检索结果-南通市图书馆

Incidence of Hospitalized Rhabdomyolysis in Patients Treated With Lipid-Lowering drugs

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Incidence of Hospitalized Rhabdomyolysis in Patients Treated...

Risk factors for long COVId in children and adolescents:a systematic review and meta-analysis

中成药上市后药物流行病学评价培训会议

作者： david J.Graham Judy A.Staffa deborah Shatin Susan E.Andrade stephanie d.schech Lois La Grenade Jerry H.Gurwitz K.Arnold Chan Michael J.Goodman Richard Platt Office of drug Safety Center for Drug Evaluation and ResearchFood and Drug AdministrationRockvilleMd MDMPH Office of drug Safety Center for Drug Evaluation and ResearchFood and Drug AdministrationRockvilleMd PhD Center for Health Care Policy and Evaluation Eden PrairieMinn PhD Meyers Primary Care Institute Fallon Foundation and the University of Massachusetts Medical SchoolWorcester ScD Center for Health Care Policy and Evaluation Eden PrairieMinn MPH Meyers Primary Care Institute Fallon Foundation and the University of Massachusetts Medical SchoolWorcester MD School of Public Health Channing Laboratory Brigham and Women's Hospital and Harvard Medical School Department of EpidemiologyHarvard MDScD Boston Mass Channing Laboratory Brigham and Women's Hospital and Harvard Medical School department of Ambulatory Care and Prevention Harvard Pilgrim Health Care and Harvard Medical School MDMSc

Context Lipid-lowering agents are widely prescribed in the United *** estimates of rhabdomyolysis risk with various lipid-lowering agents are not available. Objective To estimate the incidence of rhabdomyolysis in patients treated with different statins and fibrates,alone and in combination,in the ambulatory setting. design,Setting,and Patients drug-specific inception cohorts of statin and fibrate users were established using claims data from 11 managed care health plans across the United *** with at least 180 days of prior health plan enrollment were entered into the cohorts between January 1,1998,and June 30,***-time was classified as monotherapy or combined statin-fibrate therapy. Main Outcome Measure Incidence rates of rhabdomyolysis per 10000 person-years of treatment,number needed to treat,and relative risk of rhabdomyolysis. Results In 252460 patients treated with lipid-lowering agents,24 cases of hospitalized rhabdomyolysis occurred during *** incidence per 10000 person-years for monotherapy with atorvastatin,pravastatin,or simvastatin was 0.44(95% confidence interval[CI],0.20-0.84);for cerivastatin,5.34(95%CI,1.46-13.68);and for fibrate,2.82(95%CI,0.58-8.24).By comparison,the incidence during unexposed person-time was 0(95%CI,0-0.48;P=.056).The incidence increased to 5.98 (95%CI,0.72-216.0) for combined therapy of atorvastatin,pravastatin,or simvastatin with a fibrate,and to 1035(95%CI,389-2117) for combined cerivastatin-fibrate *** year of therapy,the number needed to treat to observe 1 case of rhabdomyolysis was 22727 for statin monotherapy,484 for older patients with diabetes mellitus who were treated with both a statin and fibrate,and ranged from 9.7 to 12.7 for patients who were treated with cerivastatin plus fibrate. Conclusions Rhabdomyolysis risk was similar and low for monotherapy with atorvastatin, pravastatin,and simvastatin;combined statin-fibrate use increased risk,especially in older patients w

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

World Journal of Pediatrics 2024年第2期20卷 133-142页

作者： daniel G.Rayner Elaine Wang Cloris Su Om d.Patel stephanie Aleluya Alessandra Giglia Evelyn Zhu Maha Siddique department of Health Research Methods Evidenceand ImpactFaculty of Health SciencesMcMaster University1280 Main St WHamiltonONL8S 4K1Canada Faculty of Health Sciences McMaster University1280 Main St WHamiltonON L8S 4K1Canada Faculty of Science McMaster University1280 Main St WHamiltonONL8S 4K1Canada

