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Biological processes involved in mechanical force transmission in connective tissue:Linking bridges for new therapeutic applications in the rehabilitative field

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BIOCELL 2025年第1期49卷 1-5页

作者： AUGUSTO FUSCO stefano BONOMI LUCA PADUA UOC Neuroriabilitazione ad Alta Intensità Fondazione Policlinico Universitario A.Gemelli IRCCSRome00168Italy Department of Geriatrics and Orthopedics UniversitàCattolica del Sacro CuoreRome00168Italy

Connective tissue is a dynamic structure that reacts to environmental cues to maintain homeostasis,including mechanical *** load influences extracellular matrix(ECM)—cell interactions and modulates cellular ***-regulation processes involve matrix modification and cell activation to preserve tissue *** ECM remodeling is crucial for force *** components are involved in force sensing and transmission,affecting cellular adhesion,motility,and gene *** mechanical loading helps to maintain tissue health,while imbalances may lead to pathological *** and passive movement,including manual mobilization,improves connective tissue elasticity,promotes ECM-cell homeostasis,and reduces *** rehabilitation,understanding mechanical-regulation processes is necessary for ameliorating and developing treatments aimed at preserving tissue elasticity and preventing *** this commentary,we aim to globally describe the biological processes involved in mechanical force transmission in connective tissue as support for translational studies and clinical applications in the rehabilitation field.

关键词： Connective tissue Cellular mechanotransduction Integrins Translational science

Trans-jugular intrahepatic portosystemic stent shunting benefits and limits

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World Journal of Gastrointestinal Surgery 2025年第1期17卷 307-309页

作者： Salvatore stefano Sciarrone Lucia Fini Luca De Luca Department of Surgery Gastroenterology and Digestive Endoscopy UnitASST Santi Paolo e CarloUniversity of MilanMilan 20142LombardyItaly

Trans-jugular intrahepatic portosystemic stent shunting(TIPSS)has been in use for many years with great results and many *** procedure essentially involves the insertion of a metal covert stent to create an Hepato-Hepatic portosystemic *** time,TIPSS has become the subject of many studies aimed at examining its clinical utility and evaluating the results of using TIPSS to manage complications related to portal *** the outset,this procedure has been met with hope and enthusiasm and give the chance to consider another possibility to treat the complications of portal hypertension without the use of *** that TIPSS is an attractive alternative to shunt surgery because it does not require the use of general anesthesia or laparotomy,in fact this method is applicable to many patients with severe liver disease not suitable for *** has been studied for the management of variceal bleeding,ascites,hepatic hydrothorax,hepatorenal syndrome,and other types of ***,some drawbacks of the TIPSS,such as shunt stenosis and hepatic encephalopathy,have also been reported in the *** the basis of the available evidence and the new epidemiological findings regarding liver disease,the following question may be posed:What is the place of TIPSS in current clinical practice?

关键词： Hepatic compensation Decompensation Trans-jugular intrahepatic portosystemic stent-shunt Bleeding Ascites

Generation,interrogation,and future applications of microglia-containing brain organoids

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Neural Regeneration Research 2025年第12期20卷 3448-3460页

作者： Julia Di stefano Federica Di Marco Ilaria Cicalini Una FitzGerald Damiana Pieragostino Marleen Verhoye Peter Ponsaerts Elise Van Breedam Laboratory of Experimental Hematology Vaccine and Infectious Disease Institute(Vaxinfectio)University of AntwerpWilrijkBelgium Bio-Imaging Lab University of AntwerpWilrijkBelgium Center for Advanced Studies and Technology(CAST) G.d’Annunzio University of Chieti-PescaraChietiItaly Department of Innovative Technologies in Medicine and Dentistry University“G.d’Annunzio”of Chieti-PescaraChietiItaly CÚRAM Center for Research in Medical DevicesBiomedical EngineeringUniversity of GalwayIreland Galway Neuroscience Center University of GalwayIreland μNEURO Research Center of Excellence University of AntwerpWilrijkBelgium

