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Current concepts and trends in the treatment of bone metastases in patients with advanced prostate cancer

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Asian Journal of Andrology 2019年第1期21卷 12-18页

作者： Miriam Hegemann Moritz Maas steffen rausch Simon Walz lens Bedke Arnulf Stenzl Tilman Todenhofer Department of Urology University Hospital TuebingenTuebingen 72076Germany.

Bone metastases have a major impact on quality of life and survival of patients with advanced prostate cancer,in the last decade,the development and approval of substances inhibiting the vicious cycle of bone metastases have enabled the reduction of complications caused by bone metastases in patients with castration-resistant prostate *** drugs have raised awareness of the importance of skeletal-related events which in the meantime represent an important end point also in trials using agents not specifically designed for bone ***-generation antihormona]drugs such as enzalutamide or abiraterone have been shown to have a positive impact on the incidence of skeletal complications and therefore provide an important tool in the armamentarium used for treating bone *** such as radium-223 dichloride([^223Ra])have been demonstrated not only to reduce skeletal-related events and bone-related pain,but also to prolong overall survival,thereby being the first bone-targeting agent showing a survival *** previous studies have not provided an obvious benefit of bone-targeted lesions in castration-sensitive disease,the use of these agents is not *** oligometastatic prostate cancer,the role of local treatment of metastases using stereotactic radiation or radiosurgery is a matter of intense debates and may play an increasing role in the future.

关键词： bone metastases bone-targeting agents denosumab hormonal therapy prostate cancer radium-223 dichloride zoledronic acid

Real-time estimation of the structural utilization level of segmental tunnel lining

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Underground Space 2024年第4期17卷 132-145页

作者： Nicola Gottardi steffen Freitag Gunther Meschke Institute for Structural Mechanics Ruhr University BochumBochum 44801Germany Institute for Structural Analysis Karlsruhe Institute of TechnologyKarlsruhe 76131Germany

Over the last decades,an expansion of the underground network has been taking place to cope with the increasing amount of moving people and *** a consequence,it is of vital importance to guarantee the full functionality of the tunnel network by means of preventive maintenance and the monitoring of the tunnel lining state over time.A new method has been developed for the real-time prediction of the utilization level in tunnel segmental linings based on input monitoring *** new concept is founded on a framework,which encompasses an offline and an online *** the former,the generation of feedforward neural networks is accomplished by employing synthetically produced *** element simulations of the lining structure are conducted to analyze the structural response under multiple loading *** scenarios are generated by assuming ranges of variation of the model input parameters to account for the uncertainty due to the not fully determined in situ *** and target quantities are identified to better assess the structural utilization of the *** latter phase consists in the application of the methodological framework on input monitored data,which allows for a real-time prediction of the physical quantities deployed for the estimation of the lining *** approach is validated on a full-scale test of segmental lining,where the predicted quantities are compared with the actual ***,it is investigated the influence of artificial noise added to the training data on the overall prediction performances and the benefits along with the limits of the concept are set out.

关键词： Segmental lining Artificial neural networks Structural utilization level Real-time prediction Structural health monitoring Monitoring data

Tau in the pancreas:understanding the link between type 2 diabetes mellitus and Alzheimer's disease

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Signal Transduction and Targeted Therapy 2024年第1期9卷 6-7页

作者： Wenlu Li steffen Tiedt Eng H.Lo Neuroprotection Research Laboratories Departments of Radiology and NeurologyMassachusetts General HospitalHarvard Medical SchoolCharlestownMA02129USA Consortium International pour la Recherche Circadienne sur l’AVC(CIRCA) BostonUSA Institute for Stroke and Dementia Research LMU University HospitalLMU MunichMunichGermany

A recent study published in Molecular Psychiatry proposes a cellular mechanism that may contribute to decreased insulin production in individuals with type 2 diabetes mellitus(T2DM).1 Using a combination of cell culture experiments,animal models and studies in T2DM patients,the authors show that an up-regulation of tau inβ-islet cells can inhibit pancreatic insulin secretion through changes in microtubule assembly.

