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Heme oxygenase-1 as a therapeutic target in inflammatory disorders of the gastrointestinal tract

World Journal of Gastroenterology 2010年第25期16卷 3112-3119页

作者： Vijith Vijayan Sebastian Mueller Eveline Baumgart-Vogt stephan immenschuh Institute for Anatomyand Cell Biology Justus-Liebig-University Giessen 35392 Gies-sen Germany Salem Medical Center and Center of Al-cohol Research University of Heidelberg 69121 HeidelbergGermany Institute for Transfusion Medicine Hannover Medical School 30625 Hannover Germany

Heme oxygenase (HO)-1 is the inducible isoform of the first and rate-limiting enzyme of heme degradation. HO-1 not only protects against oxidative stress and apoptosis, but has received a great deal of attention in recent years because ofits potent anti-inflammatory functions. Studies with HO-1 knockout animal models have led to major advances in the understanding of how HO-1 might regulate inflammatory immune responses, although little is known on the underlying mechanisms. Due to its beneficial effects the targeted induction of this enzyme is considered to have major therapeutic po- tential for the treatment ofinflammatory disorders. This review discusses current knowledge on the mechanisms that mediate anti-inflammatory protection by HO-1. More specifically, the article deals with the role of HO-1 in the pathophysiology of viral hepatitis, inflammatorybowel disease, and pancreatitis. The effects of specific HO-1 modulation as a potential therapeutic strategy in experimental cell culture and animal models of these gastrointestinal disorders are summarized. In conclusion, targeted regulation of HO-1 holds major promise for future clinical interventions in inflammatory diseases of the gastrointestinal tract.

关键词： Antioxidant Heme oxygenase Hepatitis Immunity Inflammation Inflammatory bowel disease Oxidative stress Pancreatitis

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