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Comparison of 2-acetylfuran,2-ethylfuran,and 2-methylfuran spherically expanding flame intrinsic instabilities

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Science China(Technological Sciences) 2022年第10期65卷 2388-2398页

作者： XU CangSu WANG QianWen LI XiaoLu OPPONG francis LIU WeiNan College of Energy Engineering State Key Laboratory of Clean Energy UtilizationZhejiang UniversityHangzhou 310027China College of Mechanical and Electrical Engineering Key Laboratory of Intelligent Manufacturing Quality Big Data Tracing and Analysis of Zhejiang ProvinceChina Jiliang UniversityHangzhou 310018China

The intrinsic instability of three furan derivatives, namely, 2-acetylfuran(AF), 2-ethylfuran(EF), and 2-methylfuran(MF), is experimentally and theoretically investigated and compared. A deep-learning-based end-to-end system is used to segment the cells and measure the crack length on the cellular flame front of the spherically expanding flame to quantitively investigate the flame morphology. Moreover, the flame front radius profile is quantitively investigated to shed light on the correlation between disturbance amplitude and flame radius. With the use of the linear stability model, the theoretical critical flame radius and Peclet number are obtained and compared to their corresponding experimental results to characterize the outset of cellularization and evaluate the flame instability propensity. Our analysis shows that compared with AF and EF, MF is prone to cellularization at a smaller flame radius and has a faster cell proliferation rate and crack length growth rate before reaching the hydrodynamic saturation limit. Meanwhile, the average area of saturated cells tends to be similar for the three furan derivatives. Furthermore,AF premixed flame does not exhibit cellularization before the flame radius is less than 45 mm in low initial pressure.

关键词： furan derivatives spherical expanding flame flame intrinsic instability linear stability theory

Elbow Dislocation in Children: About Two Cases and Review of the Literature

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Open Journal of Pediatrics 2024年第2期14卷 218-226页

作者： Nyanit Bob Dorcas Atangana Cédric Paterson Mantho Fopa Pauline Kouna TsalaIrène Nadine Mvouni Bob Thérèse Raissa Bekima King francis Ateaze Chrisantus Dikongue Diwondi Audrey Ndongo Réné Akoa Manga Ismael Evoni Molo Tatiana Choupo Guetchuin Stéphane Handy Eone Daniel Department of Surgery and Specialties Faculty of Medecine and Biomedical Sciences University of Yaoundé I Yaoundé Cameroon Infant Surgery Department of Yaounde Central Hospital Yaoundé Cameroon Faculty of Medecine and Pharmaceutical Sciences of Douala Douala Cameroon Troyes Hospital Center Troyes France Vire Normandie Hospital Center Normandie France Traumatology Department of Yaounde Central Hospital Yaoundé Cameroon

Background: Elbow dislocations in pediatric patients are rare injuries. This is a therapeutic emergency because a delay in treatment can have disastrous consequences on the functional level of the upper limb. Objective: To present the management of elbow dislocation in children in cases of limited resources. Presentation of the Cases: These were 2 older male children aged 7 and 9 years old, admitted to the emergency room for painful functional impotence of the right elbow after a fall and landing on the right hand. Clinical and radiological examinations were in favor of posterior elbow dislocations. The reductions were carried out under sedation and immobilization in Jersey. According to Robert’s criteria, the functional result was excellent in both patients. Conclusion: Emergency reduction and immobilization whatever the means ensure an excellent functional prognosis even in cases of limited resources.

关键词： Elbow Dislocation Child Diagnosis Treatment Limited Resources

Equitable bivalent booster allocation strategies against emerging SARS-CoV-2 variants in US cities with large Hispanic communities:The case of El Paso County,Texas

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Infectious Disease Modelling 2023年第3期8卷 912-919页

作者： francis Owusu-Dampare Anass Bouchnita Department of Mathematical Sciences The University of Texas at El PasoEl Paso79968TexasUnited States

COVID-19 is a disease that disproportionately impacts the Hispanic population,due to the prevalence of certain risk factors and the high number of essential workers in this *** this work,we analyze the vaccination strategies that would minimize the COVID-19 health disparities in El Paso County,TX,in the context of the emergence of a new highly transmissible and immune-escaping SARS-CoV-2 *** stratify an age-structure stochastic SEIR model that tracks the evolution of immunity derived from in-fections and vaccination according to Hispanic vs non-Hispanic ethnicity and parameterize it to the demographic,health and immunization data of El Paso County,*** fitting the model,the results show that increasing vaccination with bivalent boosters by five-fold in anticipation of highly transmissible and immune escaping variants would decrease the cumulative hospital admissions and mortality from Mar 1,2023,to Dec 31,2023,by 62.72%and 61.41%,***,our projections reveal that the disproportionate impact on the Hispanic community would be eliminated if approximately half of the doses that are given to the non-Hispanic group according to the equal distribution,would be re-allocated to the Hispanic *** findings can guide public health officials in US cities with large Hispanic communities and help them design vaccination strategies that minimize COVID-19 health disparities caused by emerging variants using specific vacci-nation strategies.

