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Is hepatic steatosis associated with left ventricular mass index increase in the general population?

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World Journal of Hepatology 2017年第19期9卷 857-866页

作者： Katharina Piontek Carsten O Schmidt Sebastian E baumeister Markus M Lerch Julia Mayerle Marcus Dorr stephan b felix Henry Volzke Institute for Medical Psychology University Medicine Greifswald Institute for Community Medicine University Medicine Greifswald Department of Medicine A University Medicine Greifswald Department of Cardiology University Medicine Greifswald German Centre for Cardiovascular Research Partner site Greifswald

AIM To investigate the association between hepatic steatosis and change in left ventricular mass index(LVMI) over five years, and examine whether systolic and diastolic blood pressures are mediators of the association between hepatic steatosis and LVMI using a general population *** We analyzed data from the Study of Health in Pomerania. The study population comprised 1298individuals aged 45 to 81 years. Hepatic steatosis was defined as the presence of a hyperechogenic pattern of the liver together with elevated serum alanine transferase levels. Left ventricular mass was determined echocardiographically and indexed to height2.7. Path analyses were conducted to differentiate direct and indirect paths from hepatic steatosis to LVMI encompassing systolic and diastolic blood pressure as potential mediating *** Hepatic steatosis was a significant predictor for all measured echocardiographic characteristics at baseline. Path analyses revealed that the association of hepatic steatosis with LVMI change after five years was negligibly small(β =-0.12, s.e. = 0.21, P = 0.55). Systolic blood pressure at baseline was inversely associated with LVMI change(β =-0.09, s.e. = 0.03, P between diastolic blood pressure at baseline and LVMI change was evident(β = 0.03, s.e. = 0.05, P = 0.56). The effect of the indirect path from hepatic steatosis to LVMI via systolic baseline blood pressure was small(β =-0.20, s.e. = 0.10, P = 0.07). No indirect effect was observed for the path via diastolic baseline blood pressure(β = 0.03, s.e. = 0.06, P = 0.60). Similar associations were observed in the subgroup of individuals not receiving beta-blockers, calcium channel blockers, or drugs acting on the reninangiotensin *** baseline associations between hepatic steatosis and LVMI do not extend to associations with LVMI change after five years. More studies are needed to study the longitudinal effects of hepatic steatosis on LVMI.

关键词： Hepatic steatosis Left ventricular mass index blood pressure General Population Study of Health in Pomerania

Molecular phenotypes of human parvovirus b19 in patients with myocarditis

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World Journal of Cardiology 2014年第4期6卷 183-195页

作者： C-Thomas bock Anja Düchting Friederike Utta Eva brunner bui Tien Sy Karin Klingel Florian Lang Meinrad Gawaz stephan b felix Reinhard Kandolf Department of Molecular Pathology University Hospital of Tuebingen Robert Koch Institute Department of Physiology University of Tuebingen Department of Cardiology and Cardiovascular Medicine University Hospital of Tuebingen Clinics for Internal Medicine b Ernst-MoritzArndt-University Department of Molecular Pathology University Hospital of Tuebinge

AIM:To investigate molecular phenotypes of myocardial b19V-infection to determine the role of b19V in myocarditis and dilated cardiomyopathy(DCM).METHODS:Endomyocardial biopsies(EMbs) from 498 b19V-positive patients with myocarditis and DCMwere analyzed using molecular methods and functional *** were obtained from the University Hospitals of Greifswald and Tuebingen and additionally from 36 German cardiology *** tissues were obtained at autopsy from 34 victims of accidents,crime or *** of mononuclear cell infiltrates in EMbs was performed using immunohistological ***-b19V-IgM and anti-b19V-IgG were analyzed by enzyme-linked immunosorbent assay(ELISA).b19V viral loads were determined using in-house quantitative real-time polymerase chain reaction(PCR).For b19V-genotyping a new b19V-genotype-specific restriction fragment length polymorphism(RFLP)-PCR was established.b19V-genotyping was verified by direct DNAsequencing and sequences were aligned using bLAST and bioEdit software.b19V P6-promoter and HHV6-U94-transactivator constructs were generated for cell culture *** experiments were conducted using human endothelial cells *** reporter assays were performed to determine b19Vreplication *** analysis and graphical representation were calculated using SPSS and Prism5 ***:The prevalence of b19V was significantly more likely to be associated with inflammatory cardiomyopathy(iCMP) compared to uninflamed DCM(59.6% vs 35.3%)(P b19V-mRNA replication intermediates proved that replication of b19V was ***-PCR assays showed that b19V-genotype 1(57.4%) and b19V-genotype 2(36.7%) were the most prevalent viral genotypes.b19V-genotype 2 was observed more frequently in EMbs with iCMP(65.0%) compared to DCM(35%)(P = 0.049).Although there was no significant difference in gender-specific b19V-loads,women were more frequently infected with b1

