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Oldest biliary endoprosthesis in situ

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World Journal of Gastrointestinal Endoscopy 2013年第7期5卷 356-358页

作者： Pierluigi Consolo Giuseppe Scalisi stefano F Crinò Andrea Tortora Giuseppa Giacobbe Marcello Cintolo Luigi Familiari Socrate Pallio Digestive Endoscopy Unit University Hospital98100 Messina Italy

The advantages of endoscopic retrograde cholangio-pancreatography over open surgery have made it the predominant method of treating patients with choledo-cholithiasis. After sphincterotomy, however, 10%-15% of common bile duct stones cannot be removed with a basket or balloon. The methods for managing "irretrievable stones" include surgery, mechanical lithotripsy, intraductal or extracorporeal shock wave lithotripsy and biliary stenting. The case presented was a referred 82-year-old Caucasian woman with a 7-year-old plastic biliary endoprosthesis in situ . To the best of our knowledge the examined endoprosthesis is the oldest endo-prosthesis in situ reported in the literature. Endoscopic biliary endoprosthesis placement remains a simple and safe procedure for patients with stones that are difficult to manage by conventional endoscopic methods and for patients who are unfit for surgery or who are high surgical risks. To date no consensus has been reached regarding how long a biliary prosthesis should remain in situ . Long-term biliary stenting may have a role in selected elderly patients if stones extraction has failed because the procedure may prevent stones impaction and cholangitis.

关键词： Common bile duct stones Cholangitis Biliary endoprosthesis Endoscopic retrograde cholangio-pancreatography Endoscopic sphincterotomy

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色诱狂野大地 iphone镜头着色非洲

Assessment of Potentially Attractive Tasks to Collaborative Robotics Application:A Case Study Based on Electronics Industry

摄影之友(摄影旅游) 2014年第3期

作者： stefano Pesarelli 李一毛

生活在非洲的这些年,我偏爱用手机收集那些动人的瞬间。这片狂野大地上,每天都在发生着改变,我见证马拉维天空的蓝,坦桑尼亚森林的绿,还有无处不在的大地的红。每一刻"现在"对我来说,都是一份"礼物"。（共4页)

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Journal of Mechanics Engineering and Automation 2021年第2期11卷 37-45页

作者： Mario Cesar Reis Bonifacio Jardel Silva Wolkers Matheus Salati stefano Parenti Netto Francisco IgnacioGiocondo Cesar Ieda Kanashiro Makiya Paulista University LimeiraSP 13485-342Brazil Flextronics Institute of Technology FITJaguariuna 13918-900Brazil Federal Institute of Sao Paulo IFSPPiracicabaSP 13414-155Brazil School of Applied Sciences UNICAMPLimeiraSP 13484-350Brazil

The use of robotics in the electronics industry has been of great importance to raise productivity and quality *** compared to the classic industrial robots,the collaborative ones present themselves as a trend,bringing greater flexibility,improving ergonomics,shortening implementation time and degree of ***,the correct definition of their use,when compared to industrial robots,still needs more understanding and discussion so as not to become an intuitive *** objective of this work is to present a methodology based on a time and motion study to define the tasks which have the greatest potential to be automated and to be implemented with *** validate this methodology,two consecutive stations of a packaging assembly line of smartphones were *** obtained results show feasibility and applicability in the tested solution,allowing it to be applied in other situations.

关键词： Collaborative robots automation methodology

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设计的品质——一种可行的发展战略

家具与室内装饰 2008年第6期 71-71页

作者： stefano Grande Carlo Vanicola Keiga Hung P&V

近期的设计为我们带来许多意义非凡的新元素。但同时,在国际间也存在着更激烈的竞争。由于文化的创新结合,与科技形式的演进,远不同于过往任何时代,当代设计也衍生发展出一种新的概念:设计与产品的『品质』俨然已成为一种不可忽略的趋势... 详细信息

近期的设计为我们带来许多意义非凡的新元素。但同时,在国际间也存在着更激烈的竞争。由于文化的创新结合,与科技形式的演进,远不同于过往任何时代,当代设计也衍生发展出一种新的概念:设计与产品的『品质』俨然已成为一种不可忽略的趋势了,『品质』逐渐成为备受瞩目的事实。一方面,它刺激人们的感受进而影响其使用物品的方法:另一方面,它也扩大使用者与物品之间的互动,同时带来广大的消费群。

关键词：使用者 Th 消费生产关系

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对《美德论》第9节的两条校订建议

清华西方哲学研究 2018年第2期 211-221页

作者：斯特法诺·巴岑迪特·朔耐克胡磊(译) 意大利米兰大学哲学系德国锡根大学哲学系清华大学哲学系

康德的晚年著作《道德形而上学》对于理解其整个道德哲学体系来说具有重要意义。但由于多种原因,这部著作在文本结构上存在很多问题:这些问题使得该书实际出版的文本结构与康德自己所设计的文本结构有诸多差异。有鉴于此,本文的两位作... 详细信息

