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Poor mate.nal nutrition inhibits muscle.de.e.opme.t in ovine.offspring

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Journal of Animal Scie.ce.and Biote.hnology 2015年第1期6卷 79-89页

作者： Sarah A Re.d Jose.ine.S Raja Maria L Hoffman steven A Zinn Kriste. e.Govoni De.artme.t of Animal Scie.ce University of ConnecticutStorrsCT 06269USA

Background： Mate.nal ove. and re.tricte. nutrition has ne.ative.conse.ue.ce. on the.muscle.of offspring by re.ucing muscle.fibe. numbe. and alte.ing re.ulators of muscle.growth. To de.e.mine.if ove. and re.tricte. mate.nal nutrition affe.te. muscle.growth and ge.e.fe. 60%, 100% or 140% of National Re.e.rch Council and prote.n e.pre.sion in offspring, 36 pre.nant e.e. we.e.re.uire.e.ts from d 31 ＋ 1,3 of ge.tation until parturition. Lambs from control-fe. （CON）, re.tricte.-fe. （Re.） or ove.-fe. （OVe.） e.e. we.e.ne.ropsie. within 1 d of birth （n = 18） or maintaine. on a control die. for 3 mo （n = ] 5）. Se.ite.dinosus muscle.was colle.te. for immunohistoche.istry, and prote.n and ge.e.e.pre.sion analysis. Re.ults： Compare. with CON, muscle.fibe. cross-se.tional are. （CSA） incre.se. in Re. （58%） and OVe. （47%） lambs at 1 d of age.（P〈 0.01）; howe.e. at 3 mo, CSA de.re.se. 15% and 17% compare. with CON, re.pe.tive.y （P 〈 0.01）. Compare. with CON, muscle.lipid conte.t was incre.se. in OVe. （212.4%） and Re. （92.5%） at d 1 （P 〈 0.0001）. Muscle.lipid conte.t was incre.se. 36.1% in OVe. and de.re.se. 23.6% in Re. compare. with CON at 3 mo （P 〈 0.0001）. At d 1, myostatin mRNA abundance.in whole.muscle.te.de. to be.gre.te. in OVe. （P = 0.07） than CON. Follistatin mRNA abundance.incre.se. in OVe. （P = 0.04） and te.de. to incre.se.in Re. （P = 0.06） compare. with CON at d 1. Howe.e., the.e.was no diffe.e.ce.in myostatin or follistatin prote.n e.pre.sion （P 〉 0.3）. Phosphorylate. Akt （se.473） was incre.se. in Re. at 3 mo compare. with CON （P = 0.006）. Conclusions： In conclusion, mate.nal ove. and re.tricte. nutrie.t intake.alte.s muscle.lipid conte.t and growth of offspring, possibly through alte.e. ge.e.and prote.n e.pre.sion.

关键词： Growth Mate.nal nutrition Muscle.de.e.opme.t She.p

A mode. for the.control of DNA inte.rity by the.spe.m nucle.r matrix

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Asian Journal of Andrology 2015年第4期17卷 610-615页

作者： Joanna e.Gawe.ka Jordi Ribas-Maynou Jordi Be.e. W steven Ward Clinical and Translational Re.e.rch Program Universityof Hawaii Cancer Center Honolulu HI USA Ce.l BiologyUnit Cell Biology Phisiology and Immunology DepartmentMedicine Faculty Universitat Autonoma de Barcelona08193 Bellaterra Spain Ce.te. of Male.Infe.tility andAnalysis de Barcelona Edifici Eureka PBM5 Parc deRecerca de la UAB Campus de la UAB 08193 BellaterraSpain Institute.for Bioge.e.is Re.e.rch Departmentof Anatomy Biochemistry and Physiology Honolulu HIUSA De.artme.t of Obste.rics Gynecology and Women'sHealth John A. Burns School of Medicine University ofHawaii at Manoa. Honolulu. HI 96822. USA.

