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Feasibility of pancreatectomy following high-dose proton therapy for unresectable pancreatic cancer

World Journal of Gastrointestinal Surgery 2017年第4期9卷 103-108页

作者： Kathryn e Hitchcock R Charles Nichols Christopher G Morris Debashish Bose steven J Hughes John A Stauffer Scott A Celinski elizabeth A Johnson Robert A Zaiden Nancy P Mendenhall Michael S Rutenberg Department of Radiation Oncology University of Florida Department of Surgical Oncology UF Health Cancer Center-Orlando Health Department of Surgery University of Florida Department of Surgery Mayo Clinic Department of Surgery Baylor University Medical Center at Dallas Department of Hematology/Oncology Mayo Clinic Department of Hematology/Oncology Baptist Health

AIM To review surgical outcomes for patients undergoing pancreatectomy after proton therapy with concomitant capecitabine for initially unresectable pancreatic *** From April 2010 to September 2013,15 patients with initially unresectable pancreatic cancer were treated withproton therapy with concomitant capecitabine at 1000 mg orally twice daily. All patients received 59.40 Gy(RBe) to the gross disease and 1 patient received 50.40 Gy(RBe) to high-risk nodal targets. There were no treatment interruptions and no chemotherapy dose reductions. Six patients achieved a radiographic response sufficient to justify surgical exploration,of whom 1 was identified as having intraperitoneal dissemination at the time of surgery and the planned pancreatectomy was aborted. Five patients underwent resection. Procedures included:Laparoscopic standard pancreaticoduodenectomy(n = 3),open pyloris-sparing pancreaticoduodenectomy(n = 1),and open distal pancreatectomy with irreversible electroporation(IRe) of a pancreatic head mass(n = 1). ReSULTS The median patient age was 60 years(range,51-67). The median duration of surgery was 419 min(range,290-484),with a median estimated blood loss of 850 cm^3(range,300-2000),median ICU stay of 1 d(range,0-2),and median hospital stay of 10 d(range,5-14). Three patients were re-admitted to a hospital within 30 d after discharge for wound infection(n = 1),delayed gastric emptying(n = 1),and ischemic gastritis(n = 1). Two patients underwent R0 resections and demonstrated minimal residual disease in the final pathology specimen. One patient,after negative pancreatic head biopsies,underwent IRe followed by distal pancreatectomy with no tumor seen in the specimen. Two patients underwent R2 resections. Only 1 patient demonstrated ultimate local progression at the primary site. Median survival for the 5 resected patients was 24 mo(range,10-30).CONCLUSION Pancreatic resection for patients with initially unresectable cancers is feasible after

关键词：胰腺的癌症 Pancreatectomy 胰质子治疗放射疗法

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editorial

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Journal of Science in Sport and exercise 2019年第3期1卷 193-194页

作者： Lee e.Brown Jakob L.Vingren steven J.Fleck Department of Kinesiology Strength and ConditioningCalifornia State UniversityFullertonUSA Department of Kinesiology Health Promotion and RecreationExercise Physiology and Biological SciencesApplied Physiology LaboratoryUniversity of North TexasDentonUSA FlecksRx Inc. RidgwayColoradoUSA

This special issue of the"Journal of Science in Sport and exercise"is devoted to scientific inquiry related to Strength and Conditioning *** article is an invited manu-script and authored by top researchers in the Str... 详细信息

关键词： devoted community. editorial

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GReeNHOUSe GAS AND AMMONIA eMISSION MITIGATION PRIORITIeS FOR UK POLICY TARGeTS

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Frontiers of Agricultural Science and engineering 2023年第2期10卷 268-280页

作者： Sarah BUCKINGHAM Cairistiona F.e.TOPP Pete SMITH Vera eORY David R.CHADWICK Christina K.BAXTeR Joanna M.CLOY Shaun CONNOLLY emily C.COOLeDGe Nicholas J.COWAN Julia DReWeR Colm DUFFY Naomi JFOX Asma JeBARI Becky JeNKINS Dominika J.KROL Karina A.MARSDeN Graham A.MCAULIFFe steven J.MORRISON Vincent O'FLAHeRTY Rachael RAMSeY Karl G.RICHARDS Rainer ROeHe Jo SMITH Kate SMITH Taro TAKAHASHI Rachel e.THORMAN John WILLIAMS Jeremy WILTSHIRe Robert M.ReeS Scotland’s Rural College EdinburghEH93JGUK Institute of Biological&environmental Sciences AberdeenAB243UUUK School of Natural Sciences Bangor UniversityBangorGwyneddLL572DGUK Agricultural Development and Advisory Service(ADAS) BoxworthCambridgeCB234NNUK School of Biological and Chemical Sciences University of GalwayH91 TK33Ireland Centre for ecology and Hydrology Bush EstateMidlothianEH260QBUK The James Hutton Institute DundeeDD25DAUK Rothamsted Research North WykeOkehamptonDevonEX202SBUK Ricardo energy&environment HarwellOxonOX110QRUK environment Soils and Land Use DepartmentTeagascCounty WexfordY35 TC97Ireland Agri-food and Biosciences Institute HillsboroughCounty DownBT266DRUK Bristol Veterinary School University of BristolSomersetBS405DUUK