康德的晚年著作《道德形而上学》对于理解其整个道德哲学体系来说具有重要意义。但由于多种原因,这部著作在文本结构上存在很多问题:这些问题使得该书实际出版的文本结构与康德自己所设计的文本结构有诸多差异。有鉴于此,本文的两位作者对该著作中的第二部分——《美德论的形而上学的初始根据》——之第9节('论说谎')的文本结构提出了两条校订建议,并且基于对本节文本内容的细致梳理,为两条建议分别给出了理由。这两条建议也已经被采纳进由BerndLudwig编辑、费利克斯·迈纳出版社(Felix Meiner Verlag)于2017年出版的最新德文版《美德论的形而上学的初始根据》中。本文将有助于引起研究者们对《道德形而上学》文本结构的关注,并促进他们对书中相关思想的研究。

关键词：《美德论》第9节文本结构校订建议说谎

Diffusion-weighted MRI in a liver protocol: Its role in focal lesion detection

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World Journal of Radiology 2012年第7期4卷 302-310页

作者： stefano Palmucci Letizia Antonella Mauro Martina Messina Brunella Russo Giovanni Failla Pietro Milone Massimiliano Berretta Giovanni Carlo Ettorre Radiodiagnostic and Oncological Radiotherapy Unit University Hospital "Policlinico-Vittorio Emanuele" 95123 Catania Italy Department of Medical Oncology National Cancer Institute 33081 Aviano (PN) Italy

AIM: To evaluate the role of diffusion-weighted imaging (DWI) in the detection of focal liver lesions (FLLs), using a conventional magnetic resonance imaging (MRI) protocol. METHODS: Fifty-two patients (22 males, average age 55.6 years, range: 25-82 years), studied using a 1.5 Tesla magnetic resonance scanner, were retrospectively analyzed; detection of FLLs was evaluated by considering the number of lesions observed with the following sequences: (1) respiratory-triggered diffusion-weighted single-shot echo-planar (DW SS-EP) sequences; (2) fat-suppressed fast spin-echo (fs-FSE) T2 weighted sequences; (3) steady-state free precession (SSFP) images; and (4) dynamic triphasic gadolinium-enhanced images, acquired with three-dimensional fast spoiled gradient-echo (3D FSPGR). Two radiologists independently reviewed the images: they were blinded to their respective reports. DW SS-EP sequences were compared to fs-FSE, SSFP and dynamic gadolinium-enhanced acquisitions using a t -test. Pairs were compared for the detection of: (1) all FLLs; (2) benign FLLs; (3) malignant FLLs; (4) metastases; and (5) hepatocellular carcinoma (HCC). RESULTS: Interobserver agreement was very good (weighted = 0.926, CI = 0.880-0.971); on the consensus reading, 277 FLLs were detected. In the comparison with fs-FSE, DW SS-EP sequences had a significantly higher score in the detection of all FLLs, benign FLLs, malignant FLLs and metastases; no statistical difference was observed in the detection of hepatocellular carcinoma (HCCs). In the comparison with SSFP sequences, DW SS-EP had significantly higher scores (P < 0.05) in the detection of all lesions, benign lesions, malignant lesions, metastases and HCC. All FLLs were better detected by dynamic 3D FSGR enhanced acquisition, with P = 0.0023 for reader 1 and P = 0.0086 for reader 2 in the comparison with DW SS-EP sequences; with reference to benign FLLs, DW SS-EP showed lower values than 3D FSPGR enhanced acquisition (P < 0.05). No statistical diff

关键词： Diffusion weighted magnetic resonance imaging Liver Liver disease Magnetic resonance imaging

神圣的气氛:以一座集市中的巴洛克教堂为案例研究

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马克思主义美学研究 2022年第2期25卷 56-65,466页

作者： [意大利]伊丽莎白·迪·斯蒂法诺曹凌霄(译) 意大利巴勒莫大学浙江大学

尽管建筑常常赋予以几何为基础的笛卡尔空间和视觉范式关键地位,气氛美学也可以为探索客观环境和主观表达之间的关系提供进一步的理论视角。本文强调,气氛美学应综合各种感官,作为整合传统建筑史观点的有效诠释工具。为了证明这一点,本... 详细信息

尽管建筑常常赋予以几何为基础的笛卡尔空间和视觉范式关键地位,气氛美学也可以为探索客观环境和主观表达之间的关系提供进一步的理论视角。本文强调,气氛美学应综合各种感官,作为整合传统建筑史观点的有效诠释工具。为了证明这一点,本文将重点对一座位于巴勒莫古老的集市的巴洛克式教堂——卡柏圣母教堂进行案例研究。

