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B lymphocytes regulate airway granulocytic inflammation and cytokine production in a murine model of fungal allergic asthma

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Cellular & Molecular Immunology 2015年第2期12卷 202-212页

作者： Sumit Ghosh scott A Hoselton scott V Asbach Breanne N Steffan steve B Wanjara Glenn P Dorsam Jane M Schuh Department of Veterinary and Microbiological Sciences North Dakota State University Fargo ND USA

Sensitization to fungi often leads to a severe form of asthma that is particularly difficult to manage clinically, resulting in increased morbidity and hospitalizations in these patients. Although B lymphocytes might exacerbate asthma symptoms through the production of IgE, these cells might also be important in the protective response against inhaled fungi. Through cytokine release and T-cell interactions, these lymphocytes might also influence the development and maintenance of airway wall fibrosis. JH-/- mice lack the JHgene for the heavy chain component of antibodies, which is critical for B-cell function and survival. These animals have facilitated the elucidation of the role of B iymphocytes in a number of immune responses; however, JH-/- mice have not been used to study fungal allergy. In this study, we examined the role of B lymphocytes using an Aspergillus fumigatus murine fungal aeroallergen model that mimics human airway disease that is triggered by environmental fungal exposure. We compared disease progression in sensitized wild-type BALB/c and JH-/- mice that were exposed to repeated fungal exposure and found no differences in airway hyperresponsiveness, overall pulmonary inflammation or collagen deposition around the large airways. However, the levels of the Th2-type cytokines IL-4 and IL-13 were significantly attenuated in the airways of JH-/- mice relative to the BALB/c controls. By contrast, levels of the inflammatory cytokines IL-17A and IL-6 were significantly elevated in the JH-/- animals, and there was significantly more robust airway eosinophilia and neutrophilia than in control animals. Taken together, these findings demonstrate that B lymphocytes help to regulate granulocytic responses to fungal exDosure in the pulmonary compartment.

关键词： Aspergillus fumigatus B lymphocytes inflammation

Underground mine stream crossing assessment:A multi-disciplinary approach

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International Journal of Mining Science and Technology 2021年第1期31卷 59-65页

作者： Kevin Andrews steve Keim Marshall Miller&Associates BluefieldVA 24605USA

Underground mine designs typically try to avoid extraction beneath streams and rivers of any significant size,especially when the overburden rock thickness between the stream bed and the mine is *** issues with mining beneath streams include excessive groundwater inflow to the mine,weak ground(roof,floor,and pillar)conditions,horizontal stress effects,as well as stream loss and other potential adverse environmental ***,there are times when crossing beneath a stream or river is necessary to move into a new area of mineral reserve without creating additional mine access points from the ground ***,stream crossings are completed without thorough assessment,potentially resulting in increased costs,decreased safety,and,in some cases,failure to advance the *** of the most favorable location(s)to cross the stream must account for numerous factors and the associated assessment often requires a multi-disciplinary *** crossing investigations often require geological,hydrogeological,geotechnical,and geophysical *** of stream crossing investigations include desktop evaluation of maps and aerial photography,stream bed observations,drilling,detailed rock core logging,downhole geophysical surveying,hydraulic conductivity testing(packer testing),geotechnical laboratory testing,assessment,and *** deliverables from a stream crossing assessment typically include geological,geotechnical,and hydrogeological characterization of potential stream crossing locations,classification of favorable and unfavorable crossing locations,recommendations for entry design and pillar sizing,and recommendations for if,and how,to conduct pre-grouting *** of technical aspects of data collection and assessment are provided based on decades of industry experience conducting stream crossing assessments in various underground mining scenarios.

关键词： Underground mining Geotechnical Stream-crossing Hydrogeology Characterization

The 12th Workshop on Antarctic Meteorology and Climate

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Advances in Atmospheric Sciences 2018年第7期35卷 753-756页

作者： Matthew A.LAZZARA Jordan G.POWERS Carol A.COSTANZA David H.BROMWICH scott CARPENTIER steve R.COLWELL Department of Physical Sciences School of Arts and Sciences Madison Area Technical College Madison WI 53704 USA Antarctic Meteorological Research Center Space Science and Engineering Center University of Wisconsin-Madison Madison WI 53706 USA National Center for Atmospheric Research Boulder CO 80300 USA polar Meteorology Group Byrd Polar & Climate Research Center The Ohio State University Columbus OH 43210 USA Bureau of Meteorology Hobart Tasmania 7000 Australia British Antarctic Survey Cambridge CB3 0ET United Kingdom