Agriculture is essential for providing food and maintaining food security while concurrently delivering multiple other ecosystem services. However,agricultural systems are generally a net source of greenhouse gases and ammonia. They, therefore, need to substantively contribute to climate change mitigation and net zero ambitions. It is widely acknowledged that there is a need to further reduce and mitigate emissions across sectors, including agriculture to address the climate emergency and emissions gap. This discussion paper outlines a collation of opinions from a range of experts within agricultural research and advisory roles following a greenhouse gas and ammonia emission mitigation workshop held in the UK in March 2022. The meeting identified the top mitigation priorities within the UK's agricultural sector to achieve reductions in greenhouse gases and ammonia that are compatible with policy targets. In addition, experts provided an overview of what they believe are the key knowledge gaps, future opportunities and cobenefits to mitigation practices as well as indicating the potential barriers to uptake for mitigation scenarios discussed.

关键词： agriculture ammonia greenhouse gas mitigation net zero

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Organizational behavior / 3rd ed.; international ed.

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2005年

作者： steven L. McShane Mary Ann Von Glinow.

Subtitle on cover: emerging realities for the workplace revolution.

ISBN: (数字)0072931477

ISBN: (纸本)0072976861

Subtitle on cover: emerging realities for the workplace revolution.

关键词： Organizational behavior.

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Planning a road weather information system with GIS

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Journal of Modern Transportation 2015年第3期23卷 176-188页

作者： Liuhui Zhao steven I.Chien Xiaobo Liu Weisong Liu Interdisciplinary Program in Transportation New Jersey Institute of Technology College of Automobile Chang'an University School of Transportation and Logistics Southwest Jiaotong University

The road weather information system （RWIS）, which collects and monitors weather and pavement surface conditions, has been proven effective to support winter road maintenance by improving safety, mobility, and effi- ciency. Although the geographic information systems are being widely applied for facility siting, traditional practices of sitting RWIS stations still heavily rely on the experi- ences of maintenance and operation personnel, which is time-consuming and subjective. This study develops a linear model to determine the optimal RWlS locations subject to three selection criteria： weather, traffic condition, and distance to existing RWIS sites, while considering practical constraints to satisfy specific requirements of various agencies （e.g., different weights of weather/traffic factors, various available budgets, etc.）.

关键词： RWIS Facility siting GIS Locationoptimization

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elimination of the yellow pigment gene PSY-e2 tightly linked to the Fusarium head blight resistance gene Fhb7 from Thinopyrum ponticum

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The Crop Journal 2023年第3期11卷 957-962页

作者： Xuefeng Li Dong Li Yu Xuan Ziming He Lanfei Zhao Yongchao Hao Wenyang Ge Shoushen Xu Bingqian Hou Biao Wang Jun Guo Wenwen Liu Mingzhu Li Yi Han Cunyao Bo Yinguang Bao Zengjun Qi steven S.Xu Guihua Bai Hongwei Wang Lingrang Kong State Key Laboratory of Crop Biology Shandong Key Laboratory of Crop BiologyCollege of AgronomyShandong Agricultural UniversityTai’an 271018ShandongChina State Key Laboratory of Crop Genetics and Germplasm enhancement Nanjing Agricultural UniversityNanjing 210095JiangsuChina Department of Agronomy Kansas State University2004 Throckmorton HallManhattanKS 66506USA Crop Research Institute Shandong Academy of Agricultural SciencesJinan 250100ShandongChina Cereal Crops Research Unit Red River Valley Agricultural Research CenterUSDA-ARSFargoND 58102USA USDA Hard Winter Wheat Genetics Research Unit4008 Throckmorton HallManhattanKS 66506USA

