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Pneumatosis cystoides intestinalis

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World Journal of Gastroenterology 2011年第44期17卷 4932-4936页

作者： Francesco Azzaroli Laura Turco Liza Ceroni stefania Sartoni Galloni Federica Buonfiglioli Claudio Calvanese Giuseppe Mazzella Department of Clinical Medicine Division of GastroenterologyS.Orsola-Malpighi HospitalUniversity of Bologna Department of Emergency General Surgery and TransplantationS.Orsola-Malpighi HospitalUniversity of Bologna

Pneumatosis cystoides intestinalis(PCI) is a rare condition that may be associated with a variety of *** presenting clinical picture may be very heterogeneous and represent a challenge for the *** the present paper we describe both a common and an uncommon clinical presentation of PCI and review the pertaining *** cases confirm that,apart from asymptomatic cases,the clinical presentation of PCI may be widely different and suggest that a new onset of stipsis might be the presenting *** might be suggested by a simple X-ray of the digestive tract showing a change in the characteristics of the intestinal wall in two-thirds of these ***,one third of the patients do not have a suggestive X-ray and require a computed tomography(CT) scan/nuclear magnetic resonance that may reveal a thickened bowel wall containing gas to confirm the diagnosis and distinguish PCI from intraluminal air or submucosal *** also allows the detection of additional findings that may suggest an underlying,potentially worrisome cause of PCI such as bowel wall thickening,altered contrast mucosal enhancement,dilated bowel,soft tissue stranding,ascites and the presence of portal *** results also point out that clinicians and endoscopists should be aware of the possible presentations of PCI in order to correctly manage the patients affected with this disease and avoid unnecessary *** increasing number of colonoscopies performed for colon cancer screening makes PCI more frequently casually encountered and/or provoked,therefore the possible endoscopic appearances of this disease should be well known by endoscopists.

关键词： Pneumatosis cystoides intestinalis Pneumoperitoneum Treatment Hyperbaric oxygen Endoscopy

Evidence for accuracy of pain assessment and painkillers utilization in neuropsychiatric symptoms of dementia in Calabria region,Italy

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Neural Regeneration Research 2018年第9期13卷 1619-1621页

作者： Damiana Scuteri Maria Roberta Garreffa stefania Esposito Giacinto Bagetta Maria Diana Naturale Maria Tiziana Corasaniti Preclinical and Translational Pharmacology Department of Pharmacy Health Science and NutritionUniversity of Calabria Pharmacy Unit "Mater Domini" University Hospital Department of Health Sciences University "Magna Graecia" of Catanzaro

During the clinical course of dementia,beside cognitive impairment and memory loss,a very complex challenge is posed by the neuropsychiatric symptoms（NPSs）.Accurate evaluation and treatment of pain impacts positively the agitation of demented patients aged ≥ 65 *** gather information on the utilization of pain killers in demented patients a preliminary survey has been conducted in collaboration with the Calabrian Pharmacovigilance Territorial Service of the health district of Catanzaro（Italy）.The study has taken into consideration the prescriptions of acetylcholinesterase inhibitors and memantine during the period ranging from July 2015 to June 2016 and the percentage of patients treated against pain with non steroidal antinflammatory drugs,opioids,and anticonvulsants have been *** latter have been evaluated statistically for difference between the treatment before（pre） and after（post） the settlement of acetylcholinesterase inhibitors（ACh EI） or memantine *** results do support accuracy in painkillers utilization in the course of dementia in the regional population of Calabria（Italy）.

关键词： Alzheimer's disease dementia neuropsychiatric symptoms pain appropriate prescriptions aromatherapy opioids α2δ-1 ligands

Mycobacterium avium subspecies paratuberculosis infects and multiplies in enteric glial cells

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World Journal of Gastroenterology 2007年第43期13卷 5731-5735页

作者： Leonardo A Sechi Anne Ruehl Niyaz Ahmed Donatella Usai Daniela Paccagnini Giovanna E Felis stefania Zanetti Department of Biomedical Sciences Microbiology Section University of Sassari Viale S Pietro 43/B Sassari 07100 Italy International Society of Genetic and Evolutionary Microbiology Working Group on Mycobacterial Disease Sassari Italy Department of Human Biology Technical University of Munich Hochfeldweg 2 D-85350 Freising-Weihenstephan Germany International Society of Genetic and Evolutionary Microbiology Working Group on Mycobacterial Disease Sassari Italy Pathogen Evolution Group Centre for DNA Fingerprinting and Diagnostics Hyderabad India Department of Biomedical Sciences Microbiology Section University of Sassari Viale S Pietro 43/B Sassari 07100 Italy

AIM: To establish the role of enteric glial cells during infection with Mycobacterium avium subspecies paratuberculosis (MAP) in Crohn's disease. METHODS: In order to establish the role of enteric glial cells during infection with M. avium subspecies paratuberculosis (MAP) in Crohn's disease, Map adhesion experiments on enteric glial cells were performed as well as expression analysis of Map sigma factors during infection. RESULTS: In this study, for the first time, we found a high affinity of MAP to enteric glial cells and we analyzed the expression of MAP sigma factors under different conditions of growth. CONCLUSION: The fact that Map showed a high affinity to the glial cells raises concerns about the complicated etiology of the Crohn's disease. Elucidation of the mechanisms whereby inflammation alters enteric neural control of gut functions may lead to novel treatments for Crohn's disease.