*** The 12th Workshop on Antarctic Meteorology and Climate（WAMC）,formerly known as the Antarctic Meteorological Observation,Modeling,and Forecasting（AMOMF）Workshop（AMOMFW）,was held at the National Center for Atmospheric Research（NCAR）in Boulder,Colorado,USA on 26–28 June *** annual workshop dates from 2006,and recent meetings have been the 10th AMOMF Workshop held in 2015 in Cambridge,

关键词： AWS The 12th Workshop on Antarctic Meteorology and Climate SH

Determinants of the impact of blood pressure variability on neurological outcome after acute ischaemic stroke

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Stroke & Vascular Neurology 2017年第1期2卷 1-6页

作者： Adam de Havenon Alicia Bennett Gregory J Stoddard Gordon Smith Lee Chung steve O’Donnell J scott McNally David Tirschwell Jennifer J Majersik Department of Neurology University of UtahSaltLake CityUtahUSA University of Utah SaltLake CityUtahUSA University of Washington SeattleWashingtonUSA

Introduction: Increased blood pressure variability (BPV) is detrimental after acute ischaemic stroke, but the interaction between BPV and neuroimaging factors that directly influence stroke outcome has not been explored. Methods: We retrospectively reviewed inpatients from 2007 to 2014 with acute anterior circulation ischaemic stroke, CT perfusion and angiography at hospital admission, and a modified Rankin Scale (MRS) 30- 365 days after stroke onset. BPV indices included SD, coefficient of variation and successive variation of the systolic blood pressure between 0 and 120 hours after admission. Ordinal logistic regression models were fitted to MRS with predictor variables of BPV indices. Models were further stratified by CT perfusion volumetric measurements, proximal vessel occlusion and collateral score. Results: 110 patients met the inclusion criteria. The likelihood of a 1-point rise in the MRS increased with every 10 mm Hg increase in BPV (OR for the 3 BPV indices ranged from 2.27 to 5.54), which was more pronounced in patients with larger ischaemic core volumes (OR 8.37 to 18.0) and larger hypoperfused volumes (OR 6.02 to 15.4). This association also held true for patients with larger mismatch volume, proximal vessel occlusion and good collateral vessels. Conclusions: These results indicate that increased BPV is associated with worse neurological outcome after stroke, particularly in patients with a large lesion core volume, concurrent viable ischaemic penumbra, proximal vessel occlusion and good collaterals. This subset of patients, who are often not candidates for or fail acute stroke therapies such as intravenous tissue plasminogen activator or endovascular thrombectomy, may benefit from interventions aimed at reducing BPV.

关键词： impaired perfusion cerebral

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***权威指南 1

The 10th Antarctic Meteorological Observation,Modeling,and Forecasting Workshop

丛书名： .NET系列

2003年

作者：（美）scott Mitchell （美）steve Walther等汤涛译

本书详细阐述了***的概念，提供了可阐明概念的样例代码，并为中、高级开发人员提供了逐级的代码解释。

ISBN: (纸本)7508313917

本书详细阐述了***的概念，提供了可阐明概念的样例代码，并为中、高级开发人员提供了逐级的代码解释。

关键词：互连网络程序设计

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Advances in Atmospheric Sciences 2016年第5期33卷 I0001-I0003页

作者： steve R.COLWELL Arthur M.CAYETTE Matthew A.LAZZARA Jordan G.POWERS David H.BROMWICH John J.CASSANO scott CARPENTIER British Antarctic Survey CambridgeUnited Kingdom Space and Naval Warfare System Center Office of Polar Programs North Charleston SCUSA Antarctic Meteorological Research Center Space Science and Engineering Center University of Wisconsin-Madisonand Department of Physical SciencesSchool of Arts and SciencesMadison Area Technical CollegeMadison WIUSA National Center for Atmospheric Research Boulder COUSA Polar Meteorology Group Byrd Polar&Climate Research CenterThe Ohio State UniversityColumbus OHUSA Cooperative Institute for Research in Environmental Sciences and Department of Atmospheric and Oceanic Sciences University of Colorado-BoulderBoulder COUSA Bureau of Meteorology HobartTasmaniaAustralia

1. Overview The 10th Antarctic Meteorological Observation, Modeling, and Forecasting Workshop （hereinafter AMOMFW） took place June 17-19, 2015 in the historic city of Cambridge, United Kingdom. The meeting followed its purpose of connecting Antarctic atmospheric science to weatherrelated operational issues and advances in observing, modeling, forecasting, and understanding the Antarctic environment.

