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A novel strategy for processing,production and quality control of an iron-free nutraceutical supplement that rapidly restores iron-dependent hemoglobin in red blood cells

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食物生产加工与营养(英文) 2020年第1期2卷 258-260页

作者： Debasis Bagchi Bernard W.Downs Manashi Bagchi steve Kushner VNI Inc. LederachPAUSA Texas Southern University College of Pharmacy and Health SciencesHoustonTXUSA Dr.Herbs LLC ConcordCAUSA ALM R&D OldsmarFLUSA

We hypothesize that Iron-Deficiency Anemia(IDA)has been *** the body,low blood iron is not caused by a *** primary cause of low iron,appearing to be IDA,is the expenditure of alkalinizing histidine,from heme protein,which requires the cleavage of iron and its repartitioning to other storage *** an alkaline buffer,histidine is released to counterbalance the increase in an anaerobic hypoxic(*** acidic)blood pH,thereby maintaining a pH of *** research team coined the more accurate term for this pathogenic condition,“Chronic Anemia Syndrome”(CAS).

关键词： Anemia A multi-nutrient nutraceutical VMP35 Hematology Hemoglobin

Liquid pressure sensing system based on distributed polarization crosstalk analysis in polarization maintaining fiber

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Optoelectronics Letters 2022年第11期18卷 651-657页

作者： HE Zongjiang ZHANG Zeheng FENG Ting LI Qing YAO X steve Photonics Information Innovation Center and Hebei Provincial Center for Optical Sensing Innovations College of Physics Science&TechnologyHebei UniversityBaoding 071002China NuVision Photonics Inc.Las Vegas 89109USA

A novel quasi-distributed liquid pressure sensing system based on distributed polarization crosstalk analysis(DPXA) in polarization maintaining fiber(PMF) is proposed and demonstrated. We design a special structure of liquid pressure sensing units and invent a corresponding nonlinear calibration method. Five sensing units deployed on a sensing tape can effectively transform the liquid pressure into the transverse-force applied on the sensing PMF, and the induced polarization crosstalk can be measured and located by the DPXA system, so as to further establish the relationship between liquid pressure and crosstalk through the nonlinear calibration method. The liquid pressure sensing system has good sensitivity and high repeatability, and a maximal measurement relative error of 8.96% is measured for the five sensing units, which can be much improved by optimizing the packaging of sensing units. We believe our sensing system will find great applications in the field of engineering liquid pressure sensing.

关键词： polarization fiber analysis

Immersible ergocycle prescription as a function of relative exercise intensity

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Journal of Sport and Health Science 2017年第2期6卷 219-224页

作者： Mauricio Garzon Mathieu Gayda Anil Nigam Alain-steve Comtois Martin Juneau Cardiovascular Prevention and Rehabilitation Centre (EPIC) Montreal Heart Institute and University of Montreal Montreal Quebec HIT 1N6 Canada Research Center Montreal Heart Institute and University of Montreal Montreal Quebec H1T 1C8 Canada Department of Kinesiology University of Monireal Montreal Quebec H3T 1J4 Canada Department of Medicine University of Montreal Montreal Quebec H3T 1J4 Canada Kinanthropology Department University of Quebec in Montreal (UQAM) Montreal Quebec H2X 1Y4 Canada

Purpose: The purpose of this study was to establish the relationship between various expressions of relative exercise intensity percentage of maximal oxygen uptake(%VO_(2max)), percentage of maximal heart rate(%HR_(max)), %VO_2 reserve(%VO_2R), and %HR reserve(%HRR)) in order to obtain the more appropriate method for exercise intensity prescription when using an immersible ergocycle(IE) and to propose a prediction equation to estimate oxygen consumption(VO_2) based on IE pedaling rate(rpm) for an individualized exercise training ***: Thirty-three healthy participants performed incremental exercise tests on IE and dryland ergocycle(DE) at equal external power output(Pext). Exercise on IE began at 40 rpm and was increased by 10 rpm until exhaustion. Exercise on DE began with an initial load of 25 W and increased by 25 W/min until exhaustion. VO_2 was measured with a portable gas analyzer(COSMED K4b^2) during both incremental tests. On IE and DE, %VO_2R, %HRmax, and %HRR at equal Pext did not differ(p > 0.05).Results: The %HRR vs. %VO_2R regression for both IE and DE did not differ from the identity line %VO_2R IE = 0.99 × HRR IE(%) + 0.01(r^2= 0.91, SEE = 11%); %VO_2R DE = 0.94 × HRR DE(%) + 0.01(r^2= 0.94, SEE = 8%). Similar mean values for %HRmax, %VO_2R, and %HRR at equal Pext were observed on IE and DE. Predicted VO_2 obtained according to rpm on IE is represented by: VO_2(L/min) = 0.000542 × rpm2-0.026 × rpm + 0.739(r = 0.91, SEE = 0.319 L/min).Conclusion: The %HRR–%VO_2R relationship appears to be the most accurate for exercise training prescription on IE. This study offers new tools to better prescribe, control, and individualize exercise intensity on IE.