关键词： Mycobacterium avium subspecies Paratuber-culosis Enteric glial cells Inflammatory bowel diseases Crohn's disease Sigma factors expression

Sociology Between Research and the Society of Data

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Sociology Study 2021年第6期11卷 276-289页

作者： stefania Capogna Link Campus University RomeItaly

This paper focuses on how big data guide the construction of the interpretative schemata we use to understand the world and act in *** this end,the essay describes the most significant new research elements and frontiers that sociology is obliged to address at *** the prevailing literature advocates the need to promote data literacy,the idea we wish to advance is that it is necessary to foster the comprehension of data along with an understanding of the role and the responsibility which sociology has intrepidly assumed since its foundation,that is,the study and explication of the complexity of the relationships characterising social life always and *** intent is to make a proactive contribution to the study of the digitality to bring to light perverse,unexpected and/or unwanted effects associated with naive use of big data for research purposes.

关键词： sociology big data framing social research mix methods

Identification of Tumor Evolution Patterns by Means of Inductive Logic Programming

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Genomics, Proteomics & Bioinformatics 2008年第2期6卷 91-97页

作者： Vitoantonio Bevilacqua Patrizia Chiarappa Giuseppe Mastronardi Filippo Menolascina Angelo Paradiso stefania Tommasi Polytechnic of Bari 70125 Bari Italy National Cancer Institute 70126 Bari Italy Polytechnic of Bari 70125 Bari Italy National Cancer Institute 70126 Bari Italy

In considering key events of genomic disorders in the development and progression of cancer, the correlation between genomic instability and carcinogenesis is currently under investigation. In this work, we propose an inductive logic programming approach to the problem of modeling evolution patterns for breast cancer. Using this approach, it is possible to extract fingerprints of stages of the disease that can be used in order to develop and deliver the most adequate therapies to patients. Furthermore, such a model can help physicians and biologists in the elucidation of molecular dynamics underlying the aberrations-waterfall model behind carcinogenesis. By showing results obtained some hints about further approach to the hypotheses. on a real-world dataset, we try to give knowledge-driven validations of such

关键词： array comparative genomic hybridization breast cancer cancer evolution model,gene selection inductive logic programming

Update on cardiomyopathies and sudden cardiac death

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Forensic Sciences Research 2019年第3期4卷 202-210页

作者： stefania Rizzo Elisa Carturan Monica De Gaspari Kalliopi Pilichou Gaetano Thiene Cristina Basso Cardiovascular Pathology Department of Cardio-Thoracic-Vascular Sciences&Public Health and Azienda OspedalieraUniversity of Padua Medical SchoolPaduaItaly

Sudden cardiac death (SCD) remains a leading mode of death in western *** SCD can be the first and last clinical presentation of the underlying disease,autopsy could be the only medical examination available for early diagnosis and it should be performed according to the guidelines of the Association for European Cardiovascular *** the vast majority of SCD are due to coronary artery disease,non-ischemic causes of SCD do exist and are prevalent in young people with structural (***,hypertrophic and inflammatory cardiomyopathy) and non-structural (ion channel diseases)cardiomyopathies,accounting for up to one half of cases.A standardized autopsy protocol,in combination with blood sampling to ensure feasibility of postmortem molecular testing if needed,is *** pathologist is called to provide the correct diagnosis and to advice the relatives on the need of a cascade clinical and genetic screening in the presence of a heredo-familial disease.

关键词： Forensic sciences forensic pathology autopsy cardiomyopathies genetics sudden death

Chitosan tubes enriched with fresh skeletal muscle fibers for delayed repair of peripheral nerve defects

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Neural Regeneration Research 2019年第6期14卷 1079-1084页

作者： AlessANDro Crosio Benedetta Elena Fornasari Giovanna Gambarotta Stefano Geuna stefania Raimondo Bruno Battiston Pierluigi Tos Giulia Ronchi Department of Orthopedics and Traumatology II-Surgery for Hand and Upper Limb-AOU Città della Salute e della Scienza di Torino-CTO Hospital Department of Clinical and Biological Sciences University of Torino Neuroscience Institute Cavalieri Ottolenghi University of Torino UO Microchirurgia e Chirurgia della Mano Ospedale Gaetano Pini

