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偶发性阿尔茨海默病患者的受教育程度与认知功能下降速度的关系

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世界核心医学期刊文摘(神经病学分册) 2006年第8期 55-56页

作者： Scarmeas N. Albert S.M. Manly J.J. stern y. 刘凯 Columbia University Medical Center 622 West 168th Street New York NY 10032 United States

Background: Some (but not all) epidemiological studies have noted faster rates of progression in high education patients with Alzheimer’s disease (AD), which has been attributed to harbouring/tolerating a higher pathological burden at the time of clinical dementia for subjects with higher education. We wanted to assess the relationship between education and rates of decline in AD. Methods: During the course of a community based multiethnic prospective cohort study of individuals aged ≥ 65 years living in New york, 312 patients were diagnosed with incident AD and were followed overall for 5.6 (up to 13.3) years. The subjects received an average of 3.7 (up to 9) neuropsychological assessments consisting of 12 individual tests. With the aid of a normative sample, a standardised composite cognitive score as well as individual cognitive domain scores were calculated. Generalised estimating equation models were used to examine the association between education and rates of cognitive decline. Results: Composite cognitive performance declined by 9% of a standard deviation per year. Rates of decline before and after AD incidence were similar. For each additional year of education there was 0.3% standard deviation lower composite cognitive performance for each year of follow up. The association between higher education and faster decline was noted primarily in the executive speed (0.6% ) and memory (0.5% )cognitive domains and was present over and above age, gender, ethnicity, differential baseline cognitive performance, depression, and vascular comorbidity. Conclusions: We conclude that higher education AD patients experience faster cognitive decline.

关键词：认知功能下降速度阿尔茨海默病患者偶发性受教育程度

美国国立老化研究所与阿尔茨海默病协会诊断指南写作组：阿尔茨海默病临床前阶段的定义

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中华神经科杂志 2012年第5期45卷 336-344页

作者： Sperling RA Aisen PS Beckett LA Bennett DA Craft S Fagan AM Iwatsubo T Jack CR Jr Kaye J Montine TJ Park DC Reiman EM Rowe CC Siemers E stern y yaffe K Carrillo MC Thies B Morrison-Bogorad M Wagster MV Phelps CH 贾建平（译）郭起浩（译）黄丽（译）陆璐（译）张逸驰（译）邢怡（译）不详首都医科大学宣武医院神经科北京100053 复旦大学附属华山医院神经内科

阿尔茨海默病（AD）的病理生理过程在痴呆诊断的多年前就开始了。这一长期的AD“临床前”阶段是治疗干预的关键机会，但需进一步阐明AD的病理级联过程和临床症状出现之间的联系。美国国立老化研究所和AD协会召集了一个国际工作组对AD生... 详细信息

阿尔茨海默病（AD）的病理生理过程在痴呆诊断的多年前就开始了。这一长期的AD“临床前”阶段是治疗干预的关键机会，但需进一步阐明AD的病理级联过程和临床症状出现之间的联系。美国国立老化研究所和AD协会召集了一个国际工作组对AD生物标志物、流行病学和神经心理学的证据进行综述并提出建议，以确定能够预测由“正常”认知到轻度认知功能障碍（MCI）及AD痴呆的最佳预测指标。根据目前已有的主要科学证据，我们提出了一个概念性的框架和用于操作的研究标准，以通过纵向临床研究来验证和改进这些模型。这些建议仅用于研究目的，目前不涉及临床应用。我们希望这些建议能提供一个共识，以推进临床前AD的研究，最终推动更早期治疗干预的进展，使得一些疾病减缓药物的疗效发挥最大。

关键词：阿尔茨海默病诊断指南临床前研究所协会老化美国轻度认知功能障碍

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头痛可以是亚急性闭角型青光眼的主要症状

世界核心医学期刊文摘（眼科学分册） 2005年第8期1卷 5-5页

作者： Nesher R. Epstein E. stern y. 陈立军 Department of Ophthalmology Meir Hospital Sapir Medical Center Kfar-Saba Israel Dr.

The diagnosis of subacute angle closure glaucoma is suspected in patients with narrow angles of the anterior chamber of the eye, presenting with periodic ocul ar, or periocular pain. However, some patients may present with headaches in the absence of significant ocular discomfort, which often leads to misdiagnosis and delay in specific therapy. The clinical features of 9 such patients are describ ed. Subacute angle closure glaucoma should always be considered in the different ial diagnosis of adultonset headaches.

关键词：房角眼周鉴别诊断

尸检证实为帕金森病患者并发α-共核蛋白异常的定量指数与临床预后的关系

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世界核心医学期刊文摘（神经病学分册） 2006年第6期2卷 14-14页

作者： Holtzer R. Irizarry M.C. Sanders J. y. stern 郭俊 Sergievsky Center Columbia University College of Physicians and Surgeons P and S Box 16 630 W 168th St New York NY 10032 United States Dr.

