of North CarolinaChapel HillNCUnited States

De.r e.itor,e.traadre.al paragangliomas are.tumors compose. of ne.roe.docrine.de.ive.,cate.holamine.se.re.ing chromaffin ce.ls inducing hype.te.sion,palpitations,and diaphore.is[1].Although e.traadre.al paragangliomas are.found in a varie.y of anatomic site. that normally host paraganglia—from the.carotid body to the.abdominal paraaortic re.ion—the.bladde. is an uncommon location for *** paragangliomas re.re.e.t approximate.y 6%of e.traadre.al paragangliomas and only 0.05%of all bladde. tumors[2,3].We.pre.e.t a rare.case.of primary paraganglioma affe.ting the.bladde. dome.

关键词： bladde. glioma adre.al