Background The long-term sequelae of COVId-19 in children and adolescents remain poorly understood and *** systematic review and meta-analysis sought to summarize the risk factors for long COVId in the pediatric *** We searched six databases from January 2020 to May 2023 for observational studies reporting on risk factors for long COVId or persistent symptoms those were present 12 or more weeks post-infection using multivariable regression *** registries,reference lists of included studies,and preprint servers were hand-searched for relevant ***-effects meta-analyses were conducted to pool odds ratios for each risk *** study risk of bias was rated using QUIPS,and the GRAdE framework was used to assess the certainty of evidence for each unique *** Sixteen observational studies(N=46,262)were included,and 19 risk factors were amenable to *** moderate certainty in the evidence,age(per 2-year increase),allergic rhinitis,obesity,previous respiratory diseases,hospitalization,severe acute COVId-19,and symptomatic acute COVId-19 are probably associated with an increased risk of long *** sex,asthma,comorbidity,and heart diseases may be associated with an increased risk of long COVId,and Asian and Black races may be associated with a decreased risk of long *** did not observe any credible subgroup effects for any risk *** The current body of literature presents several compelling risk factors for the development of long COVId in the pediatric *** research is necessary to elucidate the pathophysiology of long COVId.

关键词： COVId-19 Long COVId Post-acute COVId-19 syndrome Pediatrics Risk factors

Urbanization does not increase“object curiosity”in vervet monkeys,but semi-urban individuals selectively explore food-related anthropogenic items

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Current Zoology 2024年第3期70卷 383-393页

作者： Lindsey Ellington stephanie Mercier Alba Motes-Rodrigo Erica van de Waal Sofa Forss Behavioural&Physiological Ecology University of GroningenP.O.Box 111039700 CCGroningenThe Netherlands department of Ecology and Evolution University of LausanneBiophore-CH-1015LausanneSwitzerland department of Evolutionary Biology and Environmental Studies University of ZurichWinterthurerstrasse 190CH-8057ZurichSwitzerland School of Life Sciences University of KwaZulu-NatalPrivate Bag X01Scottsville3209South Africa

Urban environments expose animals to abundant anthropogenic materials and foods that facilitate foraging innovations in species with oppor-tunistic diets and high behavioral *** and exploration tendency are believed to be important behavioral traits for animals thriving in urban *** monkeys(Chlorocebus pygerythrus)are one of few primate species that have successfully adapted to urban environments,thus making them an ideal species to study these *** a within-species cross-habitat approach,we compared neophilia and exploration of novel objects(jointly referred to as"object curiosity")between semi-urban,wild,and captive monkeys to shed light on the cognitive traits facilitating urban *** measure"object curiosity:"we exposed monkeys to various types of novel stimuli and compared their approaches and explorative *** results revealed differences in the number of approaches and explorative behavior toward novel stimuli between the habitat types *** vervet monkeys were significantly more explorative than both semi-urban and wild troops,sug-gesting that positive experiences with humans and lack of predation,rather than exposure to human materials per se,influence object *** habitats,juvenile males were the most explorative age-sex *** is likely due to males being the dispersing sex and juveniles being more motivated to learn about their ***,we found that items potentially associated with human food,elicited stronger explorative responses in semi-urban monkeys than non-food related objects,suggesting that their motivation to explore might be driven by"anthrophilia'that is,their experience of rewarding foraging on similar anthropogenic food *** conclude that varying levels of exposure to humans,predation and pre-exposure to human food packaging explain variation in"object curiosity"in our sample of vervet monkeys.

关键词： animal urbanization neophilia novelty response object curiosity vervet monkeys

dNA metabarcoding reveals seasonal changes in diet composition across four arthropod-eating lizard species(Phrynosomatidae:Sceloporus)

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Integrative Zoology 2024年第3期19卷 480-495页

作者： Mauricio HERNÁNdEZ stephanie HEREIRA-PACHECO Antton ALBERdI Aníbal H.dÍAZ dE LA VEGA-PÉREZ Arturo ESTRAdA-TORRES Sergio ANCONA Yendi E.NAVARRO-NOYA doctorado en Ciencias Biológicas Centro Tlaxcala de Biología de la ConductaUniversidad Autónoma de TlaxcalaTlaxcalaMexico Estación Científica La Malinche Centro Tlaxcala de Biología de la ConductaUniversidad Autónoma de TlaxcalaTlaxcalaMexico Center for Evolutionary Hologenomics The Globe InstituteUniversity of CopenhagenCopenhagenDenmark Consejo Nacional de Ciencia y Tecnología-Centro Tlaxcala de Biología de la Conducta Universidad Autónoma de TlaxcalaTlaxcalaMexico departamento de Ecología Evolutiva Instituto de EcologíaUniversidad Nacional Autónoma de MéxicoMexico CityMexico Laboratorio de Interacciones Bióticas Centro de Investigación en Ciencias BiológicasUniversidad Autónoma de TlaxcalaSan Felipe IxtacuixtlaTlaxcalaMexico