关键词： T2DM Alzheimer tau

A simulation-based software to support the real-time operational parameters selection of tunnel boring machines

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Underground Space 2024年第1期14卷 176-196页

作者： Yaman Zendaki Ba Trung Cao Abdullah Alsahly steffen Freitag Gunther Meschke Institute for Structural Mechanics Ruhr University BochumBochum 44801Germany Institute for Structural Analysis Karlsruhe Institute of TechnologyKarlsruhe 76131Germany

With the fact that the main operational parameters of the construction process in mechanized tunneling are currently selected based on monitoring data and engineering experience without exploiting the advantages of computer methods,the focus of this work is to develop a simulation-based real-time assistant system to support the selection of operational *** choice of an appropriate set of these parameters(i.e.,the face support pressure,the grouting pressure,and the advance speed)during the operation of tunnel boring machines(TBM)is determined by evaluating different tunneling-induced soil-structure interactions such as the surface settlement,the associated risks on existing structures and the tunnel lining *** evaluate soil-structure behavior,an advanced process-oriented numerical simulation model based on the finite cell method is *** enable the real-time prediction capability of the simulation model for a practical application during the advancement of TBMs,surrogate models based on the Proper Orthogonal Decomposition and Radial Basis Functions(POD-RBF)are *** proposed approach is demonstrated through several synthetic numerical examples inspired by the data of real tunnel *** developed methods are integrated into a user-friendly application called SMART to serve as a support platform for tunnel engineers at construction *** to each user adjustment of the input parameters,i.e.,each TBM driving scenario,approximately two million outputs of soil-structure interactions are quickly predicted and visualized in seconds,which can provide the site engineers with a rough estimation of the impacts of the chosen scenario on structural responses of the tunnel and above ground structures.

关键词： Numerical simulation Surrogate model Real-time prediction Proper orthogonal decomposition Radial basis functions TBM operation Smart construction

Correcting of the unexpected localization measurement for indoor automatic mobile robot transportation based on a neural network

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Transportation Safety and Environment 2024年第2期6卷 24-35页

作者： Jiahao Huang steffen Jung inger Hui Liu Kerstin Thurow Center for Life Science Automation(CELISCA) University of RostockRostock 18119Germany Institute of Automation University of RostockRostock 18119Germany Institute of Artificial Intelligence&Robotics(IAIR) School of Traffic&Transportation EngineeringCentral South UniversityChangsha 410075HunanChina

The increasing use of mobile robots in laboratory settings has led to a higher degree of laboratory ***,when mobile robots move in laboratory environments,mechanical errors,environmental disturbances and signal interruptions are *** can compromise the accuracy of the robot’s localization,which is crucial for the safety of staff,robots and the laboratory.A novel time-series predicting model based on the data processing method is proposed to handle the unexpected localization measurement of mobile robots in laboratory *** proposed model serves as an auxiliary localization system that can accurately correct unexpected localization errors by relying solely on the historical data of mobile *** experimental results demonstrate the effectiveness of this proposed method.

关键词： mobile robots laboratory automation indoor localization neural network

Laser-induced plasma formation in water with up to 400 mJ double-pulse LIBS

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Plasma Science and Technology 2024年第1期26卷 93-100页

作者： Marion HENKEL Michelle SIEMENS Ralf METHLING Benjamin EMDE Jörg HERMSDORF steffen FRANKE Diego GONZALEZ Leibniz Institute for Plasma Science and Technology(INP) Felix-Hausdorff-Straße 2Greifswald 17489Germany Laser Zentrum Hannover e.V.(LZH) Hollerithallee 8Hannover 30419Germany

Double-pulse LIBS is a promising technique for deep-sea *** measurements in shallow water with up to 400 mJ each pulse were done to select laser parameters which promote optimized spectral line emission from plasma even at elevated pressures,where line broadening until loss of most of the spectral information can *** emission spectroscopy,using a Czerny-Turner spectrometer,has been applied to investigate the dependence of the emitted radiation on laser parameters and hydrostatic *** has been found,that higher laser pulse energies,especially with short pulse delay as required in high water pressure,can also have an adverse effect on the measured spectrum.

