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A pilot study on prevalence and cure rate of tuberculosis in selected areas of Malabar 2006-07.

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Asian Pacific Journal of Tropical Medicine 2009年第2期2卷 64-67页

作者： Dilip c Saraswathi R christapher PV Prasanth NV Sanal Dev Al Shifa college o Pharmacy KizhatturPerinthalmannaKerala.Pin-679325

Objective:To study the prevalence and cure rate of tuberculosis(TB) and the people affected by TB in selected areas,considering different factors like age,sex,percentage of people affected,dosage forms,role of hospitals, and patient ***:A detailed survey was carried out in and around Perinthalmanna and Wayanad(Urban and Rural) to understand the burden and overall trend of TB in our locality and how effective our TB control *** than 250 treatment cards were collected from the Government hospitals and TB ***:In the study,at Perinthalmanna and Wayanad,out of 250 TB patients it was found that males is more susceptible than females,rural area accounting for the greater proportion of TB patients. Greater proportion were affected with pulmonary than extra pulmonary *** incidence of tuberculosis in different age groups varied according to the *** proportion in both rural and urban areas were belonging to categoryⅡfollowed by categoryⅢ.conclusion:The nature and magnitude of TB is more in rural area than urban area mainly because of the lack of awareness of the severity of disease and improper follow up of preventive *** study suggests that the combined and committed efforts of government,non government organizations,medical and paramedical professional and society is required at large,to reach all patients and ensure that they receive high quality care.

关键词： Directly observed treat short course(DOTS) Multi drug resistant tuberculosis(MDR -TB) Revised national TB control programme(RNTcP)

NOTES ON THE MAMMALIA REMAINS FROM KWANGSI

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地质学报 1929年第2期 126-132页

作者： c. c. YOUNG Geological Survey of china

I. cHARAcTER OF THE DEPOSITS AND THE METHOD OF PRESERVATION OF THE BONES. In May 1929 Dr. V. K. Ting presented me a number of bone deposits which he collected from Wu-chow, Kwangsi during his recent geological trip in... 详细信息

关键词： very NOTES ON THE MAMMALIA REMAINS FROM KWANGSI

Millau viaduct geotechnical studies and foundations

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Journal of Rock Mechanics and Geotechnical Engineering 2013年第3期5卷 243-247页

作者： F.Schlosser c.Servant A.Guilloux A.Bergere ENPc France Eiffage Travaux Publics France Terrasol France

The Millau viaduct over the Tam River is an exceptional bridge considering the height under the deck and the 2.5 km total length. Each of the seven high piers is founded on a thick raft setting on four large piles of 5 m in diameter and 10-15 m deep. The ground schematically consists of limestone in the north and of marls in the south. As the bridge is very sensitive to foundation settlements, the concessionary company decided to use the observational method for controlling the displacements and if necessary stabilize the foundations. The measurements show that the movements have remained small and admissible, particularly in terms of the rotations. The settlements have not occurred continuously under the load, but by steps.

关键词： cable stayed bridge Foundation design Pile settlement Rotation Observational method

cyclooxygenase-2 and the inflammogenesis of breast cancer

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World Journal of clinical Oncology 2014年第4期5卷 677-692页

作者： Randall E Harris Bruce c casto Zachary M Harris The Ohio State University comprehensive cancer center The Ohio State University College of Medicine Columbus OH 43210-1351 United States college of Medicine and college of Public Health Center of Molecular Epidemiology and Environmental Health The Ohio State University Medical Center Columbus OH 43210-1351 United States

cohesive scientific evidence from molecular, animal, and human investigations supports the hypothesis that constitutive overexpression of cyclooxygenase-2(cOX-2) is a ubiquitous driver of mammary carcinogenesis, and reciprocally, that cOX-2 blockade has strong potential for breast cancer prevention and therapy. Key findings include the following:(1) cOX-2 is constitutively expressed throughout breast cancer development and expression intensifies with stage at detection, cancer progression and metastasis;(2) essential features of mammary carcinogenesis(mutagenesis, mitogenesis, angiogenesis, reduced apoptosis, metastasis and immunosuppression) are linked to cOX-2-driven prostaglandin E2(PGE-2) biosynthesis;(3) upregulation of cOX-2 and PGE-2 expression induces transcription of cYP-19 and aromatase-catalyzed estrogen biosynthesis which stimulates unbridled mitogenesis;(4) extrahe-patic cYP-1B1 in mammary adipose tissue converts paracrine estrogen to carcinogenic quinones with mutagenic impact; and(5) agents that inhibit cOX-2 reduce the risk of breast cancer in women without disease and reduce recurrence risk and mortality in women with breast cancer. Recent sharp increases in global breast cancer incidence and mortality are likely driven by chronic inflammation of mammary adipose and upregulation of cOX-2 associated with the obesity pandemic. The totality of evidence clearly supports the supposition that mammary carcinogenesis often evolves as a progressive series of highly specific cellular and molecular changes in response to induction of constitutive overexpression of cOX-2 and the prostaglandin cascade in the "inflammogenesis of breast cancer".