关键词： Mathematical modeling COVID-19 Hispanic health disparities Bivalent boosters

Tranexamic acid for major trauma patients in Ireland

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World Journal of Emergency Medicine 2022年第1期13卷 11-17页

作者： Kieran Walsh francis O’Keeff e Louise Brent Biswadev Mitra National Trauma Research Institute the Alfred HospitalMelbourne 3004Australia Critical Care Research School of Public Health and Preventive MedicineMonash UniversityMelbourne 3004Australia Emergency&Trauma Centre Alfred HealthMelbourne 3004Australia Emergency Department Mater Misericordiae University HospitalDublin D07 R2WYIreland National Offi ce for Clinical Audit Ardilaun HouseDublin D02 VN51Ireland

BACKGROUND:The Clinical Randomisation of an Anti-fibrinolytic in Significant Hemorrhage-2(CRASH-2)is the largest randomized control trial(RCT)examining circulatory resuscitation for trauma patients to date and concluded a statistically significant reduction in all-cause mortality in patients administered tranexamic acid(TXA)within 3 hours of *** the publication of CRASH-2,significant geographical variance in the use of TXA for trauma patients *** study aims to assess TXA use for major trauma patients with hemorrhagic shock in Ireland after the publication of ***:A retrospective cohort study was conducted using data derived from the Trauma Audit and Research Network(TARN).All injured patients in Ireland between January 2013 and December 2018 who had evidence of hemorrhagic shock on presentation(as defined by systolic blood pressure[SBP]1(70.68%vs.57.43%)and higher Injury Severity Score(ISS>25;49.62%vs.23.76%).Administration of TXA was not associated with mortality at hospital discharge(odds ratio[OR]0.86,95%CI 0.31–2.38).CONCLUSIONS:Among injured Irish patients presenting with hemorrhagic shock,TXA was administered to 56.8%of *** administered with TXA were on average more severely ***,a mortality benefit could not be demonstrated.

关键词： Tranexamic acid Shock Ireland Hemorrhage

Recognition of nestmate eggs in the ant Formicafusca is based on queen derived cues

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Current Zoology 2014年第1期60卷 131-136页

作者： Heikki HELANTERA stephen J. MARTIN francis L.W. RATNIEKS Centre of Excellence in Biological Interactions Department of Biosciences POB 65 University of Helsinki Finland School of Environment & Life Sciences University of Salford Manchester M5 4WT UK Laboratory ofApiculture & Social Insects (LASI) School of Life Sciences University of Sussex Falmer Brighton UK

Inclusive fitness benefits depend on recognizing the right individuals to interact with. Social insect nests protect themselves from non-kin intruders through nestmate recognition based on chemical cues. The recognition cues on adult individuals are from a mixture of genetic and environmental sources, but the ontogeny and use of recognition cues on eggs has not been previously assessed. We studied recognition by workers of eggs that were either nestmates or non-nestmates. and the ontogeny of recognition cues on eggs in the antFormica fusca, a species with precise egg recognition abilities. Workers were able to discriminate among freshly laid eggs with no nest derived cues on them, and the egg surface chemicals varied among nests in these eggs, suggesting that queen derived cues are used in nestmate recognition. The results are discussed in the light of their implications on deceptive social parasite strategies and within colony conflicts.

关键词：识别能力鲜鸡蛋出线蚂蚁社会性昆虫个体发育化学物质信号保护

Identifying Biomarkers for Diabetic Kidney Disease Using GraphSAGE Neural Network

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Journal of Computer and Communications 2023年第10期11卷 51-63页

作者： Sesugh Gabriel Abenga Kehinde Seyi Olalekan francis Akogwu Alu stephen Yavenga Uyoo Department of Computer Science Joseph Sarwuan Tarka University Makurdi Nigeria Department of Information Technology Department National Orthopaedic Hospital Lagos Nigeria Department of Information Security/Data Management Franksong Synergy Consultancy Upper Marlboro USA

Diabetic Kidney Disease (DKD) is a common chronic complication of diabetes. Despite advancements in accurately identifying biomarkers for detecting and diagnosing this harmful disease, there remains an urgent need for new biomarkers to enable early detection of DKD. In this study, we modeled publicly available transcriptome datasets as a graph problem and used GraphSAGE Neural Networks (GNNs) to identify potential biomarkers. The GraphSAGE model effectively learned representations that captured the intricate interactions, dependencies among genes, and disease-specific gene expression patterns necessary to classify samples as DKD and Control. We finally extracted the features of importance;the identified set of genes exhibited an impressive ability to distinguish between healthy and unhealthy samples, even though these genes differ from previous research findings. The unexpected biomarker variations in this study suggest more exploration and validation studies for discovering biomarkers in DKD. In conclusion, our study showcases the effectiveness of modeling transcriptome data as a graph problem, demonstrates the use of GraphSAGE models for biomarker discovery in DKD, and advocates for integrating advanced machine-learning techniques in DKD biomarker research, emphasizing the need for a holistic approach to unravel the intricacies of biological systems.

