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seventh tumor-node-metastasis staging of gastric cancer: Five-year follow-up

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World Journal of Gastroenterology 2016年第34期22卷 7748-7753页

作者： stefano rausei Laura Ruspi Federica Galli Vincenzo Pappalardo Giuseppe Di Rocco Francesco Martignoni Francesco Frattini Francesca Rovera Luigi Boni Gianlorenzo Dionigi Department of Surgery University of Insubria

Seventh tumor-node-metastasis(TNM) classification for gastric cancer,published in 2010,introduced changes in all of its three parameters with the aim to increase its accuracy in prognostication. The aim of this review is to analyze the efficacy of these changes and their implication in clinical practice. We reviewed relevant Literature concerning staging systems in gastric cancer from 2010 up to March 2016. Adenocarcinoma of the esophago-gastric junction still remains a debated entity,due to its peculiar anatomical and histological situation: further improvement in its staging are required. Concerning distant metastases,positive peritoneal cytology has been adopted as a criterion to define metastatic disease: however,its search in clinical practice is still far from being routinely performed,as staging laparoscopy has not yet reached wide diffusion. Regarding definition of T and N: in the era of multimodal treatment these parameters should more influence both staging and surgery. The changes about T-staging suggested some modifications in clinical practice. Differently,many controversies on lymph node staging are still ongoing,with the proposal of alternative classification systems in order to minimize the extent of lymphadenectomy. The next TNM classification should take into account all of these aspects to improve its accuracy and the comparability of prognosis in patients from both Eastern and Western world.

关键词： Gastric cancer Staging system Tumor node-metastasis Prognostic factors Clinical practice

Effect of perioperative blood transfusion on clinical outcomes in hepatic surgery for cancer

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World Journal of Gastroenterology 2009年第32期15卷 3976-3983页

作者： Gianlorenzo Dionigi Luigi Boni Francesca Rovera stefano rausei Salvatore Cuffari Giovanni Cantone Alessandro Bacuzzi Renzo Dionigi Department of Surgical Sciences Azienda Ospedaliera-Polo UniversitarioUniversity of InsubriaVia Guicciardini21100 VareseItaly Department of Anesthesiology Azienda Ospedaliera-Polo Universitario21100 VareseItaly

Allogeneic blood transfusion during liver resection for malignancies has been associated with an increased incidence of different types of complications: infectious complications, tumor recurrence, decreased survival. Even if there is clear evidence of transfusion-induced immunosuppression, it is difficult to demonstrate that transfusion is the only determinant factor that decisively affects the outcome. In any case there are several motivations to reduce the practice of blood transfusion. The advantages and drawbacks of different transfusion alternatives are reviewed here, emphasizing that surgeons and anesthetists who practice in centers with a high volume of liver resections, should be familiar with all the possible alternatives.

关键词： Blood transfusion Blood products Allogeneicblood transfusion Intraoperative autotransfusion Preoperative autologous blood donation Intraoperativeisovolemic hemodilution Infectious complications Liverresection Hepatocellular carcinoma

In advanced gastric cancer:Prognosis and treatment of patients with positive peritoneal cytology

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World Journal of Gastrointestinal Surgery 2013年第5期5卷 135-137页

作者： Francesco Frattini stefano rausei Corrado Chiappa Francesca Rovera Luigi Boni Gianlorenzo Dionigi Department of Surgical Sciences University of Insubria School of Medicine

Positive peritoneal cytology in gastric cancer is classified as M1 disease by the 7thEdition of American Joint Committee on Cancer staging *** the introduction of laparoscopy and peritoneal washing cytology in the staging of gastric cancer a new category of patients has been *** are patients with no macroscopic peritoneal metastases but with peritoneal cytology positive(P0C1).Prognosis and treatment of such patientsrepresent a controversial *** evaluate the state of the art of staging system in gastric cancer and discusss tandardisation in staging and treatment *** is still a lack of uniformity in the use of laparoscopy with peritoneal cytology in clinical decision making and in the surgical treatment for gastric *** of this patient subset remains *** therapies and new therapeutic strategies are required to improve the survival of these patients.

关键词： Advanced gastric cancer Peritoneal washing cytology Staging laparoscopy Reverse transcription-polymerase chain reaction

A decade in gastric cancer curative surgery:Evidence of progress(1999-2009)

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World Journal of Gastrointestinal Surgery 2012年第3期4卷 45-54页

作者： stefano rausei Gianlorenzo Dionigi Francesca Rovera Luigi Boni Caterina Valerii Luisa Giavarini Francesco Frattini Renzo Dionigi Department of Surgical Sciences University of Insubria

To investigate the progress in evidence-based surgical treatment of non-metastatic gastric cancer,we re- viewed the last ten years'*** data used in this review were identified by searches made on MED-LINE,Current Contents,PubMed,and other references taken from relevant original articles(on prospective and retrospective studies)concerning gastric cancer *** papers published in English between January 1999 and December 2009 were *** from ongoing studies were obtained in December 2009, from the trials registry of the United States National Institutes of Health(http://***).The citations list was presented according to evidence based relevance(i.e.,randomized controlled trials,pro- spective studies,retrospective series).In the last ten years,many challenges have been faced relating to the extension of gastric resection and nodal dissection as well as surgical timing,but we found only limited evidence,regardless of latitude of *** ongoing phase-Ⅲ trials may provide answers that will be valid for the coming decades,and which may bring definitive answers for the currently unresolved questions.

