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The synergistic effect of 3D-printed microscale roughness surface and nanoscale feature on enhancing osteogenic differentiation and rapid osseointegration

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Journal of Materials Science & Technology 2021年第4期63卷 18-26页

作者： Hui Wang Jiaqiang Liu Chengtao Wang steve Guofang Shen Xudong Wang Kaili Lin Department of Oral and Cranio-maxillofacial Surgery Shanghai Ninth People’s HospitalCollege of StomatologyShanghai Jiao Tong University School of MedicineNational Clinical Research Center for Oral DiseasesShanghai Key Laboratory of Stomatology&Shanghai Research Institute of StomatologyShanghai200011China School&Hospital of Stomatology Tongji UniversityShanghai Engineering Research Center of Tooth Restoration and RegenerationShanghai200072China School of Mechanical Engineering Shanghai Jiao Tong UniversityShanghai200240China Shanghai University of Medicine&Health Sciences Shanghai201318China

Personalized precision therapy and rapid osseointegration are the main development directions of dental implants.3 D printing is a vital advanced manufacturing technology for personalized precision ***,the osteogenesis of the 3 D printed Ti6 Al4 V implants is *** the bionic perspective,the hierarchical micro/nano-topography can mimic the microenvironment of the multilevel structure of natural bone tissue and may endow the implant surface with superior *** the present study,the hierarchical micro/nano-topography was successfully fabricated by construction the nanoscale feature on 3 D printed microscale roughness surface of 3 D-printed Ti6 Al4 V implants by alkali-heat treatment and hydrothermal *** the cell biological responses in vitro and osseointegration performance in vivo were systematically *** hierarchical micro/nano-topography evidently increased the roughness,improved the hydrophilicity and accelerated the hydroxyapatite deposition and mineralization,which significantly enhanced the adhesion,differentiation and extracellular matrix mineralization of bone marrow derived mesenchymal stromal cells(BMSCs).Most importantly,the hierarchical micro/nano-topography on 3 D-printed implants facilitated the new bone formation and rapid osseointegration in *** study suggested that 3 D-printed implant with micro/nano-topography may be a promising candidate to be applied in orthopedic field to meet the need of customized therapy and rapid osseointegration.

关键词： rapid roughness topography

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Identification of potential key genes in resveratrol biosynthesis via transcriptional analyses of berry development in grapevine(Vitis spp.)genotypes varying in trans-resveratrol content

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Fruit Research 2022年第1期2卷 52-61页

作者： Xiuming Zhang Yifei Wu Yichu Zhang Xiangjing Yin steve van Nocker Junqiang Guo Zhi Li Min Gao Junyang Song Xiping Wang State Key Laboratory of Crop Stress Biology in Arid Areas College of HorticultureNorthwest A&F UniversityYangling 712100China Key Laboratory of Horticultural Plant Biology and Germplasm Innovation in Northwest China Ministry of AgricultureNorthwest A&F UniversityYangling 712100China Department of Horticulture Michigan State UniversityEast Lansing 48824USA

Resveratrol is an important secondary metabolite not only owing to its function as a phytoalexin,but also its potential benefits to human *** this study,the content of trans-resveratrol was documented in seven accessions of grapevine,in the seed,pulp and skin of berries,and at three developmental *** highest amount(2.99μg g^(−1) FW)was found in the skin of berries at the ripe stage from ***‘Tonghua-3'.Resveratrol was not detected in several samples,including skin of berries at the green hard or véraison stage from ***‘Tangwei'.We carried out transcriptional profiling of developing‘Tonghua-3'and‘Tangwei'berries to identify gene expression patterns that may be linked with the difference in resveratrol content between these *** expression levels of several differentially expressed genes(DEGs)with presumed function in resveratrol biosynthesis,including STILBENE SYNTHASEs(STSs),CINNAMATE 4-HYDROXYLASEs(C4Hs)and 4-COUMARATE-COA LIGASEs(4CLs),were significantly higher in‘Tonghua-3',than in'Tangwei'during the véraison and ripe *** ontology and Kyoto Encyclopedia of Genes and Genomes analyses suggested that these DEGs were enriched for multiple biological processes at the three stages of fruit ***,we identified a total of 36 transcription factors,including MYBs,WRKYs,ERFs,bHLHs and bZIPs,that were coexpressed with 17 STSs via a weighted gene co-expression network analysis,suggesting roles as regulators of resveratrol ***,these findings provide insight into genotypic differences in resveratrol biosynthesis in grapevine,as well as the molecular genetics of its regulation.

关键词： Vitis content potential

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Light Perception:A Matter of Time

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Molecular Plant 2020年第3期13卷 363-385页

作者： Sabrina E.Sanchez Matias L.Rugnone steve A.Kay Department of Neurology Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCAUSA

Optimizing the perception of external cues and regulating physiology accordingly help plants to cope with the constantly changing environmental conditions to which they are *** array of photoreceptors and intricate signaling pathways allow plants to convey the surrounding light information and synchronize an endogenous timekeeping system known as the circadian *** biological clock integrates multiple cues to modulate a myriad of downstream responses,timing them to occur at the best moment of the day and the ***,the mechanism underlying entrainment of the light-mediated clock is not *** review addresses known interactions between the light-signaling and circadian-clock networks,focusing on the role of light in clock entrainment and known molecular players in this process.