关键词： Diabetic Kidney Disease (DKD) GraphSAGE Neural Network Personalized Treatment Transcriptome Gene Expression Differential Analysis Deep Learning End-Stage Kidney Disease (ESKD) Early Detection

Delineation of sensitive coastal zone of northern Ramanathapuram coast,Tamilnadu,India,using a GIS approach

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Geodesy and Geodynamics 2022年第5期13卷 456-463页

作者： Gurugnanam Balasubramanian Sreechitra Suresh Santonu Goswami Bairavi Swaminathan Glitson francis Pereira Centre for Applied Geology The Gandhigram Rural Institute-Deemed to Be UniversityDindigulTamil NaduIndia National Remote Sensing Centre India

This research aims to assess the sensitive coastal zones by analyzing the shoreline changes such as accretion and erosion in the eastern coastal part of Ramanathapuram District,Tamil Nadu,*** study focused on Mandapam,Pirappanvalsai,Enmanamcondam,Nagachi,Terbogi,Athyuthu,Chitrakkottai,Pathengal,Attangarai,Alagankulam,and Devipattinam *** of these areas are distinguished as highly sensitive ecological *** erosion of an area leads to irreplaceable disturbances to ***,erosion and accretion studies are top priorities when studying the coastal *** addition to GIS technology,which has been widely used in the past 20 years,the End Point Rate(EPR)and Linear Regression Rate(LRR)analyses were conducted to better understand the shoreline *** stability of the coastal region was analyzed by observing the slope variations of the beach during the profile *** the study,we analyzed that the Quaternary deposits of sand are the dominant geological feature of the study *** reefs and salt pans are highly distributed along the coastal *** coast of Mandapam village has been detected as a highly sensitive region,with an average erosion rate of-3.1 m/yr and an average accretion rate of 1.22 m/yr,resulting in high erosion and low *** coast is a steep coast with an average slope angle of 0.24°.This study provides insight into sustainable coastal zone management.

关键词： End point rate Linear regression rate Geographic information system Beach profile Ramanathapuram

Redefining resectability in pancreatic cancer after neoadjuvant therapy: are we any closer?

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Hepatobiliary Surgery and Nutrition 2023年第1期12卷 131-134页

作者： francis P.Robertson Sanjay Pandanaboyana Department of HPB and Transplant Surgery Newcastle Upon Tyne NHS Foundation TrustFreeman HospitalNewcastle Upon TyneUK Division of Surgery and Interventional Science University College LondonRoyal Free CampusLondonUK Faculty of Medical Sciences Newcastle UniversityNewcastle Upon TyneUK

Pancreatic resection with negative margins offers the only potential cure within a multimodal treatment strategy that includes chemotherapy with or without radiotherapy for patients with pancreatic *** the definition of resectability in pancreatic cancer was focused on the location of the tumour to major vascular structures surrounding the head of pancreas as described by a variety of organisations around the world,with subtle differences in definitions for resectable,borderline resectable and locally advanced pancreatic cancers(1).

关键词： Pancreatic cancer resectability neoadjuvant therapy(NAT)

Therapeutic Use of Viruses:Newcastle Disease Virus HK84 Oncolytic Treatment for Hepatocellular Carcinoma

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Journal of Clinical and Translational Hepatology 2022年第5期10卷 783-785页

作者： Leonardo Baiocchi Heather francis Gianfranco Alpini Unit of Hepatology Tor Vergata UniversityRomeItaly Division of Gastroenterology and Hepatology Department of MedicineIndiana University School of MedicineIndianapolisINUSA Research Richard L.Roudebush VA Medical CenterIndianapolisINUSA

Hepatocellular carcinoma(HCC)is the most frequent primary liver tumor worldwide and,despite regional therapeutic and diagnostic differences,it stands among the three most lethal cancers found in *** or ablative treatments,together with liver transplant,are the most successful clinical approaches,frequently ensuring complete HCC healing and the best survival ***,curative techniques are applicable only in patients at early stages of the disease(limits:one nodule≤5 cm in diameter or not more than three nodules all less than 3 cm in diameter).1 A significant percentage of HCC patients(≥50%)have a more advanced stage at diagnosis and must rely on less effective treatment or palliative care,thus signifying the need for alternative systemic ***,a tyrosine kinase inhibitor(TKI)was the first effective HCC drug treatment discovered after negative results were obtained with canonical cytotoxic *** 2018 lenvatinib,another TKI,was approved in the USA as a first line treatment for *** immunotherapy combining the checkpoint inhibitor,atezolizumab with the VEGF-antibody bevacizumab,has improved survival rates compared with previous TKI-based monotherapies.2 Despite treatment improvements,1-year survival is attained by only two-thirds of patients,thus prompting investigation of more effective therapies for advanced stage HCC.

关键词： Carcinoma healing diagnosis