diet composition and its ecological drivers are rarely investigated in coexisting closely related *** used a molecular approach to characterize the seasonal variation in diet composition in four spiny lizard species inhabiting a mountainous *** metabarcoding revealed that the lizards Sceloporus aeneus,***,***,and *** mostly consumed arthropods of the orders Hemiptera,Araneae,Hymenoptera,and *** terrestrial lizards *** and *** mostly predated ants and spiders,whereas the arboreal–saxicolous *** and saxicolous *** largely consumed grasshoppers and *** taxonomic and phylogenetic diversity of the prey was higher during the dry season than the rainy season,likely because reduced prey availability in the dry season forced lizards to diversify their diets to meet their nutritional *** and phylogenetic composition varied seasonally depending on the species,but only dietary composition varied with *** dietary turnover was greater in *** than in ***,suggesting site-specific seasonal variability in prey availability;no other differences among species were ***,which lives at the highest altitude in our study site,displayed interseasonal variation in diet *** differences were correlated with the species’feeding strategies and elevational distribution,which likely contributed to the coexistence of these lizard species in the studied geographic area and beyond.

关键词： arthropod-eating lizards diet breadth environmental barcoding mountainous ecosystem seasonal dietary shifts

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

降脂药物治疗病人需住院肌溶解症的发生率

美国医学会杂志（中文版） 2006年第1期25卷 28-33页

作者： david J, Graham Judy A , Staffa deborah shatin Susan E. Andrade stephanie d, schech Lois La Grenade Jerry H. Gurwitz K. Arnold Chan Michael .J. Goodman Richard Platt 徐成斌（译） Office of drug Safety Center for Drug Evaluation and Research Food and Drug Administration Rockvilte Md Center for Health Care Policy and Evaluation Eden Prairie Minn Meyers Pdmary Care Institute Fallon Foundation and the University of Massachusetts Medical School Worcester Channing Laboratory Brigham and Wornen＇s Hospital and Harvard Medical School department of Ambulatory Care and Prevention Harvard Pilgrim Health Care and Harvard Medical School department of Epiderniology HarvardSchool of Public Health Boston Massi and HealthPartners Research Founda＇don Minneapolis Minn 不详

背景：在美国降脂药物已获广泛应用。但是对各种降脂药物发生肌溶解症的危险性目前尚缺乏可靠的估计。目的：对门诊情况下，不同他汀及贝特类药物（单用或联用）治疗病人肌溶解症的发生率进行估计。设计、地点及病人：根据全美11个卫生... 详细信息

背景：在美国降脂药物已获广泛应用。但是对各种降脂药物发生肌溶解症的危险性目前尚缺乏可靠的估计。目的：对门诊情况下，不同他汀及贝特类药物（单用或联用）治疗病人肌溶解症的发生率进行估计。设计、地点及病人：根据全美11个卫生保健计划申报数据建立不同他汀和贝特类用药起始队列。人选本队列的病例为1998年1月1H至2001年6月30日人组保健计划前至少用药180天的病人。人-时间按照单药治疗或他汀-贝特类联合治疗分类。主要结局指标：每治疗10000人一年肌溶解症的发生率、所需治疗例数以及发生肌溶解症的相对危险性。结果：在252460例采用降脂药物治疗的病人中，24例于治疗期间发生住院的肌溶解症。采用阿托伐他汀、普伐他汀或辛伐他汀单药治疗平均每10000人一年肌溶解症的发生率为0．44（95％可信区间[confidence interval，CI]，0．20～0．84）；西立伐汀为5．34（95％CI，1．46～13．68）；贝特类为2．82（95％CI，0．58—8．24；P=0．056）。未用药者（unexposed person—time）肌溶解症的发生率为0（95％CI，0—0．48，P=0．56）。阿托伐他汀、普伐他汀与一种贝特联川肌溶解症的发生率增至5．98（95％CI，0．72～216．0），西立伐他汀与叭特类联用增至1035（95％CI，389—2117）。每治疗1年，发现1例肌溶解症的所需治疗例数他汀单药治疗为2272例，采用他汀和贝特类联合治疗的年龄较大的糖尿病人为484例，采用西立伐他汀加贝特类治疗的病人为9．7到12．7例。结论：采用阿托伐他汀、普伐他汀及辛伐他汀单药治疗发生肌溶解症的危险相似而且很低；联合使用他汀及贝特类者危险增加，特别是在老年糖尿病病人。西立伐他汀联合贝特类每年治疗10例即可能有1例发生肌溶解症。