关键词： circadian clock light signaling Arabidopsis thaliana light entrainment photoreceptors signal integration

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Research on numerical emulator of mine methane and coal dust explosion

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Journal of Coal Science & Engineering(China) 2008年第3期14卷 447-452页

作者： CAI Zhou-quan Niu steve Chongqing Institute of Coal Science Academy Chongqing 400000 China Shaw University Raleigh NC 27601 USA

The mathematical physics model of mine methane and coal dust explosion propagation was established in the research,by using continuous phase,combustion,par- ticulate equations of mathematical *** upon the data from mine methane drainage roadway explosion,and mine methane and coal dust explosion propagation ex- perimental studies,the numerical emulator system of mine methane and coal dust explo- sion software was developed by using prevalent flow simulation platform,which can be used to simulate the explosion accidents process *** addition,the system can also be used to determine whether coal dust involved in the explosion,and to simulate accurately the transition from deflagration to detonation in methane explosion,propagation velocity of explosion shock,attenuation pattern,and affected area of explosion.

关键词： mine methane and coal dust explosion continuous phase mathematica physics equations particulate phase numerical emulator system

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Special report on the fourth international conference on countermeasures to urban heat island （4th IC2UHI Conference） in Singapore

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Frontiers of Architectural Research 2016年第4期5卷 508-510页

作者： Wong Nyuk Hien steve Kardinal Jusuf School of Design and Environment Department of Building National University of SingaporeSingapore 117566 Singapore Engineering Cluster Singapore Institute of Technology Singapore 138683 Singapore

Initiated by Prof. Hashem Akbari, international conference on countermeasures to urban heat island （IC2UHI Conference） was first held in Tokyo, Japan in year 2006. Subsequently, it was held in Berkeley, USA and Veni...

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Guest editorial: Machine Learning in Wireless Networks

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CAAI Transactions on Intelligence Technology 2021年第2期6卷 133-134页

作者： Anil Kumar Budati steve S.H.Ling Department of Electronics and Communication Engineering Gokaraju Rangaraju Institute of Engineering and TechnologyHyderabadIndia School of Biomedical Engineering University of Technology SydneySydneyNew South WalesAustralia

This dedicated Special Section on Machine Learning in Wireless Networks aims to provide improved knowledge for state-of-the-art worldwide R&D communities in wireless networks and machine learning(ML)*** aims to do so by calling for novel formulations,innovative techniques,and optimised solutions to highlight the key issues related to these problems in a forum for shared research and ideas.

关键词： Wireless wireless formulation

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Overexpression of Dlx2 enhances osteogenic differentiation of BMSCs and MC3T3-E1 cells via direct upregulation of Osteocalcin and Alp

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International Journal of Oral Science 2019年第2期11卷 119-130页

作者： Jianfei Zhang Wenbin Zhang Jiewen Dai Xudong Wang steve Guofang Shen Department of Oral & Cranio-maxillofacial Surgery Shanghai Ninth People’s Hospital Shanghai Jiao Tong University School of Medicine Shanghai Key Laboratory of Stomatology

Genetic studies have revealed a critical role of Distal-homeobox (Dlx) genes in bone formation,and our previous study showed that Dlx2 overexpressing in neural crest cells leads to profound abnormalities of the craniofacial *** aim of this study was to investigate the role and the underlying molecular mechanisms of Dlx2 in osteogenic differentiation of mouse bone marrow stromal cells (BMSCs) and pre-osteoblast MC3T3-E1 ***,we observed upregulation of Dlx2 during the early osteogenesis in BMSCs and MC3T3-E1 ***,Dlx2 overexpression enhanced alkaline phosphatase (ALP) activity and extracellular matrix mineralization in BMSCs and MC3T3-E1 cell *** addition,micro-CT of implanted tissues in nude mice confirmed that Dlx2 overexpression in BMSCs promoted bone formation in ***,Dlx2 overexpression had little impact on the expression level of the pivotal osteogenic transcription factors Runx2,Dlx5,Msx2,and Osterix,but led to upregulation of Alp and Osteocalcin (OCN),both of which play critical roles in promoting osteoblast ***,luciferase analysis showed that Dlx2 overexpression stimulated both OCN and Alp promoter *** chromatin-immunoprecipitation assay and site-directed mutagenesis analysis,we provide molecular evidence that Dlx2 transactivates OCN and Alp expression by directly binding to the Dlx2-response cis-acting elements in the promoter of the two *** on these findings,we demonstrate that Dlx2 overexpression enhances osteogenic differentiation in vitro and accelerates bone formation in vivo via direct upregulation of the OCN and Alp gene,suggesting that Dlx2 plays a crucial role in osteogenic differentiation and bone formation.