The.highly conde.se. chromatin of mammalian spe.matozoa is usually conside.e. to be.biologically ine.t be.ore.fe.tilization. Howe.e., we.have.de.onstrate. that e.e. in this compacte. state. spe.m chromatin is subje.t to de.radation at ope. configurations associate. with the.nucle.r matrix through a proce.s we.have.te.me. spe.m chromatin fragme.tation （SCF）. ＂[his sugge.ts that a me.hanism e.ists to monitor the.he.lth of spe.matozoa during transit through the.male.re.roductive.tract and to de.troy the.ge.ome.of de.e.tive.spe.m ce.ls. The.site.of DNA damage.in SCF, the.matrix attachme.t site., are.the.same.that we.hypothe.ize.initiate.DNA synthe.is in the.zygote. Whe. spe.m that have.damage. DNA are.inje.te. into the.oocyte. the.ne.ly cre.te. zygote.re.ponds by de.aying DNA synthe.is in the.male.pronude.s and, if the.damage.is se.e.e.e.ough, arre.ting the.e.bryo＇s de.e.opme.t. He.e.we.pre.e.t a mode. for pate.nal DNA re.ulation by the.nucle.r matrix that be.ins during spe.m maturation and continue. through e.rly e.bryonic de.e.opme.t.

关键词： DNA mammalian spe.matozoa

Finding a role.for cance. vaccine. in pancre.tic cance.:a mode. of re.ilie.ce

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He.atobiliary Surge.y and Nutrition 2022年第1期11卷 115-118页

作者： Ge.try King steven Gre.n e.Gabrie.a Chiore.n De.artme.t of Me.icine Division of Medical OncologyUniversity of Washington School of MedicineSeattleWAUSA Clinical Re.e.rch Division Fred Hutchinson Cancer Research CenterSeattleWAUSA

Ne.adjuvant che.othe.apy with folinic acid,5-fluorouracil,irinote.an and oxaliplatin(FOLFIRINOX)or ge.citabine.plus nab-paclitaxe.(Ge.-nabP)for 4 to 6 months,pote.tially followe. by che.oradiothe.apy and an atte.pt for surgical re.e.tion for se.e.t patie.ts,re.re.e.ts the.multidisciplinary care.standard for borde.line.re.e.table.BRPC)and locally advance. pancre.tic ductal ade.ocarcinoma(LAPC)patie.ts with good pe.formance.status(1,2).With ne.adjuvant the.apy,re.e.tion rate. ave.age.65%and survival range. from 22-29 months for BRPC,whe.e.s LAPC patie.ts have.re.e.tion rate. of 15-20%and survival of 16-24 months,re.pe.tive.y(3-5).

关键词： che.othe.apy cance. patie.ts

e.fe.ts of Body Size.and e.vironme.tal Factors on the.Acoustic Structure.and Te.poral Rhythm of Calls in Rhacophorus de.nysi

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Asian He.pe.ological Re.e.rch 2012年第3期3卷 205-212页

作者： Jichao WANG Jianguo CUI Haitao SHI steven e.BRAUTH Ye.hong TANG Che.gdu Institute.of Biology Chinese Academy of Sciences De.artme.t of Biology Hainan Normal University De.artme.t of Psychology University of MarylandCollege Park MD 20742USA

In anurans, the.outcome. of male.male.conte.ts and fe.ale.choice.are.ofte. associate. with body size. In some.spe.ie., male. e.aluate.an oppone.t’s fighting ability and fe.ale. e.aluate.male.quality on the.basis of male.communication signals, which are.thought to re.le.t information conce.ning male.body size. Ne.e.the.e.s, pre.ious studie. re.e.l that male.call structure.is not always corre.ate. with body size. In the.pre.e.t study we.inve.tigate. the.re.ationships be.we.n body size.and call structure.in the.large.tre.frog, Rhacophorus de.nysi, as we.l as the.re.ationship of its calling be.avior with air te.pe.ature.and humidity. The.re.ults show that both the.dominant and fundame.tal fre.ue.cie. are.ne.ative.y corre.ate. with body size. while.inte.-note.inte.vals are.positive.y corre.ate. with body size. indicating that call characte.s could re.le.t body size.in this ***, calling in this tropical spe.ie. e.hibits a circadian rhythm insofar as re.ative.y high te.pe.ature.and low humidity during the.day is associate. with le.s vocal be.avior. Thus, individual variations in call structure.are.mainly de.e.de.t on body size.while.the.te.poral rhythm of calling activity is affe.te. by e.vironme.tal conditions in large.tre.frogs.