关键词：药物治疗糖尿病人降脂药物肌溶解发生率住院贝特类药物阿托伐他汀 interval 卫生保健计划

Robotic-assisted versus laparoscopic repair of type II, III and IV hiatal hernias: A retrospective study comparing adverse outcomes

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Laparoscopic, Endoscopic and Robotic Surgery 2024年第1期7卷 11-15页

作者： Payton Kooiker Shane Monnett stephanie Thompson Bryan Richmond West Virginia School of Osteopathic Medicine LewisburgWV24901United States department of Surgery Charleston Area Medical CenterCharlestonWV25304United States

Objective:Robotic-assisted surgery(RAS)is continuing to expand in use in surgical specialties,including foregut *** available data on its use in large hiatal hernia(HH)repair are limited and *** study sought to determine whether there are significant differences in adverse outcomes following HH repair performed with a robotic approach vs.a laparoscopic *** study was limited to outcomes in patients with type II,III,and IV HHs,as these hernias are typically more challenging to ***:A retrospective analysis was performed from data obtained from TriNetX,a large deidentified clinical database,over a 10-year *** patients who underwent type II,III,or IV HH repair were included in the *** with robotic repair was compared to laparoscopic *** were propensity score matched for demographic information and *** ratios,risk differences(Rds)with 95%confidence intervals(CIs),and t test for each examined adverse outcome were used to estimate the effects of robotic repair *** ***:In total,20,016 patients who met the inclusion criteria were identified;1,515 patients utilized RAS,and 18,501 used *** to matching,there were significant differences in age,sex,comorbidity,and BMI between the two *** 1:1 propensity score matching,analyses of 1,514 well-matched patient pairs revealed no significant differences in demographics or *** who underwent robotic repair were more likely to experience major complications,including venous thromboembolism(Rd:0.007,95%CI:0.003,0.011;p?0.002),critical care(Rd:0.023,95%CI:0.007,0.039;p?0.004),urinary/renal complications(Rd:0.027,95%CI:0.014,0.041;pd respiratory complications(Rd:0.046,95%CI:0.028,0.064;pd with a significantly shorter length of stay(32.4±27.5 h vs.35.7±50.1 h,p?0.031),although this finding indicated a reduction in the length of stay of less than 4 *** statist

关键词： Hiatal hernia Robotic-assisted surgery Laparoscopic surgery Adverse outcomes

Post-operative morbidity after neoadjuvant chemotherapy and resection for gallbladder cancer: A national surgical quality improvement program analysis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Surgery 2024年第1期16卷 95-102页

作者： Minha Kim stephanie Stroever Krist Aploks Alexander Ostapenko Xiang da dong Ramanathan Seshadri department of General Surgery Danbury HospitalDanburyCT 06810United States department of Research and Innovation Nuvance HealthDanburyCT 06810United States division of Surgical Oncology/Hepato-Pancreato-Biliary Surgery Danbury HospitalDanburyCT 06810United States