关键词： BMSCs MC3T3-E1 Osteocalcin

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An all-optical polarization monitoring scheme for polarization division multiplexed transmission

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Chinese Optics Letters 2010年第10期8卷 979-982页

作者：叶佳闫连山易安林潘炜罗斌郭振 X.steve Yao Center for Information Photonics and Communications School of Information Science and Technology Southwest Jiaotong University General Photonics Corp.

A novel polarization monitoring scheme for polarization division multiplexed （PDM） systems is proposed. By using a tag light transmitted in different but close wavelength to the data signal as the feedback control, the scheme can demultiplex automatically two orthogonal polarizations in PDM systems. The effectiveness of the scheme is demonstrated experimentally in a 2×10-Gb/s on-off-keying （OOK） PDM transmission system.

关键词： Multiplexing

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Mshpy23:a user-friendly,parameterized model of magnetosheath conditions

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Earth and Planetary Physics 2024年第1期8卷 89-104页

作者： Jaewoong Jung Hyunju Connor Andrew Dimmock steve Sembay Andrew Read Jan Soucek NASA Goddard Space Flight Center GreenbeltMDUSA Department of Astronomy University of MarylandCollege ParkMDUSA Swedish Institude of Space Physics UppsalaSweden University of Leicester LeicesterUK Institute of Atmospheric Physics Academy of Sciences of the Czech Republic

Lunar Environment heliospheric X-ray Imager(LEXI)and Solar wind−Magnetosphere−Ionosphere Link Explorer(SMILE)will observe magnetosheath and its boundary motion in soft X-rays for understanding magnetopause reconnection modes under various solar wind conditions after their respective launches in 2024 and *** conditions,namely,plasma density,velocity,and temperature,are key parameters for predicting and analyzing soft X-ray images from the LEXI and SMILE *** developed a userfriendly model of magnetosheath that parameterizes number density,velocity,temperature,and magnetic field by utilizing the global Magnetohydrodynamics(MHD)model as well as the pre-existing gas-dynamic and analytic *** this parameterized magnetosheath model,scientists can easily reconstruct expected soft X-ray images and utilize them for analysis of observed images of LEXI and SMILE without simulating the complicated global magnetosphere ***,we created an MHD-based magnetosheath model by running a total of 14 OpenGGCM global MHD simulations under 7 solar wind densities(1,5,10,15,20,25,and 30 cm)and 2 interplanetary magnetic field Bz components(±4 nT),and then parameterizing the results in new magnetosheath *** compared the magnetosheath model result with THEMIS statistical data and it showed good agreement with a weighted Pearson correlation coefficient greater than 0.77,especially for plasma density and plasma ***,we compiled a suite of magnetosheath models incorporating previous magnetosheath models(gas-dynamic,analytic),and did two case studies to test the *** MHD-based model was comparable to or better than the previous models while providing self-consistency among the magnetosheath ***,we constructed a tool to calculate a soft X-ray image from any given vantage point,which can support the planning and data analysis of the aforementioned LEXI and SMILE missions.A release of the code has been uploaded to a Git

关键词： magnetosheath python modeling

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Investigation of Combustion of Emulated Biogas in a Gas Turbine Test Rig

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Journal of Thermal Science 2018年第4期27卷 331-340页

作者： Agustin VALERA-MEDINA Anthony GILES Daniel PUGH steve MORRIS Marcel POHL Andreas ORTWEIN Cardiff University Queen's Building Cardiff CF24 3AA United Kingdom DBFZ Deutsches Biomasseforschungszentrum gemeinnutzige GmbH Leipzig 04347 Germany Hochschule Merseburg Department Engineering and Natural Sciences Merseburg 06217 Germany

Combustion of biogas in gas turbines is an interesting option for provision of renewable combined heat and power from biomass. Due to an increasing share of fluctuating renewable energies in the power grid(especially from wind and solar power), flexible power generation is of increasing importance. Additionally, with an increasing share of agricultural and municipal waste in biogas production, biogas composition is expected to be within a broader range. In this paper, the combustion of synthetic biogas(carbon dioxide and methane) in a combustion test rig with a swirl burner and a high pressure optical chamber is researched at different conditions. Results are compared to a CHEMKIN-PRO simulation using a detailed reaction mechanism. The results show that within the researched experimental matrix, stable biogas combustion for gas turbines can be achieved even with significantly changing gas composition and nominal power. Carbon dioxide concentration is varied from 0 to 60%. CO concentrations(normalized to 15% O_2) in the flue gas do not change significantly with increasing carbon dioxide in the fuel gas and, for the researched conditions, stayed below 10 ppm. NO_x concentration is below 10 ppm(normalized to 15% O_2) for pure methane, and is further decreasing with increasing carbon dioxide share in the fuel gas, which is mainly due to changing reaction paths as reaction analysis showed. Thermal load of the combustor is varied from 100% to 20% for the reference gas composition. With decreasing thermal load, normalized carbon monoxide flue gas concentration is further reduced, while NOx concentrations are remaining at a similar level around 5 ppm(normalized to 15% O_2).

关键词： gas turbine biogas combustion test chemiluminescence

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