关键词： adve.tise.e.t call body size rhythm te.pe.ature humidity Rhacophorus de.nysi

De.IGNING e.Fe.TIVe.INSTRUCTION / 4th ed.

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Coe.olution of Male.and Fe.ale.Re.ponse.Pre.e.e.ce. to Se.ual Signals in Music Frogs

2004年

作者： GARY R. MORRISON steven M. ROSS Je.ROLD e. Ke.P.

来源：畅想之星图书光盘版（南... 评论

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Asian He.pe.ological Re.e.rch 2016年第2期7卷 87-95页

作者： Jianguo CUI Jichao WANG Guangzhan FANG Xiaowe. SONG steven e.BRAUTH Ye.hong TANG Che.gdu Institute.of Biology Chinese Academy of Sciences Ministry of e.ucation Ke. Laboratory for Tropical Animal and Plant e.ology College of Life SciencesHainan Normal University School of Life.Scie.ce. Xinyang Normal University De.artme.t of Psychology University of MarylandCollege Park

Male.signaling influe.ce. both fe.ale.choice.and male.male.compe.ition. Although male.signaling characte.istics and fe.ale.pre.e.e.ce. have.be.n shown to coe.olve.in many spe.ie., fe. studie. have.e.amine. whe.he. male.signal characte.istics and male.re.e.ve. re.ponse. re.ate. to male.male.compe.ition also coe.olve. The.pre.e.t study te.te. the.hypothe.is that male.and fe.ale.signal re.e.ve. pre.e.e.ce. may coe.olve.in paralle. for flogs in the.ge.us Babina by comparing the.acoustic structure.of male.adve.tise.e.t calls of four close.y re.ate. and ge.graphically isolate. Babina spe.ie.. The. we.asse.se. the.be.avioral re.ponse. of both male.and fe.ale.B. daunchina （e.e. music frog） to male.call playbacks from e.ch of the.four spe.ie.. The.re.ults support the.hypothe.is that male.and fe.ale.signal re.e.ve. pre.e.e.ce. have.coe.olve. in this spe.ie.. Spe.ifically, both male.and fe.ale.B. daunchina re.pond strongly to the.he.e.ospe.ific calls of B. hainane.sis, sugge.ting that pre.xisting biase. e.ist in both fe.ale. and male.. Both male.and fe.ale.individuals showe. a slight re.ponse.to the.calls of B. ade.ople.ra while.no re.ponse.was e.oke. by the.calls ofB. lini. The.manife.tation of similar re.ponse.profile. in male.and fe.ale.B. daunchina to the.calls of the.four spe.ie. support the.ide. that male.and fe.ale.signal re.e.ve. pre.e.e.ce. e.olve. in paralle. and that the.origin of the.e.re.e.ve. biase. re.le.ts adaptations de.e.de.t on the.same.ne.ral and cognitive.syste.s in both se.e..

关键词： se.ual se.e.tion acoustic communication male.male.compe.ition phonotaxis te.ts coe.olution

Role.of the.e.dothe.ium in inflammatory bowe. dise.se.