BACKGROUNd Gallbladder cancer is the most common malignancy of the biliary ***-adjuvant chemotherapy(NACT)has improved overall survival by enabling R0 ***,there is no consensus of guidelines for neoadjuvant therapy in gallbladder *** investigations continue to analyze the regimen and benefit of NACT for ongoing care of gallbladder cancer patients,we examined American College of Surgeons National Surgical Quality Improvement Program(NSQIP)database to determine if there was higher morbidity among the neo-adjuvant group within the 30-day post-operative *** hypothesized patients who underwent NACT were more likely to have higher post-operative *** To investigate the 30-day post-operative morbidity outcomes between patients who received NACT and underwent surgery and patients who only had *** A retrospective analysis of the targeted hepatectomy NSQIP data between 2015 and 2019 was performed to determine if NACT in gallbladder cancer increased the risk for post-operative morbidity(bile leak,infection rate,rate of converting to open surgery,etc.)compared to the group who only had *** calculate the odds ratio for the primary and secondary outcomes,a crude logistic regression was *** Of the 452 patients,52 patients received NACT prior to *** were no statistically significant differences in the odds of morbidity between the two groups,including bile leak[odds ratio(OR),0.69;95%confidence interval(95%CI):0.16-2.10;P=0.55],superficial wound infection(OR,0.58;95%CI:0.03-3.02;P=0.61),and organ space wound infection(OR,0.63;95%CI:0.18-1.63;P=0.61).CONCLUSION There was no significant difference in the risk of 30-day post-operative morbidity between the NACT and surgery group and the surgery only group.

关键词： Gallbladder cancer Neoadjuvant chemotherapy Radical cholecystectomy National Surgery Quality Improvement Program Postoperative outcome

The association of diet quality and physical activity with cardiovascular disease and mortality in 85,545 older Australians:A longitudinal study

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Sport and Health Science 2024年第6期13卷 841-850页

作者： ding ding Joe Van Buskirk stephanie Partridge Philip Clare Edward Giovannucci Adrian Bauman Nicole Freene Robyn Gallagher Binh Nguyen Sydney School of Public Health Faculty of Medicine and Healththe University of SydneyCamperdownNSW 2006Australia Charles Perkins Centre the University of SydneyCamperdownNSW 2006Australia Sydney Local Health district CamperdownNSW 2050Australia School of Health Sciences Faculty of Medicine and Healththe University of SydneyCamperdownNSW 2006Australia National drug and Alcohol Research Centre UNSW SydneySydneyNSW 2052Australia departments of Nutrition and Epidemiology Harvard T.H.Chan School of Public HealthBostonMA 02115USA Faculty of Health University of CanberraCanberraACT 2617Australia Susan Wakil School of Nursing and Midwifery the University of SydneyCamperdownNSW 2050Australia

Background:A quality diet and an active lifestyle are both important cornerstones of cardiovascular disease(CVd)***,despite their interlinked effects on metabolic health,the 2 behaviors are rarely considered jointly,particularly within the context of CVd *** examined the independent,interactive,and joint associations of diet and physical activity with CVd hospitalization,CVd mortality,and all-cause ***:CVd-free Australian participants aged 4574 years(n=85,545)reported physical activity,diet,sociodemographic,and lifestyle characteristics at baseline(20062009)and follow-up(20122015),and data were linked to hospitalization and death registries(03/31/2019 for CVd hospitalization and all-cause mortality and 12/08/2017 for CVd mortality).diet quality was categorized as low,medium,and high based on meeting dietary *** activity was operationalized as(a)total moderate-to-vigorous physical activity(MVPA)as per guidelines,and(b)the composition of MVPA as the ratio of vigorous-intensity physical activity(VPA)to total *** used a left-truncated cause-specific Cox proportional hazards model using time-varying ***:during a median of 10.7 years of follow-up,6576 participants were admitted to the hospital for CVd and 6581 died from all causes(876 from CVd during 9.3 years).A high-quality diet was associated with a 17%lower risk of all-cause mortality than a low-quality diet,and the highest MVPA category(compared with the lowest)was associated with a 44%and 48%lower risk of CVd and all-cause mortality,*** interactions between diet and physical activity were *** all outcomes,the lowest risk combinations involved a high-quality diet and the highest MVPA *** for total MVPA,some VPA was associated with further risk reduction of CVd hospitalization and all-cause ***:For CVd prevention and longevity,one should adhere to both a healthy d

关键词： diet Physical activity Cardiovascular disease Mortality Cohort studies

The Final Chord? Trying to keep Hawaiian steel guitar music alive

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

空中英语教室（高级版．彭蒙惠英语） 2024年第9期 6-7,38,39页

作者： stephanie Yang 不详

Quincy Cortez plucks at a slim black box laid across his legs,his fingers flashing *** strings twang with each pull from the metal rings-wearable guitar picks-adorning his right thumb,index and middle finger.

关键词： Chord flash Final