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Hepatitis C in Laos： A 7-Year Retrospective Study on 1765 Patients

Virologica Sinica 2018年第4期33卷 295-303页

作者： Phimpha Paboriboune Thomas Vial Philavanh Sitbounlang stephane bertani Christian Trepo Paul Deny Francois-Xavier Babin Nicolas Steenkeste Pascal Pineau Eric Deharo Centre d'Infectiologie Lao-Christophe Merieux 3888 Vientiane Laos UMR 152 PHARMADEV IRD Universite de ToulouseUPS 31062 Toulouse France INSERM U1052 CNRS UMR 5286 Cancer Research Centre of Lyon 69008 Lyon France Universite Paris 13 Sorbonne Paris Cite Hopitaux Universitaires Paris Seine Saint Denis 93000 Bobigny France Fondation Merieux 69002 Lyon France INSERM U993 Institut Pasteur Unite 'Organisation Nucleaire et Oncogenese' 75015 Paris France

Hepatitis C virus （HCV） is a global health concern, notably in Southeast Asia, and in Laos the presentation of the HCV- induced liver disease is poorly known. Our objective was thus to describe a comprehensive HCV infection pattern in order to guide national health policies. A study on a group of 1765 patients formerly diagnosed by rapid test in health centres was conducted at the Centre of Infectiology Lao Christophe Merieux in Vientiane. The demographic information of patients, their infection status （viral load： VL）, liver function （aminotransferases） and treatments were analysed. Results showed that gender distribution of infected people was balanced; with median ages of 53.8 for men and 51.6 years for women （13-86 years）. The majority of patients （72%） were confirmed positive （VL 〉 50 IU/mL） and 28% of them had high VL （〉 61oglo）. About 23% of patients had level of aminotransferases indicative of liver damage （〉 40 IU/mL）; but less than 20% of patients received treatment. Patients rarely received a second sampling or medical imaging. The survey also showed that cycloferon, pegylated interferon and ribavirin were the drugs prescribed preferentially by the medical staff, without following any international recommendations schemes. In conclusion, we recommend that a population screening policy and better management of patients should be urgently implemented in the country, respecting official guidelines. However, the cost of biological analysis and treatment are significant barriers that must be removed. Public health resolutions should be immediately enforced in the perspective of meeting the WHO HCV elimination deadline by 2030.

关键词： Hepatitis C virus (HCV) HCV incidence Antiviral agents Laos

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