关键词： Myocarditis Dilated cardiomyopathy Parvovirus b19 b19V-genotypes b19V co-infection

Scoping review: obese elderly women with breast cancer and physical activity/exercise

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Global Health Journal 2022年第3期6卷 129-135页

作者： Mark stephan felix Department of Society and Health Faculty of Social Sciences and HumanitiesMahidol UniversitySalayaNakhon Pathom 73170Thailand

Objective:Obesity and breast cancer(bC)are diseases of concern,especially within the context of an aging *** scoping review is aimed at mapping out the literature on the subject of elderly women(EW)with breast cancer,obesity and physical activity/exercise(PAE)to identify gaps in the present extant literature,and to suggest directions for future *** sources:A total of four articles were finalized from an initial 2905 articles found via searches on the Annals of Internal Medicine by American College of Physicians(ACP)^(TM),bioMed Central(bMC)^(TM),bMJ Journals^(TM),Journal of the American Medical Association(JAMA)^(TM),PubMed^(TM),SAGE^(TM),ScienceDirect^(TM),SpringerLink(e-journals)^(TM),Taylor and Francis Online^(TM),and Wiley Online Library^(TM) ***:Recognized structural frameworks for scoping reviews were utilized to guide the methodology and technical aspects of this *** extraction was conducted via a charting ***:Research gaps identified include a paucity in research on the subject of obesity and breast cancer among elderly women;there is a limitation of the types of methodologies used in the research on this subject indicating vast opportunities for future studies using different methodologies;lack of use of the alternative types of physical activity and exercise such as Tai Chi,Qigong and Yoga;lack of focus on the older elderly population;and areas of social support from family and friends for obese elderly with breast cancer to engage in physical activity and ***:Future research would address the urgent need within academia to address the research gap of PAE and *** research should use a diverse range of both quantitative and qualitative research methodologies,while including eastern exercise regimens such as Tai Chi,Qigong and Yoga as a means of studying PAE among ***,future research may focus on the“old elderly”as a demographic group of study as well as how social suppo

关键词： Obesity breast cancer Elderly Physical activity Exercise

On combinatorial Gauss-bonnet Theorem for general Euclidean simplicial complexes

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Frontiers of Mathematics in China 2016年第5期11卷 1345-1362页

作者： stephan KLAUS Scientific Administrator of the MFO and Adjunct Professor at Mainz University Mathematisches Forschungsinstitut Oberwolfach gGmbH (MFO) Schwarzwaldstrasse 9-11 D-77709 Oberwolfach-Walke Germany

For a finitely triangulated closed surface M2, let αx be the sum of angles at a vertex x. by the well-known combinatorial version of the 2- dimensional Gauss-bonnet Theorem, it holds ∑x（2π- αx） =2αχ（M^2）, where X denotes the Euler characteristic of M^2, αx denotes the sum of angles at the vertex x, and the sum is over all vertices of the triangulation. We give here an elementary proof of a straightforward higher-dimensional generalization to Euclidean simplicial complexes K without assuming any combinatorial manifold condition. First, we recall some facts on simplicial complexes, the Euler characteristics and its local version at a vertex. Then we define δ（τ） as the normed dihedral angle defect around a simplex τ. Our main result is ∑τ（-1）^dim（τ）δ（τ） = χ（K）, where the sum is over all simplices τ of the triangulation. Then we give a definition of curvature k（x） at a vertex and we prove the vertex-version ∑x∈K0 k（x） = χ（K） of this result. It also possible to prove Morse-type inequalities. Moreover, we can apply this result to combinatorial （n ＋ 1）-manifolds W with boundary b, where we prove that the difference of Euler characteristics is given by the sum of curvatures over the interior of W plus a contribution from the normal curvature along the boundary b： χ（W）- 1/2 χ（b） = ∑τ∈W-b（-1）^dim（τ）δ（τ）＋ ∑τb（-1）^dim（τ）ρ（τ）.