Fhb7 is a major gene that was transferred from Thinopyrum ponticum to chromosome 7D of wheat(Triticum aestivum)and confers resistance to both Fusarium head blight(FHB)and Fusarium crown rot(FCR).However,Fhb7 is tightly linked to the PSY-e2 gene,which causes yellow flour,limiting its application in *** break this linkage,marker K-PSY was developed for tagging PSY-e2 and used with Fhb7 markers to identify recombination between the two *** 21,000 BC1F2 backcross progeny(Chinese Spring ph1bph1b*2/SDAU 2028)revealed two Fhb7^(+)wheat-Tp7el_(2)L lines,Shannong 2–16and Shannong 16–1,that carry a desired truncated Fhb7^(+)translocation segment without *** two lines show levels of resistance to FHB and FCR similar to those of the original translocation line SDAU 2028,but have white *** facilitate Fhb7 use in wheat breeding,STS markers were developed and used to isolate Fhb7 on a truncated Tp7el_(2) translocation ***-isogenic lines carrying the Fhb7^(+)segment were generated in the backgrounds of three commercial cultivars,and Fhb7^(+)lines showed increased FHB and FCR resistance without yield *** breakage of the tight linkage between Fhb7 and PSY-e2 via homoeologous recombination provides genetic resources for improvement of wheat resistance to FHB and FCR and permit the large-scale deployment of Fhb7 in breeding using marker-assisted selection.

关键词： Triticum aestivum Thinopyrum ponticum Fusarium head blight Fusarium crown rot Truncated Fhb7 translocation

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Impact of Cardiac Dose on Overall Survival in Lung Stereotactic Body Radiotherapy (SBRT) Compared to Conventionally Fractionated Radiotherapy for Locally Advanced Non-Small Cell Lung Cancer (LA-NSCLC)

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Journal of Cancer Therapy 2021年第7期12卷 409-423页

作者： Justin D. Anderson Jiuyun Hu Jing Li steven e. Schild Mirek Fatyga Department of Radiation Oncology Mayo Clinic Phoenix Arizona USA School of Computing Informatics and Decision Systems Engineering Tempe Arizona USA School of Industrial and Systems engineering Georgia Institute of Technology Atlanta Georgia USA

Purpose: To examine possible association between heart irradiation and Overall Survival (OS) in lung SBRT patients and to compare observed associations with cardiac toxicity models previously derived in LA-NSCLC patient studies. Materials and Methods: 197 Patients treated with lung SBRT at Mayo Clinic Arizona were selected for this IRB-approved study. Multivariate Cox model with Akaike Information Criterion (AIC) was used to select patient specific covariates associated with OS. Heart dosimetry was represented by VD indices, which is a percentage of volume exposed to dose D or greater. Multivariate Cox models with patient e="font-family:Verdana;">e="font-family:Verdana;">e="font-family:Verdana;">specific cova

关键词： Lung Cancer Lung SBRT Cardiac Toxicity Lung Radiation Therapy Non-Small Cell Lung Cancer

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employment and Patient Satisfaction after Liver Transplantation

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Journal of Clinical and Translational Hepatology 2020年第3期8卷 299-303页

作者： Christopher Cao Dina Halegoua-DeMarzio Shady Guirguis Crystal Chen Jonathan M.Fenkel steven Herrine Department of Gastroenterology and Hepatology Thomas Jefferson University HospitalsPhiladelphiaPAUSA

Background and Aims:This study serves to revisit the effects of liver transplantation(LT)on employment in an era of improving survival outcomes post-transplant,and to identify areas of improvement in the transplant process to better optimize post-LT employment and patient ***:Prospectively,patients who had undergone LT at a single tertiary LT center were surveyed in person and by *** outcomes included employment rate pre-and post-LT,annual salary,weekly hours worked,barriers to re-employment,and patient ***:Responses were collected and analyzed from 121 patients who underwent ***-LT,68(56.1%)reported full-time employment,13(10.7%)part-time employment,and 40(33.1%)***-LT,26(21.4%)reported continued full-time employment,18(14.9%)part-time employment,and 77(63.6%)*** weekly work hours decreased post-LT(16.1 h/week vs.39.9 h/week).Mean annual salaries decreased post-LT(17 earning salary≥$40,000 vs.56 earning salary≥$40,000).These outcomes differed from patient pre-LT expectations,with 81.0%of previously employed patients believing they would return to employment,resulting in decreased patient *** working physically demanding jobs pre-LT were less likely to return to *** cited for lack of return to full employment included early fatigue and difficulty regaining physical ***:Re-employment rates remain low post-LT,which is particularly true for patients working physically active *** is a significant barrier to re-employment and increased physical rehabilitation post-LT may prove to be *** should be given realistic expectations about return to employment prior to their LT.