Brain organoids encompass a large collection of in vitro stem cell–derived 3D culture systems that aim to recapitulate multiple aspects of in vivo brain development and ***,this review provides a brief introduction to the current state-of-the-art for neuroectoderm brain organoid development,emphasizing their biggest advantages in comparison with classical two-dimensional cell cultures and animal ***,despite their usefulness for developmental studies,a major limitation for most brain organoid models is the absence of contributing cell types from endodermal and mesodermal *** such,current research is highly investing towards the incorporation of a functional vasculature and the microglial immune *** this review,we will specifically focus on the development of immune-competent brain *** summarizing the different approaches applied to incorporate microglia,it is highlighted that immune-competent brain organoids are not only important for studying neuronal network formation,but also offer a clear future as a new tool to study inflammatory responses in vitro in 3D in a brainlike ***,our main focus here is to provide a comprehensive overview of assays to measure microglial phenotype and function within brain organoids,with an outlook on how these findings could better understand neuronal network development or restoration,as well as the influence of physical stress on microglia-containing brain ***,we would like to stress that even though the development of immune-competent brain organoids has largely evolved over the past decade,their full potential as a pre-clinical tool to study novel therapeutic approaches to halt or reduce inflammation-mediated neurodegeneration still needs to be explored and validated.

关键词： 3D cell culture brain organoids immune response immunocompetent model in vitro model microglia neural organoids neuroimmunology neuroinflammation

Endoscopic techniques for the diagnosis of pancreatic cystic lesions

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World Journal of Gastroenterology 2025年第1期31卷 1-7页

作者： Sahib Singh Saurabh Chandan Rakesh Vinayek Jahnvi Dhar Jayanta Samanta Gabriele Capurso Ivo Boskoski Cristiano Spada Jorge D Machicado stefano Francesco Crinò Antonio Facciorusso Department of Internal Medicine Sinai HospitalBaltimoreMD 21215United States Division of Gastroenterology and Hepatology Creighton University School of MedicineOmahaNE 68131United States Department of Gastroenterology Sinai Hospital of BaltimoreBaltimoreMD 21215United States Department of Gastroenterology Postgraduate Institute of Medical Education and ResearchChandigarh 160012India Division of Pancreato-Biliary Endoscopy and Endosonography Pancreas Translational and Clinical Research CenterIRCCS San Raffaele Scientific InstituteVita-Salute San Raffaele UniversityMilano 20132Italy Digestive Endoscopy Unit Fondazione Policlinico Universitario Agostino Gemelli IRCSSUniversitàCattolica del Sacro Cuore di RomaCenter for Endoscopic Research Therapeutics and TrainingRoma 00168Italy Department of Gastroenterology and Endoscopy Catholic UniversityRoma 00168Italy Department of Gastroenterology University of Michigan HealthAnn ArborMI 48107United States Department of Endoscopy University of VeronaVerona 37121VenetoItaly Gastroenterology Unit Department of Medical and Surgical SciencesUniversity of FoggiaFoggia 71122Italy

Pancreatic cysts are mostly incidental findings on computed tomography or magnetic resonance imaging scans,with few patients presenting with abdominal pain or other *** accurate diagnosis of cysts is important as management depends on the type(neoplastic or non-neoplastic).Cross-sectional imaging is fast being replaced with endoscopic ultrasound(EUS)and various techniques based on that such as EUS-guided fine needle aspiration,EUS-guided needle confocal laser endomicroscopy,EUS-through-the-needle biopsy,and contrast-enhanced *** studies have reported varying diagnostic and adverse event rates with these *** addition,American,European,and Kyoto guidelines for the diagnosis and management of pancreatic cysts have provided different *** this editorial,we elaborate on the clinical guidelines,recent studies,and comparison of different endoscopic methods for the diagnosis of pancreatic cysts.

