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国外医药（植物药分册） 1993年第6期8卷 251-255页

作者： steinke b 庄林根

本文建议用测定抑制血小板激活因子(PAF)引起的血小板聚集作为对市售银杏浸膏生物标准化的方法,本法对银杏苦内酯A、b、C和J是专一的,并且不受浸膏中其他成分的影响。银杏苦内酯b的IC_(50)值可用于标定由专门方法提取的各种银杏浸膏中... 详细信息

本文建议用测定抑制血小板激活因子(PAF)引起的血小板聚集作为对市售银杏浸膏生物标准化的方法,本法对银杏苦内酯A、b、C和J是专一的,并且不受浸膏中其他成分的影响。银杏苦内酯b的IC_(50)值可用于标定由专门方法提取的各种银杏浸膏中等效银杏苦内酯b的含量。为比较化学分析和生物测定的值,必须计算各银杏浸膏中等效银杏总苦内酯的含量,其计算值与气相层析结果一致。所以银杏浸膏制剂除化学标准化外,生物标准化也是可行的。

关键词：银杏浸膏生物标准化体外测试

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Wnt genes in colonic polyposis predisposition

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Genes & Diseases 2023年第3期10卷 753-757页

作者： Isabel Quintana Mariona Terradas Pilar Mur Iris b.A.Wte Paske Sophia Peters Isabel Spier Verena steinke-Lange Claudia Maestro David Torrents Montserrat Puiggròs Romina Royo Raul Tonda Genís Parra Davide Piscia Sergi beltrán Matilde Navarro Virginia Piñol Joan brunet Noemi Gonzalez-Abuin Gemma Aiza Anna Sommer Yasmijn van Herwaarden Galuh Astuti Elke Holinski-Feder Nicoline Hoogerbrugge Richarda Mde Voer Stefan Aretz Gabriel Capellá Laura Valle Hereditary Cancer Program Catalan Institute of OncologyOncobell ProgramIDIBELLHospitalet de LlobregatBarcelona 08908Spain Centro de Investigación biomédica en Red de Cáncer(CIbERONC) Madrid 28029Spain Department of Human Genetics Radboud Institute for Molecular Life SciencesRadboud University Medical CenterGA Nijmegen 6525the Netherlands Member of SOLVE-RD ERN-GENTURIS Institute of Human Genetics Medical FacultyUniversity of BonnBonn 53127Germany National Center for Hereditary Tumor Syndromes University Hospital BonnBonn 53127Germany Medizinische Klinik Und Poliklinik IV Campus InnenstadtKlinikum Der Universität MünchenMunich 80336Germany MGZ-Medizinisch Genetisches Zentrum Munich 80335Germany Life Sciences Department Barcelona Supercomputing Center(BSC)Barcelona 08034Spain ICREA Barcelona 08010Spain CNAG-CRG Centre for Genomic Regulation(CRG)Barcelona Institute of Science and TechnologyBarcelona 08028Spain Universitat Pompeu Fabra(UPF) Barcelona 08002Spain Department of Genetics Microbiology and StatisticsSchool of BiologyUniversitat de Barcelona(UB)Barcelona 08028Spain Gastroenterology Unit Hospital Universitario de Girona Dr Josep TruetaGirona 17007Spain Catalan Institute of Oncology IDIBGiGirona 17007Spain Department of Gastroenterology and Hepatology Radboud University Medical CenterGA Nijmegen 6525the Netherlands Department of Human Genetics Radboud University Medical CenterGA Nijmegen 6525the Netherlands

Much of the genetic predisposition to polyposis,and particularly to serrated polyposis(SP),remains *** germline pathogenic variants in RNF43,a tumor suppressor that exerts negative feedback in the Wnt/β-catenin signaling pathway,have been causally linked to some SP cases(bMP/TGF-β,or Wnt signaling,being the latter associated with adenomatous and serrated polyposis phenotypes.2 based on this observation,we evaluated the presence and role of germline variants in those pathways in unsolved polyposis patients.

关键词： polyposis suppressor colorectal

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氧同位素2期珠江河口的孢粉记录及其古环境意义

氧同位素2期珠江河口的孢粉记录及其古环境意义

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中国古生物学会孢粉学会第九届二次学术年会

作者：程仲景翁成郁 Stephan steinke Ricardo De Pol-Holz Dierk Hebbeln MahyarMohtadi 海洋地质国家重点实验室同济大学 MARUM – Center for Marine Environmental Sciences University of Bremen Department of Oceanography University of Concepción

海洋孢粉的来源广、沉积连续、时间序列长且便于建立年龄框架,是重建周边陆地植被和气候的重要材料。然而,南海北部冰期时的孢粉记录由于与同时期相邻陆地的孢粉记录存在较大差异,就其解释上目前还存在一些争议。加强南海孢粉搬运机制... 详细信息

海洋孢粉的来源广、沉积连续、时间序列长且便于建立年龄框架,是重建周边陆地植被和气候的重要材料。然而,南海北部冰期时的孢粉记录由于与同时期相邻陆地的孢粉记录存在较大差异,就其解释上目前还存在一些争议。加强南海孢粉搬运机制的现代观测或者获取更为区域性的孢粉沉积历史特征,有助于我们更加准确的解读南海孢粉记录中所蕴含的古环境信息。籍此,本文选取了南海北部Geo b16602钻孔进行研究,有别于之前集中于东沙群