关键词： Liver Transplant Liver transplant employment Patient satisfaction

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智能电网:改造电力系统(英文)

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南方电网技术 2010年第1期4卷 1-10页

作者： steven e.Widergren 美国太平洋西北实验室

本世纪伊始,美国能源部组建了一个工作组,专门研发为分布式能源提供通信和控制技术的工作方案。这一步骤以及后续的企业界、学术界和其他研究机构的工作,形成了今天被称作"智能电网"的概念和形象,一个交互式、具有适应性的电力系统正在... 详细信息

本世纪伊始,美国能源部组建了一个工作组,专门研发为分布式能源提供通信和控制技术的工作方案。这一步骤以及后续的企业界、学术界和其他研究机构的工作,形成了今天被称作"智能电网"的概念和形象,一个交互式、具有适应性的电力系统正在出现。由于得到2009年预算重大国家投资的支持,美国能源部、其下属的国家实验室和企业界合作者,目前正在智能电网的研发、示范工程和研究工作中作出重大的努力。在这些重大的努力中,有一点是值得强调的,他们努力确保在向智能电网转变中所采取的各种步骤,都能保持着一个可靠运行的电力系统为经济和社会服务。本文介绍了智能电网的概念,综述与现时智能电网相关努力的现状,并阐述智能电网的优越性。

关键词：智能电网开展现状研究和发展方向协作性

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Australasian microtektites across the Antarctic continent: evidence from the Sør Rondane Mountain range (east Antarctica)

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Geoscience Frontiers 2021年第4期12卷 202-214页

作者： Bastien Soens Matthias van Ginneken Stepan Chernonozhkin Nicolas Slotte Vinciane Debaille Frank Vanhaecke Herman Terryn Philippe Claeys steven Goderis Analytical Environmentaland Geo-ChemistryVrije Universiteit BrusselPleinlaan 2BE-1050 BrusselsBelgium Laboratoire G-Time UniversitéLibre de Bruxelles 50Av.F.D.Roosevelt CP 160/02BE-1050 BrusselsBelgium Centre for Astrophysics and Planetary Science University of KentCT27NZCanterburyKentUnited Kingdom Atomic&Mass Spectrometry–A&MS Research Unit Department of ChemistryGhent UniversityCampus SterreKrijgslaan 281–S12BE-9000 GhentBelgium electrochemical and Surface engineering Vrije Universiteit BrusselPleinlaan 2BE-1050 BrusselsBelgium

The~790 ka Australasian(micro)tektite strewn field is one of the most recent and best-known examples of impact ejecta emplacement as the result of a large-scale cratering event across a considerable part of earth's surface(>10%in area).The Australasian strewn field is characterized by a tri-lobe pattern consisting of a large central distribution lobe,and two smaller side lobes extending to the west and ***,we report on the discovery of microtektite-like particles in sedimentary traps,containing abundant micrometeorite material,in the Sør Rondane Mountain(SRM)range of east *** thirty-three glassy particles display a characteristic pale yellowcolor and are predominantly spherical in shape,except for a single dumbbell-shaped *** vitreous spherules range in size from220 to 570μm,with an average diameter of~370μ*** compares relatively well with the size distribution(75–778μm)of Australasian microtektites previously recovered from the TransantarcticMountains(TAM)and located ca.2500–3000 km fromthe *** addition,the chemical composition of the SRM particles exhibits limited variation and is nearly identical to the‘normal-type’(i.e.,e systematics for a single batch of SRM particles(n=26)strongly support their affiliation with TAMmicrotektites and the Australasian tektite strewn field in ***,Sr isotope ratios and Nd model ages suggest that the target material of the SRM particles was composed of a plagioclase-or carbonate-rich lithology derived from a Paleo-or Mesoproterozoic crustal *** affiliation to the Australasian strewn field requires long-range transportation,with estimated great circle distances of ca.11,600 km from the hypothetical source crater,provided transportation occurred along the central distribution *** is in agreement with the observations made for the Australasian microtektites recovered from Victoria Land(ca.11,000 km)and Larkman Nunatak(ca.12,000 km),w

关键词： Impact cratering Impact ejecta Target stratigraphy Volatilization Antarctica Microtektites

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