关键词： Endoscopic ultrasound Fine needle aspiration Needle confocal laser endomicroscopy Through-the-needle biopsy Contrast-enhanced endoscopic ultrasound

Factors associated with medical device-related pressure ulcers occurrence in hospital setting:a systematic review protocol

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Frontiers of Nursing 2025年第1期12卷 13-18页

作者： stefano Trapassi Guya Piemonte Enrico Lumini Lorenzo Righi Christian Ramacciani Isemann Mecheroni Silvana Luisa Bertò Stefania Francioni Fulvia Marini Giovanni Becattini Department of Nursing and Midwifery Alta Val d’Elsa HospitalPoggibonsi 53036Italy Department of Nursing and Midwifery Santa Maria Annunziata HospitalBagno a Ripoli 50012Italy Department of Nursing and Midwifery Profession University Hospital CareggiFlorence 50134Italy Department of Nursing and Midwifery Operation Center Medical ServiceSiena 53100Italy Department of Nursing and Midwifery Val di Chiana HospitalMontepulciano 53045Italy Department of Nursing and Midwifery Misericordia HospitalGrosseto 58100Italy Department of Nursing and Midwifery San Donato HospitalArezzo 52100Italy

Objective: To identify the principal factors associated with the occurrence and development of medical device-related pressure injuries (MDRPI) in adults admitted to hospitals. MDRPI, a peculiar subtype of pressure injuries (PI), result from the pression exerted by devices (or their fixation systems) applied for diagnostic and therapeutic purposes. MDRPI represent a serious problem for patients and healthcare systems. Understanding potential risk factors is an important step in implementing effective interventions. Methods: In this study, we will perform a systematic review;if possible, also a meta-analysis will be performed. The review will follow the preferred reporting items for systematic reviews and meta-analyses (PRISMA) reporting guidelines for systematic reviews. A rigorous literature search will be conducted both in electronic databases (Medline/PubMed, Embase, CINAHL, Web of Science, Scopus, Cochrane Library) to identify studies published since 2000 and in gray literature for unpublished studies. Pairs of researchers will identify relevant evidence, extract data, and assess risk of bias independently in each eligible study. Factors associated with the occurrence of MDRPI are considered the primary outcome. Secondary outcomes are prevalence and incidence of MDRPI, length of hospital stay, infections, and death. The evidence will be synthesized using the GRADE methodology. Results: Results are not currently available as this is a protocol for a systematic review. Conclusions: This systematic review will identify evidence on risk factors for developing MDRPI. We are confident that the results of this review will help to improve clinical practice and guide future research.

关键词： incidence medical devices pressure injury pressure ulcer prevalence risk factor

Nano-drug delivery systems integrated with low radiation doses for enhanced therapeutic efficacy in cancer treatment

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World Journal of Clinical Cases 2025年第10期13卷 14-27页

作者： Antonio Pontoriero Paola Critelli Marco Zeppieri Alberto Bosurgi Stefania Guercio Maria Caffo Filippo Flavio Angileri Silvana Parisi Salvatore Lavalle stefano Pergolizzi Radiation Oncology Unit Department of BiomedicalDental Science and Morphological and Functional ImagesUniversity of MessinaMessina 98125Italy Department of Ophthalmology University Hospital of UdineUdine 33100Italy Neurosurgery Unit Department of BiomedicalDental Science and Morphological and Functional ImagesMessinaItalyMessina 98125Italy Lavalle Department of Medicine and SurgeryUniversity of Enna"Kore"Enna 94100Italy

BACKGROUND Precision medicine is an emerging field that includes tumor-targeted delivery and tumor *** review explores the synergistic potential of combining nano-drug delivery systems with low radiation doses to achieve optimized therapeutic outcomes,particularly in the context of cancer ***-based drug carriers offer precise and targeted delivery,enhancing the therapeutic index of anticancer *** use of lower radiation doses has become a focus in radiation oncology to minimize off-target effects on healthy tissues in palliation treatment with high-target volume *** To conduct a bibliometric review of nanomedicine and glioblastoma(GBM),all relevant studies from the last two decades were *** The search strategy comprised the keywords“nanomedicine”and“glioblastoma”in the title and/or *** English-language documents from 1 January 2000 to 31 December 2023 were considered for the analysis.R code(version 4.2.0)with R Studio(version 2022.12.0-353)and the Bibliometrix package(version 4.0.1)were used for the analysis.A total of 680 documents were *** We analyzed the bibliometric features of nanomedicine in *** the limitations of the research,our analysis aims to highlight the increasing interest of researchers in the precision medicine field in GBM treatment and lead us to suggest further studies focusing on the association between nanomedicine and *** Due to the poor prognosis associated with GBM,new therapeutic approaches are *** is an increasing interest in precision medicine,which includes nanomedicine and radiotherapy,for GBM *** integration enhances the efficacy of targeted treatments and provides a promising avenue for reducing adverse effects,signifying a notable advancement in precision oncology.