Background: Lewy bodies (LBs) and Lewy neurites are frequent concomitant neuropathologic observations in clinical and neuropathologically defined Alzheimer disease (AD), but their relation to clinical features in AD is uncertain. Most studies used semiquantitative measures to determine the presence or absence of LB abnormalities. Objective: To determine the clinical consequences of LB abnormalities in the setting of AD. Design: Prospective study. Setting: Three outpatient research and treatment centers. Participants: Fourteen autopsy cases with a pathologic diagnosis of AD abnormalities and concomitant LBs followed semiannually for up to 8 years (mean age at intake, 72 years; mean age at death, 77 years; mean education, 15 years; 12 women). Main Outcome Measures: The modified Mini-Mental State Examination was used to assess cognitive function. The Unified Parkinson Disease Rating Scale was used to rate extrapyramidal motor signs. Hallucination s were evaluated using the Columbia University Scale for Psychopathology in Alzheimer’s Disease. Time from the first evaluation in which diagnostic criteria for probable AD were met to death was used to determine illness duration. Quantitative measures of LB abnormalities were obtained for the frontal cortex, entorhinal cortex, substantia nigra, and hippocampus. Results: Independent-samples t te sts were used to assess whether the degree of LB abnormality varied as a function of the presence or absence of hallucinations and extrapyramidal signs. Pearson r correlations were run to examine whether there was a relation among LB abnormalities, cognitive function, and illness duration. There was no relation between quantitative neuropathologic indexes of LB abnormalities and clinical outcome. Conclusion: The variability of clinical features in AD was not related to the presence or degree of LB abnormalities.

关键词：半定量方法蛋白异常门诊患者临床预后帕金森病指数尸检平均死亡年龄神经病理学

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最新AD研究用诊断标准:IWG-2标准

神经病学与神经康复学杂志 2014年第3期11卷 133-143页

作者：陈刚曹雯炜俞羚糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L stern y Scheltens P Cummings JL 上海交通大学医学院附属仁济医院神经内科上海200127

在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点... 详细信息

在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。

关键词：阿尔茨海默病生物标志物研究用诊断标准临床表型淀粉样蛋白诊断流程 AD IWG-2 病理生理

一种对磁场和震动具有低灵敏度的简单新颖的铷原子频标

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空间电子技术 1999年第4期 56-61页

作者： stern A Hertz A Zarfaty y Lepek A 屈勇晟西安空间无线电技术研究所助理工程师西安710000

TFL开发了一种设计简单,耐用的新型铷原子频标。这个设计在传统的设计上进行了两项改进: ·采用适当的电路措施改进震动和加速度的频率灵敏度

关键词：铷原子频标磁场振动灵敏度 RFS

Zoon’s balanitis with mucinous metaplasia: A case report and review of literature

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Open Journal of Clinical Diagnostics 2013年第2期3卷 33-36页

作者： Jin-Ping Lai Edward W. Cowen Jere B. stern Leomar y. Ballester Emily y. Chu Rodolfo E. Chirinos Richard W. Childs Chyi-Chia Richard Lee Department of Dermatology Georgetown University Hospital Washington DC USA Dermatology Branch National Cancer Institute National Institutes of Health Bethesda USA Hematology Branch National Hear Lung and Blood Institute National Institutes of Health Bethesda USA Laboratory of Pathology National Cancer Institute National Institutes of Health Bethesda USA

Mucinous metaplasia of the squamous epithelium of the glans penis is very rarely seen in the setting of Zoon’s balanitis. We report a case of 40 year old male with a past medical history of paroxysmal nocturnal hemoglobinuria, status-post allogeneic hematopoietic cell transplantation from an HLA-matched sibling 6 years prior to evaluation, complicated by oral and cutaneous chronic graft-versus-host disease. Mucinous metaplasia was confirmed by PAS and Mucin stains, and plasmacytosis was confirmed by immunohistochemistry for CD138 and MUM1 markers. Kappa and Lambda immunostains revealed a polyclonal pattern. The etiology of zoon’s balanitis as well as the significance of mucinous metaplasia in these setting are unclear and need to be further investigated.

