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Mechanisms of medicinal plants in the treatment of diabetic wound

Asian Pacific Journal of Tropical Biomedicine 2023年第6期13卷 233-241页

作者： Oluwakemi V.Adeleke stephen a.adefegha Ganiyu Oboh Functional Foods Nutraceuticals and Phytomedicine LaboratoryDepartment of BiochemistryFederal University of Technology AkureAkureNigeria Department of Science Laboratory Technology Ekiti State UniversityAdo EkitiNigeria

Wound repair is noticeably prolonged in a diabetic state due to a faulty inflammatory process and an underlying *** medicinal plants and their products have been of prime importance for the management of wounds over the *** mechanisms whereby medicinal plants elicit their action in wound repair are revealed and some plants are proven to be experimentally effective in enhancing wound closure and achieving *** mechanisms identified include hyperglycemic control,alleviation of physiological inflammation,controlled oxidative stress,infection control,and influence on gene *** in this review was sourced from research and review articles in electronic databases such as Web of Science,Scopus,PubMed,and Google Scholar.

关键词： Diabetes Infection Inflammation Medicinal plants Wound healing Oxidative stress

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In vitro inhibition activity of polyphenol-rich extracts from Syzygium aromaticum(L.)Merr.& Perry(Clove)buds against carbohydrate hydrolyzing enzymes linked to type 2 diabetes and Fe^(2+)-induced lipid peroxidation in rat pancreas

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Asian Pacific Journal of Tropical Biomedicine 2012年第10期2卷 774-781页

作者： stephen Adeniyi adefegha Ganiyu Oboh Department of Biochemistry Federal University of TechnologyAkure

To investigate and compare the inhibitory properties of free and bound phenolic extracts of clove bud against carbohydrate hydrolyzing enzymes (alpha-amylase & alpha-glucosidase) and Fe2+-induced lipid peroxidation in rat pancreas in vitro. Methods: The free phenolics were extracted with 80% (v/v) acetone, while bound phenolics were extracted from the alkaline and acid hydrolyzed residue with ethyl acetate. Then, the interaction of the extracts with alpha-amylase and alpha-glucosidase was subsequently assessed. Thereafter, the total phenolic contents and antioxidant activities of the extracts were determined. Results: The result revealed that both extracts inhibited alpha-amylase and alpha-glucosidase in a dose-dependent manner. However, the alpha-glucosidase inhibitory activity of the extracts were significantly (P<0.05) higher than their alpha-amylase inhibitory activity. The free phenolics (31.67 mg/g) and flavonoid (17.28 mg/g) contents were significantly (P<0.05) higher than bound phenolic (23.52 mg/g) and flavonoid (13.70 mg/g) contents. Both extracts also exhibited high antioxidant activities as typified by their high reducing power, 1,1 diphenyl-2- picrylhydrazyl (DPPH) and 2, 2-azinobis-3-ethylbenzo-thiazoline-6-sulfonate (ABTS) radical scavenging abilities, as well as inhibition of Fe2+-induced lipid peroxidation in rat pancreas in vitro. Conclusions: This study provides a biochemical rationale by which clove elicits therapeutic effect on type 2 diabetes.

关键词： Alpha-amylase Alpha-glucosidase Fe^(2+)-induced lipid peroxidation Pancrea Phenol Antioxidant

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