关键词： Nanomedicine Nanoparticles Drug-delivery Radiotherapy Combination therapy

Incoherent non-Hermitian skin effect in photonic quantum walks

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Light(Science & Applications) 2024年第5期13卷 885-893页

作者： stefano Longhi Dipartimento di Fisica Politecnico di MilanoPiazza L.da Vinci 32I-20133 MilanoItaly IFISC(UIB-CSIC) Instituto de Fisica Interdisciplinar y Sistemas ComplejosE-07122 Palma de MallorcaSpain

The non-Hermitian skin effect describes the concentration of an extensive number of eigenstates near the boundaries of certain dissipative *** phenomenon has raised a huge interest in different areas of physics,including photonics,deeply expanding our understanding of non-Hermitian systems and opening up new avenues in both fundamental and applied aspects of topological *** skin effect has been associated to a nontrivial pointgap spectral topology and has been experimentally demonstrated in a variety of synthetic matter systems,including photonic *** most of physical models exhibiting the non-Hermitian skin effect full or partial wave coherence is generally *** we push the concept of skin effect into the fully incoherent regime and show that rather generally(but not universally)the non-Hermitian skin effect persists under dephasing *** results are illustrated by considering incoherent light dynamics in non-Hermitian photonic quantum walks.

关键词： dynamics. quantum effect

Time reversal of a discrete system coupled to a continuum based on non-Hermitian flip

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Science Bulletin 2017年第12期62卷 869-874页

作者： stefano Longhi Dipartimento di Fisica Politecnico di Milano and Istituto di Fotonica e Nanotecnologie del Consiglio Nazionale delle RicerchePiazza L.da Vinci 321-20133 MilanoItaly

Time reversal in quantum or classical systems described by an Hermitian Hamiltonian is a physically allowed process, which requires in principle inverting the sign of the Hamiltonian. Here we consider the problem of time reversal of a subsystem of discrete states coupled to an external environment characterized by a continuum of states, into which they generally decay. It is shown that, by flipping the discrete-continuum coupling from an Hermitian to a non-Hermitian interaction, thus resulting in a non unitary dynamics, time reversal of the subsystem of discrete states can be achieved, while the continuum of states is not reversed. Exact time reversal requires frequency degeneracy of the discrete states,or large frequency mismatch among the discrete states as compared to the strength of indirect coupling mediated by the continuum. Interestingly, periodic and frequent switch of the discrete-continuum coupling results in a frozen dynamics of the subsystem of discrete states.

关键词： Non-Hermitian dynamicsTime reversalLoschmidt echo

Reply to "Discussion 1 on 'Introspection on improper seismic retrofit of Basilica Santa Maria di Collemaggio after 2009 Italian earthquake' by ***,*** and *** stefano" by Vincenzo Ciampi

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Earthquake Engineering and Engineering Vibration 2012年第2期11卷 283-288页

作者： Gian Paolo Cimellaro Andrei M.Reinhorn Alessandro De stefano Department of Structural Geotechnical & Building Engineering(DISEG)Politecnico di TorinoCorso Duca degli Abruzzi 2410129 TurinItaly Department of Civil Structural & Environmental EngineeringUniversity at Buffalothe State University of New York135 Ketter HallBuffalo NYUSA

The authors thank the discusser for his interest and careful review of the paper and his valuable comments. They also welcome this discussion,because it gives the authors the opportunity to clarify several points whic... 详细信息

关键词： Introspection on improper seismic retrofit of Basilica Santa Maria di Collemaggio after 2009 Italian earthquake by Vincenzo Ciampi Discussion 1 on Reply to De