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Anti-arthritic effect of Distemonanthus benthamianus extracts against rheumatoid arthritis in rats

Asian Pacific Journal of Tropical Biomedicine 2022年第10期12卷 411-420页

作者： William Yousseu Nana Ernest Allah Hoki Kwenteh Gilbert Ateufack Eric Gonzal Tsafack stephanie floredjuichou nguemnang Zenab Linda Fagni Njoya Albert Donatien Atsamo Vanessa Mba Matah Marthe CarineFlore Adjouzem Yacine Karelle Madjo Kouam Elvira Ngoufack Azanze Marius Mbiantcha Laboratory of Biology and Physiology of Animal Organisms Department of Biology of Animal OrganismsFaculty of ScienceThe University of Douala CameroonP.O.Box 24157DoualaCameroon Research Unit of Animal Physiology and Phytopharmacology Faculty of ScienceUniversity of DschangDschangCameroon Laboratory of Animal Physiology Faculty of ScienceUniversity of Yaounde IYaoundéCameroon

Objective:To evaluate the anti-arthritic effect of aqueous and methanolic extracts of Distemonanthus ***:Monoarthritis was induced by an injection of 0.3 mL zymosan A(0.9%NaCl,v/v)in the right posterior knee joints of ***,joint diameter and pain threshold were *** was induced by an intracaudal injection of complete Freund’s adjuvant and rats were treated from day 14 post 1st complete Freund’s adjuvant injection until 28 *** clinical,hematological,biochemical and oxidative stress parameters were *** addition,histological analysis of the knee joint was perfomed in both ***:The aqueous and methanolic extracts of Distemonanthus benthamianus at a dose of 500 mg/kg ameliorated zymosan A-induced monoarthritis,as evidenced by reduced joint diameter,increased pain threshold,as well as improved joint *** addition,both extracts of Distemonanthus benthamianus markedly increased body weight and pain threshold,while reducing paw edema in polyarthritic *** also led to a marked decrease in platelets and white blood cells(P<0.05),as well as a significant increase in red blood cells,hemoglobin and hematocrit(P<0.05).The aqueous and methanolic extracts of Distemonanthus benthamianus significantly reduced alanine aminotransferase,aspartate aminotransferase,alkaline phosphatase activities,while increasing serum protein levels(P<0.05)with no significant variation in creatinine ***,both extracts increased catalase and glutathione activities(P<0.05),and inhibited malondialdehyde and nitric oxide production(P<0.01 and P<0.001)in the liver and *** analysis of the joints showed that both extracts triggered tissue ***:Distemonanthus benthamianus could be used as a potential candidate in the treatment of rheumatoid arthritis.

关键词： Distemonanthus benthamianus Rheumatoid arthritis Anti-arthritis Complete Freund’s adjuvant Hyperalgesia Inflammation Oxidative stress

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In vitro anti-inflammatory,anti-oxidant and in vivo anti-arthritic properties of stem bark extracts from Nauclea pobeguinii(Rubiaceae) in rats

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Asian Pacific Journal of Tropical Biomedicine 2020年第2期10卷 65-77页

作者： Tsafack Eric Gonzal Djuichou nguemnang stephanie Flore Atsamo Albert Donatien Nana Yousseu William Tadjoua Tchoumbou Herve Matah Marthe Mba Vanessa Mbiantcha Marius Ateufack Gilbert Laboratory of Animal Physiology and Phytopharmacology Department of Animal BiologyFaculty of ScienceUniversity of DschangP.O.Box 67DschangCameroon Laboratory of Animal Physiology Faculty of ScienceUniversity of Yaounde IPO Box 812YaoundéCameroon

Objective:To explore the immunomodulatory,anti-inflammatory,anti-oxidant and anti-arthritic activity of aqueous and methanolic extracts of Nauclea pobeguinii stem ***:For in vitro assays,the production of reactive oxygen species(chemiluminescence technique),the proliferation of T cells(liquid scintillation counter method),as well as the inhibition of cyclooxygenase,lipoxygenase,protein denaturation,and free radicals[DPPH,ABTS and nitric oxide(NO)inhibition methods]were *** in vivo assays,a polyarthritis model was induced by complete Freund’s adjuvant in *** aqueous and methanolic extracts of Nauclea pobeguinii stem bark were administered orally at 150 and 300 mg/*** 28 days of treatment,the total blood was taken to quantify the hematological parameters and the serum was used to evaluate the biochemical parameters(alanine aminotransferase,aspartate transaminase,phenylalnine ammonialyase,and proteins)and oxidative stress parameters(malondialdehyde,catalase,superoxide dismutase,glutathione and NO),and then the knee joint was removed for histological ***:The extracts of Nauclea pobeguinii significantly reduced the production of intra-and extracellular reactive oxygen species and decreased T cell *** had an inhibitory effect on cyclooxygenase,lipoxygenase,and protein denaturation,and both extracts had antioxidant capacity on DPPH,ABTS and *** extracts alleviated joint inflammation and pain sensitivity after complete Freund’s adjuvant injection,reduced alanine aminotransferase,aspartate transaminase,alkaline phosphatase,NO and malondialdehyde levels,increased protein concentration,superoxide dismutase,catalase and glutathione activity,and restored the cytoarchitecture of the joint after complete Freund’s adjuvant ***:The aqueous and methanolic extracts of Nauclea pobeguinii have immunomodulatory,anti-inflammatory,anti-oxidant and anti-arthritic properties.

关键词： Nauclea pobeguinii Immunomodulation Antioxidant Anti-inflammatory Anti-arthritic

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