关键词： Curvature dihedral angle Euclidean simplex triangulation Euler characteristic Euler manifold combinatorial manifold pseudo manifold

Catheter ablation of atrial fibrillation facilitated by preprocedural three-dimensional transesophageal echocardiography: Long-term outcome

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World Journal of Cardiology 2017年第6期9卷 539-546页

作者： Klaus Kettering felix Gramley stephan von bardeleben Department of Cardiology University of Frankfurt HPK Heidelberger Praxisklinik für Innere Medizin Kardiologie und Pneumologie Department of Cardiology University of Mainz

AIM To evaluate the long-term outcome of catheter ablation of atrial fibrillation(AF) facilitated by preprocedural threedimensional(3-D) transesophageal *** In 50 patients, 3D transesophageal echocardiography(3D TEE) was performed immediately prior to an ablation procedure(paroxysmal AF: 30 patients, persistent AF: 20 patients). The images were available throughout the ablation procedure. Two different ablation strategies were used. In most of the patients with paroxysmal AF, the cryoablation technique was used(Arctic Front balloon, Cryo Cath Technologies/Medtronic; group A2). In the other patients, a circumferential pulmonary vein ablation was performed using the CARTO system [biosense Webster; group A1(paroxysmal AF), group b(persistent AF)]. Success rates and complication rates were analysed at 4-year *** A 3D TEE could be performed successfully in all patients prior to the ablation procedure and all four pulmonaryvein ostia could be evaluated in 84% of patients. The image quality was excellent in the majority of patients and several variations of the pulmonary vein anatomy could be visualized precisely(e.g., common pulmonary vein ostia, accessory pulmonary veins, varying diameter of the left atrial appendage and its distance to the left superior pulmonary vein). All ablation procedures could be performed as planned and almost all pulmonary veins could be isolated successfully. At 48-mo followup, 68.0% of all patients were free from an arrhythmia recurrence(group A1: 72.7%, group A2: 73.7%, group b: 60.0%). There were no major ***3 D TEE provides an excellent overview over the left atrial anatomy prior to AF ablation procedures and these procedures are associated with a favourable long-term outcome.

关键词： Pulmonary veins Catheter ablation Atrial fibrillation Transesophageal echocardiography Three-dimensional echocardiography

Response of multi-step compound pre-equilibrium reaction cross sections for the(p,n)reactions to forms of optical model parameters

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Nuclear Science and Techniques 2017年第10期28卷 65-70页

作者： felix S.Olise Oludaisi I.Oladunjoye Afis Ajala Sunday D.Olorunfunmi Hezekiah b.Oianiyi Department of Physics and Engineering Physics ObafemiAwolowo UniversityIle-Ife220005Nigeria

In furtherance to improving agreement between calculated and experimental nuclear data, the nuclear reaction code GAMME was used to calculate the multistep compound(MSC) nucleus double differential cross sections(DDCs) for proton-induced neutron emission reactions using the Feshbach-Kerman-Koonin(FKK) formalism. The cross sections were obtained for reactor structural materials involving ^(52)Cr(p, n)^(52)Mn,^(56)Fe(p,n)^(56)Co, and ^(60)Ni(p, n)^(60)Cu reactions at 22.2 MeV incident energy using the zero-range reaction mechanism. Effective residual interaction strength was 28 MeV, and different optical potential parameters were used for the entrance and exit channels of the proton-neutron interactions. The calculated DDCs were fitted to experimental data at the same backward angle of 150°, where the MSC processes dominate. The calculated and experimental data agree well in the region of pre-equilibrium(MSC) reaction dominance against a weaker fit at the lower emission energies. We attribute underestimations to contributions from the other reaction channels and disagreement at higher outgoing energies to reactions to collectively excited states. Contrary to the FKK multi-step direct calculations, contributions from the higher stages to the DDCs are significant. Different sets of parameters resulted in varying levels of agreement of calculated and experimental data for the considered nuclei.

