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Cardiorespiratory fitness,white blood cell count,and mortality in men and women

Journal of Sport and Health Science 2022年第5期11卷 605-612页

作者： stephen W.Farrell David Leonard Kerem Shuval Laura F.DeFina Carolyn e.Barlow Andjelka Pavlovic William L.Haskell Research Division The Cooper InstituteDallasTX 75230USA Department of Medicine Stanford UniversityPalo AltoCA 94305USA

Background:We examined the associations of cardiorespiratory fitness(CRF) and white blood cell count(WBC) with mortality ***: A total of 52,056 apparently healthy adults completed a comprehensive health examination,including a maximal treadmill test and blood chemistry *** was categorized as high,moderate,or low by age and sex;WBC was categorized as sex-specific ***:During 17.8± 9.5 years(mean± SD) of follow-up,a total of 4088 deaths *** regressed jointly,significantly decreased allcause mortality across CRF categories was observed within each quartile of WBC in *** WBC Quartile 1,all-cause mortality hazard ratios(HRs) with a 95% confidence interval(95%CI) were 1.0(referent),1.29(95%CI:1.06-1.57),and 2.03(95%CI:1.42-2.92) for high,moderate,and low CRF categories,respectively(p for trend ends were observed in the remaining 3 *** the exception of cardiovascular disease(CVD) mortality within Quartile 1(p for trend=0.743),there were also similar trends across CRF categories within WBC quartiles in men for both CVD and cancer mortality(p for trend en,there were no significant trends across CRF categories for mortality outcomes within Quartiles ***,we observed significantly decreased all-cause mortality across CRF categories within WBC Quartile 4(HR=1.05(95%CI:0.76-1.44),HR=1.63(95%CI:1.20-2.21),and HR=1.87(95%CI:1.29-2.69) for high,moderate,and low CRF,respectively(p for trend=0.002)).Similar trends in women were observed for CVD and cancer mortality within WBC Quartile 4 ***:There are strong joint associations between CRF,WBC,and all-cause,CVD,and cancer mortality in men;these associations are less consistent in women.

关键词： Complete blood count epidemiology Inflammation Physical fitness

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e-beam manipulation of Si atoms on graphene edges with an aberration-corrected scanning transmission electron microscope

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Nano Research 2018年第12期11卷 6217-6226页

作者： Ondrej Dyck Songkil Kim Sergei V.Kalinin stephen Jesse Center for Nanophase Materials Science Oak Ridge National LaboratoryOak RidgeTN 37830USA Institute for Functional Imaging of Materials Oak Ridge National LaboratoryOak RidgeTN 37830USA School of Mechanical engineering Pusan National UniversityBusan 46241Republic of Korea

The burgeoning field of atomic-level material control holds great promise for future breakthroughs in quantum and memristive device manufacture and fundamental studies of atomic-scale chemistry. Realization of atom-by-atom control of matter represents a complex and ongoing challenge. Here, we explore the feasibility of controllable motion of dopant Si atoms at the edges of graphene via the sub-atomically focused electron beam in a scanning transmission electron microscope. We demonstrate that the graphene edges can be cleaned of Si atoms and then subsequently replenished from nearby source material. It is also shown how Si edge atoms may be “pushed” from the edge of a small hole into the bulk of the graphene lattice and from the bulk of the lattice back to the edge. This is accomplished through sputtering of the edge of the graphene lattice to bury or uncover Si dopant atoms. Finally, we demonstrate e-beam mediated hole healing and incorporation of dopant atoms. These experiments form an initial step toward general atomic-scale material control.

关键词： atomic manipulation graphene scanning transmission electron microscopy edge passivation silicon dopant electron beam dynamics

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Mesenchymal stem cell therapy in patients with small bowel transplantation:Single center experience

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World Journal of Gastroenterology 2014年第25期20卷 8215-8220页

作者： Sait Murat Do?an sel?uk K?l?n? eyüp Kebap?? Cem Tu?men Mustafa ?lmez Cezmi Karaca Alp Gürkan Ma?allah Baran Yusuf Kurtulmu? Organ Transplantation Center SB Tepecik Teaching and Research Hospital35121 Izmir Turkey Organ Transplantation Center Caml?ca University Hospital34360 IstanbulTurkey Department of Gastroenterology SB Tepecik Teaching and Research Hospital35121 IzmirTurkey Tissue Typing Laboratory SB Tepecik Teaching and Research Hospital 35121 Izmir Turkey

AIM: To study the effects of mesenchymal stem cell (MSC) therapy on the prevention of acute rejection and graft vs host disease following small bowel transplantation.