关键词： Exercise prescription Heart rate Immersed ergocycle Oxygen uptake Pedaling rate

A technological breakthrough in developing a state-of-the-art nutraceutical sports nutrition formulation to enhance vitality, mental acuity, vigilance, energy, and stamina

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Food Production, Processing and Nutrition 2022年第1期4卷 69-71页

作者： Debasis Bagchi Bernard W.Downs Manashi Bagchi steve Kushner R&D VNI Inc.Bonita SpringsFLUSA Texas Southern University College of Pharmacy and Health Sciences HoustonTXUSA Department of Biology Adelphi UniversityGarden CityNYUSA R&D Dr.Herbs LLCConcordCAUSA ALM R&D OldsmarFLUSA

The researchers demonstrate the development of a novel Prodosome technology-derived PL425 PEC phytonutrient-enriched electrolyte formulation and its significant contribution in fluid homeostasis as well as enhanced neuromuscular function, cardio-protection, pulmonary, and other physiological cellular and organ functions. Electrolytes enriched in phytonutrients including polyphenolic bioflavonoids, anthocyanins, saccharides, sulforaphanes, carotenoids and exotic spices, in conjunction with a full spectrum of sea water-derived electrolytes, such as sodium, chloride, potassium, calcium, phosphate, magnesium and bicarbonate, along with vitamin C, all of which are encapsulated in the proprietary Prodosome technology enabling enhanced bioavailability. This technology will maintain important biological functions including metabolic and energy homeostasis, pH equilibration, free radical inhibition, cell-to-cell communication, muscular integrity, enhanced neuronal, cardiovascular, pulmonary, and kidney functions. Moreover, these phytonutrients and electrolytes enhance energy metabolism, ATP production, and activate nitric oxide production without L-Arginine. Ongoing research studies are in progress.

关键词： Phytonutrients Electrolyte balance Micronutrients PL425PEC Prodosome technology Metabolic homeostasis Immune and brain health

Neurolemma-Injected Xenopus Oocytes: An Innovative Ex Vivo Approach to Study the Effects of Pyrethroids on Ion Channels in Their Native State

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Engineering 2020年第5期6卷 515-521页

作者： John Clark steve Symington University of Massachusetts AmherstMA 01003USA Salve Regina University NewportRI 02840USA

Microtransplantation of rat brain neurolemma into the plasma membrane of Xenopus laevis oocytes is an ex vivo method used to study channels and receptors in their native state using standard electrophysiological *** this review,we show that oocytes injected with adult rat brain neurolemma elicited tetrodotoxin-sensitive inward ion currents upon membrane depolarization,which were increased in a concentration-dependent manner by treatment with the pyrethroid insecticides permethrin and *** our initial protocols,oocyte health was reduced over time and neurolemma incorporation varied between batches of oocytes from different frogs,limiting the usefulness of the assay for regulatory issues.A collection of changes to the assay procedure,data acceptance criteria,and analysis method yield substantially improved precision and,hence,assay *** changes established this ex vivo approach as a toxicologically relevant assay to study the toxicodynamic action of pyrethroids on ion channels in their native state using neurolemma fragments prepared from juvenile and adult rat brains.

关键词： Microtransplantation Pyrethroids Rat brain neurolemma Toxicodynamics Voltage-sensitive sodum channels Xenopus laevis

Bactericera cockerelli(Sulc), a potential threat to China’s potato industry

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Journal of Integrative Agriculture 2020年第2期19卷 338-349页

作者： Oluwashola OLANIYAN Neus RODRÍGUEZ-GASOL Nathalie CAYLA Eleonor MICHAUD steve D.WRATTEN Bio-Protection Research Centre Lincoln UniversityLincoln 7647New Zealand Institute for Research and Technology in Food and Agriculture(IRTA) Lleida 25003Spain Agrocampus Ouest Institut National Supérieur des Sciences AgronomiquesAgroalimentairesHorticoles et du PaysageRennes Cedex 35000France