关键词： Breast cancer cyclooxygenase-2 Nonsteroidal anti-inflammatory drugs Inflammogenesis Estrogen Aromatase

IMPROVING 9-INTERSEcTION MODEL BY REPLAcING THE cOMPLEMENT WITH VORONOI REGION

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Geo-Spatial Information Science 2000年第1期3卷 1-10页

作者： cHEN Jun LI chengming LI Zhilin Gold c M National Geomatics Center of China Beijling China

9-intersection model is the most popular framework used for formalizing the spatial relations between two spatial objectsA andB. It transforms the topological relationships between two simple spatial objectsA andB into point-set topology problem in terms of the intersections ofA’s boundary (?A), interior (A 0) and (A ?) withB’s boundary (?B), interior (B 0) and exterior (B ?). It is shown in this paper that there exist some limitations of the original 9-intersection model due to its definition of an object’s exterior as its complement, and it is difficult to distinguish different disjoint relations and relations between complex objects with holes, difficult or even impossible to compute the intersections with the two object’s complements (?A∩B ?,A 0∩?B ?,A ?∩?B,A ?∩B 0 andA ?∩B ?)since the complements are infinitive. The authors suggest to re-define the exterior of spatial object by replacing the complement with its Voronoi region. A new Voronoi-based 9-intersection (VNI) is proposed and used for formalizing topological relations between spatial bojects. By improving the 9-intersection model, it is now possible to distinguish disjoint relations and to deal with objects with holes. Also it is possible to compute the exterior-based intersections and manipulate spatial relations with the VNI.

关键词： 9-intersection model Voronoi region topological relationship

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Ac-PDP中等离子体电场的实验研究

核聚变与等离子体物理 2003年第2期23卷 108-112页

作者：周艳 Ki-Woong Whang J H Yang D c Jeong c H Ha 核工业西南物理研究院成都610041 国立汉城大学

用激光荧光技术直接测量了Ac PDP单元高气压He和He Xe0 1%放电中的电场行为,估算了由放电电场产生的Ac PDP单元上的壁电压。选用高气压下寿命较长的氦的亚稳态2s3S,比较主量子数n=8和n=9的Stark分裂谱,使电场的测量精度提高到10%。电场... 详细信息

用激光荧光技术直接测量了Ac PDP单元高气压He和He Xe0 1%放电中的电场行为,估算了由放电电场产生的Ac PDP单元上的壁电压。选用高气压下寿命较长的氦的亚稳态2s3S,比较主量子数n=8和n=9的Stark分裂谱,使电场的测量精度提高到10%。电场和壁电压的时间分布描述了PDP单元的放电行为。

关键词： Ac-PDP 等离子体电场实验研究激光荧光技术壁电压放电等离子体显示器

FESE’s Best Papers of 2021

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Frontiers of Environmental Science & Engineering 2022年第6期16卷 177-178页

作者： Qu, Jiuhui crittenden, John c.

Frontiers of Environmental Science&Engineering(FESE),is pleased to announce the best paper awards for *** 2021,we published 133 research and review papers in Volume 15 of *** order to acknowledge the past contributions and encourage more submissions,the FESE editorial board selected three distinguished research papers for their profound insights into current serious environmental issues and contributions to practical treatment *** hope these papers will inspire and promote innovation in the environmental science and engineering research field.

关键词： field. insight contributions

Same soup different taste-how to best manage the future liver remnant-a surgical perspective

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Hepatobiliary Surgery and Nutrition 2021年第5期10卷 734-736页

作者： John R.Bergquist Patrick Starlinger Brendan c.Visser Division of Hepatobiliary and Pancreatic Surgery Department of SurgeryStanford UniversityStanfordCAUSA Division of Hepatobiliary and Pancreatic Surgery Department of SurgeryMayo ClinicRochesterMNUSA

A small but measurable percentage of major hepatic resection patients will experience major morbidity or mortality due post-hepatectomy liver failure after major liver ***-operative optimization,in particular pre-operative induction of liver growth to increase the future liver remnant(FLR)volume,has become frequently used in patients considered to be high ***,this process of hepatic augmentation remains incompletely understood,particularly in *** advances in techniques for FLR management have resulted in dramatic expansion of the liver surgeon’s armamentarium.

关键词： operative hepatic mortality

Extract of codiaeum luzonicum Merr. overcomes multidrug resistance in human colon cancer cells by modulating P-glycoprotein

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Asian Pacific Journal of Tropical Biomedicine 2022年第9期12卷 400-410页

作者： Regina Joyce E.Ferrer Marc Justin c.Ong Sonia D.Jacinto Institute of Biology University of the Philippines DilimanQuezon CityMetro ManilaPhilippines

Objective:To investigate anti-multidrug resistance(MDR)activity and safety of the bioactive fraction(cL11)from codiaeum luzonicum crude leaf ***:cytotoxic activity of cL11 against MDR and nonresistant colon cancer cells was assessed using MTT *** of cell death was investigated by annexin V-propidium iodide staining,TUNEL,and Jc-1 *** examine mechanism of action,the effect on the expression and function of the MDR-implicated protein P-glycoprotein was tested using Western blotting and calcein assay,***:cL11 had an Ec50 of 0.18,1.03 and 38.52µg/mL against HcT-15,HcT-15/Dox and HcT116,*** was mediated by inhibition of P-glycoprotein function and *** mode of cell death involved mitochondrial membrane depolarization and was mostly non-apoptotic at Ec50 concentrations against HcT-15 and HcT-15/***:Fraction cL11 of codiaeum luzonicum induces nonapoptotic cell death in MDR cancer cells by overcoming MDR through inhibition of P-glycoprotein expression and function.

关键词： Natural product Leaf extract codiaeum luzonicum MDR cancer P-gp inhibitor colorectal cancer