关键词： Short gut syndrome Small bowel transplantation Mesenchymal stem cells Acute rejection Stem cell therapy

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The association between sexual function and prostate cancer risk in US veterans

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Asian Journal of Andrology 2017年第2期19卷 191-195页

作者： Daniel F Zapata Lauren e Howard Jennifer Frank Ross M Simon Cathrine Hoyo Delores J Grant stephen J Freedland Adriana C Vidal Duke University Medical Center Division of Urology Department of Surgery Durham NC 27710 USA Durham Veterans Affairs Medical Center Urology Division Durham NC 27710 USA North Carolina State University Department of Biology Raleigh NC 27695 USA North Carolina Central University Department of Biology Durham NC 27707 USA Department of Surgery Division of Urology Samuel Oschin Comprehensive Cancer institute Cedars-Sinai Medical Center Los Angeles California 90048 USA

Sexual dysfunction and prostate cancer are common among older men. Few studies explored the association between these two illnesses. We examined whether sexual function is associated with prostate cancer risk among older men. Among 448 men undergoing prostate biopsy at the Durham Veterans Affairs Hospital, sexual function was ascertained from the expanded Prostate Cancer Index Composite sexual assessment. We tested the link between sexual function and prostate cancer risk adjusting for multiple demographic and clinical characteristics using logistic regression. Multinomial logistic regression was used to test the associations with risk of low-grade （Gleason 〈6） and high-grade （Gleason 〉7 or 〉4 ＋ 3） disease versus no cancer. Of 448 men, 209 （47%） had a positive biopsy; these men were less likely to be white （43% vs 55%, P=0.013）, had higher prostate-specific antigen （PSA）（6.0 vs 5.4 ng ml-1, P 〈 0.001）, but with lower mean sexual function score （47 vs 54, P = 0.007）. There was no difference in age, BMI, pack years smoked, history of heart disease and/or diabetes. After adjusting for baseline differences, sexual function was linked with a decreased risk of overall prostate cancer risk （OR. 0.91 per lO-point change in sexual function, P= 0.004） and high-grade disease whether defined as Gleason ≥7 （OR： 0.86, P= 0.001） or 〉4 ＋ 3 （OR： 0.85, P= 0.009）. Sexual function was unrelated to low-grade prostate cancer （OR： 0.94, P = 0.13）. Thus, among men undergoing prostate biopsy, higher sexual function was associated with a decreased risk of overall and high-grade prostate cancer. Confirmatory studies are needed.

关键词： erectile dysfunction prostate prostate cancer risk sexual function

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皮肤科综合药物治疗学暂无

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2016年

作者： stephen e.Wolverton原

该书为《ComprehensiveDermatologicDrugTherapy》第3版的译著，包括皮肤科常用药物及新增药物的适应证和禁忌证、药物相互作用、监测指南、不良反应等，并在每章后提供了推荐阅读和参考文献，对皮肤科医生具有重要指导和参考价值。

ISBN: (纸本)9787565913013

关键词：药物疗法皮肤病

来源：畅想之星图书光盘版（南... 畅想之星图书光盘版（南... 评论

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A giant central red disk galaxy at redshift z=0.76:Challenge to theories of galaxy formation

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Science China(Physics,Mechanics & Astronomy) 2021年第7期64卷 137-141页