关键词：巴洛克式建筑神圣的建筑氛围美学气氛

Hypolactasia is associated with insulin resistance in nonalcoholic steatohepatitis

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World Journal of Hepatology 2016年第24期8卷 1019-1027页

作者： Daniel Ferraz de Campos Mazo Rejane Mattar Jose Tadeu stefano Joyce Matie Kinoshita da Silva-Etto Marcio Augusto Diniz Sebastiao Mauro Bezerra Duarte Fabíola Rabelo Rodrigo Vieira Costa Lima Priscila Brizolla de Campos Flair Jose Carrilho Claudia P Oliveira Division of Gastroenterology and Hepatology Department of Gastroenterology(LIM 07)University of Sao Paulo School of Medicine

AIM To assess lactase gene(LCT)-13910C>T polymorphisms in Brazilian non-alcoholic fatty liver disease(NAFLD) and nonalcoholic steatohepatitis(NASH) patients in comparison with healthy *** This was a transverse observational clinical study with NAFLD patients who were followed at the Hepatology Outpatient Unit of the Hospital das Clínicas, S?o Paulo, Brazil. The polymorphism of lactase non-persistence/lactase persistence(LCT-13910C>T) was examined by PCR-restriction fragment length polymorphism technique in 102 liver biopsy-proven NAFLD patients(steatosis in 9 and NASH in 93) and compared to those of 501 unrelated healthy volunteers. Anthropometric, clinical, biochemical and liver histology data were analyzed. Continuous variables were compared using the t or Mann-Whitney tests, and categorical data were compared with the Fisher's exact test. Univariate logistic regression and multivariate logistic regression adjusted for gender and age were *** No differences in the LCT-13910 genotype frequencies were noted between the NAFLD patients(66.67% of the patients with steatosis were CC, 33.33% were CT, and none were TT; 55.91% of the patients with NASH were CC, 39.78% were CT, and 4.3% were TT; P = 0.941) and the healthy controls(59.12% were CC, 35.67% were CT, and 5.21% were TT) or between the steatosis and NASH patients. That is, the distribution of the lactase non-persistence/lactase persistence polymorphism(LCT-13910C>T) in the patients with NAFLD was equal to that in the general population. In the NASH patients, the univariate analysis revealed that the lactase nonpersistence(low lactase activity or hypolactasia) phenotype was associated with higher insulin levels(23.47 ± 15.94 μU/m L vs 15.8 ± 8.33 μU/m L, P = 0.027) and a higher frequency of insulin resistance(91.84% vs 72.22%, P = 0.02) compared with the lactase persistence phenotype. There were no associations between the LCT genotypes and diabetes(P = 0.651), dyslipidaemia(P = 0.328), h

关键词： Lactose intolerance Genetic polymorphism Insulin resistance Non-alcoholic fatty liver disease Nonalcoholic steatohepatitis

Activity of Secondary Bacterial Metabolites in the Control of Citrus Canker

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Agricultural Sciences 2015年第3期6卷 295-303页

作者： Leticia Sayuri Murate Admilton Goncalves de Oliveira Allan Yukio Higashi Andre Riedi Barazetti Ane stefano Simionato Caroline Santos da Silva Glenda Cavalari Simoes Igor Matheus Oliveira dos Santos Marlon Renan Ferreira Martha Viviana Torres Cely Miguel Octavio Pérez Navarro Vanessa Fogaca de Freitas Marco Antonio Nogueira Joao Carlos Palazzo de Mello Rui Pereira Leite Jr. Galdino Andrade Department of Microbiology Londrina State UniversityLondrinaBrazil Embrapa Soja LondrinaBrazil Department of Pharmacy and Pharmacology Maringa State UniversityMaringáBrazil Plant Protection Agronomic Institute of ParanáIAPARLondrinaBrazil

This study investigated the protective effects of secondary bacterial metabolites, produced by Pseudomonas sp. (bacterium strain LN), on citrus canker disease caused by Xanthomonas axonopodis pv. citri (Xac 306). The LN bacteria strain was cultured in liquid medium and the supernatant free-cells was treated with methanol (AMF) and ethyl acetate (AEF), respectively, and then the extract was concentrated, filtrated, lyophilized and fractionated by vacuum liquid chromatography (VLC). After VLC, eight fractions were obtained. All fractions’ activity against Xac 306 by agar well diffusion assay and minimum inhibitory concentration but in different concentrationswere tested. Cytotoxicity effects were observed in all fractions in 50 μg·mL-1 concentration. The comet assay demonstrated that the fractions EAF, VLC2 and VLC3 presented no genotoxic effects at tested concentrations. In plants only VLC3 showed significant results (p<0.05), reducing the incidence of citrus canker lesions.

关键词： X.axonopodis pv.citri Citrus sinensis Antibiosis Biological Control Natural Antibiotic