关键词：南海北部冰期海洋孢粉珠江流域植被

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肩难产:传统的危险因素是否为可靠的预测指标

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世界核心医学期刊文摘（妇产科学分册） 2005年第10期1卷 10-10页

作者： Ouzounian J.G Gherman R.b steinke R 张丽娟 Department of Obstetrics and Gynecology Kaiser Permanente Medical Center 1011 Baldwin Park Blvd Baldwin Park CA 91706 United States.Dr

Objective: Our purpose was to determine the rate of associated risk factors for shoulder dystocia from a large cohort of patients delivered within our Southern California perinatal program. Study design: A retrospective analysis was performed of patients delivered from January 1991 to June 2001. Patients with and without shoulder dystocia were identified from our computer- stored perinatal database and compared. Statistical methods used included: χ 2 test, t test, calculation of odds ratios, and Fisher exact test, as indicated. Results: Among the 267,228 vaginal births during the study period, there were 1,686 cases of shoulder dystocia (rate 0.6% ). Rates for operative vaginal delivery, diabetes, epidural use, multiparity, and postdatism were similar among cases with and without shoulder dystocia. The clinical triad of oxytocin use, labor induction, and birth weight greater than 4,500 g yielded a cumulative odds ratio of 23.2 (95% CI 17.3- 31.0) for shoulder dystocia, but its sensitivity and positive predictive value were only 12.4% and 3.4% , respectively. Conclusion: Historic obstetric risk factors for shoulder dystocia are not useful predictors for the event. Furthermore, although shoulder dystocia was observed more frequently with increasing birth weight, current limitations in estimating birth weight antenatally with accuracy preclude its practical use as a reliable predictor.

关键词：肩难产阴道分娩者队列研究过期妊娠分娩孕妇阴道手术催产素使用硬膜外麻醉精确检验阳性预测值

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Targets for high repetition rate laser facilities:needs,challenges and perspectives

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High Power Laser Science and Engineering 2017年第3期5卷 10-40页

作者： I.Prencipe J.Fuchs S.Pascarelli D.W.Schumacher R.b.Stephens N.b.Alexander R.briggs M.büscher M.O.Cernaianu A.Choukourov M.De Marco A.Erbe J.Fassbender G.Fiquet P.Fitzsimmons C.Gheorghiu J.Hund L.G.Huang M.Harmand N.J.Hartley A.Irman T.Kluge Z.Konopkova S.Kraft D.Kraus V.Leca D.Margarone J.Metzkes K.Nagai W.Nazarov P.Lutoslawski D.Papp M.Passoni A.Pelka J.P.Perin J.Schulz M.Smid C.Spindloe S.steinke R.Torchio C.Vass T.Wiste R.Zaffino K.Zeil T.Tschentscher U.Schramm T.E.Cowan Institute of Radiation Physics Helmholtz–Zentrum Dresden–Rossendorf LULI–CNRS Ecole PolytechniqueCEA:UniversitéParis-Saclay European Synchrotron Radiation Facility Ohio State University University of Pennsylvania Inertial Fusion Technologies General Atomics Peter Grünberg Institute PGI-6 Forschungzentrum Jülich Heinrich-Heine-University Düsseldorf Horia Hulubei National Institute for R&D in Physics and Nuclear Engineering(IFIN-HH)–Extreme Light Infrastructure–Nuclear Physics(ELI-NP) Institute of Physics ASCR FZUELI-Beamlines project Department of Macromolecular Physics Faculty of Mathematics and PhysicsCharles University in Prague Institute of Ion beam Physics and Materials Research Helmholtz–Zentrum Dresden–Rossendorf Technische Universitüt Dresden Institut de minéralogie de physique des matériaux et de cosmochimie Schafer Corporation European XFEL Laboratory for Chemistry and Life Science Institute of Innovative Research(IIR)Tokyo Institute of Technology ELI-ALPS ELI-HU Non-Profit Ltd. Department of Energy Politecnico di Milano INFN-Sezione di Milano CEA Grenoble INACService des Basses Temperatures Science and Technology Facilities Council Rutherford Appleton Laboratory Scitech Precision Ltd Rutherford Appleton Laboratory Lawrence berkeley National Laboratory Institute of Microelectronics of barcelona National Center of MicroelectronicSpanish Research Council University of St.Andrews

A number of laser facilities coming online all over the world promise the capability of high-power laser experiments with shot repetition rates between 1 and 10 Hz. Target availability and technical issues related to the interaction environment could become a bottleneck for the exploitation of such facilities. In this paper, we report on target needs for three different classes of experiments: dynamic compression physics, electron transport and isochoric heating, and laser-driven particle and radiation sources. We also review some of the most challenging issues in target fabrication and high repetition rate operation. Finally, we discuss current target supply strategies and future perspectives to establish a sustainable target provision infrastructure for advanced laser facilities.

关键词： high-energy density physics target design and fabrication

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