作者： Kun Xu ChengZe Liu YiPeng Jing Marcin Sawicki stephen Gwyn Department of Astronomy School of Physics and AstronomyShanghai Jiao Tong UniversityShanghai200240China Tsung-Dao Lee Institute Shanghai Key Laboratory for Particle Physics and CosmologyShanghai Jiao Tong UniversityShanghai200240China Canada Research Chair Department of Astronomy&Physics and the Institute for Computational AstrophysicsSaint Mary’s UniversityHalifaxB3H 3C3Canada NRC-Herzberg Astronomy and Astrophysics National Research Council of CanadaVictoriaV9E 2E7Canada

We report a giant red central disk galaxy in the XMM-LSS north region. The region is covered with a rich variety of multi-band photometric and spectroscopic observations. Using the photometric data of the Canada-France-Hawaii Telescope Legacy Survey(CFHTLS) and spectroscopic observation of the baryon oscillation spectroscopic survey(BOSS), we find that the galaxy has a stellar mass of ~1011.6 M⊙. The galaxy has a red color and has an old stellar population, and thus its star formation has *** the photometric image data of the Hyper Suprime-Cam(HSC) Subaru Strategic Program, we demonstrate that its luminosity profile is perfectly described by a Sérsic form with n=1.22 consistent with that of a disk. We also analyze its environment based on the VIMOS Public extragalactic Redshift Survey(VIPeRS) photometric catalog, and find that its close neighbors are all less massive, indicating that our observed galaxy is sitting at the center of its dark matter host halo. existence of such a giant red central disk galaxy seriously challenges the current standard paradigm of galaxy formation, as there is no known physical mechanism to explain the quenching of its star formation. This conclusion is supported by state-of-the-art hydrodynamical simulations of galaxy formation.

关键词： disk galaxies galaxy quenching massive galaxies

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Broadband electroluminescence from reverse breakdown in individual suspended carbon nanotube pn-junctions

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Nano Research 2020年第10期13卷 2857-2861页

作者： Bo Wang Sisi Yang Yu Wang Younghee Kim Ragib Ahsan Rehan K.apadia stephen KDoorn Han Htoon stephen B.Cronin Department of Physics and Astronormy University of Southern CalforniaLos AngelesCA 90089USA Ming Hsieh Department of electrical engineering University of Southern CaliforniaLos AngelesCA 90089USA Mork Farmily Department of Chemical engineering and Materials Science University of Southern CaliforniaLos AngelesCA 90089USA Center for Integrated Nanotechnologies Materials Physics and Applications DivisionLos Alamos National LaboratoryLos AlamosNM 87545USA

There are various mechanisms of light emission in carbon nanotubes (CNTs), which give rise to a wide range of spectral emission characteristics that provide important information regarding the underlying physical processes that lead to photon emission. Here, we report spectra obtained from individual suspended CNT dual-gate field effect transistor (FeT) devices under different gate and bias conditions. By applying opposite voltages to the gate electrodes (i.e., Vg1 = –Vg2), we are able to create a pn-junction within the suspended region of the CNT. Under forward bias conditions, the spectra exhibit a peak corresponding to e11 exciton emission via thermal (i.e., blackbody) emission occurring at electrical powers around 8 μW, which corresponds to a power density of approximately 0.5 MW/cm2. On the other hand, the spectra observed under reverse bias correspond to impact ionization and avalanche emission, which occurs at electrical powers of ~ 10 nW and exhibits a featureless flat spectrum extending from 1,600 nm to shorter wavelengths up to 600 nm. Here, the hot electrons generated by the high electric fields (~ 0.5 MV/cm) are able to produce high energy photons far above the e11 (ground state) energy. It is somewhat surprising that these devices do not exhibit light emission by the annihilation of electrons and holes under forward bias, as in a light emitting diode (LeD). Possible reasons for this are discussed, including Auger recombination.