关键词： Bone Marrow Transplant Squamous Cell Carcinoma Erythroplasia of Querat Graft versus Host Disease

Chalcogenoviologen Enhanced Host–Guest Recognition

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CCS Chemistry 2024年第11期6卷 2679-2691页

作者： yuanning Feng Xingang Zhao Daniel A.Appleton Han Han Ryan M.young Wenqi Liu Christopher K.Lee Weixingyue Li Bai-Tong Liu yong Wu Chun Tang Aspen X-y.Chen Charlotte L.stern Dong Jun Kim Michael R.Wasielewski yunyan Qiu J.Fraser Stoddart Department of Chemistry and Biochemistry The University of OklahomaNormanOklahoma 73019 Weinberg College of Arts and Sciences Northwestern UniversityEvanstonIllinois 60208 Department of Chemistry The University of Hong KongHong Kong SAR 999077 Paula M.Trienens Institute for Sustainability and Energy Northwestern UniversityEvanstonIllinois 60208 Department of Chemistry University of South FloridaTampaFlorida 33620 School of Chemistry University of New South WalesSydneyNSW 2052 Department of Chemistry National University of SingaporeSingapore 117543 Center for Regenerative Nanomedicine Northwestern UniversityChicagoIllinois 60611 Stoddart Institute of Molecular Science Department of ChemistryZhejiang UniversityHangzhou 310027 ZJU-Hangzhou Global Scientific and Technological Innovation Center Hangzhou 311215

In the field of supramolecular chemistry,cyclophanes with novel properties are highly sought after since they can be tailored to fulfill specific *** this article,we incorporate chalcogenoviologen-based units into tetracationic cyclophanes,resulting in enhanced host–guest *** cyclophanes can be tuned through the addition of chalcogen bridging atoms—S,Se,and Te—which enhance their rigidity,regulate bond rotation and introduce additional steric *** cyclophanes containing chalcogen bridging atoms were synthesized and characterized in both the solution and solid *** energy barriers for their interconversion between syn-and anti-conformations in solution were found to be correlated with chalcogen atom *** photophysical properties of the cyclophanes are strongly dependent on the chalcogen atomic number,with intersystem crossing rates increasing from S to Se to ***–vis-NIR spectroscopic and fluorometric titrations revealed that the chalcogenoviologenbased cyclophanes exhibit significantly stronger binding with electron-rich guests compared to the well-known,unsubstituted cyclobis(paraquat-pphenylene).This enhancement in binding can be attributed to restricted rotation within the chalcogenoviologen *** research provides insight into the rational design and tailored synthesis of cationic cyclophanes.

关键词： binding titrations chalcogens host–guest systems molecular recognition supramolecular chemistry

抗氧化剂治疗慢性丙型肝炎病毒感染:I期临床试验结果

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世界核心医学期刊文摘（胃肠病学分册） 2006年第1期2卷 49-50页

作者： Melhem A. stern M. Shibolet O. y. Ilan 陈瑜 Liver Unit Department of Medicine Hadassah University Hospital P.O.B. 12000 Jerusalem 91120 Israel Dr.

Background: The pathogenesis of chronic hepatitis C virus (HCV) infection is associated with a defective host antiviral immune response and intrahepatic oxidative stress. Oxidative stress and lipid peroxidation play major roles in the fatty liver accumulation (steatosis) that leads to necro-inflammation and necrosis of hepatic cells. Previous trials suggested that antioxidative therapy may have a beneficial effect on patients with chronic HCV infection. Aims: To determine the safety and efficacy of treatment of chronic HCV patients via a combination of antioxidants. Methods: Fifty chronic HCV patients were treated orally on a daily basis for 20 weeks with seven antioxidative oral preparations (glycyrrhizin, schisandra, silymarin, ascorbic acid, lipoic acid, L-glutathione, and alpha-tocopherol), along with four different intravenous preparations (glycyrrhizin, ascorbic acid, L-glutathione, B-complex) twice weekly for the first 10 weeks, and followed-up for an additional 20 weeks. Patients were monitored for HCV-RNA levels, liver enzymes, and liver histology. Assessment of quality of life was performed using the SF-36 questionnaire. Results: In one of the tested parameters (eg, liver enzymes, HCV PvNA levels, or liver biopsy score), a combination of antioxidants induced a favorable response in 48% of the patients (24). Normalization of liver enzymes occurred in 44% of patients who had elevated pretreatment ALT levels (15 of 34). ALT levels remained normal throughout follow-up period in 72.7% (8 of 11). A decrease in viral load (one log or more) was observed in 25% of the patients (12). Histologic improvement (2-point reduction in the HAI score) was noted in 36.1% of the patients. The SF-36 score improved in 26 of 45 patients throughout the course of the trial (58% of the patients). Treatment was well tolerated by all patients. No major adverse reactions were noted. Conclusions: These data suggest that multi antioxidative treatment in chronic HCV patients is well toler

关键词： I期临床试验临床试验结果抗氧化剂脂质过氧化反应氧化应激肝脏组织学水飞蓟素甘草皂苷抗病