Nerve regeneration after delayed nerve repair is often unsuccessful. Indeed, the expression of genes associated with regeneration, including neurotrophic and gliotrophic factors, is drastically reduced in the distal stump of chronically transected nerves; moreover, Schwann cells undergo atrophy, losing their ability to sustain regeneration. In the present study, to provide a three-dimensional environment and trophic factors supporting Schwann cell activity and axon re-growth, we combined the use of an effective conduit(a chitosan tube) with a promising intraluminal structure(fresh longitudinal skeletal muscle fibers). This enriched conduit was used to repair a 10-mm rat median nerve gap after 3-month delay and functional and morphometrical analyses were performed 4 months after nerve reconstruction. Our data show that the enriched chitosan conduit is as effective as the hollow chitosan conduit in promoting nerve regeneration,and its efficacy is not statistically different from the autograft, considered the "gold standard" technique for nerve reconstruction. Since hollow tubes not always lead to good results after long defects(> 20 mm), we believe that the conduit enriched with fresh muscle fibers could be a promising strategy to repair longer gaps, as muscle fibers create a favorable three-dimensional environment and release trophic factors. All procedures were approved by the Bioethical Committee of the University of Torino and by the Italian Ministry of Health(approval number: 864/2016/PR) on September 14, 2016.

关键词： tubulization Schwann cells scaffold tissue engineering nerve reconstruction morphometrical analyses grasping test secondary repair median nerve nerve regeneration

Natural killer cells activity in a metastatic colorectal cancer patient with complete and long lasting response to therapy

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World Journal of Clinical Cases 2017年第11期5卷 390-396页

作者： Alessandro Ottaiano Maria Napolitano Monica Capozzi Salvatore Tafuto Antonio Avallone stefania Scala Department of Abdominal Oncology Istituto Nazionale per lo Studio e la Cura dei Tumori "Fondazione Giovanni Pascale" - I.R.C.C.S. Immunology Unit Istituto Nazionale per lo Studio e la Cura dei Tumori "Fondazione Giovanni Pascale" - I.R.C.C.S.

Here we report a case of a 70-year-old man who received adjuvant chemotherapy with fluorouracile, folinic acid and oxaliplatin after a left hemicolectomy for a stage Ⅲb adenocarcinoma in May 2009. During followup he de-veloped abdominal lymphnodes metastases evidenced by positron emission tomography-computed tomography(PET-CT) scan and increase of carcinoembryonic antigen(CEA) level. Chemotherapy with capecitabine, oxaliplatin and bevacizumab was started in April 2012. Restaging showed a complete response and normalization of CEA. The patient received maintenance therapy with bevacizumab which was stopped in December 2013 for patient choice. In October 2014, a new increase in CEA was documented and PET-CT scan showed lung metastases. Analysis of RAS status revealed the absence of mutations, then the patient started a second-line chemotherapy with fluorouracile, folinic acid, irinotecan(folfiri) and panitumumab achieving, in January 2015, a complete response and normalization of CEA. Thereafter, folfiri was discontinued for toxicity; furthermore, upon the third occurrence of a grade 3 dermatologic toxicity, panitumumab was continued from June 2015 at 60% of the original dose and it was administered every three weeks. Until presentation of this case, the patient maintains a complete response, has no symptoms of disease and CEA is normal. Interestingly, this patient presented a high proportion of circulating natural killer(NK) cells(35.1%) with high cytotoxic activity against tumor cells. Study on the role of NK in patients with advanced colorectal cancer are ongoing.

关键词： Colorectal cancer Panitumumab Natural killers Regulatory cells Chemotherapy

Emerging environmental stressors and oxidative pathways in marine organisms:Current knowledge on regulation mechanisms and functional effects

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BIOCELL 2022年第1期46卷 37-49页

作者： MAURA BENEDETTI MARIA ELISA GIULIANI MARICA MEZZELANI ALESSANDRO NARDI LUCIA PITTURA stefania GORBI FRANCESCO REGOLI Dipartimento di Scienze della Vitaedell’Ambiente UniversitàPolitecnica delle MarcheAncona60131Italy

Oxidative stress is a critial condition derived from the imbalance between the genention of reactive oxygen species and the sophisticated network of antioidant *** pollut ants and envronmental factors can afet this system through connected mechanisms,indirect relationships,and cascade effects from pre-transcriptional to catalytic level,by either enhancing intracellular ROS formation or impairing antioxidant *** review summariaces the current kmnowledge on the pro oxidant challenges from emerging environmental stressors threatening marine organisms,such as pharmaceutials microplastics and dimate related ocean *** will be placed on oxidative pathways,including signaling proteins and transcription factors involved in regulation of antioxidant *** insights and lack of knowdedge will be pointed out by presenting single and combined efects of multiple stessors,unraveling questions to be adresed by future resarch in marine ectoicology.

关键词： Antioxidant Pharmaceuticals Microplastics/Nanoplastics Ocean acidification Thermal stress