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World Journal of Gastroe.te.ology 2011年第5期17卷 578-593页

作者： Walte. e.Crome. J Michae. Mathis Danie. N Grange. Ganta V Chaitanya J steven Ale.ande. De.artme.t of Ce.lular Biology and Anatomy LSU Health Sciences Center-Shreveport1501 Kings HighwayShreveportLA 71130-3932United States De.artme.t of Ce.lular and Mole.ular Physiology LSU Health Sciences Center-Shreveport1501 Kings HighwayShreveportLA 71130-3932United States

Inflammatory bowe. dise.se.(IBD) are.a comple. group of dise.se. involving alte.ations in mucosal immunity and gastrointe.tinal physiology during both initiation and progre.sive.phase. of the.*** the.core.of the.e.alte.ations are.e.dothe.ial ce.ls,whose.continual adjustme.ts in structure.and function coordinate.vascular supply,immune.ce.l e.igration,and re.ulation of the.tissue.*** of the.e.dothe.ium in IBD(angioge.e.is),me.iate. by inflammatory growth factors,cytokine. and che.okine.,is a hallmark of active.gut dise.se.and is close.y re.ate. to dise.se.*** e.dothe.ium in ne.ly forme. or inflame. ve.se.s diffe.s from that in normal ve.se.s in the.production of and re.ponse.to inflammatory cytokine.,growth factors,and adhe.ion mole.ule.,alte.ing coagulant capacity,barrie. function and blood ce.l re.ruitme.t in *** re.ie. e.amine. the.role. of the.e.dothe.ium in the.initiation and propagation of IBD pathology and distinctive.fe.ture. of the.inte.tinal e.dothe.ium contributing to the.e.conditions.

关键词： Microvasculature e.dothe.ium Inflamma-tion Nitric oxide Adhe.ion mole.ule. Crohn's dise.se Ulce.ative.colitis Cytokine. Che.okine. Growth factors

Be.avioral and Ne.roge.omic Re.ponse. to Acoustic and Visual Se.ual Cue. are.Corre.ate. in Fe.ale.Torre.t Frogs

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Asian He.pe.ological Re.e.rch 2021年第1期12卷 88-99页

作者： Longhui ZHAO Jichao WANG Yanlin CAI Jianghong RAN steven e.BRAUTH Ye.hong TANG Jianguo CUI Che.gdu Institute.of Biology Chinese Academy of SciencesChengdu 610041SichuanChina Ke. Laboratory of Bio-Re.ource.and e.o-e.vironme.t of Ministry of e.ucation College of Life SciencesSichuan UniversityChengdu 610041SichuanChina Unive.sity of the.Chine.e.Acade.y of Scie.ce. Beijing 100049China Ke. Laboratory for Tropical Plant and Animal e.ology of Ministry of e.ucation College of Life SciencesHainan NormalUniversityHaikou 571158HainanChina De.artme.t of Psychology University of MarylandCollege ParkMaryland 27042USA

Dive.se.a nimal spe.ie. use.multimodal communica tion signals to coordina te.re.roductive.*** active.re.e.rch in this fie.d,the.brain me.hanisms unde.lying multimodal communication re.ain poorly *** to humans and many mammalian spe.ie.,anurans ofte. produce.auditory signals accompanie. by conspicuous visual cue.(e.g.,vocal sac inflation).In this study,we.use. vide. playbacks to de.e.mine.the.role.of vocal-sac inflation in little.torre.t frogs(Amolops torre.tis).The. we.e.pose. fe.ale. to blank,visual,auditory,and audiovisual stimuli and analyze. whole.brain tissue.ge.e.e.pre.sion change. using *** re.ults showe. that both auditory cue.(i.e.,male.adve.tise.e.t calls)and visual cue. we.e.attractive.to fe.ale.frogs,although auditory cue. we.e.more.attractive.than visual *** pre.e.re. simultane.us bimodal cue. to unimodal *** hie.archical cluste.ing of diffe.e.tially e.pre.se. ge.e. showe. a close.re.ationship be.we.n ne.roge.omic state. and mome.tarily e.pre.se. se.ual *** also found that the.Ge.e.Ontology te.ms and Ke.G pathways involve. in e.e.gy me.abolism we.e.mostly incre.se. in blank contrast ve.sus visual,acoustic,or audiovisual stimuli,indicating that brain e.e.gy use.may play an important role.in re.ponse.to the.e.*** sum,be.avioral and ne.roge.omic re.ponse. to acoustic and visual cue. are.corre.ate. in fe.ale.little.torre.t frogs.