关键词： ballistic avalanche high-field band-to-band photoemission

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Manifold learning of four-dimensional scanning transmission electron microscopy

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npj Computational Materials 2019年第1期5卷 1097-1104页

作者： Xin Li Ondrej e.Dyck Mark P.Oxley Andrew R.Lupini Leland McInnes John Healy stephen Jesse Sergei V.Kalinin Center for Nanophase Materials Sciences Oak Ridge National LaboratoryOak RidgeTN 37831USA Institute for Functional Imaging of Materials Oak Ridge National LaboratoryOak RidgeTN 37831USA Tutte Institute for Mathematics and Computing OttawaCanada

Four-dimensional scanning transmission electron microscopy(4D-STeM)of local atomic diffraction patterns is emerging as a powerful technique for probing intricate details of atomic structure and atomic electric ***,efficient processing and interpretation of large volumes of data remain challenging,especially for two-dimensional or light materials because the diffraction signal recorded on the pixelated arrays is *** we employ data-driven manifold leaning approaches for straightforward visualization and exploration analysis of 4D-STeM datasets,distilling real-space neighboring effects on atomically resolved deflection patterns from single-layer graphene,with single dopant atoms,as recorded on a pixelated *** extracted patterns relate to both individual atom sites and sublattice structures,effectively discriminating single dopant anomalies via multimode *** believe manifold learning analysis will accelerate physics discoveries coupled between data-rich imaging mechanisms and materials such as ferroelectric,topological spin,and van der Waals heterostructures.

关键词： manifold straight details

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A Systematic Review on Antituberculosis Drug Discovery and Antimycobacterial Potential of Biologically Synthesized Silver Nanoparticles:Overview and Future Perspectives

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Infectious Microbes & Diseases 2022年第4期4卷 139-148页

作者： Christian K.ezeh Chibuzor N.eze Uju M.e.Dibua stephen C.emencheta Department of Microbiology University of NigeriaNsukkaEnugu StateNigeria Department of Pharmaceutical Microbiology University of NigeriaNsukkaEnugu StateNigeria

Rapid emergence and quick evolution of drug-resistant and aggressive mycobacterial strains have resulted in the present antimycobacterial drug crisis and the persistence of tuberculosis as a major public health ***/biological nanotechnologies constitute an interesting area of research for discovering antimycobacterial *** review focused on the biological(green)synthesis of silver nanoparticles(AgNPs)as an alternative source of antimycobacterial *** for this study were searched and screened from three electronic databases(Google Scholar,PubMed and ScienceDirect)following the Preferred Reporting Items for Systematic Reviews and Meta-analyses *** from in total 17 eligible studieswere reported in this systematic *** of the 17 studies used plants to fabricate AgNPs,whereas the remaining five studies used microorganisms(bacteria and/or fungi).Silver as part of silver nitrate(AgNO3)was themetal precursor reported for the synthesis of AgNPs in these *** nanoparticles were mostly spherical,with sizes ranging from12 *** minimum inhibitory concentrations varied between studies and were divided into three groups:(i)those more effective than the antibiotic(controls),(ii)those more effective than plant extracts,and(iii)those less effective than the antibiotic *** addition,little or no cytotoxicity effects were *** nanoparticles were also shown to be highly specific or selective toward mycobacterial *** systematic review highlights the antimycobacterial potential of biologically synthesized AgNPs,underscoring the possibility of discovering/developing new antimycobacterial agents using biological synthesis approaches with less toxicity and high selectivity.

关键词： antimycobacterial activity silver nanoparticles cytotoxicity biological synthesis tuberculosis mycobacterial

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New Methods and Synthetic Applications of Asymmetric Nitrogen Transfer

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Chinese Journal of Chemistry 2005年第9期23卷 1270-1272页

作者： ARMSTRONG, Alan eDMONDS, lan COOKe, Richard S. SHANAHAN, stephen e. KNIGHT, Jamie D. CUMMING, Graham R. Department of Chemistry Imperial College London South Kensington London SW7 2AZ UK

Structure/reactivity relationships of N-alkoxycarbonyl- and N-carboxamidooxaziridines are explored, and conditions are discovered for the efficient amination of sulfides and primary amines. Reactions of these oxaziridines with alkenes are also examined, and lead to interesting new heteroatom transfer reaction products. Finally, the aminative rearrangement of 2-alkoxydihydropyrans leads to a useful stereocontrolled synthesis of pyrrolidines which can undergo synthetic manipulations to give [2.2.1 ]- and [3.2.1 ]-azabicycles.

关键词： N-alkoxycarbonyl N-carboxamidooxazinidine amination

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