关键词： double-pulse LIBS underwater plasma formation emission spectrosocpy

BLE beacons for sample position estimation in a life science automation laboratory

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Transportation Safety and Environment 2024年第3期6卷 111-123页

作者： Haiping Wu steffen Junginger Thomas Roddelkopf Hui Liu Kerstin Thurow Institute of Artificial Intelligence&Robotics(IAIR) Key Laboratory of Traffic Safety on Track of Ministry of EducationSchool of Traffic and Transportation EngineeringCentral South UniversityChangsha 410075HunanChina Institute of Automation(IAT) University of Rostock18119 RostockGermany Center of Life Science Automation(celisca) University of Rostock18119 RostockGermany

Estimation of the sample position is essential for working process monitoring and management in the life science automation lab*** low-energy(BLE)beacons have the advantages of low price,small size and low energy consumption,which make them a promising solution for sample position estimation in the automated *** fingerprinting models have been proposed to achieve indoor localization with the received signal strength(RSS)***,most of the research depends on intensive beacon *** estimation,which depends entirely on one beacon,is more suitable for sample position estimation in large automated *** complexity of the life science automation laboratory environment brings challenges to the traditional path loss model(PLM),which is a widely used radio wave propagation model-based proximity estimation *** this paper,BLE sensing devices for sample position estimation are *** BLE beacon-based proximity estimation is discussed in the framework of machine learning,in which the support vector regression(SVR)is utilized to model the nonlinear relationship between the RSS data and distance,and the Kalman filter is utilized to decrease the RSS data *** experimental results over different environments indicate that the SVR outperforms the PLM significantly,and provides 1 m absolute errors for more than 95%of the testing *** Kalman filter brings benefits to stable distance *** from proximity-based sample position estimation,the proposed framework turned out to be effective in position estimation between parallel workbenches and position estimation on an automated workstation.

关键词： BLE beacon position estimation proximity estimation received signal strength(RSS) support vector regression(SVR) life science automation laboratory

Speed and surface steepness affect internal tibial loading during running

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Journal of Sport and Health Science 2024年第1期13卷 118-124页

作者： Hannah Rice Markus Kurz Patrick Mai Leon Robertz Kevin Bill Timothy R.Derrick steffen Willwacher Department of Physical Performance Norwegian School of Sport SciencesOslo 0806Norway Sports Tech Research Centre Mid Sweden UniversityÖstersund SE-83125Sweden Department of Mechanical and Process Engineering Offenburg University of Applied SciencesOffenburg 77652Germany Institute of Biomechanics and Orthopaedics German Sport University CologneCologne 50933Germany Department of Kinesiology Iowa State UniversityAmesIA 50011USA

Background:Internal tibial loading is influenced by modifiable factors with implications for the risk of stress *** encounter varied surface steepness(gradients)when running outdoors and may adapt their speed according to the *** study aimed to quantify tibial bending moments and stress at the anterior and posterior peripheries when running at different speeds on surfaces of different ***:Twenty recreational runners ran on a treadmill at 3 different speeds(2.5 m/s,3.0 m/s,and 3.5 m/s)and gradients(level:0%;uphill:+5%,+10%,and+15%;downhill:-5%,-10%,and-15%).Force and marker data were collected synchronously *** moments were estimated at the distal third centroid of the tibia about the medial-lateral axis by ensuring static equilibrium at each 1%of *** was derived from bending moments at the anterior and posterior peripheries by modeling the tibia as a hollow ***-way repeated-measures analysis of variance were conducted using both functional and discrete statistical ***:There were significant main effects for running speed and gradient on peak bending moments and peak anterior and posterior *** running speeds resulted in greater tibial *** uphill at+10%and+15%resulted in greater tibial loading than level *** downhill at-10%and-15%resulted in reduced tibial loading compared to level *** was no difference between+5%or-5%and level ***:Running at faster speeds and uphill on gradients≥+10%increased internal tibial loading,whereas slower running and downhill running on gradients≥-10%reduced internal *** running speed according to the gradient could be a protective mechanism,providing runners with a strategy to minimize the risk of tibial stress injuries.

关键词： Bending moments Gradient Musculoskeletal modeling Overuse injury Tibial stress Training factors

Many faces of neuronal activity manipulation in Drosophila

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Neural Regeneration Research 2025年第9期20卷 2574-2576页

作者： Amber Krebs steffen Kautzmann Christian Klämbt Institut für Neuro-und Verhaltensbiologie MünsterGermany

Animals exhibit complex responses to external and internal *** information is computed by interconnected neurons that express numerous ion channels,which modulate the neuronal membrane *** can neuronal activity orchestrate complex motor patterns or allow learning from previous experience?To answer such questions,we need the ability not only to record,but also to modulate neuronal activity in both space(e.g.,neuronal subsets)and time.

关键词： manipulation potential. neuronal