检索结果-南通市图书馆

Compressive deformation of ultralong amyloid fibrils

Acta Mechanica Sinica 2010年第6期26卷 977-986页

作者： Raffaella Paparcone steven cranford Markus J.Buehler Laboratory for Atomistic and Molecular Mechanics

Involved in various neurodegenerative diseases, amyloid fibrils and plaques feature a hierarchical structure, ranging from the atomistic to the micrometer *** the atomistic level,a dense and organized hydrogen bond network is resembled in a beta-sheet rich secondary structure, which drives a remarkable stiffness in the range of 10-20GPa,larger than many other biological nanofibrils, a result confirmed by both experiment and ***, the understanding of how these exceptional mechanical properties transfer from the atomistic to the nanoscale remains *** we report a multiscale analysis that, from the atomistic-level structure of a single fibril,extends to the mesoscale level,reaching size scales of hundreds of *** use parameters directly derived from full atomistic simulations of Aβ（1-40） amyloid fibrils to parameterize a mesoscopic coarse-grained model,which is used to reproduce the elastic properties of amyloid *** then apply our mesoscopic model in an analysis of the buckling behavior of amyloid fibrils with different lengths and report a comparison with predictions from continuum beam theory. An important implication of our results is a severe reduction of the effective modulus due to buckling,an effect that could be important to interpret experimental results of ultralong amyloid *** model represents a powerful tool to mechanically characterize molecular structures on the order of hundreds of nanometers to micrometers on the basis of the underlying atomistic *** work provides insight into structural and mechanical properties of amyloid fibrils and may enable further analysis of larger-scale assemblies such as amyloidogenic bundles or plaques as found in disease states.

关键词： Amyloid Coarse-grain Molecular simulation Nanomechanics Materiomics

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：