关键词： e.e.gy me.abolism multimodal communication little.torre.t frogs ne.roge.omic state. se.ual traits

Culture.conditions for e.uine.bone.marrow me.e.chymal ste. ce.ls and e.pre.sion of ke. transcription factors during the.r diffe.e.tiation into oste.blasts

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Journal of Animal Scie.ce.and Biote.hnology 2014年第2期5卷 163-172页

作者： e.izabe.h R A Glynn Alfre.o Sanche. Londono steven A Zinn Thomas A Hoagl Kriste. e.Govoni De.artme.t of Animal Scie.ce University of Connecticut3636 Horsebarn Road Ext.Unit 4040StorrsCT 06269-4040USA De.artme.t of e.vironme.tal and Population He.lth Tufts University North GraftonMA 01536USA

Background： The.use.of e.uine.bone.marrow me.e.chymal ste. ce.ls （BMSC） is a nove. me.hod to improve.fracture.he.ling in horse.. Howe.e., additional re.e.rch is ne.de. to ide.tify optimal culture.conditions and to de.e.mine.the.me.hanisms involve. in re.ulating BMSC diffe.e.tiation into oste.blasts. The.obje.tive. of the.e.pe.ime.ts we.e.to de.e.mine. 1） if autologous or comme.cial se.um is be.te. for prolife.ation and diffe.e.tiation of e.uine.BMSC into oste.blasts, and 2） the.e.pre.sion of ke. transcription factors during the.diffe.e.tiation of e.uine.BMSC into oste.blasts. e.uine.BMSC we.e.isolate. from the.ste.na of 3 horse., tre.te. with purchase. fe.al bovine.se.um （FBS） or autologous horse.se.um （HS）, and ce.l prolife.ation de.e.mine.. To induce.oste.blast diffe.e.tiation, ce.ls we.e.incubate. with L-ascorbic acid-2-phosphate.and glyce.ol-2-phosphate.in the.pre.e.ce.or abse.ce.of human bone.morphoge.e.ic prote.n2 （BMP2）, de.ame.hasone.（De.）, or combination of the.two. Alkaline.phosphatase.（ALP） activity, a marke. of oste.blast diffe.e.tiation, was de.e.mine. by e.ISA. Total RNA was isolate. from diffe.e.tiating BMSC be.we.n d 0 to 18 to de.e.mine.e.pre.sion of runt-re.ote. tronscrJption foctor2 （Runx2）, oste.ix （Osx）, and T-box3 （Tbx3）. Data we.e.analyze. by ANOVA. Re.ults： Re.ative.to control, FBS and HS incre.se. ce.l numbe. （133 ± 5 and 116 ± 5%, re.pe.tive.y; P 〈 0.001） and 5-bromo- 2＇-de.xyuridine.（BrdU） incorporation （167 ± 6 and 120 ± 6%, re.pe.tive.y; P 〈 0.001）. Tre.tme.t with De. incre.se. ALP activity compare. with control （1,638 ± 38%; P 〈 0.001）. In the.abse.ce.and pre.e.ce.of De., BMP-2 did not alte. ALP activity （P 〉 0.8）. Runt-re.ote. transcription foctor2 e.pre.sion incre.se. 3-fold （P 〈 0.001） by d 6 of culture. Oste.ix e.pre.sion incre.se. 94old （P 〈 0.05） by d 18 of culture. e.pre.sion of Tbx3 incre.se. 1.8-fold at d 3 （P 〈 0.01）; howe.e. e.pre.sion was re.uce. 4-fold at d 18 （P 〈 0.01）. Conclusions： De.ame.hasone. but not BMP-2, is re.uir

关键词： Bone.marrow me.e.chymal ste. ce.ls Ce.l culture e.uine Oste.blasts Transcription factors