关键词： AMRC Modeling

Projected Future Wind Speed and Wind Power Density Trends over the Western US High Plains

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Atmospheric and Climate Sciences 2012年第1期2卷 32-40页

作者： J. scott Greene Matthew Chatelain Mark Morrissey steve Stadler 不详

This manuscript presents the results of research on future changes in wind speed and wind power density across the western US High Plains in an area known for its high wind energy resources. Many current policies and economic analyses involving the rapidly expanding wind energy industry have assumed a constant or near constant wind resource. However, any future change in wind speeds will result in changes in the reliability of wind power as an energy resource. This paper uses current data (1970-2000) and future model output (2040-2070) to analyze decadal and seasonal changes in wind speed across the study area. In addition, estimated hub height wind power densities have been analyzed. Results show projections of a slight overall decreasing wind power in the future across the region. The greatest magnitude changes are estimated to be in the seasonal trends with the most substantial decreases occurring in winter and spring. As climate changes and warms overall, there will be shifts in the temperature gradients and the synoptic storm tracks that drive wind speeds. Thus, it is theorized that the wind speeds will be the result of an earlier transition to, and longer duration of, a calmer summertime pattern. This longer duration of a summertime pattern will lead to the decreased wind speeds and lower wind power output identified in this research. This decrease needs to be factored in for any estimates of the long-term costs and benefits of wind farms in the area.

关键词： Wind Climatology Renewable Energy Climatic Variability

Estimation of alfalfa fall dormancy using spaced plant and sward trials across multiple environments

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Grassland Research 2023年第1期2卷 15-21页

作者： scott A.Newell Daniel J.Undersander Donald Viands Julie Hansen steve Orloff Daniel H.Putnam E.Charles Brummer Department of Plant Sciences University of CaliforniaDavisDavisCaliforniaUSA Department of Agronomy University of WisconsinMadisonMadisonWisconsinUSA Plant Breeding&Genetics Section School of Integrated Plant SciencesCornell UniversityIthacaNew YorkUSA Univeristy of California Cooperative Extension YrekaCaliforniaUSA

Background:Alfalfa is a globally important forage *** are characterized by fall dormancy(FD).FD affects biomass yield and winter survival and is used to identify appropriate growing regions of *** has historically been assessed by measuring the natural height of regrowth in autumn of spaced plants in the *** commercial alfalfa is normally grown as a solid planted sward,FD could be different if plants were grown under real production *** objective of this experiment was to assess whether FD ratings obtained from swards were similar to those obtained on spaced ***:We evaluated 20 alfalfa cultivars in field trials established in 2015 at five locations in the United *** harvested the trials in early autumn and measured regrowth plant height approximately 3 weeks later in 2015 and ***:Autumn plant height responded as expected for the established check cultivars in all *** dormancy ratings for cultivars under both management systems were highly ***:Estimating FD from spaced plant height measurements in autumn is very robust,and using height data from sward plots gives equivalent results to that measured in spaced plant *** finding has many practical advantages.

关键词： alfalfa fall dormancy lucerne Medicago sativa plant height

Air quality monitoring using mobile microscopy and machine learning

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Light(Science & Applications) 2017年第1期6卷 555-566页

作者： Yi-Chen Wu Ashutosh Shiledar Yi-Cheng Li Jeffrey Wong steve Feng Xuan Chen Christine Chen Kevin Jin Saba Janamian Zhe Yang Zachary scott Ballard Zoltán Göröcs Alborz Feizi Aydogan Ozcan Electrical Engineering Department University of CaliforniaLos AngelesCA 90095USA Bioengineering Department University of CaliforniaLos AngelesCA 90095USA California NanoSystems Institute(CNSI) University of CaliforniaLos AngelesCA 90095USA Computer Science Department University of CaliforniaLos AngelesCA 90095USA David Geffen School of Medicine University of CaliforniaLos AngelesCA 90095USA

Rapid,accurate and high-throughput sizing and quantification of particulate matter(PM)in air is crucial for monitoring and improving air *** fact,particles in air with a diameter of≤2.5μm have been classified as carcinogenic by the World Health *** we present a field-portable cost-effective platform for high-throughput quantification of particulate matter using computational lens-free microscopy and *** platform,termed c-Air,is also integrated with a smartphone application for device control and display of *** mobile device rapidly screens 6.5 L of air in 30 s and generates microscopic images of the aerosols in *** provides statistics of the particle size and density distribution with a sizing accuracy of~93%.We tested this mobile platform by measuring the air quality at different indoor and outdoor environments and measurement times,and compared our results to those of an Environmental Protection Agency–approved device based on beta-attenuation monitoring,which showed strong correlation to c-Air ***,we used c-Air to map the air quality around Los Angeles International Airport(LAX)over 24 h to confirm that the impact of LAX on increased PM concentration was present even at 47 km away from the airport,especially along the direction of landing *** its machinelearning-based computational microscopy interface,c-Air can be adaptively tailored to detect specific particles in air,for example,various types of pollen and mold and provide a cost-effective mobile solution for highly accurate and distributed sensing of air quality.

关键词： air-quality monitoring holography machine learning particulate matter