关键词： Gastric cancer Evidence-based surgery D2 lymphadenectomy Laparoscopic gastrectomy Endo-scopic treatment Neoadjuvant therapy

Multimodal treatment of gastric cancer

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World Journal of Gastrointestinal Surgery 2014年第4期6卷 55-58页

作者： Ilaria Proserpio stefano rausei Sabrina Barzaghi Francesco Frattini Federica Galli Domenico Iovino Francesca Rovera Luigi Boni Gianlorenzo Dionigi Graziella Pinotti Department of Oncology Ospedale di Circolo and University of Insubria Department of Surgery Ospedale di Circolo and University of Insubria

Gastric cancer is the second leading cause of death from malignant disease *** complete surgical resection remains the only curative modality for early stage gastric cancer,surgery alone only provides long-term survival in 20%of patients with advancedstage *** improve current results,it is necessary to consider multimodality treatment,including chemotherapy,radiotherapy and *** clinical trials have shown survival benefit of combining different neoadjuvant or adjuvant protocols compared with surgery with curative ***,the implementation of chemotherapy with novel targeted agents could play an important role in the multimodal management of advanced gastric *** this paper,we focus on a multidisciplinary approach in the treatment of gastric cancer and discuss future strategies to improve the outcome for these patients.

关键词： Gastric cancer Gastrectomy Lymphadenectomy Multimodal treatment Adjuvant therapy Neoadjuvant therapy Chemotherapy Radiotherapy Targeted therapy

Incoherent non-Hermitian skin effect in photonic quantum walks

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Light(Science & Applications) 2024年第5期13卷 885-893页

作者： stefano Longhi Dipartimento di Fisica Politecnico di MilanoPiazza L.da Vinci 32I-20133 MilanoItaly IFISC(UIB-CSIC) Instituto de Fisica Interdisciplinar y Sistemas ComplejosE-07122 Palma de MallorcaSpain

The non-Hermitian skin effect describes the concentration of an extensive number of eigenstates near the boundaries of certain dissipative *** phenomenon has raised a huge interest in different areas of physics,including photonics,deeply expanding our understanding of non-Hermitian systems and opening up new avenues in both fundamental and applied aspects of topological *** skin effect has been associated to a nontrivial pointgap spectral topology and has been experimentally demonstrated in a variety of synthetic matter systems,including photonic *** most of physical models exhibiting the non-Hermitian skin effect full or partial wave coherence is generally *** we push the concept of skin effect into the fully incoherent regime and show that rather generally(but not universally)the non-Hermitian skin effect persists under dephasing *** results are illustrated by considering incoherent light dynamics in non-Hermitian photonic quantum walks.

关键词： dynamics. quantum effect

Time reversal of a discrete system coupled to a continuum based on non-Hermitian flip

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Science Bulletin 2017年第12期62卷 869-874页

作者： stefano Longhi Dipartimento di Fisica Politecnico di Milano and Istituto di Fotonica e Nanotecnologie del Consiglio Nazionale delle RicerchePiazza L.da Vinci 321-20133 MilanoItaly

Time reversal in quantum or classical systems described by an Hermitian Hamiltonian is a physically allowed process, which requires in principle inverting the sign of the Hamiltonian. Here we consider the problem of time reversal of a subsystem of discrete states coupled to an external environment characterized by a continuum of states, into which they generally decay. It is shown that, by flipping the discrete-continuum coupling from an Hermitian to a non-Hermitian interaction, thus resulting in a non unitary dynamics, time reversal of the subsystem of discrete states can be achieved, while the continuum of states is not reversed. Exact time reversal requires frequency degeneracy of the discrete states,or large frequency mismatch among the discrete states as compared to the strength of indirect coupling mediated by the continuum. Interestingly, periodic and frequent switch of the discrete-continuum coupling results in a frozen dynamics of the subsystem of discrete states.

关键词： Non-Hermitian dynamicsTime reversalLoschmidt echo

Reply to "Discussion 1 on 'Introspection on improper seismic retrofit of Basilica Santa Maria di Collemaggio after 2009 Italian earthquake' by ***,*** and *** stefano" by Vincenzo Ciampi

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Earthquake Engineering and Engineering Vibration 2012年第2期11卷 283-288页

作者： Gian Paolo Cimellaro Andrei M.Reinhorn Alessandro De stefano Department of Structural Geotechnical & Building Engineering(DISEG)Politecnico di TorinoCorso Duca degli Abruzzi 2410129 TurinItaly Department of Civil Structural & Environmental EngineeringUniversity at Buffalothe State University of New York135 Ketter HallBuffalo NYUSA

The authors thank the discusser for his interest and careful review of the paper and his valuable comments. They also welcome this discussion,because it gives the authors the opportunity to clarify several points whic... 详细信息

关键词： Introspection on improper seismic retrofit of Basilica Santa Maria di Collemaggio after 2009 Italian earthquake by Vincenzo Ciampi Discussion 1 on Reply to De

Reply to "Discussion 2 on 'Introspection on improper seismic retrofit of Basilica Santa Maria di Collemaggio after 2009 Italian earthquake' by G.P. Cimellaro, A.M. Reinhorn and *** stefano" by Enzo Cartapati

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Earthquake Engineering and Engineering Vibration 2012年第2期11卷 291-292页

作者： Gian Paolo Cimellaro Andrei M. Reinhorn Alessandro De stefano Department of Structural Geotechnical & Building Engineering (DISEG) Politecnico di Torino Corso Duca degli Abruzzi 24 10129 Turin Italy Department of Civil Structural & Environmental Engineering University at Buffalo the State University of New York 135 Ketter Hall Buffalo NY USA

The authors thank the discusser for the additional information,which is provided related to the historical interventions of the church through the centuries. This information was known to the authors,however they deci... 详细信息

关键词： Reply to A.M Reinhorn and A.De stefano Introspection on improper seismic retrofit of Basilica Santa Maria di Collemaggio after 2009 Italian earthquake by G.P Discussion 2 on De