关键词：反应截面光学势参数预平衡模型参数多步复合相互作用强度实验数据

A large-area single-filament infrared emitter and its application in a spectroscopic ethanol gas sensing system

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Microsystems & Nanoengineering 2021年第5期7卷 19-29页

作者： stephan Schrder Floria Ottonello briano Henrik FfodjegSrd Maksym bryzgalov Jonas Orelund Kristinn b.Gylfason Goran Stemme Frank Niklaus KTH Royal Institute of Technology Micro and NanosystemsMalvinas vag 10StockholmSweden SenseAir Ab Stationsgatan 12DelsboSweden

Nondispersive infrared(NDIR)spectroscopy is an important technology for highly accurate and maintenance-free sensing of gases,such as ethanol and carbon ***,NDIR spectroscopy systems are currently too expensive,e.g.,for consumer and automotive applications,as the infrared(IR)emitter is a critical but costly component of these ***,we report on a low-cost large-area IR emitter featuring a broadband emission spectrum suitable for small NDIR gas spectroscopy *** infrared emitter utilizes Joule heating of a Kanthal(FeCrAI)filament that is integrated in the base substrate using an automated high-speed wire bonding process,enabling simple and rapid formation of a long meander-shaped *** describe the critical infrared emitter characteristics,including the effective infrared emission spectrum,thermal frequency response,and power ***,we integrate the emitter into a handheld breath alcohol analyzer and show its operation in both laboratory and real-world settings,thereby demonstrating the potential of the emitter for future low-cost optical gas sensor applications.

关键词： emitter utilize thereby

Structural and chemical mechanisms governing stability of inorganic Janus nanotubes

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npj Computational Materials 2021年第1期7卷 380-387页

作者： felix T.bölle August E.G.Mikkelsen Kristian S.Thygesen Tejs Vegge Ivano E.Castelli Department of Energy Conversion and Storage Technical University of DenmarkKgs.LyngbyDenmark Department of Physics Technical University of DenmarkKgs.LyngbyDenmark

One-dimensional inorganic nanotubes hold promise for technological applications due to their distinct physical/chemical properties,but so far advancements have been hampered by difficulties in producing single-wall nanotubes with a well-defined *** this work we investigate,based on Density Functional Theory(DFT),the formation mechanism of 135 different inorganic nanotubes formed by the intrinsic self-rolling driving force found in asymmetric 2D Janus *** show that for isovalent Janus sheets,the lattice mismatch between inner and outer atomic layers is the driving force behind the nanotube formation,while in the non-isovalent case it is governed by the difference in chemical bond strength of the inner and outer layer leading to steric *** our pool of candidate structures we have identified more than 100 tubes with a preferred radius below 35Å,which we hypothesize can display distinctive properties compared to their parent 2D *** descriptors have been identified to accelerate the discovery of small-radius tubes and a bayesian regression approach has been implemented to assess the uncertainty in our predictions on the radius.

关键词： inorganic chemical radius

Application of the woodchuck animal model for the treatment of hepatitis b virus-induced liver cancer

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World Journal of Gastrointestinal Oncology 2021年第6期13卷 509-535页

作者： Manasa Suresh stephan Menne Department of Microbiology and Immunology Georgetown University Medical CenterWashingtonDC 20057United States

This review describes woodchucks chronically infected with the woodchuck hepatitis virus(WHV)as an animal model for hepatocarcinogenesis and treatment of primary liver cancer or hepatocellular carcinoma(HCC)induced by the hepatitis b virus(HbV).Since laboratory animal models susceptible to HbV infection are limited,woodchucks experimentally infected with WHV,a hepatitis virus closely related to HbV,are increasingly used to enhance our understanding of virus-host interactions,immune response,and liver disease progression.A correlation of severe liver pathogenesis with high-level viral replication and deficient antiviral immunity has been established,which are present during chronic infection after WHV inoculation of neonatal woodchucks for modeling vertical HbV transmission in *** in chronic carrier woodchucks develops 17 to 36 mo after neonatal WHV infection and involves liver tumors that are comparable in size,morphology,and molecular gene signature to those of HbV-infected ***,woodchucks with WHV-induced liver tumors have been used for the improvement of imaging and ablation techniques of human *** addition,drug efficacy studies in woodchucks with chronic WHV infection have revealed that prolonged treatment with nucleos(t)ide analogs,alone or in combination with other compounds,minimizes the risk of liver disease progression to *** recently,woodchucks have been utilized in the delineation of mechanisms involved in innate and adaptive immune responses against WHV during acute,self-limited and chronic *** interventions based on modulating the deficient host antiviral immunity have been explored in woodchucks for inducing functional cure in HbV-infected patients and for reducing or even delaying associated liver disease sequelae,including the onset of ***,woodchucks with chronic WHV infection constitute a well-characterized,fully immunocompetent animal model for HbV-induced liver cancer and for preclinical

关键词： Woodchuck Hepatitis b virus Chronic infection Liver disease Hepatocellular carcinoma Cancer treatment