The potato psyllid Bactericera cockerelli(Hemiptera:Triozidae)has recently emerged as a serious pest of potatoes and other solanaceous *** causes direct feeding damage and also vectors Candidatus Liberibacter solanaceaerum(Lso),a pathogen that causes zebra chip disease in potatoes and which potentially costs growers millions of dollars each *** producers rely on frequent sprays of pesticides for psyllid control but the results are unsatisfactory and there are negative side *** psyllid has spread beyond its native range in southwest US and northern Mexico to Canada,El Salvador,Honduras,Guatemala and Nicaragua via medium to long range dispersal flights perhaps aided by wind currents,and through anthropogenic *** was accidentally introduced into New Zealand in 2006 and most recently Australia,most likely through the importation of infested plant *** review summarizes information from studies on the biology,impact and management of ***,and highlights the imminent risk of this insect and its associated pathogen invading China,the world’s largest producer of fresh *** of risk maps leading to increased surveillance,could prevent or delay an incursion and facilitate early detection or eradication should this ***-term management with Lso-tolerant potato cultivars and psyllid control using the parasitic wasp Tamarixia triozae and other natural enemies should be pursued,rather than depending on synthetic pesticides.

关键词： Bactericera cockerelli tomato-potato psyllid invasive pest Candidatus Liberibacter solanaceaerum biological control Tamarixia triozae

The Formation of Anthocyanic Vacuolar Inclusions in Arabidopsis thaliana and Implications for the Sequestration of Anthocyanin Pigments

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Molecular Plant 2010年第1期3卷 78-90页

作者： Lucille Pourcel Niloufer G. Irani Yuhua LU Ken Riedl steve Schwartz Erich Grotewold Department of Plant Cellular and Molecular Biology and Plant Biotechnology Center Ohio State University Columbus OH 43210 USA Department of Food Science and Technology The Ohio State University Columbus OH 43210 USA Present address: Department of Plant Systems Biology Flanders Institute for Biotechnology and Department of Plant Biotechnology and Genetics GhentUniversity 9052 Ghent Belgium Current address: Department of Chemistry Eastern Illinois University Charleston IL 61920 USA

Anthocyanins are flavonoid pigments that accumulate in the large central vacuole of most plants. Inside the vacuole, anthocyanins can be found uniformly distributed or as part of sub-vacuolar pigment bodies, the Anthocyanic Vacuolar Inclusions （AVIs）. Using Arabidopsis seedlings grown under anthocyanin-inductive conditions as a model to un- derstand how AVIs are formed, we show here that the accumulation of AVIs strongly correlates with the formation of cyanidin 3-glucoside （C3G） and derivatives. Arabidopsis mutants that fail to glycosylate anthocyanidins at the 5-0 position （Sgt mutant） accumulate AVIs in almost every epidermal cell of the cotyledons, as compared to wild-type seedlings, where only a small fraction of the cells show AVIs. A similar phenomenon is observed when seedlings are treated with vanadate. Highlighting a role for autophagy in the formation of the AVIs, we show that various mutants that interfere with the autophagic process （atg mutants） display lower numbers of AVIs, in addition to a reduced accumulation of anthocyanins. Interestingly, vanadate increases the numbers of AVIs in the atg mutants, suggesting that several pathways might participate in AVl formation. Taken together, our results suggest novel mechanisms for the formation of sub-vacuolar compartments capable of accumulating anthocyanin pigments.

关键词： Anthocyanin autophagy cyanidin 3-glucoside vacuolar inclusion vanadate.

Genetic Improvement of Willow for Bioenergy and Biofuels

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Journal of Integrative Plant Biology 2011年第2期53卷 151-165页

作者： Angela Karp steve J.Hanley Sviatlana O.Trybush William Macalpine Ian Shield Centre for Bioenergy and Climate Change Plant and Invertebrate Ecology DepartmentRothamsted Research

Willows （Salix spp.） are a very diverse group of catkin-bearing trees and shrubs that are widely distributed across temperate regions of the globe. Some species respond well to being grown in short rotation coppice （SRC） cycles, which are much shorter than conventional forestry. Cop- picing reinvigorates growth and the biomass rapidly accumulated can be used as a source of renewable carbon for bioenergy and biofuels. As SRC willows re-distribute nutrients during the perennial cycle they require only minimal nitrogen fertilizer for growth. This results in fuel chains with potentially high greenhouse gas reductions. To exploit their potential for renewable energy, willows need to be kept free of pests and diseases and yields need to be improved without significantly increasing the requirements for fertilizers and water. The biomass composition needs to be optimized for different end-uses. Yields also need to be sustainable on land less productive for food crops to reduce conflicts over land use. Advances in understanding the physiology and growth of willow, and in the identification of genes underlying key traits, are now at the stage where they can start to be used in breeding programs to help achieve these goals.

关键词： Genetic Improvement of Willow for Bioenergy and Biofuels QTLs SRC

Computer solutions in physics with applications in astrophysics, biophysics, differential equations, and engineering steve Van Wyk.

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